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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer

Yao Xing, Min Gu

BACKGROUND Postoperative radiotherapy reduces local recurrence in locally advanced colorectal cancer, but its efficacy depends on accurate target volume delineation. This study assessed the impact of delineation accuracy on treatment outcomes. AIM To investigate the impact of target volume delineation accuracy on treatment outcomes of postoperative radiotherapy for colorectal cancer. METHODS Clinical data of 218 colorectal cancer patients who underwent radical surgery followed by adjuvant radiotherapy at our hospit …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Acute pancreatitis, hypercalcemia, and kidney stones: True incidence or unveiled prevalence?

Selcuk Yuksel

Recent study reported an association between hypercalcemia and nephrolithiasis in acute pancreatitis and proposed a striking rate of de novo stone formation during a 7-day hospitalization. Their work is valuable because it draws attention to the endocrine-metabolic dimension of acute pancreatic injury and to a potentially vulnerable subgroup of patients. However, the reported endpoint raises major biological and methodological concerns. Lithogenesis is a multistep process requiring urinary supersaturation, nucleati …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Metallic clip-associated colonic perforation after peroral endoscopic myotomy: A case report

Geng-Yuan Zhang, Shi-Gong Chen, Zhong-Ti Gao, Zhu-Tang Huang, Sheng-Fu Che, Long Li, Bo Long, Fei-Fei Ding, Ze-Yuan Yu, Hui-Nian Zhou, Zuo-Yi Jiao

BACKGROUND Colonic perforation secondary to a metallic clip following peroral endoscopic myotomy is exceptionally rare, particularly in patients with achalasia and concomitant chronic constipation. CASE SUMMARY We presented a case of a 48-year-old woman with acute abdominal symptoms in which intraoperative exploration revealed a detached metal clip adjacent to the colonic perforation site. A sigmoid colectomy with colostomy was subsequently performed. No discomfort was reported during the 5-month follow-up period. …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Correction to: “Liuzijue” Qigong training enhances early pulmonary function recovery after esophageal cancer surgery

Yu Bai, Yi-Bin Wu

Correction to: Bai Y, Zhang ZL, Qiao L, Shi LL, Wang J, Nian H, Du QC, Tian ZH, Yao ZL, Wu YB. "Liuzijue" Qigong training enhances early pulmonary function recovery after esophageal cancer surgery. World J Gastrointest Surg 2025; 17(12): 113408 [PMID: 41479713 DOI: 10.4240/wjgs.v17.i12.113408]. In this article, we have identified an error in Tables 3 and 4: The columns labeled “Control group” and “Experimental group” were inadvertently transposed during a post-publication review.

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Magnetic compression anastomosis in gastrointestinal and biliary disease: Techniques and clinical applications

Ravi Teja Reddy, Amit Bagrodia, Kartik Mehta, Venkatesh Vaithiyam, Supraja L Mohan, Nikhil Sirohi, Ashok Dalal, Siddharth Srivastava, Sanjeev Sachdeva

Magnetic compression anastomosis (MCA) is an emerging minimally invasive technique that enables the creation of gastrointestinal anastomoses without surgical suturing or stapling. This technique involves the placement of paired magnets across an obstructed or discontinuous lumen, generating localized compression that induces ischemic necrosis of the intervening tissue, and subsequent formation of a neo-anastomotic tract. Over the past decade, MCA has gained increasing attention in the management of complex gastroin …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Sutureless portal vein reconstruction in porcine orthotopic liver transplantation using a microvascular coupler: A randomized study with artificial intelligence-assisted histopathology

Jun-Jie Li, Jian Yang, Yan Xie, Jia-Ming Shang, Jiang Li, Chi-Yi Chen, Li-Na Liu, Zhong-Ying Zhang, Bing-Hui Pan, Wen-Tao Jiang

BACKGROUND Portal vein reconstruction is a critical step in liver transplantation. Hand-sutured anastomosis is time-consuming and may predispose to malalignment, needle-hole bleeding, and stenosis. A sutureless, mechanically coupled anastomotic principle that minimizes mechanical trauma and foreign body reaction could improve healing. AIM To compare a microvascular anastomotic coupler (embodying the sutureless principle) with conventional hand-suturing for portal vein reconstruction in a translational porcine ortho …

27.08.2026journal-article

African Journal of Laboratory Medicine

Implementing laboratory quality management systems in Ghana: A quality audit of accreditation readiness in clinical and public health laboratories (2021–2023)

Emma E. Kploanyi, David W. Dowdy, Joseph Kenu, Benjamin Buade, Benedicta Owusu-Arthur, David A. Opare, Franklin Asiedu-Bekoe, Alfred E. Yawson, Ernest Kenu, Lee F. Schroeder

