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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

British Journal of Radiology

Systematic review: Stereotactic Body Radiation Therapy for Pancreatic Cancer: Evaluating its Efficacy, Safety, and Future Prospects

Biplab Sarkar

Abstract Aim This systematic narrative review evaluates the efficacy, safety, and future potential of Stereotactic Body Radiation Therapy (SBRT) in locally advanced pancreatic cancer (LAPC), particularly for patients unsuitable for surgery. Methods A systematic search of PubMed, Embase, and the Cochrane Library identified English and select non-English studies published between January 2010 and November 2025. Search terms included “pancreatic cancer,” “SBRT,” “locally advanced pancreatic cancer,” “adaptive radiothe …

24.08.2026journal-article

Frontiers in Immunology

S-ketamine dampens effector T-cell function, thereby promoting tumor progression

Dongge Niu, Lei Wang, Ruiyuan Wei, Lan Yao

Background S-ketamine, a widely used clinical analgesic drug and also employed as a therapeutic regimen in cancer pain management, but whether S-ketamine influence on effector immune cells when conquering tumor cells remains unclear. Methods In this study, we established effector T cells (chimeric antigen receptor T cells (CAR- T cells) and TCR-engineered T cells (TCR-T cells)) and treated with different concentrations of S-ketamine and investigated its impact on antitumor efficacy of effective T cell in vitro and …

24.08.2026journal-article

The American Journal of Chinese Medicine

Ginseng-Containing Sijunzi Decoction Inhibits Colorectal Cancer Progression by Regulating MARCHF3-ALOX15-Mediated Ferroptosis

Yong Gao, Guoqun Chen, Xinyu Jiang, Wenbin Gao, Zhengyong Li, He Zhao, Jiefeng Liu, Zhenquan Wang

Colorectal cancer (CRC) frequently develops resistance to 5-fluorouracil (5-FU)-based chemotherapy, which remains a major obstacle to successful treatment. Ginseng-containing Sijunzi Decoction (SJZD), a classical Traditional Chinese Medicine formula, has demonstrated antitumor activity; however, whether and how SJZD enhances 5-FU sensitivity remains largely unclear. In this study, SJZD-containing serum was prepared and administered to 5-FU-resistant CRC cell lines (HCT116/5-FU and SW480/5-FU). Chemosensitivity was …

24.08.2026journal-article

Cardiology in Review

Osimertinib-Associated Cardiotoxicity in EGFR-Mutant Non–Small Cell Lung Cancer: Mechanisms, Phenotypes, and Surveillance

Sooraj Srirangadhamu Gopu, Abul Hasan Shadali Abdul Khader, Siddharth Pravin Agrawal, Salman Ayub Jajja, Anjali Pareshbhai Patel, William H. Frishman, Wilbert S. Aronow

Osimertinib, a third-generation EGFR-TKI, is now the standard first-line treatment for EGFR-mutant non–small cell lung cancer and is increasingly given in the adjuvant setting for up to 3 years and in combination with chemotherapy. As exposure has lengthened and shifted toward curative-intent settings, its cardiac effects have acquired greater clinical weight, because patients may remain on therapy for years and survive long enough for cardiovascular outcomes to matter. This review argues that the dominant cardiac …

24.08.2026journal-article

Diagnostics

Endometrioid Immunohistochemical Prognostic Score Integrating SIRT1, HMGB1, Bcl-2, and Caspase-3 Expression in Endometrioid-Type Endometrial Cancer

Birant Boldan, Batuhan Kunt, Figen Efe Çamili, Atilla Kunt, Abdurrahman Yiğit, Gürhan Güney, Mine İslimye Taşkın, Gülay Turan, Yunus Emre Yörük, Selim Afsar

Background/Objectives: Prognostic stratification of stage I endometrioid-type endometrial cancer remains imperfect when based on clinicopathological variables alone. This retrospective study evaluated immunohistochemical markers reflecting stress adaptation, inflammatory signaling, autophagy regulation, and apoptotic balance, and developed an exploratory Endometrioid Immunohistochemical Prognostic Score (EIPS) based on SIRT1, HMGB1, Bcl-2, and Caspase-3 expression. Methods: Using surgical specimens from 139 patient …

24.08.2026journal-article

Frontiers in Immunology

First-Line treatment for transplant-ineligible newly diagnosed multiple myeloma: a Bayesian network meta-analysis of efficacy, safety, and high-risk subgroups

Dani Zhong, Hao Cheng, Lin Zeng, Chun Tian, Chunchun Liang, Hongyu Wei, Mengling Xu, Meili Pang, Qing Ke, Xiaohong Tan, Hong Cen, Chengcheng Liao

