Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Medizin · Seite 69

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Annals of Pharmacotherapy

Relacorilant in Combination With Nab-Paclitaxel for the Treatment of Adults With Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Emilie J. Lynch, Lauren T. Carpenter, Kelli N. Corona, Adebola O. Fatimilehin, Nathan D. Seligson

Objective: To review the pharmacology, efficacy, and safety of relacorilant (Lifyorli) in combination with nab-paclitaxel (NP) for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received 1 to 3 prior lines of systemic therapy, including at least one bevacizumab-containing regimen. Data Sources: A literature search was conducted using Embase and PubMed/MEDLINE, applicable published abstracts, and ongoing studies from ClinicalTrials.gov betwee …

27.08.2026journal-article

Cancers

Prognostic Significance of Peri-Treatment Inflammatory Burden Index in Patients with Rectal Cancer Undergoing Preoperative Chemoradiotherapy

Takanobu Mori, Yoshinaga Okugawa, Tadanobu Shimura, Ma Ruiya, Naru Mizuno, Shinji Yamashita, Akira Yamamoto, Takahito Kitajima, Hiroki Imaoka, Mikio Kawamura, Yuhki Koike, Hiromi Yasuda, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Tomofumi Koide, Masaki Ohi, Yuji Toiyama

Background/Objectives: Systemic inflammatory responses influence treatment response and oncological outcomes in patients with cancer. Growing evidence indicates that the inflammatory burden index (IBI) serves as a reliable prognostic indicator across various malignancies. However, the clinical significance of the peri-treatment inflammatory status in patients with rectal cancer (RC) undergoing preoperative chemoradiotherapy (CRT) remains unclear. Methods: We assessed the pre- and post-treatment IBI in 97 patients w …

27.08.2026journal-article

Journal of Clinical Medicine

Claudin 18.2 Expression in Cholangiocarcinoma: Clinicopathological Heterogeneity, Prognostic Significance, and Impact of Positivity Thresholds

Tugba Toyran, Kivilcim Eren Ates, Ferhat Can Piskin, Tolga Köşeci, Hatice Asoglu, Yusuf Kemal Arslan, Ugur Topal, Arbil Acikalin

Background/Objectives: Claudin 18.2 (CLDN18.2) has emerged as a clinically actionable therapeutic target in gastrointestinal malignancies; however, its expression profile and prognostic significance in cholangiocarcinoma (CCA) remain incompletely characterized. This study investigated CLDN18.2 expression in CCA and evaluated its associations with clinicopathological characteristics and overall survival (OS). Methods: This retrospective study included 124 patients with histologically confirmed CCA who were diagnosed …

27.08.2026journal-article

European Journal of Neurology

Clinical Variability and Genotype‐Driven Outcomes in CHRND ‐Related Congenital Myasthenic Syndrome

David Muhmann, Göknur Haliloğlu, Maria Antonia Grimalt, Damjan Osredkar, Ana Vesperinas Castro, Silvia Cerezo Corredera, Angela Abicht, Adalet Elçin Yıldız, Johann Böhm, Ulrike Schara‐Schmidt, Anja Troha Gergeli, Berta Estevez‐Arias, Elena Cortes Vicente, Andres Nascimento, Adela Della Marina, Daniel Natera‐de Benito, Andreas Roos

ABSTRACT Background Congenital myasthenic syndromes (CMS) caused by pathogenic variants in CHRND , encoding the δ‐subunit of the nicotinic acetylcholine receptor (AChR), are rare, and data on genotype–phenotype correlations and long‐term outcomes are limited. Methods We performed a retrospective, multicenter study of nine patients with genetically confirmed CHRND ‐related CMS from specialized neuromuscular centers. Clinical, electrophysiological, genetic, and therapeutic data were systematically collected. All diag …

27.08.2026journal-article

Frontiers in Microbiology

The gut-brain axis in Alzheimer’s disease: traditional Chinese medicine constituents as modulators of gut-brain homeostasis

Yichao Liang, Qian Kong, Xiao Du, Yunting Sun, Shuling Wang

Alzheimer’s disease (AD) currently lacks curative treatments, and the gut–brain axis plays an important role in regulating neuroinflammation during AD progression. Multiple bioactive components from traditional Chinese medicine (TCM), including polysaccharides, alkaloids, flavonoids and saponins, protect neurons through regulating gut microbiota composition, maintaining intestinal barrier function and modulating short-chain fatty acid (SCFA) metabolism. Different from previous reviews that mainly elaborate correlat …

27.08.2026journal-article

Journal of Endocrinological Investigation

Prediabetes: diagnostic aspects, clinical features, and emerging therapeutic opportunities, with a focus on Vitamin D

G. Aimaretti, A. Avogaro, R. Buzzetti, R. Candido, A. Colao, G. P. Fadini, L. Luzi, L. Morviducci, N. Napoli, A. Giustina

