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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Mathematics

An Uncertainty-Guided Evidential Deep Learning Framework for Reliability-Aware Multimodal Fusion in Cancer Prognosis

Yalu Huang, Yushuai Yuan, Wenbin Ye, Wenlong Ming

Background: Reliability-aware integration of heterogeneous data sources remains a fundamental challenge in multimodal deep learning: prevailing fusion strategies assume uniform reliability across sources and instances, limiting their responsiveness to data-dependent trustworthiness. Methods: We introduce REM-Fuse (Reliability-aware Evidential Multimodal Fusion), an evidential deep learning (EDL) framework in which per-source Dirichlet uncertainty adaptively weights each source through dual-channel weighting, asymme …

25.08.2026journal-article

Statistics in Medicine

Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models

Lukas Owens, Dimitris Rizopoulos, Jonathan Fainberg, Sigrid Carlsson, Nicole Liso, Sean McBride, Vincent Laudone, Ruth Etzioni, Jeremy M. G. Taylor

ABSTRACT Prostate cancer patients with biochemical recurrence (BCR) face a decision of whether to start salvage therapy (ST), which may reduce the probability of metastatic progression at the cost of side effects. To inform the decision to start ST at or after BCR, models that make counterfactual predictions incorporating treatment are highly desirable. However, estimation of such models using observational data requires care due to time‐varying confounding by the longitudinal biomarker prostate‐specific antigen (P …

25.08.2026journal-article

International Journal of Research in Orthopaedics

A hospital-based prospective study comparing nonoperative and operative treatment of type 2 tibial spine fractures

Rajesh Kumar, Zakir Hussain, Rajat Kumar

Background: Type 2 tibial spine fractures present a therapeutic dilemma because both nonoperative and operative treatment are commonly used, with no universal consensus regarding the optimal approach. Methods: This prospective hospital-based study included 60 patients with Type 2 tibial spine fractures treated at SMS Medical College, Jaipur, from August 2023 to July 2024. Thirty patients underwent operative fixation and 30 received nonoperative management. Outcomes assessed included complications, knee stability, r …

25.08.2026journal-article

Archives of Toxicology

The role of toll-like receptors in tributyltin-, dibutyltin-, and pentachlorophenol-induced stimulation of tumor necrosis factor-alpha (TNFα) production in human immune cells

Latoya M. Daniel, Aleshia Seaton-Terry, Ellie Bray, Meaghan Lewis, Zinia Hunter, Sophia Fisher, Brian Townsend, Margaret M. Whalen

Abstract Tributyltin (TBT), Dibutyltin (DBT), and Pentachlorophenol (PCP) are persistent environmental contaminants that increase immune-cell production of pro-inflammatory cytokines and thus have the capacity to cause chronic inflammation and its associated pathologies such as cancer, cardiovascular disorders, and autoimmune conditions. TBT has been detected in human blood at concentrations up to 260 nM, DBT up to 0.3 µM, and PCP between 0.15 and 5 µM. Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cyto …

25.08.2026journal-article

International Journal of Molecular Sciences

Integrative Molecular Profiling of miR-548f-3p in Triple-Negative Breast Cancer Highlights ANP32E as a Candidate Downstream Effector

Samira Behroozi, Mahdieh Salimi, Hossein Lanjanian, Najaf Allahyari Fard, Mahsa Torkamanian-Afshar, Mitra Ataei

Triple-negative breast cancer (TNBC) remains a major therapeutic challenge due to pronounced molecular heterogeneity, transcriptional plasticity, and frequent treatment resistance. MicroRNA (miRNA)-based strategies have emerged as potential approaches for modulating dysregulated gene expression networks in TNBC; however, the contribution of understudied miRNA families to TNBC-associated regulatory programs remains incompletely understood. This study aimed to investigate the tumor-suppressive role of miR-548f-3p in …

25.08.2026journal-article

Frontiers in Oncology

Perioperative management of pancreaticoduodenectomy for pancreatic ductal adenocarcinoma in a patient with moyamoya disease: a rare case report

Shuhao Bi, Zheng Wang, Hongyu Zhuang, Bo Hu, Lei Liu, Junke Wang, Hongxu Chen, Xiaojiang Ning

Background Moyamoya disease (MMD) is a rare chronic occlusive cerebrovascular disorder associated with a high risk of perioperative ischemic or hemorrhagic stroke. Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive system tumor with high surgical risk. The coexistence of MMD and PDAC is extremely rare, and no consensus on standardized perioperative management protocols has been established to date. The core clinical challenge lies in balancing the goal of radical tumor resection against the pre …

