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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Molecular Cancer Therapeutics

New Therapeutic Cancer Vaccine with Lenalidomide Induces Potent T-cell Immunity and Inhibits HPV E6/E7–Expressing Tumor Growth in Mice

Yohannes Gemechu, Sonia Mukherjee, Jeffrey A. Gelfand, Timothy A. Brauns, Ann E. Sluder, Pierre R. Leblanc, Yuki Agarwala, James Adeosun, Abigail Colley, Daiki Sugita, Jacob J. Smith, George Steinfels, Paul Korner, Ishan Capila, Patrick M. Reeves, Mark C. Poznansky

Abstract Current prophylactic human papillomavirus (HPV) vaccines prevent infection but have limited therapeutic benefit in established HPV-driven malignancies. To address this unmet need, we developed VTX-067, a modular self-assembling therapeutic cancer vaccine consisting of a recombinant Mycobacterium tuberculosis heat shock protein 70–avidin fusion (MAV) noncovalently bound to biotinylated HPV E6/E7 MHC class I– and II–restricted peptide concatemers. MAV is produced in Chinese hamster ovary cells with minimal e …

24.08.2026journal-article

Frontiers in Health Services

Operationalizing patient flow in high-complexity service lines: a health system perspective using oncology care

Robert Figlin, Kate O’Shaughnessy, Setu Shah, Chad Giese, Jamie Bachman, Matthew Bednar, Jennifer Scalise, Aleksandar Zafirovski

Background Health systems face increasing oncology demand amid workforce constraints and rising care complexity. Outpatient cancer volumes in the United States are projected to grow nearly 18% over the next decade, driven by earlier diagnoses, evolving screening guidelines, and continued site-of-care shifts — while inpatient volumes remain essentially flat but grow in case mix complexity. Many organizations attempt to improve access through isolated interventions — navigation programs, clinic expansion, or scheduli …

24.08.2026journal-article

Frontiers in Immunology

Building bridges to immunotherapy: a knowledge-mapping analysis of cervical cancer organoid research

Yuanyuan Tian, Hui Chang, Jinjin Liu, Wenjun Ding, Jian Jin, Chi Qin, Shuoshi Zhao, Xin Zhao

Cervical cancer, a human papillomavirus (HPV) -driven malignancy with inherent viral antigenicity, serves as a key model in immuno-oncology. Yet, the variable efficacy of immune checkpoint inhibitors highlights a critical gap: the lack of preclinical models that accurately mirror the patient-specific tumor microenvironment (TME). Patient-derived organoids (PDOs) offer a transformative solution, preserving autologous tumor and immune components for personalized therapeutic testing. This study provides the first bibl …

24.08.2026journal-article

Revista Sustinere

Vivências Relativas Ao Câncer De Mama: Insights Categoriais Com Suporte em Pesquisas Indexadas Na Scopus

Fabiana Pinto de Almeida Bizarria, Eurizando Gomes Caomique, Juliana Carvalho de Sousa, Flavia Lorenne Sampaio Barbosa, Rogeane Morais Ribeiro

Esse trabalho possui como objetivo mapear a produção indexada na Scopus sobre a experiência de mulheres com câncer de mama e sintetizar impactos físicos, psicossociais e socioeconômicos. Métodos: estudo bibliométrico descritivo (1961–2022), guiado por princípios do PRISMA aplicáveis à triagem e elegibilidade: busca TITLE-ABS-KEY (“breast cancer” AND “prevention” AND “management”), filtros article/review; extração e análise em VOSviewer (co-ocorrência, co-citação e acoplamento). Dois revisores realizaram triagem de …

24.08.2026journal-article

The Laryngoscope

Endoscopic Assisted Transoral Approach for Maxillofacial Tumor Resection—A Retrospective Study

Shuai Chen, Guanru Wang, Heyi Tang, Chenxi Yu, Zifan Lin, Chunjie Li, Bing Yan

ABSTRACT Objective Surgical resection of maxillofacial tumors requires balancing radical resection with functional and esthetic preservation. Endoscopic‐assisted and transoral techniques offer minimally invasive alternatives, but each has limitations. This retrospective study evaluates the endoscopic‐assisted transoral approach (EATA) for maxillofacial tumor resection, analyzing its technical characteristics, perioperative outcomes, and safety. Methods Patients who underwent tumor resection via EATA at West China H …

24.08.2026journal-article

International Journal of Health Sciences

Solid Pseudo Papillary Neoplasm of the Pancreas (Frantz Tumor) in a 19-Year-Old Female: A Case Report