Abstract Background Prediabetes is a highly prevalent and heterogeneous condition associated with an increased risk of type 2 diabetes mellitus (T2DM), cardiovascular disease, and other cardiometabolic complications. Growing evidence suggests a potential role of vitamin D in glucose metabolism and diabetes prevention. Objective To provide a clinically oriented interpretation of the available evidence on epidemiology, pathophysiology, clinical implications, and management of prediabetes, with a specific focus on the …

27.08.2026journal-article

International Journal of Environmental Medicine

Delivery of Nebulized Prebiotic/Postbiotic Formulations: Spatial Deposition and Exposure Characterization by GC–MS

Edoardo Cavalieri D’Oro, Claudio De Maio, Rita White, Enrico Greco

Indoor environments are increasingly recognized as key determinants of human microbial exposure and skin health. Microbiome-aware interventions, including probiotic and prebiotic formulations, have been proposed to complement conventional environmental hygiene. However, quantitative data on the spatial distribution of nebulized prebiotic/postbiotic mixtures in enclosed spaces are lacking. The aim of this exploratory study was to characterize the aerosolization efficiency and spatial deposition of a prebiotic/postbi …

27.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

Shengqingjiangzhuo Capsules Alleviates Renal Fibrosis by Targeting Glomerular Endothelial Cells Exosome miR ‐31‐5p/ HO ‐1 to Suppress Tubular Epithelial Cells Ferroptosis

Feng Pan, Jinhong Lu, Gaxi Ye, Haifeng Zhu, Hongyuan Ma, Jiale Li, Xingyu Yang, Hongtao Yang, Anrong Tong

ABSTRACT Objective Chronic renal failure (CRF) represents the advanced stage of chronic kidney disease, for which no specific pharmacological treatments are currently available. Traditional Chinese medicine has demonstrated notable efficacy in managing CRF. Shengqingjiangzhuo capsules (SQJZ capsules), a traditional Chinese medicinal formulation, are employed clinically in the treatment of CRF. However, the precise mechanisms underlying its therapeutic effects remain insufficiently understood. Methods The SQJZ capsu …

27.08.2026journal-article

Journal of Clinical Nursing

Education and Training Programmes for Health Professionals' Competence in Virtual Consultations: A Scoping Review

Britt Holst Lisbjerg, Louise Meyer Wind Mathiesen, Bettan Bagger, Lene Lauge Berring, Ditte Høgsgaard, Heidi Myglegård Andersen, Stine Thestrup Hansen, Mai‐Britt Hägi‐Pedersen

ABSTRACT Aims To map and synthesize which education and training programmes are available for current and future health professionals' competence in virtual consultations, with a special focus on training elements and structure. Design Scoping review following the PRISMA‐ScR framework. Methods Studies describing structured education or training in synchronous virtual consultations were included. Data were charted and synthesised to map training modes, educational elements, and terminology. Data Sources MEDLINE, CIN …

27.08.2026journal-article

Cancer Medicine

Demographic, Clinicopathological Characteristics, and Prognosis of 81 Chinese Elderly Patients With Acral Melanoma

Kaidi Yang, Xin Cai, Jin Wu, Kui Jiang, Weizhen Zhang, Hongfeng Zhou, Fang Liu, Yan Wang, Jiwei Liu, Di Wu

ABSTRACT Purpose Acral melanoma (AM) is a rare melanoma subtype involving palms, soles, and nail beds. Clinical‐pathological features and survival of elderly AM patients remain insufficiently understood. This study aimed to investigate the characteristics and survival of elderly Chinese AM patients to support clinical management. Methods Consecutive AM patients aged ≥ 75 years treated at five Chinese melanoma centers between January 2012 and March 2025 were enrolled. Results A total of 81 elderly AM patients were i …

27.08.2026journal-article

Inflammatory Bowel Diseases

Reporting and representation of participant race, ethnicity, and sex in pediatric IBD clinical trials

Yunlin Jiang, Jiaying Tan, Long Qin, Mingye Zhao, Zhenyi Wang

Abstract Background and Aims Pediatric inflammatory bowel disease (IBD) incidence is rising among racial and ethnic minority children, yet to our knowledge no comprehensive evaluation of demographic representation in pediatric IBD trials exists. We systematically evaluated the reporting and representation of race, ethnicity, and sex in pediatric IBD clinical trials, stratified by Crohn disease (CD) and ulcerative colitis (UC). Methods We performed a cross-sectional study of pediatric IBD trials identified in PubMed …

27.08.2026journal-article

International Journal of Psychological and Brain Sciences

Trust and Misinformation in Youth Digital Mental Health Information-Seeking in Kenya: Implications for Diagnosis Accuracy and Treatment-Seeking Behavior

