Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Therapie & Reha · Seite 64

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

International Journal of Molecular Sciences

Toward Standardized Platelet-Rich Plasma Therapy in Tendon Healing: Integrating Biological Characterization with Clinical Translation

Jeries Issa Alghishan, Bogdan Andor

Platelet-rich plasma (PRP) has emerged as one of the most extensively investigated orthobiologic therapies for tendon disorders because of its potential to modulate inflammation, enhance extracellular matrix remodeling, and promote tissue regeneration through the delivery of concentrated platelets and bioactive molecules. However, despite compelling biological rationale and encouraging preclinical evidence, clinical outcomes remain inconsistent across different tendon pathologies. This narrative review critically e …

18.08.2026journal-article

Neurology, Neuropsychiatry, Psychosomatics

A comparative clinical and economic advisability of neuroprotective therapy with ethylmethylhydroxypyridine succinate and Cerebrolysin in patients with ischaemic stroke

E. K. Kochetkova, A. A. Astapovskiy, V. N. Drozdov, E. V. Shikh

The high cost of managing stroke patients is due not only to the care provided during the most acute and acute phases, but also to the subsequent costs associated with rehabilitation and potential disability. Achieving a favourable functional outcome is one of the key factors in reducing the economic burden of stroke on the healthcare system. Objective: to assess the clinical and economic advisability of incorporating ethylmethylhydroxypyridine succinate (Mexidol) or Cerebrolysin into the treatment of ischaemic str …

18.08.2026journal-article

Small

Combining Type I&II Photosensitizer With Hypoxia‐Activated Prodrug Enables Oxygen‐Unrestricted Synergistic Photocatalytic Therapy

Haoran Hou, Hanhan Lu, Yingnan Wu, Tai Sun, Gaobo Hong, Yanliang Zhao, Jianjun Du, Fengling Song, Xiaojun Peng

ABSTRACT The oxygen heterogeneity within tumors restricts the therapeutic efficacy of hypoxia‐activated prodrugs (HAPs) and traditional photosensitizers (PSs) when administered alone. To overcome this limitation, we present an oxygen‐unrestricted synergistic therapeutic strategy to concurrently potentiate treatment efficacy in both hypoxic and normoxic tumor compartments. By introducing TEMPO, we developed an efficient PS capable of simultaneous Type I and Type II photocatalytic reactions. This PS, named DT , was c …

18.08.2026journal-article

Signal Transduction and Targeted Therapy

Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies

Daniela Paasch, Kathrin Haake, Chloe Kan, Cristiana Ulpiano, Eirini Nikolouli, Mi-Sun Jang, Mark-Christian Klassen, Michael Epstein, Ryohichi Sugimura, Nico Lachmann

Abstract Macrophages have emerged as promising candidates for cell-based immunotherapies due to their intrinsic plasticity, tissue-infiltrating capabilities, and central roles in orchestrating immune responses. Their phenotypic and functional diversity within tissues and the tumor microenvironment has driven interest in harnessing these cells for therapeutic purposes. Integrating recent knowledge in signaling cascades balancing the activity of macrophages in combination with genetic engineering have enabled the dev …

18.08.2026journal-article

Frontiers in Medicine

Integrating case-based learning into the ADDIE model for higher vocational rehabilitation nursing courses: a quasi-experimental study

Weihua Li, Yuhan Wang, Xiaoqiong Hu, Zhenrong Zhang, Shuangli Li

Background Traditional lecture-based instruction remains predominant in higher vocational rehabilitation nursing education and emphasizes the delivery of theoretical knowledge. Passive learning and the separation of theory from practice may limit the development of students’ practical skills, critical thinking, and humanistic caring competence. Guided by the ADDIE instructional design framework, this study integrated case-based learning (CBL) to develop and evaluate an instructional model for higher vocational reha …

18.08.2026journal-article

Cancers

Standardizing pCR/MPR Assessment in NSCLC After Neoadjuvant Therapy: Challenges and Perspectives

Andrea Ascione, Flavia Adotti, Luigi Vittori, Caterina Chiappetta, Paolo Graziano

The expansion of neoadjuvant immune checkpoint blockade, chemoimmunotherapy, and targeted therapies in oncogene-driven tumors is reshaping the management of resectable non-small cell lung cancer (NSCLC). Major pathologic response (MPR) and pathologic complete response (pCR), defined respectively as 10% or less residual viable tumor (RVT) within the primary tumor bed and the complete absence of viable tumor in both the resected primary tumor and sampled regional lymph nodes, have become widely adopted early efficacy …

