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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Updates in Surgery

Quality of life in breast cancer survivors: a comparative analysis between breast conservative treatment (BCT) and post-mastectomy breast reconstruction (PMBR) using either autologous or prosthetic reconstruction

Emanuele Cammarata, Federico Coppola, Giovanni Zabbia, Mara Franza, Salvatore Vieni, Calogero Cipolla, Adriana Cordova, Francesca Toia

Abstract Breast cancer remains the most commonly diagnosed cancer in women, with surgical intervention as a cornerstone treatment. Options include breast-conserving therapy (BCT) and mastectomy with or without post-mastectomy breast reconstruction (PMBR). This study aimed to compare quality of life (QoL) outcomes between breast-conserving therapy (BCT) and post-mastectomy breast reconstruction (PMBR), with either autologous DIEP flap or expander/prosthetic reconstruction. A single-institution retrospective study wa …

24.08.2026journal-article

Journal of Comparative Effectiveness Research

Indirect treatment comparisons find enhanced effectiveness of pegcetacoplan versus crovalimab in both complement inhibitor-naïve and -experienced patients with paroxysmal nocturnal hemoglobinuria

Raymond Siu Ming Wong, Koo Wilson, Zalmai Hakimi, Mikolaj Parkitny, Piotr Wojciechowski, Catherine Flynn, Francis Fatoye

Aim: Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare hematological condition, which if undertreated, is associated with significant morbidity and early mortality. This indirect treatment comparison (ITC) evaluated the effectiveness of pegcetacoplan (the first approved proximal inhibitor) versus crovalimab, a new C5i inhibitor (C5i), for treatment of PNH in C5i-naive and C5i-experienced patients. Materials & methods: In the C5i-naive, an unanchored matching-adjusted indirect comparison (MAIC) was conducte …

24.08.2026journal-article

Holistic Integrative Oncology

Acute myeloid leukaemia-myelodysplasia related (AML-MR) presented with acute basophilic leukaemia at diagnosis

Jian-xin Liu, Chun-jian Wang, Mei-xiang Zhang

Abstract Acute myeloid leukaemia-myelodysplasia related (AML-MR) are clonal myeloid neoplasms with a poor prognosis. Acute basophilic leukaemia (ABL) is a rare subtype of AML characterized with rapid clinical course, symptoms of hyperhistaminemia, and resistance to therapy. We herein presented a case of a 67-year-old male with hematologic parameters met the criteria for AML-MR and ABL. This patient was diagnosed with AML-MR presented with ABL and classified to a high-risk category with TP53 mutation and complex kar …

24.08.2026journal-article

Annals of Surgical Oncology

Definitive Chemoradiotherapy for Adenocarcinoma of the Esophagus or Esophago-Gastric Junction: A Dutch Population-Based Cohort Study

S. S. G. Gangaram Panday, O. Khoma, H. W. M. van Laarhoven, L. van Doorn, J. Nuyttens, P. S. N. van Rossum, R. H. A. Verhoeven, B. P. L. Wijnhoven, B. Mostert, S. M. Lagarde

Abstract Background Locally advanced esophageal adenocarcinoma has a poor prognosis and limited treatment options when surgery is not possible or desired. Although definitive chemoradiotherapy (dCRT) is currently administered as a curatively intended treatment, limited data exist regarding its efficacy for patients with adenocarcinoma of the esophagus, necessitating further evaluation of survival outcomes. Methods Patients with a diagnosis of adenocarcinoma of the esophagus or esophago-gastric junction who had unde …

24.08.2026journal-article

Advanced Science

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green

ABSTRACT Background & Aims : Primary liver cancer is the third leading cause of cancer death worldwide, and about 70% of hepatocellular carcinomas (HCCs) do not respond to systemic immunotherapies. Transarterial chemoembolization (TACE) remains standard treatment for intermediate‐stage HCC, but long‐term survival is poor. We aimed to develop a polymeric TACE‐like platform to sensitize liver cancer to checkpoint inhibitors by enabling sustained co‐delivery of panobinostat and IL‐12. Methods : Patient‐derived liver c …

24.08.2026journal-article

Cancer Drug Resistance

Adenylosuccinate lyase in pancreatic ductal adenocarcinoma chemoresistance: from purine metabolism to metabolic vulnerability

Tung-Wei Hsu, Chih-Ming Su, Yen-Hao Su, Po-Hsiang Liao, Charupong Saengboonmee, Wan-Yu Wang, Hsin-An Chen

