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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Current Urology

Explainable artificial intelligence in prostate and bladder cancer: A review of imaging, digital pathology, molecular profiling, and clinical data

Dimitrios Diamantidis, Georgios Tsakaldimis, Nikolaos Smyrlis, Chousein Chousein, Charalampos Kafalis, Konstantina Foutzitzi, Evangelia Deligeorgiou, Nikolaos Panagiotopoulos, Stavros Lailisidis, Chrysostomos Georgellis, Stavros Giannopoulos, Stilianos Giannakopoulos, Christos Kalaitzis

Artificial intelligence (AI) models are increasingly applied across the detection, staging, treatment selection, and surveillance of prostate and bladder cancer. Explainable AI links predictions to identifiable features, spatial regions, or architectural constraints, supporting clinical audit and informed use. This narrative review synthesizes evidence across both cancers in imaging, digital pathology, molecular and liquid-biopsy data, and clinical applications and assesses deployment readiness. Two parallel struct …

25.08.2026journal-article

Nature Communications

SPOP-mediated ZMYND8 ubiquitination and phase separation exclusion drives mTOR inhibitor resistance in kidney cancer

Bo Tang, Rui Sun, Jingwei Shao, Qi-You Wu, Yuqian Yan, Dejie Wang, Zhixian Yu, Lianxin Hu, Yicheng Chen, Chengheng Liao, Qiang Wei, Yige Bao, Haojie Huang

Abstract mTOR inhibitors including everolimus and temsirolimus have been approved by US FDA for treatment of clear cell renal cell carcinoma (ccRCC) in clinic. However, resistance to these drugs has been inevitable and the underlying mechanism remains poorly understood. Histone modifier ZMYND8 paradoxically acts as a transcription coactivator or corepressor. Here we show that SPOP, a CULLIN3-RING E3 ubiquitin ligase (CRL) substrate-binding protein that is often overexpressed in ccRCC in patients, promotes K63-linke …

25.08.2026journal-article

International Journal of Molecular Sciences

CHEK2 Germline Variants in Cancer Predisposition: Whole Genome Sequencing Results

Marina V. Nemtsova, Maria V. Makarova, Anastasiia M. Danishevich, Maria M. Byakhova, Olesya S. Mishina, Alevtina E. Kiseleva, Maxim S. Belenikin, Anastasia A. Krinitsina, Olesya V. Sagaydak, Anna B. Semenova, Natalia A. Bodunova, Igor E. Khatkov, Irina A. Demidova, Aleksey S. Tsukanov, Vsevolod N. Galkin, Saida M. Gadzhyeva

While pathogenic germline CHEK2 variants are known to increase cancer risk, there is currently insufficient evidence regarding the precise risk of developing malignant neoplasms associated with specific missense variants or variants of uncertain significance. As a result, no clear clinical guidelines exist regarding consultation, monitoring and specific treatment options for those patients. For the first time in Russia, clinical data and whole-genome sequencing (WGS) results were analyzed for 3150 patients with can …

25.08.2026journal-article

Cells

PDCD10-Deficient Tumor Cells Reprogram Angiogenesis Through Paracrine Endothelial Activation and GSC-like Plasticity in GBM

Zhong-Rong Chen, Zhen Chen, Xue-Yan Wan, Maike Anna Busch, Nicole Dünker, Laurèl Rauschenbach, Ulrich Sure, Yuan Zhu

Glioblastoma (GBM) is characterized by extensive neo-angiogenesis, which drives rapid tumor growth and therapeutic resistance. We previously identified PDCD10 as a tumor suppressor in GBM. Here, we investigated whether PDCD10 loss promotes neo-angiogenesis through paracrine signaling and GBM cell plasticity. PDCD10 knockdown (shPDCD10) enhanced endothelial angiogenic activity after treatment with conditioned medium (CM) from shPDCD10 cells and in a direct co-culture model. Moreover, application of CM to the chicken …