Anti-CD38 monoclonal antibody-based regimens have emerged as the first-line standard of care for transplant-ineligible newly diagnosed multiple myeloma (NDMM), yet direct head-to-head comparisons between individual regimens remain limited. The systematic review identified 11 eligible randomised controlled trials; 6 of these, involving 3162 patients, entered the Bayesian network meta-analysis to systematically evaluate the efficacy, safety, and benefits in the cytogenetically high-risk subgroup across 7 treatment no …

24.08.2026journal-article

Frontiers in Pharmacology

Anti-cancer effects of plant extracts in head and neck squamous cell carcinoma

Haoran Zhou, Yafei Li, Lu Liu, Bo Li

Current treatments for head and neck squamous cell carcinoma (HNSCC) often encounter difficulties such as local tumor recurrence, distant metastasis, drug resistance, and significant toxic side effects. Plant extracts have become important resources for the development of anti-HNSCC drugs due to their multi-target action mechanisms, abundance of bioactive components, reversal of drug resistance, and high selectivity/low toxicity. The challenges faced by plant extracts during anti-cancer clinical translation include …

24.08.2026journal-article

Frontiers in Medicine

Cost-effectiveness analysis of eltrombopag, hetrombopag and romiplostim for second-line treatment of primary immune thrombocytopenia in China

Xi Chen, Yadi Liu, Jianping Zhang, Rong Xu, Cheng Guo

Background Primary immune thrombocytopenia (ITP) is a chronic autoimmune bleeding disorder requiring long-term second-line treatment in patients refractory to corticosteroids and immunoglobulins. In China, eltrombopag, hetrombopag, and romiplostim are all available after national reimbursement negotiations, but comparative economic evidence to inform optimal therapeutic selection remains limited. This study aimed to evaluate the cost-effectiveness of eltrombopag, hetrombopag, and romiplostim as second-line treatmen …

24.08.2026journal-article

Journal of the Chinese Medical Association

Risk factors of hepatotoxicity with ribociclib in hormone receptor-positive breast cancer

Wei-Chi Lin, Yu-Li Chang, Sheng-Fan Wang, Chia-Chen Hsu, Chian-Ying Chou, Ling-Ming Tseng, Ta-Chung Chao

Background: The standard first-line treatment for hormone receptor-positive metastatic breast cancer is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, including palbociclib, ribociclib, or abemaciclib, combined with endocrine therapy. Hepatobiliary toxicity is an important adverse effect of ribociclib. This study compared the risk of hepatotoxicity between ribociclib and palbociclib and identified factors associated with hepatotoxicity. Methods: This retrospective cohort study included patients with hormone rece …

24.08.2026journal-article

Frontiers in Oncology

From detection to action: ctDNA-MRD surveillance and translational strategies in early breast cancer

Jing Feng, Yujun Tong, Zhen Zhang, Ye Zhang

Recurrence remains a major cause of mortality in early breast cancer (EBC), and conventional follow-up often identifies relapse only after clinically detectable disease has emerged. Circulating tumor DNA–based minimal residual disease (ctDNA-MRD) testing offers the possibility of detecting molecular relapse earlier and refining recurrence-risk assessment during follow-up. This narrative review examines the evolving role of ctDNA-MRD in EBC, focusing on assay interpretation, longitudinal surveillance, MRD-guided tri …

24.08.2026journal-article

Frontiers in Chemical Biology

Molecular hydrogen in cancer: reprogramming oncogenic signaling pathways and emerging pharmacological potential

Anirban Kumar Maity, Ajay Mallick, Debbie C. Crans, Srikanta Goswami, Soumyajit Roy

Molecular hydrogen (H 2 ) is a chemically inert, non-toxic, highly diffusible gas that has recently attracted considerable interest as a novel bioactive mediator with growing therapeutic relevance in oncology. Emerging evidence suggests that H 2 modulates multiple pathways involved in cancer initiation and progression, including attenuation of oncogenic signaling, suppression of metastatic dissemination, enhancement of therapeutic responsiveness, and regulation of epigenetic, mitochondrial, and immune-associated on …

24.08.2026journal-article

Cancer Prevention Research

TP53-Mutated Preneoplastic Colonies, Adaptive Immune Response, and Risk for Lung Cancer and COPD

James C. Willey, Andrew R. Boring, Erin L. Crawford, Kevin N. Lei, Thomas M. Blomquist, Christopher I. Amos, Stephen A. Deppen, Eric L. Grogan, Heidi Chen, Mohamed Omballi, Daniel J. Craig

