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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

International Journal of Creative and Open Research in Engineering and Management

A Modular Multimodal Framework for Automated Misinformation Investigation: Integrating OCR, NLP, Vision-Language Captioning, and Speech Analysis for Evidence-Based Trust Scoring

Shivani Tiwari

The rapid spread of manipulated images, doctored videos, and misleading text across digital platforms has created a pressing need for automated tools that can assist human fact-checkers rather than replace them. This paper presents the design and implementation of a modular, multimodal misinformation investigation platform that combines optical character recognition (OCR), natural language processing (NLP), vision-language image captioning, and automatic speech recognition (ASR) within a single evidence-fusion pipe …

19.08.2026journal-article

Healthcare

Explainable Machine Learning for Concurrent Screening of Elevated Work-Related Fatigue Using Routine Working-Hour and Occupational Health Data Among Manufacturing Workers: A Cross-Sectional Model Development and Internal Validation Study

Chien-Chih Wang, Ming-Shu Chen

Background: Work-related fatigue is a preventable occupational health concern in high-intensity manufacturing environments. However, supervisors and occupational health services often lack transparent criteria to support the preventive review of overtime practices. This study developed and internally validated an explainable human-in-the-loop concurrent screening model to identify employees with currently elevated work-related fatigue using routinely collected working-hour records and occupational health examinatio …

19.08.2026journal-article

Supportive Care in Cancer

Oral rehabilitation of patients with cancer: challenges following surgical resection

Sérvulo da Costa Rodrigues Neto, Thaís Cristina Araújo Moreira, Marta Maria Alves Pereira, Mila Oliveira Santos Viana

Abstract Objective To discuss the main challenges in oral rehabilitation of patients with oral cancer after surgical resection and to present viable strategies to overcome these limitations. Methods A comprehensive literature search was conducted and the principal clinically relevant challenges identified were reduced bone height, flap volume, glossectomy, limited mouth opening, velopharyngeal dysfunction, and xerostomia. Results Maxillary palatal ramp prostheses, mandibular guidance prostheses, and twin occlusion …

19.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

Design and Development of a Real-Time Indian Sign Language Conversion System to Text and Speech Using ISLGesture50 Dataset

Chirag R. Prajapati, Atul M Gonsai

Indian Sign Language (ISL) is the first language for millions of deaf and mute people in India. However, the development of efficient, real, time automatic ISL interpretation systems has been hindered by numerous challenges such as signer variability, scarcity of large annotated datasets, complicated hand articulations, and time constraints for processing. In this work, we demonstrate a real, time vision, based system for transforming Indian Sign Language gestures into Hindi text and speech, which involves the crea …

19.08.2026journal-article

Industry and Higher Education

Linking occupational prestige to entrepreneurial intention: The roles of perceived desirability and entrepreneurship education

Ayse Merve Urfa Yilmaz

This study examines the relationship between occupational prestige and university students’ entrepreneurial intention by drawing on the Entrepreneurial Event Model (EEM) and complementing it with Organismic Integration Theory (OIT). A moderated mediation model is proposed in which perceived desirability mediates the relationship between occupational prestige and entrepreneurial intention, while entrepreneurship education moderates the relationship between perceived desirability and entrepreneurial intention. Using …

19.08.2026journal-article

Urology Research and Practice

Impact of Neoadjuvant Androgen Deprivation Therapy on Urinary Continence and Longitudinal Quality of Life After Robot-Assisted Radical Prostatectomy

Hisanori Taniguchi, Junichi Ikeda, Yuki Masuo, Hidefumi Kinoshita

Objective: Neoadjuvant androgen deprivation therapy (ADT) is commonly administered before robot-assisted radical prostatectomy (RARP) in selected patients with localized prostate cancer, particularly those with high-risk disease. Despite its potential oncologic benefits, the association of neoadjuvant ADT with postoperative urinary function and health-related quality of life remains unclear. Therefore, this study aims to evaluate the association between neoadjuvant ADT and functional recovery following RARP. Method …

19.08.2026journal-article

Frontiers in Cardiovascular Medicine

Multitarget mechanisms and clinical integration of traditional Chinese medicine in cardiac rehabilitation: a narrative review

