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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Immunology

Research advances on postbiotics in promoting skin wound healing: mechanisms, formulations, and clinical translation

Yu Xing, Jinyu Song, Bingbing Shang, Guangdi Yang, Ye Zhao, Ming Li, Binbin Hou

Wound healing is a complex process involving different cell types, molecules and stages in the dermis, epidermis and associated microbiome. Chronic wounds caused by pressure, diabetes, or immunodeficiency often have huge economic and therapeutic costs. Postbiotics, in particular inactivated bacteria, cell components and metabolites, are emerging as novel treatments targeting the skin microbiome and provide precise treatment options for wound healing, inflammation, angiogenesis and re-epithelialization. We review th …

27.08.2026journal-article

TEM Journal

Machine Learning-Driven IoT System for Patient Monitoring

Adham Mohsen Saeed, Yasamin Hamza Alagrash, Meriam Noureddine Jemel, Lamjed Ben Said

In this paper, a healthcare monitoring system is introduced under IoT based on WiFi enabled Arduino boards to deliver patient data to the cloud through the ThingSpeak platform. It checks abnormalities in health, such as body temperature, level of oxygen, heart rate and vibration, which are checked by the system. A Long Short-Term Memory (LSTM) model is used to generate a synthetic dataset consisting of 14,664 samples, each labeled as either normal or abnormal based on expert assessment. A comparative approach betwe …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

A composite model incorporating systemic inflammatory burden and GRACE score for enhanced identification of elevated myocardial stress in acute myocardial infarction: an exploratory analysis

Peng Libao, Lin Wenji, Wang Mengjiao, Zou Jiali

Introduction Acute myocardial infarction (AMI) remains a leading cause of mortality and heart failure worldwide. Early identification of patients with elevated myocardial stress, a key driver of adverse outcomes, is clinically important. However, the utility of a composite inflammatory burden score for this purpose remains unclear. Methods This retrospective study enrolled 302 consecutive patients hospitalized for AMI at Shenzhen Qianhai Shekou Hospital between January 2023 and December 2024, with 50 healthy contro …

27.08.2026journal-article

Clinical Oral Investigations

Visual distractions for pediatric patients in a dental environment using eye-tracking technology: a cross-sectional study

Alhowra A. Alshaikh, Ghalia Y. Bhadila, Osama M. Felemban, Heba M. Elkhodary, Amani A. Al Tuwirqi

Abstract Objective To evaluate visual attention patterns in anxious versus non-anxious children toward various environmental distractions in a dental clinic using eye-tracking technology and assess the impact of visual distractors on gaze behavior. Materials and methods This cross-sectional study, including 121 children 6–12 years of age. Anxiety levels were determined using the Children’s Fear Survey Schedule–Dental Subscale. Standardized operatory images, with and without distractors, were presented while eye-tra …

27.08.2026journal-article

Journal of Ophthalmic Inflammation and Infection

Clinical course of multiple sclerosis-associated uveitis: a retrospective series of 49 cases

William Gil, Sabine Mainbourg, Robin Jacquot, Ludovic Trefond, Louis Olagne, Pierre Clavelou, Sébastien Trouillier, Antoine Bardy, Marc Andre, Géraldine Androdias-Condemine, Caroline Vasseneix, Laurent Kodjikian, Thomas El-Jammal, Sandra Vukusic, Pascal Sève

Abstract Background The temporal relationship between uveitis and neurological relapses in multiple sclerosis (MS)–associated uveitis is poorly documented; and MS-targeted disease-modifying therapies (DMTs) may influence the ocular course. Objective To evaluate the temporal relationship between uveitis and neurological relapses in MS-associated uveitis, and to assess the impact of MS treatments on uveitis outcomes. Methods This is a retrospective multicenter study. Uveitis cases were identified from the “Lyon Uvéit …

27.08.2026journal-article

Journal of Personalized Medicine

AI-Enabled Digital Phenotyping for Personalized Risk Stratification in Internet Gaming Disorder: A Privacy-Preserving Simulation Study

Athanasios Kranas, Evgenia Paxinou, Ioannis Bazakidis, Christina Koufopoulou, Petros Koufopoulos, Georgios Feretzakis, Vassilios S. Verykios

Background/Objectives: Assessment of Internet Gaming Disorder (IGD) relies on retrospective self-reports and clinical interviews, which may be affected by recall and social desirability biases and may be insensitive to behavioral change. This study evaluated an artificial intelligence (AI)-enabled, privacy-preserving digital phenotyping framework for personalized IGD risk stratification under controlled simulation assumptions. Methods: A synthetic dataset of 1000 virtual user profiles was generated with a 20% eleva …