25.08.2026journal-article

Frontiers in Pharmacology

Association of germline ABCB1 and ERCC1 polymorphisms with CDK4/6 inhibitor-induced neutropenia in patients with breast cancer: a systematic review and meta-analysis

Marina-Daniela Dimulescu, Cristian Virgil Lungulescu, Anca-Lelia Riza, Ioana Streata, Radu Antoniu Patrascu, Anca-Maria Capraru, Mihaela-Simona Naidin, Bogdan Silviu Ungureanu, Ioana Andreea Gheonea, Adina Turcu-Stiolica

Background CDK4/6 inhibitors are standard-of-care for HR+/HER2− advanced breast cancer, but grade 3/4 neutropenia occurs in up to 60% of patients. Germline polymorphisms in ABCB1 , encoding the P-glycoprotein efflux transporter, have been investigated as predictors of CDK4/6 inhibitor–induced neutropenia, with conflicting results across populations. No meta-analysis has previously pooled these findings. Methods PubMed, Scopus, and Web of Science were systematically searched. Studies reporting genotype-stratified gr …

25.08.2026journal-article

Sağlık Bilimleri Dergisi

Development and Psychometric Evaluation of the Fear of Developing Cancer Scale

Pınar Serçekuş, Elif Uludağ

Cancer is a disease that has inspired fear. There is a need for interventions to measure and reduce the fear of cancer in individuals. It is not clear how best to measure the fear of developing cancer, and there is currently no brief measurement tool available to assess this fear. This study aimed to develop and validate the Fear of Developing Cancer Scale. This is a methodological study. The study was conducted with 450 participants who had not been diagnosed with cancer in Türkiye. Data were collected with a soci …

25.08.2026journal-article

Cancer Research Communications

Community-Based Hereditary Breast and Ovarian Cancer Family History Assessment and Genetic Testing among Spanish-Speaking Hispanic/Latina Women in California

Daisy M. Montoya, Amanda F. Corpuz, Karla E. Gonzalez, Kaylee Santos, Alyssa Reed, Julie H.T. Dang, Helen K. Chew, Guadalupe Polanco-Echeverry, Lizeth I. Tamayo, Miriam T. Hernandez, Alejandra Martinez, Elad Ziv, Susan L. Neuhausen, Luis G. Carvajal-Carmona, Ysabel Duron, Laura Fejerman

Abstract Breast cancer is the most common cancer among women in the United States, and the leading cause of cancer incidence and mortality among Hispanic/Latina (H/L) women. For women with a genetic predisposition to hereditary breast and ovarian cancer (HBOC), genetic counseling has been shown to aid in the decision-making process and engagement in risk-reducing strategies for cancer prevention and early detection. However, H/L women are less likely to receive genetic testing and undergo genetic counseling than No …

25.08.2026journal-article

Scientific Reports

The impact of HIV and antiretroviral therapy on cervical cancer burden in Zambia: a modelling study

John Andoh, Herbert Kapesa, Susan Citonje Msadabwe, Albert Manasyan, Paul Kamfwa, Watson Zulu, Cliff Kerr, Matthias Egger, Eliane Rohner, Robyn Stuart, Cari van Schalkwyk

Abstract Cervical cancer is the leading cause of cancer death among women in Zambia, where widespread HIV infection elevates cervical cancer risk. However, HIV’s contribution to Zambia’s cervical cancer burden and the extent to which antiretroviral therapy (ART) has mitigated this burden, remain poorly quantified. We adapted HPVsim, an existing open-source mathematical model simulating human papillomavirus (HPV) and cervical cancer natural history, to capture the dual burden of cervical cancer and HIV in Zambian wo …

25.08.2026journal-article

Scientific Reports

Early esophageal cancer diagnosis in Central Oromia, Ethiopia: patient and provider perspectives on barriers and facilitators

Teresa Kisi Beyen, Edom Seife, Biniyam Tefera Deressa, Girma Taye, Adamu Addissie