Yali Zhang, Jiahui Zhang, Shiwan Deng, Luting Zhao, Xiaoxia Yu

Cardiovascular diseases (CVD) are a major global public health burden. Annually in the United States, over one million patients undergo arduous cardiac rehabilitation (CR) after experiencing cardiovascular events such as myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass grafting, cardiac valve surgery, and heart transplantation. Although CR can reduce mortality, it fails to fully address residual risks, including chronic inflammation, autonomic dysfunction, and psychologic …

19.08.2026journal-article

Diagnostics

Two-Dimensional Cephalometric Assessment of Skeletal and Dentoalveolar Changes Following Alt-RAMEC with a 2-Hinged Maxillary Expander and RME/Facemask Therapy in Skeletal Class III Patients with Maxillary Retrusion: A Retrospective Comparative Study

Nuri Can Tanrısever, Hatice Gökalp

Background/Objectives: This retrospective cephalometric study evaluated skeletal, alveolar, and dentoalveolar changes following alternate rapid maxillary expansion and constriction using a two-hinged maxillary expander (Alt-RAMEC/2-HME) and rapid maxillary expansion with facemask therapy (RME/FM) in skeletal Class III patients with maxillary retrusion, using a Le Fort I osteotomy group as a surgical reference. Methods: Pre-treatment (T0) and post-treatment (T1) lateral cephalometric radiographs of 42 patients were …

19.08.2026journal-article

Soft Science

Hypoxia-responsive soft biohybrid bacteria for breast cancer therapy

Yunshi Li, Yuejun Jiang, Weilin Lu, Yalin He, Hong Wang, Cong Xu, Hanfeng Qin, Hao Tian, Yingfeng Tu, Yingjia Li, Lihan Shen

Because of their distinct physical and chemical characteristics, soft materials with low modulus, great deformability, and large compliance have progressively emerged as a significant area of study. However, the responsiveness of traditional soft materials is inherently limited by passive diffusion and equilibrium thermodynamics. Thus, by incorporating stimuli-responsive artificial materials into motile bacterial species with anticancer properties, a soft biohybrid bacterial system has been created, converting soft …

19.08.2026journal-article

New Zealand Journal of Music Therapy

Establishing a Music Therapy Programme in a Specialist Children’s Palliative Care Service in Aotearoa, New Zealand: Benefits and Challenges

Angela Jeong, Gemma Aburn

This paper outlines the development and delivery of a philanthropically funded music therapy programme within a specialist paediatric palliative care (PPC) service in Aotearoa, New Zealand. Developed in partnership with a music therapy centre, the initiative sought to address needs of children with serious illness and their whānau (family), especially those experiencing medical fragility, social isolation, and limited access to therapeutic services. The programme, delivered predominantly in the home environment, ut …

19.08.2026journal-article

Media Publikasi Promosi Kesehatan Indonesia (MPPKI)

Towards Health-Promoting Occupational Health and Safety in Aluminium Smelter Feasibility Planning: A Macroergonomic Case Study

Ahmadan Ulul Azmi, Hendra Djamalus

Introduction: Aluminium smelter feasibility studies must address not only technical and economic viability but also the early design of a safe socio-technical work system. This study evaluated how occupational safety, process safety, human factors, contractor interfaces, and operational readiness were integrated into one aluminium smelter feasibility study Methods: An evaluative qualitative case study combined a structured document review, literature- and standards-based benchmarks, and semi-structured interviews w …

19.08.2026journal-article

Discover Applied Sciences

Automated depression detection from human speech using acoustic feature analysis and deep learning

Abhay Sharma, Partha Paul, Rekha Chaturvedi, Kamlesh Lakhwani, Anubhava Srivastava

Abstract Depression is a prevalent mental health condition impacting millions worldwide; however, many cases remain undiagnosed due to social stigma, limited clinical accessibility, and reliance on subjective assessment methods. Automated speech analysis offers a promising, non-invasive approach for early diagnosis by identifying behavioral and physiological patterns expressed in vocal features. This study proposes a novel multimodal depression recognition framework that combines handcrafted acoustic characteristic …

19.08.2026journal-article

Chinese Medical Journal

Extracellular matrix targeting peptide functionalized plant-derived lipid nanoparticles for gene therapy in osteoarthritis

Zoya Iqbal, Maryum Shabbir, Faiz Rasul, Jiang Xia, Hui Zeng, Yujie Liang, Li Duan

Abstract Background: The pathogenesis of osteoarthritis (OA) involves the degradation of the extracellular matrix (ECM) of cartilage, which is mainly mediated by matrix metalloproteinases (MMPs). Small interfering RNA (siRNA)-based gene therapy has shown promise in treating various diseases, including OA, but its effectiveness is hindered by poor stability and low uptake efficiency. Additionally, the avascular nature of cartilage poses a challenge for drug delivery. This study aims to develop a novel plant-derived …