27.08.2026journal-article

Neuro-Oncology

90 Developing Patient-Focused Outcomes for Routine Clinical Care in Glioma: A Synthesis of Qualitative Evidence from the COMBaT Study

Noreen Hopewell-Kelly, Vimeeka Raj Devarajan, Silvia Goss, Helen Bulbeck, Rhian Burke, Anthony Byrne, Andrew Carson-Stevens, Gwawr Evans, Cerys Harris, Cressida Lorimer, James Powell, Sarah Puntoni, Alasdair G Rooney, Kathy Seddon, Colin Watts, Andrew Wright, Stephanie Sivell, Ameeta Retzer

Abstract Introduction There is a critical need to identify and routinely measure the outcomes that matter most to people living with glioma. Care needs in this population are complex and variable, yet current clinical practice lacks consistent, systematic approaches to assessing them. This may limit timely symptom management, personalised treatment and improvements in quality-of-life. We present findings from the first stage of the COMBaT study, to develop a person-focused core outcome set for routine glioma care. …

27.08.2026journal-article

JAMA Network Open

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast Cancer

Trang Thuy Do, Jordan Maccora, Rebecca Wallace, Veronica Aedo-Lopez, Marliese Alexander, Sonia Ancoli-Israel, Bei Bei, Robert Blum, Frances Boyle, Daphne Day, Justine Diggens, Prudence A. Francis, Maria Ftanou, Sheila N. Garland, Alysia Kepert, Duncan Mortimer, Andrew J. K. Phillips, Sharad Sharma, Lesley Stafford, Michelle White, Joshua F. Wiley

Importance Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) both alone and in combination, and few have evaluated the use of either during chemotherapy. Objective To determine the main effects of CBT-I and BLT on insomnia and fatigue symptoms in women undergoing chemotherapy for breast cancer. Design, Setting, …

27.08.2026journal-article

PLOS One

Efficacy and safety of 15 mA transcranial alternating current stimulation (tACS) in the therapy of treatment-resistant depression with increased inflammatory activity: Study protocol for a randomized, double-blind, sham-controlled trial

Xuguang An, Jin Zhang, Xiaofei Hou, Chenghao Yang

Background and Objectives Treatment-resistant depression (TRD) poses a significant clinical challenge, with traditional antidepressant therapies often ineffective. Elevated peripheral inflammation has emerged as a potential biological subtype of TRD, highlighting the need for novel treatments. Transcranial alternating current stimulation (tACS) has garnered attention for its potential antidepressant effects, particularly through its impact on glial cells, which are involved in neuroinflammation and neuronal interac …

27.08.2026journal-article

Clinical Case Reports

Beyond the Rash: Simultaneous Bilateral Facial Nerve Palsy Following Childhood Varicella Infection

Mohamed Sheikh Hassan, Abdiwahid Ahmed Ibrahim, Said Abdi Mohamed, Nor Osman Sidow, Said Abdirahman Ahmed, Nur Adam Mohamed, Mohamed Mukhtar Mohamed, Saadaq Adan Hussein

ABSTRACT Bilateral facial nerve palsy is a rare neurological condition in children and is infrequently associated with primary Varicella (chickenpox) infection. We report the case of a 10‐year‐old previously healthy girl who developed simultaneous bilateral lower motor neuron facial weakness 3 weeks after a self‐limiting varicella infection. The patient presented with acute onset inability to close both eyes, difficulty smiling, drooling of saliva, and impaired oral competence. At presentation, the characteristic v …

27.08.2026journal-article

Clinical Rehabilitation

Effects of short-term compression in people with knee osteoarthritis: A sham-controlled randomised trial

Angelica Viana Ferrari, Hugo Jario Almeida Silva, Glauko A.F. Dantas, Julya P.M. Perea, Gabriel M. Ferretti, Tarcísio F. De Campos, Francisco Alburquerque-Sendín, Tania F. Salvini

Objective To evaluate the effects of knee compression using elastic bandages on pain intensity and physical function in individuals with knee osteoarthritis in the short term. Design Three-arm, randomised controlled trial. Setting Individuals with knee osteoarthritis received compression, sham compression, or no bandaging. Main measures Ninety participants were assessed at baseline (Day 1), Day 6 after intervention, and 12 and 24 weeks post-intervention. The primary outcomes were pain intensity assessed using the V …

27.08.2026journal-article

Journal of General and Family Medicine

Eligibility‐Identification Difficulty and Self‐Reported Preventive Care Implementation Among Japanese Primary Care Physicians