Background: The Stepwise Laboratory Improvement Process Towards Accreditation (SLIPTA) checklist has demonstrated improvement in laboratory quality in Africa. In Ghana, however, implementation has targeted mainly higher-tier clinical laboratories. A balanced approach across the laboratory network is needed to strengthen national laboratory quality. Objective: To evaluate the quality management performance and accreditation readiness of clinical and public health laboratories (PHLs) in Ghana. Methods: Using a modifi …

27.08.2026journal-article

Frontiers in Medicine

Digital intelligence in dental technology education: curriculum and practical teaching reform

Zhi-Fa Wang, Yao-Xiang Xu, Hao-Ran Zhao, Wen-Lin Xiao

Oral healthcare is rapidly progressing from basic digitalization toward increasingly AI-enabled and data-driven practice, reshaping the competencies required of dental technology professionals and challenging traditionally technician-oriented educational models. This narrative review examines how digital intelligence can support curriculum development and practical teaching reform in dental technology education, with particular attention to application-oriented undergraduate universities. Drawing on representative …

27.08.2026journal-article

Clinical Cancer Research

A Phase 2 Basket Trial of Ado-Trastuzumab Emtansine for Patients with HER2 Amplified Cancers: A Non-Randomized Clinical Trial

Jessica S. Ross, Winston Wong, Lauren Schoech, Alex Makhnin, Dazhi Liu, Ranieri Yllanes, Jonathan Loi, Ala'A Damrah, Amanda Johnson, Michelle S. Ginsberg, Vetri Sudar Jayaprakasam, Mark Dunphy, Ronglai Shen, Nora Katabi, Kanika Arora, Michael F. Berger, David B. Solit, Mark Y. Jeng, Charles Hsu, Alexander Drilon, Vicky Makker, Gopakumar Iyer, Rona Yaeger, Gregory J. Riely, Mark G. Kris, Bob Li, Alan Ho, Jamie E. Chaft

Abstract Purpose: To evaluate the efficacy of ado-trastuzumab emtansine (T-DM1) among patients with advanced/metastatic HER2-amplified solid tumors. Patients and Methods: This was a single-center, non-randomized phase 2 basket trial conducted at Memorial Sloan Kettering Cancer Center. All 95 patients had HER2-amplified metastatic/advanced disease and were enrolled in 1 of 5 cohorts. HER2 amplification was diagnosed either with next-generation sequencing or in-situ hybridization. All patients received intravenous T- …

27.08.2026journal-article

The Canadian Journal of Psychiatry

Targeting Addiction Treatment Engagement: A Canadian Randomized Effectiveness Trial of Remotely Administered Contingency Management for Treatment Attendance: Cibler l’engagement en matière de traitement des dépendances : essai d’efficacité à répartition aléatoire mené au Canada portant sur la gestion des contingences mise en œuvre à distance pour la participation au traitement

David C. Hodgins, Jane Yi, Angela Wallace, Laurence Macrae Lynch, Ashley Ethier, Luija Long, Megan E. Cowie

Introduction Contingency management (CM) is an evidence-based treatment used as a stand-alone treatment or an adjunct to usual care for individuals with substance use disorders (SUDs). However, its use in clinical practice is limited, particularly in Canada. This study implemented and evaluated the effectiveness of CM for SUDs in 2 outpatient addiction clinics in Alberta. Methods A 3-month, 2-armed, parallel-group, unblinded intervention comparing attendance-based CM ( n = 43) with a treatment-as-usual (TAU) contro …

27.08.2026journal-article

Academic Medicine

Group decision-making in medical school competency committees: a multi-institutional ethnographic study

Michael S Ryan, Pim Teunissen, Sally A Santen, Daniel J Schumacher, Andrew S Parsons, Rachel S Poeppelman, Shahab Jolani, R Logan Jones, Christina M Vitto, Alexandra Vinson, UME Competency Committee Collaborators, Alexandra H Vinson, Pim W Teunissen, Amanda Emke, Rachel Poeppelman, Anita V Shelgikar, Elizabeth Bradley, Matthew Kelleher

Abstract Purpose Competency committees use group decision-making procedures to determine when learners may advance in their training. These committees have been well-described in graduate medical education (GME) and efforts have explored transferability of this model to undergraduate medical education (UME). Existing research in UME has focused on committee structure and member perspectives, with little examination of decision-making processes. This study explored how UME competency committees use group decision-ma …

27.08.2026journal-article

World Journal of Surgery

A Population‐Based Study of Incidence, Presentation, Treatment and Short‐Term Outcomes of Acute Thromboembolic Ischemia in the Lower Limbs

Jørgen B. Vennesland, Kjetil Søreide, Jan Terje Kvaløy, Andreas Reite, Morten Vetrhus