Abstract In Ethiopia, 70–90% of esophageal cancer patients are diagnosed at advanced stages (III and IV), with the highest burden in Oromia’s Arsi and Bale zones. Despite the burden of esophageal cancer, little is known about the factors influencing its early diagnosis in Central Oromia. This qualitative study sought to address this gap by exploring barriers and facilitators from the perspectives of both patients diagnosed at late stages and healthcare providers. Between August 17 and September 26, 2025, in-depth i …

25.08.2026journal-article

Angewandte Chemie

Theranostic Potential of an NAD(P)H‐Activatable Fluorophore: Assessing Cancer Aggressiveness and Triggering Apoptosis

Yujin Cha, Taehoon Oh, Hui Joo Kim, Minju Kang, Shin A Yoon, Yul Lee, Yeon‐Ju Lee, Sun Young Park, Dong‐Sik Shin, Sung‐Kyun Ko, Jiyou Han, Min Hee Lee

ABSTRACT Molecular theranostics, integrating precise diagnosis with targeted therapy, represents a cornerstone of personalized medicine. As a pivotal metabolic cofactor, reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) is intrinsically linked to cancer progression and survival when dysregulated. In this study, we report DE‐CQ , an NAD(P)H‐activatable fluorophore that enables both cancer imaging and apoptosis. DE‐CQ allows the real‐time quantification and visualization of intracellular NAD(P)H, servin …

25.08.2026journal-article

Calcified Tissue International

Improvement of Bone Healing by Combined Treatment with Selective Androgen and Estrogen Receptor Modulators in Female and Male Rats

Komrakova Marina, Brunnert Fabian Nicolai, Anders Christian, Böker Kai Oliver, Schilling Arndt Friedrich, Roch Paul Jonathan, Hoffmann Daniel Bernd, Lehmann Wolfgang, Sehmisch Stephan

Abstract With age, both men and women experience a decline of sex-hormones and impaired bone repair. This study examined whether bone healing could be improved by combined treatment with the selective androgen and estrogen receptor modulators ostarine (Ost) and raloxifene (Ral), and compared its efficacy with monotherapy in female and male rat models. Three‑month‑old female (Experiment 1, n = 15/group) and 8‑month‑old male (Experiment 2, n = 15/group) Sprague–Dawley rats were either intact (healthy control) or ovar …

25.08.2026journal-article

Frontiers in Medicine

The use of MRI in the diagnosis of ovarian cancer

Zhenglin Li, Kunlong Meng, Xinqiao Mao, Hengrun Ju, Yuying Dong, Tong Li, Wenjia Liu, Qianqian Li

Ovarian cancer is a malignant tumor of the female reproductive system with a high mortality rate. Currently, China has the highest number of new ovarian cancer cases worldwide; therefore, preoperative diagnosis is of particular importance. Magnetic resonance imaging (MRI), with its excellent soft tissue resolution and absence of ionizing radiation risk, has become a key imaging modality for the non-invasive diagnosis of ovarian cancer in clinical practice. This article systematically reviews the latest research adv …

25.08.2026journal-article

Frontiers in Oncology

Innovative pathological and therapeutic approaches for poorly cohesive gastric cancer

Margherita Muratore, Francesco Giulio Sullo, Alessandro Bittoni, Lina Cardisciani, Martina Valgiusti, Giulia Bartolini, Luca Esposito, Chiara Molinari, Richard Camara, Alessandro Passardi

Poorly cohesive gastric cancer (PCGC) represents a biologically distinct subtype of gastric cancer, characterized by diffuse growth, marked intratumoral heterogeneity, and a consistently worse prognosis compared with other histological subtypes. Despite advances in pathological classification and molecular profiling, treatment strategies remain largely independent of histological subtype, and no specific therapeutic approaches have been established for PCGC. In this review, we summarize current evidence on the biol …

25.08.2026journal-article

Sri Lankan Journal of Applied Sciences

Enhancing Operational Efficiency in Wastewater Treatment: STOAT Modelling and Optimization of the Kurunegala WWTP

R. M. L. D. Rathnayake, W. S. C. Wijewickrama, P. G. S. N. Wimalarathne, H. C. N. Dilshan, N. M. W. Buddhika, G. B. B. Herath