19.08.2026journal-article

Science Translational Medicine

A phase 1 feasibility trial of BE-CAR33, an “off-the-shelf” base-edited CAR33 T cell therapy for acute myeloid leukemia

Christos Georgiadis, Robert Chiesa, Hebatalla Rashed, Bethany K. Hughes, Roland Preece, Oliver Gough, Danielle Pinner, Stuart Adams, Rebecca Thomas, Annie Etuk, Avijeet Mishra, Hong Zhan, Toni Braybrook, Kimberly Gilmour, Victoria Potter, Jack Bartram, Phillip Ancliff, Martin Sauer, Waseem Qasim, for the Base Edited-CAR T cell group, Syed Farhatullah, Akshay Joshi, Renuka Kadirkamanathan, Agnieszka Kubat, Batoul Ahmed, Antonio Grasso, Antonio Perez-Martinez, Anupama Rao, Archana Rauthan, Arina Lazareva, Barry Flutter, Carolyn Chan, Catherine Crosby, Cheryl Hua, Danny Cheng, David O’Connor, Elizabeth Rivers, Hamza Patel, Harini Rao, Ilaria Schena

Chimeric antigen receptor (CAR) T cell therapy for acute myeloid leukemia (AML) is constrained by antigen heterogeneity and shared expression with healthy compartments, and there are often challenges in obtaining autologous T cells from heavily pretreated patients. To address these challenges, we developed universal donor-derived, base-edited, anti-CD33 CAR T cells (BE-CAR33) that used precise multiplexed cytidine deamination to simultaneously disrupt the TRAC , CD52 , and CD7 loci to prevent graft-versus-host dise …

19.08.2026journal-article

Medwave

Efficacy and safety of goserelin vs. leuprolide in premenopausal breast cancer patients receiving adjuvant endocrine therapy: A retrospective cohort study

Jiahao Xu, Yicheng Tai, Qi Fang, Hui Xue, Nan Hu

Introduction Goserelin and leuprolide are gonadotropin-releasing hormone (GnRH) agonists used for ovarian function suppression in premenopausal breast cancer patients. Whether their different molecular structures lead to clinically meaningful differences in efficacy and safety remains unclear. Objectives To compare the efficacy and safety of goserelin versus leuprolide as adjuvant endocrine therapy (combined with tamoxifen) in premenopausal women with hormone receptor-positive breast cancer after curative surgery. …

19.08.2026journal-article

Food Ethics

Balancing Public Health and Commercial Speech: The Case for Front-of-Pack Warning Labels

Darshen Naidoo, Mikateko Mafuyeka, Aisosa Jennifer Omoruyi, Petronell Kruger

Abstract The rising burden of non-communicable diseases (NCDs) has intensified global attention on the commercial determinants of health, particularly the marketing and labelling practices of the food and beverage industry. In South Africa, Draft Regulation R.3337 proposes mandatory front-of-pack warning labels (FOPL) and marketing restrictions on unhealthy foods and beverages, aligning with international standards and WHO guidance. These measures, however, face strong opposition from industry stakeholders who invo …

19.08.2026journal-article

INTERNATIONAL JOURNAL OF SOCIAL SCIENCES AND MANAGEMENT RESEARCH

Effects of Cognitive Behavioural Therapy on the Financial Goals and Financial Budgeting Skills of Secondary School Teachers in Ganye, Adamawa State, Nigeria

Rahab Suvallari Joel Pweddon

The study investigated the effects of cognitive behavioural therapy (CBT) on the financial goals and financial budgeting skills of secondary school teachers in Ganye, Adamawa State, Nigeria. The study used a true experimental research design, especially the pre-test -post-test control group design. The population consisted of all 341 teachers from the 40 Government Secondary Schools (GSS) in Ganye Local Government Area of Adamawa State. The sample of 60 teachers were randomly assigned to two equal groups 30 teacher …

19.08.2026journal-article

Internal Medicine Journal

Tigecycline combination therapy for fulminant Clostridioides difficile infection: an Australian experience

Emma Bishop, Tanya Ravipati, Steven Mileto, Eugene Athan, Dena Lyras, Ravindranath Tiruvoipati