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal human malignancies and is characterized by profound metabolic reprogramming and marked therapeutic resistance. Among the metabolic enzymes that sustain tumor fitness, adenylosuccinate lyase (ADSL) has emerged as a critical regulator of de novo purine biosynthesis with broader roles in oncogenic signaling, metabolic adaptation, and chemoresistance. ADSL catalyzes two key reactions in purine synthesis, contributing to adenylosuccinate-to-adenosine monop …

24.08.2026journal-article

Current Oncology

Identifying Barriers and Strategies to Support a Community Navigator-Driven Approach for Lung Cancer Screening

Miranda J. Reid, Jennifer H. LeLaurin, Saba Ali, Caroline Sorial, Carma L. Bylund, Jennifer N. Woodard, Easton N. Wollney, Dianne L. Goede, Ji-Hyun Lee, Danielle S. Nelson, Lisa Carter-Bawa, Ramzi G. Salloum

Background/Objectives: Although lung cancer is the leading cause of cancer-related deaths in the United States, rates of screening have remained persistently low nationwide. This study sought to identify barriers, facilitators, and support strategies necessary for implementing a novel community health navigator workflow to improve lung cancer screening uptake in both rural and urban settings. Methods: Semi-structured interviews were conducted with primary care providers (n = 5), community scientists (n = 7), commun …

24.08.2026journal-article

Supportive Care in Cancer

Oxycodone combined with pulsed radiofrequency for refractory cancer pain from spinal metastases: a randomized controlled study

L Li, Hj Wang, Xj Wang, Sc Xing, Jh Zhong

Abstract Objectives To assess the clinical efficacy and safety of oxycodone combined with pulsed radiofrequency (PRF) in the treatment of refractory cancer pain (RCP) arising from spinal metastasis. Methods A randomized controlled trial enrolled 60 patients with RCP due to spinal metastases. Participants were randomly allocated to the oxycodone alone group (Group A, n = 30) or the oxycodone combined with PRF group (Group B, n = 30). Primary outcomes comprised pain scores on the Numerical Rating Scale (NRS) and epis …

24.08.2026journal-article

Frontiers in Oncology

Case Report: The role of nodal staging in periocular merkel cell carcinoma — lessons from three cases

Wojciech Adamski, Anna Rzeszotarska, Barbara Paprzycka

Merkel cell carcinoma (MCC) of the eyelid is a rare, aggressive cutaneous neuroendocrine malignancy. We report three patients with upper eyelid MCC managed at a single ophthalmology centre. Patients were aged 74, 78 and 65 years; two were female and one male. All underwent wide local excision and complex eyelid reconstruction using Cutler-Beard and adjunctive flap techniques. Outcomes differed substantially: the patient who underwent neither nodal staging nor adjuvant therapy developed parotid metastases within two …

24.08.2026journal-article

Frontiers in Oncology

SFRT alleviates symptoms associated with bulky advanced cancer: a retrospective single-center cohort analysis

Haiqin Zhang, Jian Zhang, Chen Su, Yanming Wang, Chuanyong Liu, Yan Dou, Jie Liu, Weichong Zhao, Sen Liu, Changsheng Cong, Jin Yu, Meili Sun

Objective/background To evaluate the impact of Spatially Fractionated Radiation Therapy (SFRT) on symptomatic relief and survival outcomes in patients with large-volume tumors. Methods A total of 60 cancer patients who received SFRT between February 2023 and May 2025 were analyzed in this retrospective study. Collected data comprised demographic characteristics, as well as follow-up information on symptomatic response, best overall response, survival duration, and treatment-related adverse events. Results By the en …

24.08.2026journal-article

BMC Cancer

Postoperative surveillance strategy in patients undergoing neoadjuvant chemoradiotherapy followed by curative resection for locally advanced rectal cancer

Zhifang Zheng, Xiaojie Wang, Hongfeng Pan, Zhun Liu, Xingrong Lu, Ying Huang, Pan Chi

Abstract Background There are no consistent recommendations for postoperative surveillance intervals for rectal cancer in the major guidelines. Knowledge about recurrence hazards can help develop appropriate surveillance schedules. This study aimed to investigate transitions in recurrence hazard and peak recurrence time in patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT). Methods Between 2011 and 2016, 785 consecutive patients with LARC who underwent nCRT and cur …

24.08.2026journal-article

Discovery Medicine

Advances in the Diagnostic Evolution and Treatment of Atypical Lobular Endocervical Glandular Hyperplasia

