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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Clinical Journal of Health Sciences

EMDR Therapy: Theoretical Foundations, Clinical Effectiveness, and a Comparative Review with Trauma-Focused Cognitive Behavioral Therapy

Deniz Erdoğan, Reşat Güven, Demet Karakartal

This study is a systematic review examining the theoretical foundations, historical development, neuropsychological mechanisms, and clinical effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy within the framework of psychiatry, clinical psychology, and trauma literature. Developed by Francine Shapiro in the 1980s, EMDR is a structured and integrative psychotherapy method that combines elements of psychodynamic, cognitive, behavioral, and client-centered approaches and is based on the repr …

27.08.2026journal-article

Microbiology Spectrum

Performance evaluation of clinical diagnostic kits for Group B Streptococcus available in China

Rong Su, Xiaoli Chen, Shouneng Lu, Yujie Zhou, Yue Liu, Qiongzi Huang, Ying Zhang, Xinyan Zheng, Mengting Li, Wangheng Hou, Kunyu Yang, Huiming Ye, Yunfeng Lv, Zimin Tang, Shengxiang Ge

ABSTRACT Group B Streptococcus (GBS) is a significant pathogen capable of causing postpartum bacteremia in pregnant women and vertical transmission to neonates, which can result in fatal outcomes. Therefore, prenatal screening for vaginal GBS colonization is essential for preventing neonatal transmission. This study conducted an external quality assessment to evaluate the performance of 12 commercially available GBS detection kits in China. A total of 12 GBS detection kits (three antigen-based and nine nucleic acid …

27.08.2026journal-article

International Journal of Teaching and Learning in Higher Education

Contextualizing Second Language Anxiety in Multilingual Higher Education: Classroom Conditions and Clinical Settings

Busayo O Ige

In South African universities, multilingual students whose first language is not English face distinct challenges that impact academic participation and success. This qualitative study examines how second language (L2) anxiety shapes first-year students’ classroom and clinical experiences at the University of Cape Town. Drawing on open-ended survey data, the study reveals that fear of negative evaluation, communicative apprehension, and prevailing language ideologies contribute to students’ reluctance to speak, fee …

27.08.2026journal-article

Textile Research Journal

Wool felt-based hospital bedding for reducing pressure injury incidence: an integrated microstructural, mechanical, and clinical study

Heloisa Nazaré dos Santos, Samuel Gomes Gontijo, Thalita Felício Soares, Túlio Vinicius Oliveira Campos, Carlos Alberto Silva de Miranda, Nelcy Della Santina Mohallem, Gustavo Fóscolo de Moura Gomes, Artur Caron Mottin, José Henrique Martins Neto, Helan Xu

This study was an investigation of the influence of using wool felt-based hospital bedding as a way of preventing the incidence of pressure injuries in patients with high risk of developing them. The influence of the number of wash cycles on lipid content, morphology, and mechanical performance of wool felt-based bedding was studied. A combined approach was adopted, including Soxhlet extraction for lipid content analysis, mechanical testing (traction, stretching, and tearing), scanning electron microscopy, and a ra …

27.08.2026journal-article

Veterinary Sciences

Modeling Canine Hemangiosarcoma Progression Using Patient-Derived 2.5D Organoids and Orthotopic Xenografts

Yishan Liu, Haru Yamamoto, Mohamed Elbadawy, Amira Abugomaa, Masahiro Kaneda, Yomogi Shiota, Tadashi Kondo, Tatsuya Usui, Kazuaki Sasaki

Canine hemangiosarcoma (HSA) is a highly aggressive vascular malignancy encountered in veterinary practice and exhibits histopathological and molecular similarities to human angiosarcoma (AS). Despite its clinical importance, the molecular mechanisms driving canine HSA remain poorly understood, limiting the development of effective therapeutic approaches. To address this challenge, we established patient-derived canine HSA 2.5D organoids as a preclinical model. Following validation of lineage-specific marker expres …

27.08.2026journal-article

Global Wound Care Journal

The efficacy, safety and patient satisfaction of platelet-rich plasma and fluid platelet-rich fibrin in chronic wound healing (2017–2025): A systematic review

Zahreh Khodashenas, Hanieh Pourkalhor

Background: Chronic wounds pose significant clinical challenges due to delayed healing and high complication rates. Platelet-rich plasma (PRP) and fluid platelet-rich fibrin (PRF) are autologous regenerative therapies that release growth factors to promote healing, yet evidence remains heterogeneous. Aim: This systematic review evaluates the efficacy, safety and patient-reported outcomes of PRF and PRP in chronic wound healing. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, Embase and …