25.08.2026journal-article

PLOS One

Evaluation of the accuracy of peri-operative CEUS in measuring the effect of microwave ablation treatment of uterine fibroids, in comparison with MRI

Marie Beermann, Gudny Jonsdottir, Annika Cronsioe, Klara Hasselrot, Helena Kopp-Kallner

Objective The objective of this study was to determine if peri-operative contrast enhanced ultrasound (CEUS) is as accurate as magnetic resonance imaging (MRI) in measuring the immediate effect of microwave ablation (MWA) treatment of uterine fibroids. Secondary outcomes were ablation ratio and proportion of recurrence of treated fibroids at 6 months. Methods The study was a prospective observational trial. Seventeen patients with symptomatic uterine fibroids were included and treated with percutaneous ultrasound g …

25.08.2026journal-article

Pakistan Journal of Medical Sciences

Interlocking intramedullary nailing versus compression plating in the treatment of humeral fractures: Analysis of shoulder functional recovery, complication rates, and risk factors for reoperation

Dingtao Li, Zhanshan Zhang, Qiang Wang

Objective: To explore the effects and reoperation risks of interlocking intramedullary nailing(IMN) versus compression plating for the treatment of humeral fractures. Methodology: This was a retrospective study. Sixty patients with humeral fractures admitted to Baoding Forensic Hospital between November 2022 to November 2024 were enrolled as the study subjects. Information about surgical parameters (duration of operation [DoO], intraoperative blood loss[IBL]), postoperative shoulder function recovery, complications …

25.08.2026journal-article

Drug and Alcohol Review

Integrating Smoking Cessation With Lung Cancer Screening in Aotearoa New Zealand: Equity Considerations and Implications for Policy Development

Nina Bevin, Phyu Sin Aye, Nathan J. Harrison, Kate Parker, Karen Bartholomew, Andrew Waa, Natalie Walker, Sue Crengle

ABSTRACT International evidence increasingly supports integrating smoking cessation services within lung cancer screening programs, yet limited guidance exists for Aotearoa New Zealand, where smoking‐related harm and lung cancer disproportionately affect Māori. In this commentary, we summarise literature on smoking cessation interventions delivered alongside lung screening, focusing on intervention modality, intensity, timing and equity implications relevant to a future national program. Evidence from 25 studies an …

25.08.2026journal-article

Acta Dermato-Venereologica

Truncal Acne Is Independently Associated with Stigmatization, Poorer Treatment Adherence and Greater Healthcare Utilization: A 20-country Survey

Marco Rocha, Valérie Mangeaut, Jean-Daniel Daumont, Virginie Ribet, Charles Taieb, Bruno Halioua

Truncal acne (TA) affects 40–50% of adults with acne vulgaris and remains understudied despite its psychosocial impact. We aimed to evaluate the association of TA with stigmatization, psychosocial burden, healthcare utilization and treatment adherence, compared with exclusively facial acne (FA). We hypothesized that TA would be independently associated with greater psychosocial burden and healthcare utilization than FA alone. In this cross-sectional international online survey of 1,879 adults with physician-diagnos …

25.08.2026journal-article

Physics in Medicine & Biology

From optimization of radiation dose distributions to optimal cancer treatments

Thomas Bortfeld, Steve Webb

Abstract The history of optimization in radiation oncology is closely intertwined with the history of Physics in Medicine & Biology ( PMB ). Over the past four decades, many of the conceptual advances that transformed radiotherapy—from forward planning to inverse planning, from physical to biological optimization, and from treatment planning to treatment strategy optimization—were first reported in the pages of this journal. Looking back from the perspective of PMB’s seventieth anniversary, one can trace a remarkab …

25.08.2026journal-article

Physchem

Quantitative Comparative Evaluation of Aluminum- and Iron-Based Coagulants for Domestic Greywater Treatment

Mauricio Aarón Pérez-Romero, Iván Lenín Cruz-Jaramillo, Leonardo Gabriel Vega-Macotela, Armando Josué Piña-Díaz

Greywater treatment is an essential component of sustainable water management strategies, particularly in regions experiencing water scarcity. This study presents a quantitative comparative evaluation of three conventional inorganic coagulants—aluminum sulfate (Al2(SO4)3), ferric sulfate (Fe2(SO4)3), and ferric chloride (FeCl3)—for domestic greywater treatment using standardized jar test procedures. The initial turbidity of the greywater was 186 ± 5 NTU. Coagulant performance was assessed based on final turbidity, …