ABSTRACT Objectives To investigate the current epidemiology and short‐term outcomes in patients with acute lower limb ischemia (ALI) in a well‐defined Norwegian population. Methods A retrospective, single‐center, observational cohort study in a defined population catchment area. All patients with ALI from the catchment area were included in the period from January 2000 to December 2019. Age‐ and sex‐adjusted incidence rates were calculated using population demographics from Statistics Norway. Results A total of 359 …

27.08.2026journal-article

Clinical Case Reports

Intestinal Metaplasia of the Distal Esophagus in a Patient With Untreated Achalasia—An Unusual Case and Review of Literature

Rohan Karkra, Mahinaz Mohsen, Salil Chowdhury, Kaveh Hajifathalian, Ahmed Al‐Khazraji

ABSTRACT Barrett's esophagus (BE) and achalasia are distinct esophageal disorders with opposing pathophysiologic mechanisms, making their coexistence exceedingly rare. We describe a 51‐year‐old woman who presented with progressive dysphagia, postprandial vomiting, and significant weight loss over 8 months.

27.08.2026journal-article

International Wound Journal

Multisite Implementation of a Digital Wound Model of Care: A Post‐Implementation Multimethods Evaluation of Patient and Clinician Perspectives and Lessons Learned

Michelle Barakat‐Johnson, Clementine Mak, Michelle Lai, Phillip Baharudin, Darren Dela Rosa, Katja Heuer, Natalie Ko, Thomas Leong, Vivien Low‐Clarke, Apryl Repole‐Li Vaccari, Melissa T. Baysari

ABSTRACT This study evaluated district‐wide implementation of a digital wound model of care combining an artificial intelligence–enabled application with a virtual command centre across four hospitals and five community health centres in Australia. A post‐implementation multimethods evaluation (January 2024–January 2026) of patients ( n = 94), frontline clinicians ( n = 75), and senior wound nurses ( n = 9) and a product manager ( n = 1) using surveys, semi‐structured interviews and analysis of governance meeting m …

27.08.2026journal-article

Annals of Gastroenterological Surgery

Achievement of the Ideal Outcome After Pancreatectomy for Pancreatic Ductal Adenocarcinoma Is Associated With Earlier Initiation and Higher Completion Rates of Adjuvant Chemotherapy and Improved Long‐Term Survival

Ryosuke Fukushima, Kenichiro Araki, Ryo Muranushi, Kouki Hoshino, Kei Hagiwara, Shunsuke Kawai, Mariko Tsukagoshi, Takamichi Igarashi, Norio Kubo, Ken Shirabe

ABSTRACT Background The Ideal Outcome is a composite quality indicator reflecting optimal postoperative course after pancreatic surgery. This study aimed to clarify the prognostic significance of achieving the Ideal Outcome and its influence on the initiation and completion of adjuvant chemotherapy. Methods We retrospectively analyzed 187 patients who underwent pancreatectomy for pancreatic ductal adenocarcinoma between 2016 and 2024. The Ideal Outcome was defined as absence of in‐hospital mortality, severe complic …

27.08.2026journal-article

Journal of Family Medicine and Health Care

Prevalence and Predictors of Multimorbidity Among Older Adults Attending the General Outpatient Clinic of Federal Teaching Hospital Birnin-Kebbi

Hope Abitare

Multimorbidity is an emerging public health challenge associated with poor health outcomes, increased healthcare utilization, and rising healthcare costs, particularly among older adults. Despite its growing burden, evidence on multimorbidity among older adults in Northwestern Nigeria remains limited. This study determined the prevalence and predictors of multimorbidity among older adults attending the General Outpatient Clinic of the Federal Teaching Hospital, Birnin-Kebbi, Nigeria. A hospital-based cross-sectiona …

27.08.2026journal-article

npj Digital Medicine

Implementing digital health transformation policies in Latin America: insights from four national case studies

Paola Abril Campos Rivera, Pablo Villalobos Dintrans, Berenice Alfaro-Ponce, Beatriz Michelle Ramírez Pérez, Daniel Choperena, Adolfo Rubinstein, Cintia Cejas, Felix Liberona, Michael R. Reich

Abstract Digital health transformation (DHT) policies can improve the performance of health systems. However, there are few empirical studies on how these policies are implemented in practice. This article examines four national cases of implementing DHT policies in the Latin American region. The study employs a qualitative methodology based on 32 semi-structured interviews and a multiple case study approach in Uruguay, Argentina, Chile, and Mexico—selected for their diversity in governance structures and different …

27.08.2026journal-article

Journal of Clinical Medicine

Premature Consolidation of Regenerated Bone During Limb Lengthening with External Fixation in Achondroplastic Patients: Case Series and Literature Review

Edoardo Verme, Luca Bianco Prevot, Domenico Curci, Eleonora Caboni, Fabio Verdoni