Hironori Yamada, Kei Miyazaki, Makito Yaegashi, Kuniko Nakayama, Rei Suganaga, Nobuaki Kusaka, Wataru Hirohashi, Tomio Suzuki

ABSTRACT Background Primary care is an important setting for prevention, but implementation gaps may arise before clinicians can identify patients eligible for preventive services. We described self‐reported preventive care implementation among Japanese primary care physicians and examined whether lower implementation co‐occurred with eligibility‐identification difficulty. Methods We conducted a nationwide web‐based cross‐sectional survey of physician members of the Japan Primary Care Association from May to June 2 …

27.08.2026journal-article

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

Mastoid Obliteration versus Open Cavity Technique in Radical Mastoidectomy Procedures in Pediatric Population: A Comparative Study

Mohamed Ahmed Alhussaini, Mariam Barakat Daniel, Ahmed Abuelwafa Abdelgaliel, Mohamed Omar Ahmed Gad

Abstract Background: Cholesteatoma is a common medical condition affecting the younger population. It is a medical challenge for management and therapy since it is more widespread and expansile and has a high recurrence rate. The primary method of managing cholesteatoma is surgery, usually using an open or closed cavity technique. This surgery aims to completely eradicate bone and epithelial disease, stop recurrence, create a dry, safe ear, and regain functional hearing. Open cavities are frequently used to remove …

27.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Comparing four training modalities on body composition, cardiorespiratory fitness and cardiovascular responses in sedentary young men: a randomized trial

Weihua Zheng, Shuai Han, Shunzhe Piao, Runrong Tang, Hansen Li, Weipeng Liu, Yang Cao

Abstract Background Although high-intensity interval training (HIIT), high-intensity continuous training (HICT), moderate-intensity interval training (MIIT), and moderate-intensity continuous training (MICT) have all been shown to improve health outcomes, few studies have compared these four modalities within the same framework. Therefore, this study aimed to compare the effects of 8 weeks of HIIT, HICT, MIIT, and MICT on body composition, cardiorespiratory fitness, and cardiovascular responses in sedentary young m …

27.08.2026journal-article

Journal of Clinical Practice and Medical Research

Knowledge and Awareness of Amblyopia Among Families Attending Primary Care Clinics: A Cross-Sectional Study

Mohammed Mousa Almousa, Mustafa Kofi, Basil Khalid Alsahabi

Background: Amblyopia causes lifelong monocular visual impairment when detection or treatment is delayed. Families influence screening and adherence, yet knowledge in primary care populations remains incompletely characterized. Objective: To assess objective and perceived amblyopia knowledge, identify associated factors, and examine agreement between self-rated and objectively scored knowledge among families attending primary care clinics. Methods: This cross-sectional survey analyzed 105 attendees from July 12–15, …

27.08.2026journal-article

International Journal of Scientific Research and Modern Technology

Evaluation of Patient Satisfaction as a Quality Indicator in the Ophthalmology Service of Hospital Central de San Cristóbal Under the SERVQUAL Quality Model

Carmen Soraida Niño de Pernia, Alexis Isauro Apolinar Márquez, Nicolás Castillo Pinillos, Doris Romelia Rozo Fernández, Angela Verónica Villamizar Gutiérrez, Daicy Yasmin Gómez Bueno

This study aims to analyze the Ophthalmology Service of the Hospital Central de San Cristóbal to design and propose a systematic tool, based on the SERVQUAL model, aimed at assessing patient satisfaction, thereby transforming user perception into a key indicator for evidence-based clinical management. Theoretical Framework: From a theoretical standpoint, the research conceives healthcare quality as a management imperative sustained by user experience, approaching this evaluation from a transcomplexity perspective b …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Efficacy of thrombin spray combined with clip closure after colorectal endoscopic mucosal resection and endoscopic submucosal dissection

Shi-Song Gu, Peng Zhang, Ke-Dong Zhu

BACKGROUND Postoperative bleeding is a common and serious complication of colorectal endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), with reported incidences of 2%-10% and 5%-15%, respectively. Although titanium clip closure is the current standard for wound management, its efficacy is limited for large or irregular wounds. Combining topical thrombin spray with mechanical clip closure may offer synergistic hemostatic benefits, but supporting clinical evidence remains scarce. AIM To as …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Curative endoscopic closure of a chronic esophagopleural fistula after Boerhaave syndrome using an over-the-scope clip: A case report