25.08.2026journal-article

Homœopathic Links

Adjuvant Homeopathic Treatment for Respiratory Sequelae following COVID-19: A Pilot Study

Bindu Sharma, Jyoti Chhikara, Pankhuri Misra, Garima Srivastava, Divya Taneja, Saurabh Mittal, Pawan Sharma, Anil Khurana, Subhash Kaushik, Karan Madan, Vijay Hadda, Randeep Guleria, Anant Mohan

Abstract Persistent respiratory symptoms are frequently reported following recovery from COVID-19 infection and may affect pulmonary function, exercise capacity, and quality of life. While supportive therapies are commonly used in clinical practice, evidence regarding integrative approaches such as homeopathy as an adjunct to conventional management remains limited. To evaluate clinical outcomes of individualized homeopathic treatment administered as an adjunct to conventional care in patients experiencing respirat …

25.08.2026journal-article

International Journal of Management, Knowledge and Learning

The Relevance of AI-Powered Analytics as a Strategic Tool for Injury Prevention in Training, Treatment, and Communication Management

Ioseb Gabelaia, Max Walgern

Today's complex sports-related injuries and the limited prevention mechanisms call for more intelligent, data-informed strategies in physical education (PE). The purpose of this research was to explore the relevance of AI-powered analytics as a strategic tool for injury prevention across training, treatment, and communication management in PE. There is a notable research gap regarding the incorporation of AI-powered analytics into educational and sports management frameworks. The authors aimed to identify key measu …

25.08.2026journal-article

Journal of Clinical Medicine

Same-Session Hybrid Embolization and Microsurgery Versus Endovascular-Only Treatment for Cerebral Arteriovenous Malformations: A Retrospective Single-Center Comparative Cohort Study

Hasan Bilen Onan, Bişar Akbaş, Ferhat Can Pişkin, Kadir Oktay, Kerem Mazhar Özsoy, Duygu Özgül Özesen, Erol Akgül

Background/Objectives: Same-session hybrid treatment joins embolization to immediate microsurgical resection under one anesthetic, closing the interval of partial devascularization that follows staged embolization. Comparative data are scarce. We set out to compare angiographic, functional and safety outcomes after hybrid and after endovascular-only treatment and to judge how far any difference reflects case selection and calendar period rather than the strategies themselves. Methods: We reviewed 43 consecutive pat …

25.08.2026journal-article

Nature Cancer

Galanin impairs tumor immunity in glioblastoma by promoting infiltration and ferroptosis resistance of myeloid-derived suppressor cells

Lizhi Pang, Yang Liu, Fei Zhou, Songlin Guo, Fatima Khan, Heba Ali, Hardik Shah, Sara Huber, Barbara Kofler, Craig M. Horbinski, Peiwen Chen

Abstract Glioblastoma (GBM) is a highly aggressive and lethal form of brain tumor that resists immunotherapy. Here we show that neuropeptide galanin (GAL) drives immunosuppression and immunotherapy resistance in GBM. Mechanistically, GBM cell-secreted GAL interacts with its receptor GALR3 on monocytic myeloid-derived suppressor cells (mMDSCs), triggering USP51-mediated deubiquitination of estrogen receptor-α, thereby engaging membrane-bound O -acyltransferase domain-containing 1 signaling. This signaling cascade, i …

25.08.2026journal-article

Pakistan Journal of Medical Sciences

Clinical efficacy of bladder hydrodistension combined with oral mirabegron and intravesical instillation in the treatment of interstitial cystitis

Lei Du, Ziyue Ma, Wenyong Xue, Wei Li

Objective: To evaluate the therapeutic efficacy of bladder hydrodistension combined with oral mirabegron and intravesical instillation in patients with interstitial cystitis(IC). Methodology: This was a retrospective study. Ninety patients diagnosed with IC at The Second Hospital of Hebei Medical University between October 2023 to October 2025 were retrospectively enrolled and randomized into two groups(n=45 each). All participants underwent cystoscopic examination followed by bladder hydrodistension. Patients in t …

25.08.2026journal-article

Journal of Clinical Oncology

The Patient Who Could Not Die

Erika Ramsdale

An oncologist meets a patient who was never born and would never die and considers what AI can (and can't) teach about the art of connection.