Abstract Background Recent European Society of Clinical Microbiology and Infection and Australasian Society of Infectious Diseases Clostridioides difficile infection (CDI) management guidelines endorse the addition of intravenous tigecycline in patients who are progressing to fulminant infection. However, there are very limited data regarding clinical outcomes with this approach. Aims We aimed to evaluate mortality and adverse outcomes after tigecycline combination therapy was commenced at the time of fulminant CDI …

19.08.2026journal-article

Research, Society and Development

Descontinuação da terapia farmacológica na insuficiência cardíaca com fração de ejeção melhorada: Uma revisão narrativa sobre risco de recaída e fatores associados

Giovanna Cardoso Maia

A insuficiência cardíaca com fração de ejeção melhorada (ICFEm) caracteriza-se pela elevação da fração de ejeção do ventrículo esquerdo após período prévio de disfunção sistólica, sem que isso represente, necessariamente, resolução definitiva da doença miocárdica. Este estudo teve como objetivo analisar criticamente as evidências disponíveis sobre a descontinuação ou desintensificação da terapia farmacológica em pacientes com ICFEm, com ênfase no risco de recaída e nos fatores associados à recorrência. Trata-se de …

18.08.2026journal-article

Frontiers in Oncology

NED-oriented oncology in metastatic breast cancer: a hypothesis-driven framework integrating the tumor immune microenvironment, antibody-drug conjugates, and metastasis-directed therapy

Shinichiro Kashiwagi

Metastatic breast cancer (MBC) has traditionally been managed as an incurable systemic disease in which the main goals are survival extension, symptom control, and preservation of quality of life. This principle remains appropriate for most patients. However, contemporary systemic therapies, high-resolution imaging, antibody-drug conjugates (ADCs), immune checkpoint inhibition, liquid biopsy, and metastasis-directed therapy (MDT) have made prolonged no evidence of disease (NED) clinically recognizable in selected p …

18.08.2026journal-article

Indian Journal of Plastic Surgery

Closed-Incision Negative Pressure Wound Therapy in 18-Days Old Neonate: A Case Report

Kamlesh Kumar, Manoj Johar, Digjeet Kaur

Abstract The most common challenge in neonatal meningomyelocele repair is wound dehiscence due to fragile skin, elevated cerebrospinal fluid (CSF) pressure, and limited soft-tissue reserves. While flap-based reconstruction provides durable coverage, maintaining suture-line integrity remains a significant challenge. This case report describes the successful use of closed-incision negative pressure wound therapy (ciNPWT) as an adjunct following flap reconstruction in an 18-day-old neonate with a ruptured lumbosacral …

18.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Associations between work-related musculoskeletal symptoms, physical activity, and quality of life among vocational high school students: A cross-sectional comparative study

Ahsen Öztaş, Fatma Demir, A. Aktuğ Ertekin

Background Early exposure to different physical workloads during vocational education may influence musculoskeletal symptoms, physical activity patterns, and quality of life before entry into working life. Understanding these relationships is important for preventive rehabilitation strategies. Objective To compare musculoskeletal symptoms, physical activity levels, and health-related quality of life between vocational high school students from different programs and to examine the associations among these variables …

18.08.2026journal-article

Lecture Notes in Education Psychology and Public Media

A Review on Gender Differences in Minors with Autism Spectrum Disorder and the Application of Music Therapy

Fengdi Zhang

Nowadays, Autism Spectrum Disorder (ASD) is not far from us, it exists in different people with different ages or jobs. ASD is congenital and currently incurable, yet several systematic interventions exist. Besides conventional approaches, music and other creative therapies are widely used as adjuncts to primary treatment, and they have shown effectiveness. While patients with ASD may appear similar, symptom presentation varies due to multiple factors—among which gender is the focus of this essay. In this essay, I …

18.08.2026journal-article

International Journal of Molecular Sciences

Toward Standardized Platelet-Rich Plasma Therapy in Tendon Healing: Integrating Biological Characterization with Clinical Translation

Jeries Issa Alghishan, Bogdan Andor

Platelet-rich plasma (PRP) has emerged as one of the most extensively investigated orthobiologic therapies for tendon disorders because of its potential to modulate inflammation, enhance extracellular matrix remodeling, and promote tissue regeneration through the delivery of concentrated platelets and bioactive molecules. However, despite compelling biological rationale and encouraging preclinical evidence, clinical outcomes remain inconsistent across different tendon pathologies. This narrative review critically e …