27.08.2026journal-article

Revista de Geopolítica

SEGURANÇA DO PACIENTE EM CENTRO CIRÚRGICO: SIGNIFICADO PARA A EQUIPE MULTIPROFISSIONAL

Gabriela Bonetti Giusti, Elaine Rossi Ribeiro

A segurança do paciente tem se consolidado como um dos pilares centrais da qualidade assistencial, especialmente em ambientes de alta complexidade como os centros cirúrgicos, onde múltiplos fatores técnicos, humanos e organizacionais interagem constantemente. Nesse contexto, o presente estudo teve como objetivo apreender o significado da segurança do paciente para a equipe multiprofissional atuante em centro cirúrgico, considerando suas experiências, práticas e percepções individuais e coletivas. Trata-se de um est …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Structured game and parental education on postoperative pain and anxiety in children with appendicitis

Si Chen, Xiao-Qian Dun

BACKGROUND Acute appendicitis is a common surgical emergency in children. Postoperative pain and anxiety are prevalent among pediatric patients, and parents often experience significant negative emotions during the perioperative period. AIM To explore the effect of structured game intervention combined with parental empowerment education model on postoperative pain control and anxiety levels in children undergoing appendicitis surgery. METHODS Sixty children with appendicitis who underwent surgical treatment in Shi …

27.08.2026journal-article

Journal of Clinical Nursing

Education and Training Programmes for Health Professionals' Competence in Virtual Consultations: A Scoping Review

Britt Holst Lisbjerg, Louise Meyer Wind Mathiesen, Bettan Bagger, Lene Lauge Berring, Ditte Høgsgaard, Heidi Myglegård Andersen, Stine Thestrup Hansen, Mai‐Britt Hägi‐Pedersen

ABSTRACT Aims To map and synthesize which education and training programmes are available for current and future health professionals' competence in virtual consultations, with a special focus on training elements and structure. Design Scoping review following the PRISMA‐ScR framework. Methods Studies describing structured education or training in synchronous virtual consultations were included. Data were charted and synthesised to map training modes, educational elements, and terminology. Data Sources MEDLINE, CIN …

27.08.2026journal-article

International Journal of Psychological and Brain Sciences

Trust and Misinformation in Youth Digital Mental Health Information-Seeking in Kenya: Implications for Diagnosis Accuracy and Treatment-Seeking Behavior

Rosemary Odhiambo

Digital platforms have become primary environments through which Kenyan youth seek mental health information, interpret psychological distress, and decide whether to pursue professional care. While digital mental health information-seeking can enhance awareness, reduce stigma, and provide immediate psychosocial support, the credibility of online content remains uneven, exposing youth to misinformation, unregulated pseudo-therapy, and algorithm-reinforced diagnostic narratives. This study examines how trust and misi …

27.08.2026journal-article

Inflammatory Bowel Diseases

Reporting and representation of participant race, ethnicity, and sex in pediatric IBD clinical trials

Yunlin Jiang, Jiaying Tan, Long Qin, Mingye Zhao, Zhenyi Wang

Abstract Background and Aims Pediatric inflammatory bowel disease (IBD) incidence is rising among racial and ethnic minority children, yet to our knowledge no comprehensive evaluation of demographic representation in pediatric IBD trials exists. We systematically evaluated the reporting and representation of race, ethnicity, and sex in pediatric IBD clinical trials, stratified by Crohn disease (CD) and ulcerative colitis (UC). Methods We performed a cross-sectional study of pediatric IBD trials identified in PubMed …

27.08.2026journal-article

Annals of Pharmacotherapy

Relacorilant in Combination With Nab-Paclitaxel for the Treatment of Adults With Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Emilie J. Lynch, Lauren T. Carpenter, Kelli N. Corona, Adebola O. Fatimilehin, Nathan D. Seligson

Objective: To review the pharmacology, efficacy, and safety of relacorilant (Lifyorli) in combination with nab-paclitaxel (NP) for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received 1 to 3 prior lines of systemic therapy, including at least one bevacizumab-containing regimen. Data Sources: A literature search was conducted using Embase and PubMed/MEDLINE, applicable published abstracts, and ongoing studies from ClinicalTrials.gov betwee …

27.08.2026journal-article

Cancer Medicine

Demographic, Clinicopathological Characteristics, and Prognosis of 81 Chinese Elderly Patients With Acral Melanoma

Kaidi Yang, Xin Cai, Jin Wu, Kui Jiang, Weizhen Zhang, Hongfeng Zhou, Fang Liu, Yan Wang, Jiwei Liu, Di Wu

ABSTRACT Purpose Acral melanoma (AM) is a rare melanoma subtype involving palms, soles, and nail beds. Clinical‐pathological features and survival of elderly AM patients remain insufficiently understood. This study aimed to investigate the characteristics and survival of elderly Chinese AM patients to support clinical management. Methods Consecutive AM patients aged ≥ 75 years treated at five Chinese melanoma centers between January 2012 and March 2025 were enrolled. Results A total of 81 elderly AM patients were i …