This study evaluates the energy optimization potential of the Kurunegala Wastewater Treatment Plant (WWTP) using STOAT, a freely available wastewater process simulation tool. The plant’s treatment process, based on an anoxic-oxic (AO) configuration, was modelled and calibrated using measured influent and effluent quality parameters. The validated model accurately predicted key performance indicators such as BOD, TSS, ammonia, and nitrate, confirming STOAT’s reliability. Sensitivity analysis identified influent flow …

25.08.2026journal-article

Frontiers in Oncology

Case Report: Tyrosine kinase inhibitors in ROS1-rearranged and granulocyte colony-stimulating factor-producing lung squamous cell carcinoma

Ruijie Li, Shengjie Zhang, Zhenghe Liu, Xuan Wu

Background c-ros oncogene 1 (ROS1) fusions occur in less than 0.2% of lung squamous cell carcinomas (SqCCs). Concurrent production of granulocyte colony-stimulating factor (G-CSF) induces marked leukocytosis and is associated with aggressive tumor behavior and resistance to conventional therapies. Here, we report a case with this rare and aggressive dual-pathology subtype response to tyrosine kinase inhibitors. Case presentation A 53-year-old male smoker with stage IVb SqCC (cT3N3M1) presented marked leukocytosis, …

25.08.2026journal-article

International Advanced Researches and Engineering Journal

Effect of post weld heat treatment on P9 and P11 steel weld joints produced by GTAW and SMAW methods

Esin Tuğba Şimşek Çelik, Başar Ersegün Çelik, Şükrü Talaş

Post-weld stress-relieving heat treatments are commonly used to improve the mechanical performance of welded steel joints, especially when there is a risk of cracking in the weld zone. This study investigated four different welding configurations using A335 Gr. P11 and P9 pipes of different thicknesses. Firstly, an 8.18 mm-thick A335 Gr. P11 pipe was welded using the GTAW process with ER80S-B2 filler metal. Secondly, a 30 mm thick A335 Gr. P11 pipe was welded using a combination of the GTAW (ER80S-B2) and SMAW (E80 …

25.08.2026journal-article

Brain Sciences

Beyond the Plateau: Repeated Treatment Opportunities Are Associated with Improved Naming in Chronic Post-Stroke Aphasia

Sigfus Kristinsson, Sophia Coolsen, Saeed Ahmadi, Leonardo Bonilha

Background/Objectives: Speech-language treatment improves recovery in chronic post-stroke aphasia, but whether individuals continue to benefit from repeated treatment exposure remains unclear. We tested whether successive treatment episodes were associated with continued naming improvement and whether gains were reduced in later episodes relative to earlier episodes. Methods: We analyzed retrospective longitudinal data from 35 participants with post-stroke aphasia who completed at least two aphasia treatment studie …

25.08.2026journal-article

International Journal of Research in Orthopaedics

A hospital-based prospective study comparing nonoperative and operative treatment of type 2 tibial spine fractures

Rajesh Kumar, Zakir Hussain, Rajat Kumar

Background: Type 2 tibial spine fractures present a therapeutic dilemma because both nonoperative and operative treatment are commonly used, with no universal consensus regarding the optimal approach. Methods: This prospective hospital-based study included 60 patients with Type 2 tibial spine fractures treated at SMS Medical College, Jaipur, from August 2023 to July 2024. Thirty patients underwent operative fixation and 30 received nonoperative management. Outcomes assessed included complications, knee stability, r …

25.08.2026journal-article

Frontiers in Psychiatry

Association between psychological resilience and global health status/quality of life in patients with brain metastases after resection of primary non-small cell lung cancer

Caijun Dong, Yafen Jiang

Background Brain metastases after resection of primary non-small cell lung cancer (NSCLC) impose substantial burdens. We examined the concurrent association between psychological resilience and global health status/quality of life (GHS/QoL). Methods This single-center retrospective study included 207 adults who first developed brain metastases after primary NSCLC resection. Records from the 25-item Connor-Davidson Resilience Scale (CD-RISC), European Organisation for Research and Treatment of Cancer Quality of Life …