25.08.2026journal-article

JCO Oncology Practice

Outpatient Treatment-Related Toxicity After Hospital Discharge Among Patients Receiving Lifileucel for Advanced Melanoma

Mia Andreoli, Hannah L. Kalvin, Elizabeth R. Cathcart, Erin Walicki, Allison S. Betof, Michael A. Postow, Jae H. Park, Charlotte E. Ariyan, Katherine S. Panageas, Alexander N. Shoushtari, James W. Smithy

PURPOSE Although inpatient toxicity associated with tumor-infiltrating lymphocyte (TIL) therapy and interleukin-2 administration is well characterized, risks facing patients after hospital discharge are less understood. Better characterization of outpatient adverse events (AEs) could guide the optimal frequency and duration of follow-up in delivering care for this growing patient population. METHODS We conducted a retrospective analysis of all patients with advanced melanoma discharged from Memorial Sloan Kettering …

25.08.2026journal-article

Social Science and Human Research Bulletin

The Impact of Stigma on Access to Addiction Treatment Services in Iringa Municipality: A Case Study of Iringa Sober House

Finehas Yona Kinganga

Stigma is widely recognized as a barrier to accessing addiction treatment, yet how internal and external forms of stigma jointly constrain treatment access within community-based rehabilitation settings in Tanzania remains underexplored. This study examined the impact of stigma on access to addiction treatment services in Iringa Municipality, using Iringa Sober House as a case study, guided by two objectives: to examine the impact of internal stigma on treatment access, and to examine the impact of external stigma …

25.08.2026journal-article

Scientific Reports

Combined disulfiram and MK-8776 treatment reveals cell line–dependent antitumor activity in different 3D ovarian cancer subtypes

Wiktoria Bębenek, Arkadiusz Gajek, Aneta Rogalska

Abstract Disulfiram (DSF) is an FDA-approved drug with pleiotropic anticancer activity, including induction of cellular stress and effects on stemness-associated phenotypes in ovarian cancer. Here, we investigated whether DSF enhances the antitumor efficacy of the CHK1 inhibitor MK-8776 in ovarian cancer models, with emphasis on 3D spheroids that better reflect tumor architecture than conventional monolayer culture. Initial 2D screening confirmed cytotoxic activity of both agents, whereas the models used for subseq …

25.08.2026journal-article

Frontiers in Immunology

Decoding the tumor microenvironment of triple-negative breast cancer: from immune evasion to precision immunotherapy

Hongyu Cao, Meicheng Tao, Xuepeng Qin, Hong Guo

Triple-negative breast cancer (TNBC) represents a highly aggressive breast cancer subtype characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression, resulting in limited targeted therapeutic options and poor clinical outcomes. Although immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of TNBC, therapeutic responses remain restricted to a subset of patients due to substantial heterogeneity within the tumor immune microenvironment (TIME). Increasing evide …

25.08.2026journal-article

Cancer Imaging

Krenning score enhances integrated biomarker models for survival prediction in PRRT-treated GEP-NET: a retrospective cohort study

Christian A. Dascalescu, Felix L. Herr, Ricarda Ebner, Victoria Fusch, Moritz L. Schnitzer, Matthias P. Fabritius, Christine Schmid-Tannwald, Mathias J. Zacherl, Vera Wenter, Matthias Brendel, Adrien Holzgreve, Christoph J. Auernhammer, Christine Spitzweg, Thomas Knösel, Tanja Burkard, Jens Ricke, Johannes Rübenthaler, Maurice M. Heimer, Gabriel T. Sheikh, Rudolf A. Werner, Konrad Klimek, Clemens C. Cyran

Abstract Background Purpose of this study is to evaluate the value of a routinely available baseline SSTR-PET imaging parameter, the Krenning score (KS), within integrated biomarker models for overall survival prediction in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients undergoing peptide receptor radionuclide therapy (PRRT). Methods We retrospectively analyzed 178 patients with GEP-NET who underwent PRRT. At baseline, the KS, clinical, histopathological, and laboratory parameters were integrated an …

25.08.2026journal-article

Cancer Science

Elucidating PI3K / AKT / PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR +/ HER2 − Metastatic Breast Cancer

Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino

ABSTRACT Alterations in the PI3K signaling pathway are common in hormone receptor‐positive (HR+)/HER2‐negative metastatic breast cancer (MBC) and are associated with response to PI3K and AKT inhibitor‐targeted therapies. When metastasis biopsy is unavailable for genetic testing, circulating tumor DNA (ctDNA) analysis is an alternative strategy for tumor genotyping, but it is less sensitive for gain and loss analysis. Here, we assess molecular alterations of the genes of this axis— PIK3CA , AKT1 , and PTEN —in circu …