27.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

Shengqingjiangzhuo Capsules Alleviates Renal Fibrosis by Targeting Glomerular Endothelial Cells Exosome miR ‐31‐5p/ HO ‐1 to Suppress Tubular Epithelial Cells Ferroptosis

Feng Pan, Jinhong Lu, Gaxi Ye, Haifeng Zhu, Hongyuan Ma, Jiale Li, Xingyu Yang, Hongtao Yang, Anrong Tong

ABSTRACT Objective Chronic renal failure (CRF) represents the advanced stage of chronic kidney disease, for which no specific pharmacological treatments are currently available. Traditional Chinese medicine has demonstrated notable efficacy in managing CRF. Shengqingjiangzhuo capsules (SQJZ capsules), a traditional Chinese medicinal formulation, are employed clinically in the treatment of CRF. However, the precise mechanisms underlying its therapeutic effects remain insufficiently understood. Methods The SQJZ capsu …

27.08.2026journal-article

American Journal of Forensic Medicine & Pathology

An Unusual Taphonomic Case Report of Human Skeletal Remains in an Urban Aqueduct

Ellen E.I. Fricano, Stephanie A. Torres, Alicia Morgan

Decomposition patterns and taphonomic changes associated with aquatic environments present unique challenges for forensic interpretation because they are influenced by the complex interactions among water temperature, flow dynamics, sediment deposition, and animal scavenging. The authors present an unusual case of water-submerged human remains that were discovered in a large, municipal, clean water feeder pipe. The remains were exposed to high-pressure, continuous water flow for several years, resulting in multiple …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Mechanisms underlying the reversal of hypoxia-induced energy metabolic reprogramming in cardiomyocytes by Poria cocos triterpenoids: integrated regulation of mitochondrial dynamics and the autophagy–lysosomal pathway

Zuoyue Wu, Jiadan Liao, Huilei Xu, Hongwei Hou, Jia Song

Objective To elucidate the mechanisms by which Poria cocos triterpenoids reverse hypoxia-induced energy metabolic reprogramming in cardiomyocytes through integrated regulation of mitochondrial dynamics and the autophagy–lysosomal pathway. Methods A hypoxic injury model was established in H9c2 rat cardiomyoblasts. Cells were randomized into five groups: normal control, hypoxia model, and low-, medium-, and high-dose Poria cocos triterpenoid–treated groups. Cell viability was assessed using the Cell Counting Kit-8 (C …

27.08.2026journal-article

Frontiers in Medicine

From transcriptomic profiling to precision oncology: a bibliometric analysis of RNA sequencing in acute myeloid leukemia

Yuye Ren, Jiao Ma, Wenya Hu, Lan Zhang, Xiaomin Wang

Background RNA sequencing (RNA-seq) has become an important tool for investigating the molecular heterogeneity of acute myeloid leukemia (AML); however, the global development and thematic evolution of this field remain inadequately characterized. Objective To map the global landscape of AML RNA-seq research and identify major knowledge domains, emerging themes, and temporal changes in research priorities. Methods Publications indexed in the Web of Science Core Collection and Scopus between January 1, 2007, and Aug …

27.08.2026journal-article

Frontiers in Endocrinology

Non-pharmacological therapies of traditional Chinese medicine in prediabetes: a systematic review and network meta-analysis of randomized controlled trials

Ximing Qi, Tianzuo Wang, Lin Liao

Background Prediabetes is an independent risk factor for diabetes complications and all-cause mortality. Non-pharmacological therapies of traditional Chinese medicine (NPTTCM) offer promising alternatives for prediabetes, yet their comparative efficacy remains unclear. Objective The present study aimed to evaluate the efficacies of 6 NPTTCM (acupuncture, acupoint catgut embedding (ACE), Baduanjin, electroacupuncture, massage and Taiji) in prediabetes intervention. Methods Eight databases were searched for randomize …

27.08.2026journal-article

Regenerative Medicine Reports

Natural products for treating bone diseases by targeting ferroptosis and promoting regeneration: A narrative review

Chuanxin Wang, Bingyang Yan, Wenfei Wu, Di Luo, Haisheng Yu, Duanrui Liu, Wenzhao Wang, Liang Ma

Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, plays a critical dual role in the pathogenesis and treatment of bone diseases. While it can be therapeutically harnessed to eliminate malignant cells in osteosarcoma, its aberrant activation contributes to the degeneration of bone and cartilage in osteoporosis, osteoarthritis, and intervertebral disc degeneration, thereby severely impairing the intrinsic regenerative and repair capacity of musculoskeletal tissues. A significa …