25.08.2026journal-article

Mathematics

An Uncertainty-Guided Evidential Deep Learning Framework for Reliability-Aware Multimodal Fusion in Cancer Prognosis

Yalu Huang, Yushuai Yuan, Wenbin Ye, Wenlong Ming

Background: Reliability-aware integration of heterogeneous data sources remains a fundamental challenge in multimodal deep learning: prevailing fusion strategies assume uniform reliability across sources and instances, limiting their responsiveness to data-dependent trustworthiness. Methods: We introduce REM-Fuse (Reliability-aware Evidential Multimodal Fusion), an evidential deep learning (EDL) framework in which per-source Dirichlet uncertainty adaptively weights each source through dual-channel weighting, asymme …

25.08.2026journal-article

Frontiers in Immunology

Thymic regeneration and tumor immunotherapy

Zengkuan Chen, Qi Wang, Qiqi Lu, Weiwei Liu, Xianguo Wu

The thymus, as a vital immune organ in the human body, provides the essential microenvironment for the development, differentiation, and maturation of T lymphocytes. With advancing age, the thymus gradually undergoes atrophy and degeneration, primarily characterized by structural disruption of thymic epithelial cells, leading to slowed T cell development and reduced output. Experimental studies have identified multiple regenerative pathways, including IL-7, KGF, BMP4, IL-22, RANKL, regulatory T cells, FOXN1-directe …

25.08.2026journal-article

Archives of Toxicology

The role of toll-like receptors in tributyltin-, dibutyltin-, and pentachlorophenol-induced stimulation of tumor necrosis factor-alpha (TNFα) production in human immune cells

Latoya M. Daniel, Aleshia Seaton-Terry, Ellie Bray, Meaghan Lewis, Zinia Hunter, Sophia Fisher, Brian Townsend, Margaret M. Whalen

Abstract Tributyltin (TBT), Dibutyltin (DBT), and Pentachlorophenol (PCP) are persistent environmental contaminants that increase immune-cell production of pro-inflammatory cytokines and thus have the capacity to cause chronic inflammation and its associated pathologies such as cancer, cardiovascular disorders, and autoimmune conditions. TBT has been detected in human blood at concentrations up to 260 nM, DBT up to 0.3 µM, and PCP between 0.15 and 5 µM. Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cyto …

25.08.2026journal-article

Statistics in Medicine

Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models

Lukas Owens, Dimitris Rizopoulos, Jonathan Fainberg, Sigrid Carlsson, Nicole Liso, Sean McBride, Vincent Laudone, Ruth Etzioni, Jeremy M. G. Taylor

ABSTRACT Prostate cancer patients with biochemical recurrence (BCR) face a decision of whether to start salvage therapy (ST), which may reduce the probability of metastatic progression at the cost of side effects. To inform the decision to start ST at or after BCR, models that make counterfactual predictions incorporating treatment are highly desirable. However, estimation of such models using observational data requires care due to time‐varying confounding by the longitudinal biomarker prostate‐specific antigen (P …

25.08.2026journal-article

Polymers

Curcumin-Loaded Ligand-Conjugated Chitosan Nanoparticles: A Comparative Study of Folic Acid, Phenylalanine, and Butyric Acid Conjugates for Colorectal Cancer

Chayut Fongsuk, Chutwadee Krisanapun, Duangratana Shuwisitkul

Colorectal cancer therapy requires drug delivery systems that improve treatment efficacy and minimize systemic toxicity. In this study, chitosan-based nanoparticles were fabricated and functionalized with folic acid (FA), phenylalanine (PA), and butyric acid (BA) to enhance the delivery of curcumin to Caco-2 cancer cells. The nanoparticles were prepared using an ionic gelation method, and their physicochemical properties, cellular uptake efficiency, and cytotoxicity—including safety evaluation against normal HIEC-6 …