Naoto Takahashi, Shigeaki Baba, Yosuke Toya, Haruka Nikai, Ryosuke Fujisawa, Fumitaka Endo, Akira Umemura, Takeshi Iwaya, Hiroyuki Nitta, Akira Sasaki

BACKGROUND Spontaneous esophageal rupture (Boerhaave syndrome) remains a life-threatening condition associated with high mortality rates. In recent years, various treatment strategies for it, including conservative and endoscopic approaches, have been increasingly reported. However, chronic esophagopleural fistula developing after conservative management is often difficult to treat, and no standard therapeutic strategy for it has been established. We report a case of a refractory chronic esophagopleural fistula suc …

27.08.2026journal-article

Journal of Clinical Immunology & Microbiology

Inflammaging and Immunosenescence: The New Biological Paradigm of Periodontal Disease in Older Adults. Narrative Review

Maria Angelica Zambrano, Carmen Hernandez Ojeda, Karen Osorio Oritz, Rocio Diaz Hernandez, Claudia Sosa Machado, Ariadna Tamayo

Periodontitis has long been described as a chronic inflammatory disease driven by the interaction between a dysbiotic biofilm and an altered host immune response. This model, however, does not fully explain the greater susceptibility, faster progression and poorer treatment response observed in older adults. From a geroscience perspective, biological aging itself reshapes the periodontal environment through inflammaging and immunosenescence, contributing to loss of periodontal homeostasis beyond microbial dysbiosis …

27.08.2026journal-article

Aging Clinical and Experimental Research

The association of physical activity with intrinsic capacity: findings from longitudinal analysis in CHARLS and HRS

Xiaoxian Yang, Yan Zhuang, Hui Huang

Abstract Background Physical activity (PA) is a pivotal modifiable determinant of intrinsic capacity (IC), a core component of healthy aging. Aims This study aimed to examine the association between PA and the risk of IC impairment among middle-aged and older adults using nationally representative cohorts from China and the United States. Methods Data from CHARLS (2011–2015) and HRS (2010–2018) were used, including 781 and 2,601 participants, respectively. PA was quantified by metabolic equivalents (MET), and IC im …

27.08.2026journal-article

Eurasian Journal of Medicine and Oncology

Systemic inflammation and risk stratification in pheochromocytoma: Insights from PASS components, TNM stage, and the tumor immune microenvironment

Ümit Çavdar, Tuğçe Tekinaslan, Özlem Eren, Emine Özlem Gür, Serkan Karaıslı, Mehmet Haciyanli, Selda Gücek Haciyanli, Aslı Kahraman, Mehmet Sercan Ertürk, Barış Önder Pamuk, Serkan Yener

Introduction: The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and Tumor–Node–Metastasis (TNM) staging capture histopathological and anatomical risk features in adrenal pheochromocytoma, but do not incorporate systemic inflammation. Objectives: To investigate the associations of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with individual PASS components and American Joint Committee on Cancer TNM stage in adrenal pheochromocytoma. Methods: We retr …

27.08.2026journal-article

Frontiers in Digital Health

Bridging semantics and clinical fidelity: a section-based assessment of a vision–language model (RadVLM) for chest x-ray report generation

Saleh Alzughaibi

Background Artificial intelligence-generated radiology reports may reduce clinician burden, but their factual accuracy remains uncertain. This study evaluated whether surface-level semantic similarity in AI-generated Impression sections reliably reflects structural fidelity in the underlying Findings. Methods RadVLM, a radiology-focused vision–language model, generated Findings and Impression sections for 3,000 public chest radiograph studies. A section-aware evaluation framework assessed Findings-level entity-rela …

27.08.2026journal-article

Med Research

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong

ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability. Currently, the clinical management of TBI relies primarily on palliative care, whereas complex secondary injury cascades limit the ability of traditional single‐target drugs to achieve consistent clinical benefits. Exosomes, as natural nanoscale extracellular vesicles, offer a highly promising innovative strategy for neuroprotection and repair in TBI due to their inherent abi …

27.08.2026journal-article

Biometrical Journal

Comparison of Methods for Incorporating Related Data When Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen P. Martin, Frieder Braunschweig, Jonas Faxén, Joakim Alfredsson, David A. Jenkins

ABSTRACT Clinical Prediction Models (CPMs) compute an individual's risk of an outcome, given a set of predictors. Guidance states CPMs should be constructed using data sampled from the target population. However, researchers might have access to ancillary data sets from different time points, countries, or healthcare settings, which could support model development. This study explores in which situations the ancillary data affect CPM performance, given potential heterogeneity. We conducted a simulation study to ass …