27.08.2026journal-article

Frontiers in Microbiology

The gut-brain axis in Alzheimer’s disease: traditional Chinese medicine constituents as modulators of gut-brain homeostasis

Yichao Liang, Qian Kong, Xiao Du, Yunting Sun, Shuling Wang

Alzheimer’s disease (AD) currently lacks curative treatments, and the gut–brain axis plays an important role in regulating neuroinflammation during AD progression. Multiple bioactive components from traditional Chinese medicine (TCM), including polysaccharides, alkaloids, flavonoids and saponins, protect neurons through regulating gut microbiota composition, maintaining intestinal barrier function and modulating short-chain fatty acid (SCFA) metabolism. Different from previous reviews that mainly elaborate correlat …

27.08.2026journal-article

Cancers

Prognostic Significance of Peri-Treatment Inflammatory Burden Index in Patients with Rectal Cancer Undergoing Preoperative Chemoradiotherapy

Takanobu Mori, Yoshinaga Okugawa, Tadanobu Shimura, Ma Ruiya, Naru Mizuno, Shinji Yamashita, Akira Yamamoto, Takahito Kitajima, Hiroki Imaoka, Mikio Kawamura, Yuhki Koike, Hiromi Yasuda, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Tomofumi Koide, Masaki Ohi, Yuji Toiyama

Background/Objectives: Systemic inflammatory responses influence treatment response and oncological outcomes in patients with cancer. Growing evidence indicates that the inflammatory burden index (IBI) serves as a reliable prognostic indicator across various malignancies. However, the clinical significance of the peri-treatment inflammatory status in patients with rectal cancer (RC) undergoing preoperative chemoradiotherapy (CRT) remains unclear. Methods: We assessed the pre- and post-treatment IBI in 97 patients w …

27.08.2026journal-article

Journal of Clinical Medicine

Claudin 18.2 Expression in Cholangiocarcinoma: Clinicopathological Heterogeneity, Prognostic Significance, and Impact of Positivity Thresholds

Tugba Toyran, Kivilcim Eren Ates, Ferhat Can Piskin, Tolga Köşeci, Hatice Asoglu, Yusuf Kemal Arslan, Ugur Topal, Arbil Acikalin

Background/Objectives: Claudin 18.2 (CLDN18.2) has emerged as a clinically actionable therapeutic target in gastrointestinal malignancies; however, its expression profile and prognostic significance in cholangiocarcinoma (CCA) remain incompletely characterized. This study investigated CLDN18.2 expression in CCA and evaluated its associations with clinicopathological characteristics and overall survival (OS). Methods: This retrospective study included 124 patients with histologically confirmed CCA who were diagnosed …

27.08.2026journal-article

European Journal of Neurology

Clinical Variability and Genotype‐Driven Outcomes in CHRND ‐Related Congenital Myasthenic Syndrome

David Muhmann, Göknur Haliloğlu, Maria Antonia Grimalt, Damjan Osredkar, Ana Vesperinas Castro, Silvia Cerezo Corredera, Angela Abicht, Adalet Elçin Yıldız, Johann Böhm, Ulrike Schara‐Schmidt, Anja Troha Gergeli, Berta Estevez‐Arias, Elena Cortes Vicente, Andres Nascimento, Adela Della Marina, Daniel Natera‐de Benito, Andreas Roos

ABSTRACT Background Congenital myasthenic syndromes (CMS) caused by pathogenic variants in CHRND , encoding the δ‐subunit of the nicotinic acetylcholine receptor (AChR), are rare, and data on genotype–phenotype correlations and long‐term outcomes are limited. Methods We performed a retrospective, multicenter study of nine patients with genetically confirmed CHRND ‐related CMS from specialized neuromuscular centers. Clinical, electrophysiological, genetic, and therapeutic data were systematically collected. All diag …

27.08.2026journal-article

Journal of Endocrinological Investigation

Prediabetes: diagnostic aspects, clinical features, and emerging therapeutic opportunities, with a focus on Vitamin D

G. Aimaretti, A. Avogaro, R. Buzzetti, R. Candido, A. Colao, G. P. Fadini, L. Luzi, L. Morviducci, N. Napoli, A. Giustina

Abstract Background Prediabetes is a highly prevalent and heterogeneous condition associated with an increased risk of type 2 diabetes mellitus (T2DM), cardiovascular disease, and other cardiometabolic complications. Growing evidence suggests a potential role of vitamin D in glucose metabolism and diabetes prevention. Objective To provide a clinically oriented interpretation of the available evidence on epidemiology, pathophysiology, clinical implications, and management of prediabetes, with a specific focus on the …