18.08.2026journal-article

BLACK SEA REGION AT THE CROSSROADS OF CIVILIZATIONS

მერისის ხეობის მკვიდრთა მეტყველების მორფოლოგიური თავისებურებების შესახებ

ცისნამი ბერიძე

წინამდებარე ნაშრომი ეხება აჭარული დიალექტის ერთ-ერთი გამორჩეული ერ­თეუ­ლის, მერისის ხეობის მეტყველების ზოგიერთ მორფოლოგიურ თავისებურებას. კვლევა ეფუძნება საველე-დიალექტოლოგიური მუშაობის შედეგად ჩემ მიერ მოპოვებულ ემპირიულ მასალასა და ცოცხალ მეტყველებას. ნაშრომში დეტალურადაა განხილული ის გრამატიკული მოვლენები, რომ­ლებიც ვლინდება სახელის ფორმაწარმოებაში, ზმნის სტრუქტურაში, ზმნისწინთა ფუნქციონი­რე­ბასა და დამხმარე მეტყველების ნაწილთა (კავშირები, თანდებულები, ნაწილაკები) გამოყენების სპეციფიკაში. მერისის ხეობის ლინგვისტ …

18.08.2026journal-article

Journal of Occupational & Environmental Medicine

Disease Burden Attributable to Six Occupational Risk Factors in China, 1990–2035: A Quantitative Assessment and Future Projection

HeRen Lou, JiMian Zhang, Xin Wang, Yang Ni, Yi Tao Liu, Qiang Zeng

Objective: To evaluate the temporal trends and future burden of six occupational risk factors in China from 1990 to 2035. Methods: Data were obtained from the Global Burden of Disease Study 2021. Age-standardized rates, age-period-cohort analysis, and Bayesian age-period-cohort models were used to assess trends and project disease burden. Results: In 2021, six occupational risk factors accounted for 17.90 million disability-adjusted life years in China. The age-standardized rate declined by 58.8%, from 2,362.18 in …

18.08.2026journal-article

Nanotechnology

Targeted therapy of colon cancer with aptamer-functionalized albumin nanoparticles loaded with disulfiram

Yacong An, Zhen Yu, Ting Li, Xundou Li, Qiping Jiang

Abstract Chemotherapy remains the primary treatment for most patients with metastatic colorectal cancer (mCRC), yet its efficacy is often limited by severe adverse effects. Drug repurposing offers a promising strategy to accelerate oncology drug development. Disulfiram (DSF), a licensed anti-alcoholism agent, has demonstrated broad-spectrum anticancer activity in preclinical models. However, its clinical translation for oncology is hindered by poor aqueous solubility, rapid metabolism, and lack of tumor selectivity …

18.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Neuralgic Amyotrophy Following Rotator Cuff Repair

James A. Whitlock, Michael Friedrichs, Jennifer Pine, Daniel M. Cushman

Neuralgic amyotrophy (NA) is an uncommon but potentially debilitating cause of pain and weakness that is felt to be inflammatory in nature. This patient-focused case report describes the experience of a 64-year-old active male who developed severe periscapular pain eight days after uncomplicated arthroscopic rotator cuff repair with biceps tenodesis, followed by marked weakness and inability to abduct the shoulder. He was treated with prolonged, progressive physical therapy, including passive and assisted range-of- …

18.08.2026journal-article

Small

Environmentally Responsive Catalytic Microneedles Enable Cascade Fenton Reaction for Antibacterial Therapy and Accelerated Infected Wound Healing

Yongjie Cai, Xianghe Jiang, Yuemin Wang, Fangyuan Li, Xiaoming Huang, Miao Zhang, Jie Weng, Jianshu Li, Xingyu Chen

ABSTRACT The persistence of bacterial biofilms and resistance limits the efficacy of traditional therapies, slowing tissue regeneration. Here, we report an innovative pH‐responsive catalytic microneedle system (GZIF@Fe MN) designed to combat bacterial infections by disrupting bacterial redox homeostasis through a cascade Fenton reaction, generating highly reactive hydroxyl radicals (·OH). The system utilizes a Schiff base reaction between oxidized hyaluronic acid and carboxymethyl chitosan to construct a pH‐sensiti …

18.08.2026journal-article

Journal of Midwifery & Women's Health

Strengthening the Midwifery Workforce Through State Investment in Midwifery Education: The New Jersey Midwifery Education Project