Jane Racheal Ayikoru, Phiona Eyotaru, Kirabo Iga, Vianney Kweyamba

We report the case of a 19-year-old female who presented with a one-month history of epigastric pain, nausea and occasional vomiting. Contrast-enhanced computed tomography demonstrated a characteristic solid-cystic mass in the pancreatic head suggestive of solid pseudo papillary neoplasm (SPN) of the pancreas. The patient underwent open pancreatico-duodenectomy (Whipple procedure). Histopathology confirmed a low-grade SPN with clear margins. Postoperative complications, including pancreatic fistula, acute pancreati …

24.08.2026journal-article

Pharmaceuticals

Harmine Hydrochloride from Peganum harmala L. Targets NFAT1 for Proteasomal Degradation to Suppress Ovarian Cancer Progression

Xingli Zhang, Huili Zhu, Chengshu Yu, Shuang Huang, Dongdong Fang

Background/Objectives: Ovarian cancer is a prevalent gynecological malignancy with high mortality rates worldwide. Harmine hydrochloride (HMH), a tricyclic β-carboline alkaloid derived from the seeds of the medicinal plant Peganum harmala L., has demonstrated anti-tumor activity. This study investigated the effect of HMH on ovarian cancer and elucidated its underlying molecular mechanism. Methods: The anti-ovarian cancer effects of HMH were evaluated using the CCK-8 assay, cell cycle and apoptosis analyses, as well …

24.08.2026journal-article

International Journal of Biology and Life Sciences

The Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment and the Mechanism of Immune Therapy Resistance

Ganyu Yi

The efficacy of immune checkpoint inhibitors (ICIs) is often limited by primary and acquired resistance induced by the tumor microenvironment (TME), with the metabolic reprogramming of immune cells being the core mechanism. This review systematically analyzes the three key metabolic stresses in the TME: glucose deprivation, lactate accumulation, and adenosine accumulation. How these metabolic stresses, by reshaping the metabolic states and functions of T cells, macrophages, and dendritic cells, jointly construct an …

24.08.2026journal-article

Current Treatment Options in Neurology

Idiopathic Intracranial Hypertension and Pregnancy: Recent Developments

Leanne Stunkel

Abstract Purpose to Review This review summarizes what is currently known about idiopathic intracranial hypertension (IIH) during pregnancy, with a focus on recent developments. Monitoring of IIH during pregnancy, pharmacologic and surgical treatment options, prognostic factors, and comorbidities are discussed. Recent Findings Although this is an understudied area, several recent prospective and large database studies have expanded knowledge of this important topic. Recent data continues to support prior understand …

24.08.2026journal-article

Journal of Patient-Reported Outcomes

Treatment completion and quality of life in inpatient alcohol treatment: a secondary observational analysis within a randomized controlled trial in Interior Alaska

Austin Henderson, Robert Rosenman, Carolyn Noonan, Spero M. Manson

Abstract Background Long-term inpatient alcohol treatment is commonly used to reduce disordered drinking and improve quality of life (QoL). While prior research has identified associations between treatment completion and improved QoL, this relationship may reflect selection: patients with higher baseline QoL may be more likely to complete treatment. Methods Drawing upon data from the Transitions to Recovery (TTR) study, a randomized controlled trial conducted among patients exiting acute detoxification in Interior …

24.08.2026journal-article

Frontiers in Microbiology

Development of 3D spheroids of AGS gastric cancer cells in vitro for exploration of H. pylori influence on tumor environment and anti-cancer activity of PLA-His-DOX nanoparticles

Patrycja Jaroniek, Magdalena Chmiela, Marek Brzeziński, Weronika Gonciarz

Introduction Gastric cancer (GC) is a complex disease, which may have infectious origin. Helicobacter pylori ( H. pylori ) Gram-negative bacteria are linked with GC development. There is growing interest in nanotechnology to develop therapeutic solutions for the treatment of GC in situ . The predictive assessment of nanomedicine efficacy in GC remains limited due to the lack of physiologically relevant models that capture tumor architecture and infection-driven reprogramming of gastric environment. Methods The aim …

24.08.2026journal-article

Frontiers in Oncology

Evaluation of the efficacy and safety of first-line therapies for peripheral T-cell lymphoma: a systematic review and network meta-analysis

Jiaxing Zhao, Bailin Wu, Youchao Jia

Objective To compare the efficacy and safety of first-line therapies for peripheral T-cell lymphoma (PTCL) via network meta-analysis. Methods We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials (RCTs) evaluating first-line treatments in untreated PTCL patients (up to March 1, 2025). Two investigators independently screened studies, extracted data, and assessed bias risk. Network meta-analysis was performed using R (v4.3.0). Results Seven RCTs (1,334 patie …

24.08.2026journal-article

Frontiers in Pharmacology

A biomarker-guided framework for corticosteroid treatment stratification in acute exacerbation of idiopathic pulmonary fibrosis