Abstract The purpose of this study was to better characterize the prevalence and size distributions of TP53-mutated preneoplastic colonies in relation to the risk for lung cancer and chronic obstructive pulmonary disease (COPD). Ultrasensitive next-generation sequencing was used to assess colonies comprising as few as 100 cells in airway epithelium. Specimens from 59 subjects with a heavy smoking history were assessed in four cohorts: lung cancer with (n = 14) or without COPD (n = 16) and non–lung cancer with (n = …

24.08.2026journal-article

Scientific Reports

Parental knowledge, attitude and acceptability of Human Papillomavirus vaccine: implications for the prevention of cervical cancer in India

Akanksha Singh, Varun Kumar S G, Anusree Prabhakaran, Prabhu Dutta Shaw, Arathi P. Rao

Abstract The Human Papillomavirus (HPV) vaccine is a key tool for cervical cancer prevention; however, vaccine uptake in India remains low despite its recent introduction as a free single-dose vaccine through the public health system. Parental acceptance to vaccination is key to ensure vaccine uptake of adolescent girls. Hence, this study was conducted to assess the knowledge, attitude and acceptability of HPV vaccination parents of adolescent girls, during the early phase of HPV vaccine rollout. This community-bas …

24.08.2026journal-article

Middle Black Sea Journal of Health Science

The Effect of Training Given To The Caregivers of The Patients Receiving Hemodialysis Treatment on The Care Burden and The Patients’ Quality of Life: A Quasi- Experimental Study

Betül Bayrak, Birsel Demirbağ

Objective: To evaluate the effect of structured training in home given by the nurse to the caregivers of the patients receiving hemodialysis treatment on the care burden of the caregivers and the patients’ quality of life.Methods: This study employed a single-group quasi-experimental pre-post-test design. The study was conducted with 35 caregivers of patients undergoing hemodialysis treatment. The data were collected using a Patient and Caregiver Information Forms, the Barthel Index, the SF 36 Scale, the Zarit Care …

24.08.2026journal-article

Supportive Care in Cancer

Oxycodone combined with pulsed radiofrequency for refractory cancer pain from spinal metastases: a randomized controlled study

L Li, Hj Wang, Xj Wang, Sc Xing, Jh Zhong

Abstract Objectives To assess the clinical efficacy and safety of oxycodone combined with pulsed radiofrequency (PRF) in the treatment of refractory cancer pain (RCP) arising from spinal metastasis. Methods A randomized controlled trial enrolled 60 patients with RCP due to spinal metastases. Participants were randomly allocated to the oxycodone alone group (Group A, n = 30) or the oxycodone combined with PRF group (Group B, n = 30). Primary outcomes comprised pain scores on the Numerical Rating Scale (NRS) and epis …

24.08.2026journal-article

Discover Oncology

AKR7A3 rs1738023 association with susceptibility to female hepatocellular carcinoma and its role in AFB1 metabolism and tumor

Jiakao Zhang, Yuan Liao, Ketuan Huang, Yongfei He, Meifeng Chen, Shutian Mo, Qiang Gao, Xinping Ye, Tao Peng, Chuangye Han

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancer worldwide. In this study, we performed a two-stage exome-chip association analysis and found that the aldo-keto reductase family7 member A3 (AKR7A3) rs1738023 may be a potential susceptibility locus for HCC in females. We aimed to explore its role and mechanism. Methods The association between genotype and phenotype was analyzed through GWAS method. The expression of AKR7A3 in cancer tissue and blood analysis by qRT-PCR. The relatio …

24.08.2026journal-article

Frontiers in Genetics

FOXP1 transcriptionally activates NUSAP1 to induce M2 polarization of tumor-associated macrophages via glycolysis in hepatocellular carcinoma

Zhiwei Wang, Yuyi Mao, Jiangang Wang, Yafeng Yu, Jiawei Shao, Yingming Fei, Jinlong Zhu, Mingjiong Tong

Background In hepatocellular carcinoma (HCC), the polarization of tumor-associated macrophages (TAMs) towards the M2 phenotype is a key factor driving the formation of an immunosuppressive microenvironment and malignant progression, a process frequently associated with glycolytic metabolic reprogramming. Nucleolar and spindle associated protein 1 (NUSAP1) is aberrantly overexpressed in various malignancies. However, whether it promotes HCC progression by driving TAM M2 polarization through regulating tumor cell gly …

24.08.2026journal-article

Updates in Surgery

Quality of life in breast cancer survivors: a comparative analysis between breast conservative treatment (BCT) and post-mastectomy breast reconstruction (PMBR) using either autologous or prosthetic reconstruction

Emanuele Cammarata, Federico Coppola, Giovanni Zabbia, Mara Franza, Salvatore Vieni, Calogero Cipolla, Adriana Cordova, Francesca Toia