Julie Blumenfeld, Amy Alspaugh, Elizabeth Auricchio, Laura Lindberg,

Abstract State‐level investment in midwifery education strengthens the workforce by addressing long‐standing structural barriers in training and clinical education. We describe the development, implementation, and early outcomes of the New Jersey Midwifery Education Project (NJ‐MEP), a state‐funded initiative designed to sustain, expand, and diversify the midwifery workforce through targeted improvements in educational and training infrastructure. The NJ‐MEP's successes illustrate how policy engagement, advocacy, a …

18.08.2026journal-article

Brain

Rethinking multiple sclerosis therapy beyond clinical phenotypes

Maria Pia Sormani, Heinz Wiendl, Xavier Montalban, Jiwon Oh

Sormani et al. argue that multiple sclerosis should be viewed as a biological continuum rather than distinct clinical forms. Evidence from recent trials suggests that therapies targeting shared biological mechanisms can slow disability progression across the disease spectrum, supporting a shift away from traditional classifications.

18.08.2026journal-article

Annals of Hematology

Combination therapy of sutimlimab and rituximab can lead to stable remission in autoimmune hemolytic anemia: a case series

Julian List, Anna Katharina Foerster, Alexandra Kutilina, Justus Duyster, Jesus Duque-Afonso, Reinhard Marks

Abstract Autoimmune hemolytic anemia (AIHA) is associated with a significant impairment of quality of life for affected patients and can lead to life-threating hemolytic crises. Complement-mediated destruction of antibody-opsonized erythrocytes is a central pathomechanism in many cases of AIHA. Complement inhibition is therefore a promising and logical therapeutic strategy. Sutimlimab, a monoclonal antibody that targets complement factor C1s was approved in 2022 and can effectively inhibit hemolysis. However, this …

18.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Comparative Efficacy of Body Acupuncture, Electroacupuncture, and Auricular Acupuncture in Stroke Rehabilitation

Xueqi Qian, Jun Rong, Cunxin Wang, Heng Mou

Objective: To compare the efficacy of body acupuncture, electroacupuncture, and auricular acupuncture on motor, functional, and neurological recovery after stroke. Design: Systematic review and meta-analysis of randomized controlled trials. Eligible studies enrolled adult stroke survivors receiving one of three acupuncture modalities versus control treatments. Primary outcome was motor function (Fugl–Meyer Assessment). Secondary outcomes included activities of daily living, neurological function, and safety. Pairwi …

18.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Beyond Disability

Natalia V. S. Jordão, Felipe R. De Queiroz, Maninderpal Kaur, Julius Sun, John R. Bach

Work participation is a core rehabilitation goal, yet individuals with severe neuromuscular diseases (NMD) often face workforce exclusion due to the misconception that severe physical impairment, or ventilatory dependence, implies unemployability. This review synthesizes data on employment rates, barriers, and facilitators to demonstrate that employment can be fostered through workplace accommodations and technology, sometimes through simple communication adaptations. We explore the roles of assistive technology (A …

18.08.2026journal-article

Social Theory & Health

A critical realist critique on evidence conceptions in occupational mental health research

Philip Negt, Marcel Sieberer

Abstract The increasingly dynamic nature of modern workplaces and the growing complexity of factors influencing mental health challenge conventional understandings of evidence in occupational health research. Drawing on critical realism (CR) as a contemporary philosophy of science, this article examines limitations of narrow conceptions of evidence that continue to shape intervention research at the intersection of work and mental health. Using an abductive approach, we develop a CR-lens for examining how evidence …

18.08.2026journal-article

Frontiers in Immunology

A protracted diagnostic journey of pediatric PAPA syndrome and subsequent response to tofacitinib therapy: a case report and literature review

Shuien He, Hao Deng, Jinghua Yang, Wenwen Jiang

PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) is a rare autosomal dominant autoinflammatory disorder caused by mutations in the PSTPIP1 gene. In pediatric patients, arthritis often precedes cutaneous manifestations by several years, leading to frequent misdiagnosis as septic arthritis. Treatment is challenging, with IL-1 inhibitors being the most pathophysiology-based first-line therapy, but their accessibility is limited by high costs. We reported an 11-year-old Chinese boy with a 7-ye …

18.08.2026journal-article

Frontiers in Immunology

Association between gut microbiota characteristics and therapeutic efficacy of multimodal combination therapy in hepatocellular carcinoma with portal vein tumor thrombus: a secondary analysis of a prospective phase II trial

Xinwen Liang, Ye Li, Minhui Liang, Zhiming Zeng, Kai Hu, Lihua Yang, Hui Yan, Muyun Li, Jie Zeng, Jing Tang, Yufeng Lv, Li Liang, Jiali Meng, Huabin Su, Jie Ma, Ning Mo