Guoqiu Dong, Liying Yu, Xiaoqin Zhang, Lifeng Xu

Atypical lobular endocervical glandular hyperplasia (ALEGH) is a cervical precancerous lesion that develops independently of high-risk human papillomavirus (HPV) infection. It is regarded as a key intermediate stage in the progression from lobular endocervical glandular hyperplasia to gastric-type endocervical adenocarcinoma (G-EAC). Because these lesions are often located in the upper endocervical canal or deep cervical stroma, and their cytological and histological atypia may be subtle, ALEGH is prone to being mi …

24.08.2026journal-article

Theoretical and Natural Science

Comparative Effects of Synthesized BACE1 and EGFR Antagonists on Lung Cancer Metastasis

Xinyue Xu, Mohan Liu

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality, largely due to high rates of multi-organ metastasis and emerging drug resistance to conventional therapies. Recent findings implicate beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in driving NSCLC brain metastasis by cleaving the extracellular domain of epidermal growth factor receptor (EGFR) and activating downstream Ras-Raf-MEK-ERK signaling. To address metastatic spread and overcome resistance, this study evaluates tw …

24.08.2026journal-article

Sexually Transmitted Diseases

LIMIT Trial: Lidocaine with Intramuscular Injection of Benzathine Penicillin G for Treponema pallidum Treatment

Joseph Cherabie, Germysha Weatherall, Patrick Kojima, Caleb Bender, Donald Hong, Lauren Karpman, Andrew Brand, Aditi Ramakrishnan, Rachel Presti, Hilary Reno

Background: Studies have shown that intramuscular benzathine penicillin G (BPG) or bicillin injections cause severe pain in many patients, which may reduce adherence. Local anesthetics mixed with BPG may reduce injection pain without affecting drug effectiveness. The objective of this study was to examine if there is any benefit of adding 0.5 ml 1% lidocaine to prepackaged Benzathine Penicillin G, with respect to pain, compared to standard of care, in the treatment of Treponema pallidum infections, both 10 minutes …

24.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Designing the matrix: extracellular matrix-informed strategies for bioengineered cancer models

Nathalie Bock, Anu Thomas Koikalethu, Luke Hipwood, Minne Dekker, Brooke Lundon, Sugandha Bhatia, Jacqui A. McGovern

Bioengineered three-dimensional (3D) cancer models have improved the replication of tumour architecture and microenvironmental complexity, yet their predictive value and reproducibility remain inconsistent. A key reason is that extracellular matrix (ECM) context is often treated as a background culture condition rather than as an explicit experimental variable. Cancer cells respond not only to dimensionality, but also to coupled biochemical, structural, mechanical and dynamic matrix cues, including ligand presentat …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

Effect of chemotherapy on cognition and depression among solid tumor cancer patients in a tertiary care hospital

Jenanee Velayutham, Jayasutha Jayram, A. Vengadeswaran, S. Sivasupriya, K. Malini Prithiva Kumari, N. Arunagiri, Charupriya, Lisiya, Lourdu Akshaya, Sindhu Selvam, Ravichandran A. Selvam

Background: Chemotherapy is a key treatment modality for solid tumors but is often associated with cognitive impairment, depression, and reduced quality of life. Early identification of these complications is important for improving patient outcomes and treatment adherence. Methods: A prospective cohort study was conducted over six months in the Department of Medical Oncology, Sri Ramachandra Hospital, Chennai. Adult patients (18-65 years) with solid tumors receiving platinum-based agents, taxanes, or antitumor ant …

24.08.2026journal-article

Indian Dermatology Online Journal

Role of Ultrasonography in the Diagnosis and Treatment of Hidradenitis Suppurativa: A Narrative Review

Apoorva Sharma, Hridya Karakkattil, Anindita Sinha, Nikita Verma, Sunil Dogra

Abstract Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disorder that predominantly affects the axillae, anogenital, and inguinal regions in the form of recurrent painful, suppurative abscesses, nodules, and fistulae. The major challenge in the management of HS lies not only in the difficulty of early diagnosis but also in the initial treatment decisions, which heavily rely on the stage of the disease. Multiple studies in the literature have concluded that clinical examination significan …

24.08.2026journal-article

Middle Black Sea Journal of Health Science

Clinical Results of Microvascular Decompression in the Treatment of Trigeminal Neuralgia

Durmuş Oğuz Karakoyun, Ümit Kocaman

Objective: This study aimed to evaluate the clinical outcomes of microvascular decompression (MVD) in patients with trigeminal neuralgia (TN) and to emphasize the importance of meticulous intraoperative identification of the responsible neurovascular compression.Methods: This retrospective single-center case series included 12 patients who underwent trigeminal nerve MVD between 2024 and 2025. Preoperative magnetic resonance imaging findings, intraoperative compression characteristics, pain distribution, petrosal ve …