Abstract Breast cancer remains the most commonly diagnosed cancer in women, with surgical intervention as a cornerstone treatment. Options include breast-conserving therapy (BCT) and mastectomy with or without post-mastectomy breast reconstruction (PMBR). This study aimed to compare quality of life (QoL) outcomes between breast-conserving therapy (BCT) and post-mastectomy breast reconstruction (PMBR), with either autologous DIEP flap or expander/prosthetic reconstruction. A single-institution retrospective study wa …

24.08.2026journal-article

Advanced Science

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green

ABSTRACT Background & Aims : Primary liver cancer is the third leading cause of cancer death worldwide, and about 70% of hepatocellular carcinomas (HCCs) do not respond to systemic immunotherapies. Transarterial chemoembolization (TACE) remains standard treatment for intermediate‐stage HCC, but long‐term survival is poor. We aimed to develop a polymeric TACE‐like platform to sensitize liver cancer to checkpoint inhibitors by enabling sustained co‐delivery of panobinostat and IL‐12. Methods : Patient‐derived liver c …

24.08.2026journal-article

Annals of Surgical Oncology

Definitive Chemoradiotherapy for Adenocarcinoma of the Esophagus or Esophago-Gastric Junction: A Dutch Population-Based Cohort Study

S. S. G. Gangaram Panday, O. Khoma, H. W. M. van Laarhoven, L. van Doorn, J. Nuyttens, P. S. N. van Rossum, R. H. A. Verhoeven, B. P. L. Wijnhoven, B. Mostert, S. M. Lagarde

Abstract Background Locally advanced esophageal adenocarcinoma has a poor prognosis and limited treatment options when surgery is not possible or desired. Although definitive chemoradiotherapy (dCRT) is currently administered as a curatively intended treatment, limited data exist regarding its efficacy for patients with adenocarcinoma of the esophagus, necessitating further evaluation of survival outcomes. Methods Patients with a diagnosis of adenocarcinoma of the esophagus or esophago-gastric junction who had unde …

24.08.2026journal-article

Journal of Comparative Effectiveness Research

Indirect treatment comparisons find enhanced effectiveness of pegcetacoplan versus crovalimab in both complement inhibitor-naïve and -experienced patients with paroxysmal nocturnal hemoglobinuria

Raymond Siu Ming Wong, Koo Wilson, Zalmai Hakimi, Mikolaj Parkitny, Piotr Wojciechowski, Catherine Flynn, Francis Fatoye

Aim: Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare hematological condition, which if undertreated, is associated with significant morbidity and early mortality. This indirect treatment comparison (ITC) evaluated the effectiveness of pegcetacoplan (the first approved proximal inhibitor) versus crovalimab, a new C5i inhibitor (C5i), for treatment of PNH in C5i-naive and C5i-experienced patients. Materials & methods: In the C5i-naive, an unanchored matching-adjusted indirect comparison (MAIC) was conducte …

24.08.2026journal-article

Holistic Integrative Oncology

Acute myeloid leukaemia-myelodysplasia related (AML-MR) presented with acute basophilic leukaemia at diagnosis

Jian-xin Liu, Chun-jian Wang, Mei-xiang Zhang

Abstract Acute myeloid leukaemia-myelodysplasia related (AML-MR) are clonal myeloid neoplasms with a poor prognosis. Acute basophilic leukaemia (ABL) is a rare subtype of AML characterized with rapid clinical course, symptoms of hyperhistaminemia, and resistance to therapy. We herein presented a case of a 67-year-old male with hematologic parameters met the criteria for AML-MR and ABL. This patient was diagnosed with AML-MR presented with ABL and classified to a high-risk category with TP53 mutation and complex kar …

24.08.2026journal-article

JCO Oncology Practice

Interconnectedness of Factors Affecting Patient Willingness to Discuss Prostate Cancer Clinical Trials With Physicians

Janaka S.S. Liyanage, Vy Ong, Lauren M. Hamel, Susan Eggly, Michael A. Carducci, Dina G. Lansey, Elisabeth I. Heath, Tanina F. Moore, Terrance L. Albrecht, Mark A. Manning, Seongho Kim

PURPOSE Racial disparities in prostate cancer clinical trial participation persist. Sociodemographic and psychosocial predictors of willingness to discuss trials are often studied in separate models that do not account for intercorrelations. Using consent-time data from the Partnering Around Cancer Clinical Trials (PACCT) study (ClinicalTrials.gov identifier: NCT02906241 ), we examined multidimensional group-based medical mistrust (GBMM) and related factors within one structural equation model (SEM). METHODS We con …