Background Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) carries a poor prognosis. Although SBRT combined with cadonilimab and lenvatinib has shown encouraging antitumor activity in a prior prospective phase II trial, marked interpatient heterogeneity remains. Gut microbiota may influence antitumor immunity and could help identify patients more or less likely to benefit from this regimen. Objective To characterize baseline and longitudinal gut microbiota features in treatment-naïve HCC patie …

18.08.2026journal-article

Journal of Midwifery & Women's Health

Women's Perceptions of Sexual Function During the Postpartum Period: Systematic Review of Qualitative Evidence

Verónica Mejía‐Mercado, Cristina Gallego‐Gómez, Ana Torres‐Costoso, Vicente Martínez‐Vizcaíno, Claudia Andrea Quezada‐Bascuñán, Sandra Martínez‐Bustelo, Eva Rodríguez‐Gutiérrez, Sergio Núnez de Arenas‐Arroyo, Asunción Ferri‐Morales

Introduction Sexuality is a multifaceted aspect of life influenced by several dimensions, including biology, psychology, socioeconomics, and spirituality. Postpartum sexual health remains an understudied and relevant area for women. This systematic review of qualitative studies aimed to synthesize knowledge of the perceptions of sexuality of women who are postpartum in relation to their psychosexual adjustment and sexual functioning and the contextual and relational influences affecting them during this period. Met …

18.08.2026journal-article

Journal of The Society of Obstetricians and Gynaecologists of Pakistan

Effect of myo-inositol and D-chiro-inositol combination therapy on improvement in menstrual irregularities and biochemical characteristics in patients with polycystic ovarian syndrome

Amna Razzaq, Mehnaz Khakwani, Fouzia Shafi, Tehseen Aslam, Fatima Arshad

Objective: To compare improvement in menstrual irregularity and hormone levels in females with polycystic ovarian syndrome (PCOS) treated with myo-inositol (MI) and D-chiro-inositol (DCI) combination therapy versus placebo. Design: Randomized Controlled Trial Place and Duration of Study: Obstetrics and Gynecology department, Nishtar Hospital Multan. Over 06 months (1st June 2025 to 30th November 2025). Methodology: Sixty women aged 18-45 years with PCOS were enrolled and allocated to combination therapy or placebo …

18.08.2026journal-article

Mind & Language

Non‐assertoric Moorean speech acts

Maciej Tarnowski

This paper offers a unified account of Moorean speech acts beyond assertion. While the knowledge norm of assertion provides a familiar explanation of Moorean assertions, it does not generalize easily to non‐assertoric cases. I argue that Stalnaker's model of common ground provides a suitable framework for explaining these phenomena. Speech acts propose updates to the common ground, understood as targeting common knowledge, involving both their satisfaction and sincerity conditions, and Moorean speech acts universal …

18.08.2026journal-article

Journal of Clinical Medicine

Effectiveness of Single-Use Negative Pressure Wound Therapy (Pico 7) in Chronic Lower Limb Wounds: A Randomized Clinical Trial

Celia Villalba-Aguilar, José Alberto Laredo-Aguilera, Lucía Villalba-Aguilar, Esperanza Barroso-Corroto, Cristina Del Viso-Cudero, Víctor Serrano-Fernández, Juan Manuel Carmona-Torres

Background: Chronic lower limb wounds, such as diabetic and vascular ulcers, affect up to 2% of the global population, imposing high healthcare costs and a significant risk of amputation. Although nursing care and traditional treatments are fundamental, single-use portable Negative Pressure Wound Therapy PICO 7 system, has emerged as a cost-effective alternative. The objective of this study was to evaluate the effectiveness of PICO 7, compared to the usual treatment in chronic lower limb wounds or their dehiscence …

18.08.2026journal-article

Journal of Clinical Medicine

Optimizing Vestibular Rehabilitation: From Neuroplastic Mechanisms to Multimodal Therapeutic Strategies

Brahim Tighilet, Emna Marouane, Frédéric Xavier, Christian Chabbert

Peripheral vestibulopathy (PV) is a common disorder that causes dizziness and balance impairment, substantially affecting patients’ quality of life. When symptoms persist, they frequently lead to anxiety, depression, and an increased risk of social isolation. Although central vestibular compensation (CVC) often promotes functional recovery, current pharmacological options remain limited and are primarily aimed at symptom control. Consequently, they should be considered adjuncts rather than alternatives to rehabilit …