Background: Premature consolidation of the regenerated bone is a relevant and underreported complication of limb lengthening in achondroplasia, with a reported incidence of 7–15% in the international literature. The gain-of-function fibroblast growth factor receptor 3 (FGFR3) mutation paradoxically enhances bone-healing capacity, predisposing patients to accelerated callus maturation during distraction osteogenesis and exposing patients to a risk of invasive procedures to treat this issue. This study reports the in …

27.08.2026journal-article

Neuro-Oncology

26 Investigating boron neutron capture therapy for the treatment of glioblastoma

Bethany Mackinnon

Abstract Introduction With an average survival of 12-18 months, glioblastoma is the most commonly diagnosed malignant brain tumour in adults. Despite treatment advances, survival outcomes have shown minimal improvements over the past decades. Persistent treatment resistance, and disease recurrence, highlight the need for alternative, more effective, therapies to be explored. Driven by advances in accelerator-based neutron sources and next-generation boron compounds, boron neutron capture therapy (BNCT) has re-emerg …

27.08.2026journal-article

Frontiers in Oncology

Case Report: How to tailor adjuvant radiotherapy after open partial laryngeal surgery in the setting of a secure R0-resection?

Pierluigi Bonomo, Maja Guberina, Jon Cacicedo

In this report, we discuss this clinical case, when the laryngeal remnant, or “neo-larynx”, is not part of the clinical target volume, it should be delineated as a bona-fide organ at risk or avoidance structure: recognizing the post-surgical anatomy could help maximize the preservation of the functional outcome. In addition, raising awareness on this rare yet very challenging disease presentation could foster a more homogeneous practice among radiation oncologists treating laryngeal cancer analogue to thoracic canc …

27.08.2026journal-article

Frontiers in Surgery

Association of preoperative serum 25-hydroxyvitamin D levels with deep vein thrombosis after total knee arthroplasty: a hypothesis-generating analysis of coagulation function mechanisms

He Shang, Jun Li, Tao Ma, Yuan Wei, Jinpeng Liang, Yumei Ding, Xing He, Biao Ma, Yaxing Ma, Ruoyu Wang, Yi Wang, Desheng Chen

Objective This hypothesis-generating study aimed to explore the association of preoperative serum 25-hydroxyvitamin D [25(OH)D] levels with deep vein thrombosis (DVT) risk after total knee arthroplasty (TKA) and clarify the potential coagulation-related mechanisms. Methods A total of 193 patients undergoing primary unilateral TKA in a single center were stratified into 25(OH)D deficiency (<20 ng/mL, n = 106), insufficiency (20–29 ng/mL, n = 47), and sufficiency (≥30 ng/mL, n = 40) groups. Postoperative DVT (dete …

27.08.2026journal-article

Cancers

Treatment Sequencing of CDK4/6 Inhibitors in Bone-Only Hormone Receptor-Positive Metastatic Breast Cancer: Multi-Center Real-World Data Revealing a Numerical Trend Favoring Later-Line Use

Serkan Yıldırım, Büşra Bülbül, Bekir Ucun, İrem Turgut Yeğen, Cengiz Yılmaz, Atike Pınar Erdoğan, Ece Şahin Hafızoğlu, Erhan Gökmen, Murat Araz, Ahmet Oruç, Orhan Önder Eren

Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy represent the gold standard in the first-line treatment of hormone receptor (HR)-positive, HER2-negative metastatic breast cancer (MBC). However, the optimal timing of CDK4/6i initiation in patients with bone-only disease (BoD) remains a matter of clinical discussion. This multicenter retrospective study evaluated the impact of CDK4/6i treatment line (first-line vs. second-or-later-line) on progression-free survival (PFS) a …

27.08.2026journal-article

Undergraduate Research in Natural and Clinical Science and Technology Journal

The University of Ottawa Healthcare Symposium (UOHS) 2026 Pitch-O-Rama: Undergraduate Elevator Pitch Research Competition

Maryam Al-Zadjali, Donya Sobati

The University of Ottawa Healthcare Symposium (UOHS) is an undergraduate conference that highlights the role of interdisciplinary collaboration in healthcare. Now in its sixteenth year, UOHS brings together students and researchers from fields such as biomedical sciences, engineering, health policy, and digital health to explore current challenges and advancements in healthcare. The conference provides a platform for discussions on emerging technologies, healthcare delivery, and the integration of research into cli …

27.08.2026journal-article

Journal of Wellness

A Language We Built Together: A Physician Assistant’s Reflection on a Renal Transplant

Oviya Mahendran, Sampathkumar Sakthi Selvakumar

This is not just a story of kidney transplantation in a tertiary care hospital in a tier-2 city of South India. It is all about a true clinical journey of resilience, where a young woman with congenital hearing loss, battling chronic kidney disease, discovered hope, understanding, and companionship through a physician assistant's compassionate communication.