Qinglong Chen, Yingying Zhang, Jialu Li, Qingjun Zhu, Ziyue Wang, Xin Wen

Acute exacerbation of idiopathic pulmonary fibrosis is a fatal acute-on-chronic respiratory event with limited evidence-based treatment options. Systemic corticosteroids remain widely used, yet their benefit in unselected patients is uncertain, and indiscriminate immunosuppression may expose some patients to harm. A major translational gap is that most available biomarkers describe diagnosis, risk, or prognosis, but do not identify whether corticosteroids actually modify patient outcomes. This Hypothesis and Theory …

24.08.2026journal-article

Healthcare

Menopausal Symptom Burden, Quality of Life, Healthcare-Seeking Behavior, and Treatment Satisfaction: A Cross-Sectional Study of Romanian Women

Andrei Pescaru, Flavia Crișan, Radu Ioan Lala, Adrian Cosmin Ilie, Norbert Wellmann, Adelina Marițescu, Alaviana Monique Faur, Daian Ionel Popa, Roxana Folescu

Background/Objectives: Menopausal symptoms can impair quality of life and influence healthcare use. This study examined symptom burden, menopause-specific quality of life, healthcare seeking, consultation delay, treatment satisfaction, and associated demographic and clinical factors among Romanian women. Methods: This cross-sectional study included 204 peri- and postmenopausal women. We assessed symptoms and quality of life using the Menopause Rating Scale (MRS) and the Menopause-Specific Quality of Life Questionna …

24.08.2026journal-article

Russian Journal of Anesthesiology and Reanimatology

Plasma exchange in the treatment of sepsis: a review of randomized clinical trials

D.D. Kartashev, D.L. Shukevich

Plasma exchange is one of the extracorporeal treatment methods for sepsis. Despite extensive research of plasma exchange, changes in definitions of sepsis, heterogeneous patient populations and differences in study design make it difficult to define the target population for this method. The purpose of this review was to analyze publications devoted to plasma exchange for the treatment of sepsis. Searching was conducted in PubMed database using appropriate keywords. Final searching session was conducted on February …

24.08.2026journal-article

American Journal of Hospice and Palliative Medicine®

Individualized Opioid Titration for Complex Symptom Management in Terminally Ill Cancer Patients Receiving Home Hospice Care: A Prospective Cohort Study

Kunihiko Watanabe, Kumi Tochimura, Hiromi Fujita, Yukie Kushima, Kazuhiko Kushima, Yuki Kamiyama, Akemi Hemmi

Background Individualized opioid titration is recommended for symptom management in patients with advanced cancer, but prospective data from home hospice care remain limited. We evaluated individualized opioid titration in terminally ill cancer patients receiving physician-led home hospice care. Methods This prospective observational study included 501 consecutive terminally ill cancer patients who died under the care of a home hospice clinic between January 2020 and December 2025. Opioids were prescribed for cance …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Core Bottlenecks and Optimization Strategies of Delivery Systems for Cancer Gene Therapy: Intracellular Delivery Barriers, Deficient Targeting, and Insufficient Stability

Jialin Shi

Cancer gene therapy can intervene in cancer progression at the genetic level, which is an important innovative direction for tumor treatment. Its clinical application is limited by the safety and efficiency of nucleic acid delivery in the body. With the continuous optimization of related technologies and vectors, the academic circle has made key progress in overcoming in vivo delivery barriers and improving material systems. Nevertheless, existing delivery systems still face key challenges such as the difficulty in …

24.08.2026journal-article

Anti-Cancer Drugs

Prophylactic tramadol for oxaliplatin-induced peripheral vascular pain: a single-arm retrospective study

Fumitaka Kawaguchi, Takafumi Tsuneki, Michiko Kobayashi, Motohiko Sano

Oxaliplatin-induced peripheral vascular pain (OIVP) often requires central venous port placement. Conventional preventive strategies have limited efficacy, and the use of some effective analgesics is restricted. This single-center retrospective study evaluated the efficacy and safety of prophylactic tramadol. Electronic medical records of patients who received oxaliplatin-based chemotherapy via a peripheral intravenous line and experienced vascular pain [numerical rating scale (NRS) score ≥ 4] were reviewed. Patien …

24.08.2026journal-article

Holistic Integrative Oncology

Body composition and chemotherapy-related toxicities in early-stage breast cancer: implications for personalized treatment strategies

Xiaotong Tang, Jinyue Wang, Doudou Feng, Yuan Tian, Xiyue Zhang, Minghui Zhang, Yang Zhang, Bin Yang, Xin Zhou, Jinping Zhao, Wei Tao, Yuting Liu, Zhenhua Zhai