24.08.2026journal-article

Chinese Medical Journal

Tumor–host metabolic interactions in the microenvironment and macroenvironment: Mechanisms and targeting strategies

Yi Zhang, Caixia Suo, Linchong Sun

Abstract Tumor metabolic reprogramming is a hallmark of cancer and is driven not only by intrinsic mechanisms of tumor cells but also by dynamic interactions between the local tumor microenvironment (TME) and the host macroenvironment. This review systematically elaborates on the central role of “tumor–host” metabolic crosstalk in reshaping both the TME and the broader host macroenvironment. In the TME, hypoxia, nutrient deprivation, metabolic waste accumulation, and metabolic interactions among immune and stromal …

24.08.2026journal-article

Frontiers in Medicine

Comparative efficacy and safety of transarterial treatment strategies for hepatocellular carcinoma: a systematic review and network meta-analysis of randomized controlled trials

Jiajun Chen, Ganfa Huang, Fengyi Mo, Zijun Liao, Chang Zhao

Background Transarterial therapy is widely used for unresectable or intermediate-stage hepatocellular carcinoma (HCC), but the comparative efficacy and safety of available techniques remain uncertain. We compared the efficacy and safety of conventional TACE (cTACE), drug-eluting bead TACE (DEB-TACE), degradable starch microsphere TACE (DSM-TACE), balloon-occluded TACE (B-TACE), transarterial embolization (TAE), and transarterial radioembolization (TARE). Methods We performed a PROSPERO-registered systematic review …

24.08.2026journal-article

International Journal of Molecular Sciences

Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BRCA Multi-Gene Panel Testing and Cancer Surveillance

Ava Kwong, Cecilia Y. S. Ho, Sze Keong Tey, Chun Hang Au, Edmond S. K. Ma

Breast cancer remains highly prevalent, where the lifetime risk before age 75 is one in 13. However, known genetic factors were only identified in 14.7% of cases in our Hong Kong Hereditary Breast Cancer Family Registry. Our current local policy for genetic testing does not cover the detection of beyond BRCA1/2. Here we highlight the clinical value of extending testing to beyond BRCA susceptibility genes for improved prevention, diagnosis, and management. We recruited 6597 hereditary breast and ovarian cancer (HBOC …

24.08.2026journal-article

Indian Journal Of Science And Technology

Application of Artificial Intelligence in HPV Related Cervical Cancer Diagnosis: A Systematic Review

Tumpa Dey Barua

Objectives: This review aims to quantify AI diagnostic performance specifically for HPV-related cervical cancer detection, stratified by methodological category, and to evaluate the added value of HPV genotype integration. Methods: A systematic review was conducted following PRISMA 2020 guidelines. SciSpace, PubMed/MEDLINE, Google Scholar, and ArXiv were searched for records published between January 2015 and May 2025, yielding 647 records; after deduplication (n=450) and two-stage screening, 37 studies met inclusi …

24.08.2026journal-article

Journal of Clinical and Translational Research

The three-month referral threshold as an independent prognostic marker of cancer-specific survival in advanced oncological disease

Anda-Elena Crișan, Andrada Nemesis Crișan, Roxana Elena Sicoe, Liliana-Eleonora Semenescu, Oana Ciobănescu, Adina Mitrea

Background: Guidelines recommend the early integration of palliative care in advanced cancer; however, “earliness” remains heterogeneously defined, with no temporal consensus, and timing studies are vulnerable to immortal-time bias and do not model competing risks. Objective: To evaluate a pre-specified three-month threshold as a prognostic marker of cancer-specific survival (CSS) and as a potential auditable indicator of timely access to palliative care. Methods: A retrospective observational cohort st …

24.08.2026journal-article

Journal of Medicine, Nursing and Public health

Perceived Quality of Nursing Care Among Cancer Patients Attending Machakos Level Five Hospital, Machakos County, Kenya

Hellen W. Wanjau, Lister Onsongo, Elizabeth Ambani

This study sought to determine the perceived quality of nursing care among cancer patients at Machakos Level 5 Hospital in Machakos County, Kenya. This was an analytical cross-sectional inquiry conducted among adult patients with cancer at Machakos Level 5 Hospital. A total of 161 patients receiving treatment for varied forms of cancer in the hospital’s oncology unit were targeted. The respondents were selected using a simple random sampling approach. They filled out a questionnaire that included the QONCS scale. I …