Abstract Background Chemotherapy-related toxicity may result in dose reduction, treatment interruption, or premature discontinuation in patients with early-stage breast cancer. Conventional body surface area-based dosing does not adequately account for interindividual differences in muscle mass, adiposity, or fat distribution, which may influence drug disposition and treatment tolerance. Aims This study aimed to summarize the assessment methods, clinical indicators, potential mechanisms, and current evidence linkin …

24.08.2026journal-article

Clinical Cancer Research

Landmark ctDNA Molecular Response Represents an Early Predictor of Immunotherapy Outcomes in Lung Cancer: A Clinical Validity Study

Noushin Niknafs, Lavanya Sivapalan, Archana Balan, Jaime Wehr, Gavin Pereira, Samira Hosseini-Nami, Nisha Rao, Shreshtha Jolly, Kavya Velliangiri, Iiasha Beadles, Tiffany Loftus, Bryan Chesnick, Jamie Medina, Wenming Xiao, Aliyah Pabani, Kristen A. Marrone, Qing Kay Li, Joseph C. Murray, Lorenzo Rinaldi, Nicholas C. Dracopoli, Mark Sausen, Christine L. Hann, Susan C. Scott, Josephine Feliciano, Vincent K. Lam, Benjamin Levy, Victor E. Velculescu, Julie R. Brahmer, Patrick M. Forde, Paz J. Vellanki, Valsamo Anagnostou

Abstract Purpose: Circulating tumor DNA (ctDNA) analyses are informative as an early indicator of immunotherapy response in advanced non–small cell lung cancer (NSCLC); however, the clinical value of ctDNA molecular response (mR) requires further validation. Experimental Design: As part of a prospective clinical protocol (NCT05995821), we conducted targeted error-correction sequencing of ctDNA (n = 328) and matched white blood cell (WBC) DNA (n = 109) from 109 patients with metastatic NSCLC who received anti–PD-(L) …

24.08.2026journal-article

Lecture Notes in Education Psychology and Public Media

Attention-Deficit/Hyperactivity Disorder: A Review of Neurocognitive Mechanisms, Diagnosis, and Treatment

Yue Cao

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that involves long-term issues with attention regulation, impulse control and activity regulation which may disrupt various core functions like learning, socializing and daily functioning. The epidemiological data of ADHD worldwide show that the prevalence of this disorder is very high in females throughout their lives. Over fifty percent of child patients carry their core symptoms into adulthood and most of them also have high comorbi …

24.08.2026journal-article

British Journal of Radiology

Systematic review: Stereotactic Body Radiation Therapy for Pancreatic Cancer: Evaluating its Efficacy, Safety, and Future Prospects

Biplab Sarkar

Abstract Aim This systematic narrative review evaluates the efficacy, safety, and future potential of Stereotactic Body Radiation Therapy (SBRT) in locally advanced pancreatic cancer (LAPC), particularly for patients unsuitable for surgery. Methods A systematic search of PubMed, Embase, and the Cochrane Library identified English and select non-English studies published between January 2010 and November 2025. Search terms included “pancreatic cancer,” “SBRT,” “locally advanced pancreatic cancer,” “adaptive radiothe …

24.08.2026journal-article

Frontiers in Immunology

S-ketamine dampens effector T-cell function, thereby promoting tumor progression

Dongge Niu, Lei Wang, Ruiyuan Wei, Lan Yao

Background S-ketamine, a widely used clinical analgesic drug and also employed as a therapeutic regimen in cancer pain management, but whether S-ketamine influence on effector immune cells when conquering tumor cells remains unclear. Methods In this study, we established effector T cells (chimeric antigen receptor T cells (CAR- T cells) and TCR-engineered T cells (TCR-T cells)) and treated with different concentrations of S-ketamine and investigated its impact on antitumor efficacy of effective T cell in vitro and …

24.08.2026journal-article

The American Journal of Chinese Medicine

Ginseng-Containing Sijunzi Decoction Inhibits Colorectal Cancer Progression by Regulating MARCHF3-ALOX15-Mediated Ferroptosis

Yong Gao, Guoqun Chen, Xinyu Jiang, Wenbin Gao, Zhengyong Li, He Zhao, Jiefeng Liu, Zhenquan Wang

Colorectal cancer (CRC) frequently develops resistance to 5-fluorouracil (5-FU)-based chemotherapy, which remains a major obstacle to successful treatment. Ginseng-containing Sijunzi Decoction (SJZD), a classical Traditional Chinese Medicine formula, has demonstrated antitumor activity; however, whether and how SJZD enhances 5-FU sensitivity remains largely unclear. In this study, SJZD-containing serum was prepared and administered to 5-FU-resistant CRC cell lines (HCT116/5-FU and SW480/5-FU). Chemosensitivity was …