Rosemary Odhiambo

Digital platforms have become primary environments through which Kenyan youth seek mental health information, interpret psychological distress, and decide whether to pursue professional care. While digital mental health information-seeking can enhance awareness, reduce stigma, and provide immediate psychosocial support, the credibility of online content remains uneven, exposing youth to misinformation, unregulated pseudo-therapy, and algorithm-reinforced diagnostic narratives. This study examines how trust and misi …

27.08.2026journal-article

Communication & Sport

Tommy John Surgery, Sports Medicine, and Baseball’s Rhetorics of Fair Play

John W. Jordan

Tommy John Surgery (TJS) revolutionized baseball by repairing a previously career-ending injury. Its invention necessarily altered traditional narratives about athletic performance and decline, but John’s subsequently improved pitching gave rise to suspicions that TJS was an unnatural performance enhancement. John’s counterargument successfully enabled TJS to be approved by baseball, but undermined the seriousness of the surgery and the cause behind the injury. Doctors and former players are now calling for a chang …

27.08.2026journal-article

Scientific Reports

Clinical evaluation of a sit-to-stand dual-posture mobility device for people with spinal cord injuries

Yukiyo Shimizu, Hideki Kadone, Yosuke Eguchi, Kai Sasaki, Shunsuke Kido, Diego Paez-Granados, Modar Hassan, Yang Chen, Shigeki Kubota, Masashi Yamazaki, Yasushi Hada, Kenji Suzuki

Abstract Wheelchair users face health risks from prolonged sitting and social barriers owing to the vertical gap between their seated position and standing able-bodied individuals. We present Qolo, a novel standing mobility device equipped with passive exoskeletons for intuitive sit-to-stand transitions. Three prototypes were iteratively evaluated with 13 unique participants with spinal cord injury (SCI) from cervical to lumbar levels (C5-L3): Qolo-1 (n = 4), Qolo-2 (n = 12), and Qolo-3 (n = 5), with 3 participants …

27.08.2026journal-article

Cellular and Molecular Life Sciences

Human nasal epithelial cells as an integrated platform for biomarker discovery, functional airway studies, and patient-specific stem cell generation

Giulia Gorrieri, Fabiana Ciciriello, Rosaria Casciaro, Floriana Guida, Ilaria Musante, Federico Alghisi, Simona Baldassari, Sofia Vaccaro, Federico Zara, Paolo Scudieri

Abstract Studying epithelial dysfunction in respiratory diseases requires physiologically relevant human models that faithfully recapitulate airway structure and function. Primary human nasal epithelial cells (hNECs) represent an accessible and clinically validated system, widely used for mutation-specific drug theratyping. However, the broader potential of hNECs as an integrated experimental platform remains underexplored. Here, we establish a customized hNEC-based platform spanning ex vivo, in vitro, and stem cel …

27.08.2026journal-article

Frontiers in Surgery

Application of the guidewire anchoring technique in lateral approach transforaminal endoscopic lumbar foraminoplasty: a propensity score–matched retrospective study

Guoxing Ding, Huijing Shang, Fuhai Yan, Weijie Cui, Zhi Li, Yiheng Zhang, Zhan Wang, Yifan Feng, Junxiao Su, Hui Zhang

Objective Safe and rapid bony localization for intervertebral foraminoplasty is essential in lateral transforaminal endoscopic lumbar discectomy (TELD). This study introduces a novel guidewire anchoring puncture technique and compares it with conventional puncture to evaluate operative efficiency, safety, and clinical outcomes. Methods A retrospective 1:1 propensity score-matched (PSM) analysis was performed on 60 patients with single-level L4/5 or L5/S1 disc herniation receiving TELD (anchoring group = 30, convent …

27.08.2026journal-article

Infection Control & Hospital Epidemiology

Impact of ethyl alcohol nasal treatment on hospital-onset Staphylococcus aureus bacteremia at a tertiary health system

Donna Nucci, Jennifer H. Sather, Michael Aniskiewicz, Scott C. Roberts

Abstract Introduction: Staphylococcus aureus is a common pathogen that can cause nosocomial infection. Ethyl alcohol has emerged as a potential alternative to mupirocin and povidone-iodine for nasal decolonization; however, data on real-world application are limited. Methods: A quasi-experiment study was performed. Twice daily 62% ethyl alcohol nasal swabs were offered to inpatients at risk for MRSA acquisition. Compliance was monitored and reasons for non-adherence were evaluated. Rates of hospital-onset S. aureus …

27.08.2026journal-article

Cancers

From the Thoracoscope to the Robot: The Evolving Landscape of Minimally Invasive Pulmonary Surgery

Raghav Chandra, Amanda Soe, Amartya Dave, Johannes R. Kratz

Surgical resection is the main curative option for non-small-cell lung cancer. Pulmonary resections have historically been performed through a highly morbid open thoracotomy. Minimally invasive approaches to pulmonary resection have revolutionized the field with reduced perioperative morbidity, including less postoperative pain, length-of-stay, and complications, while potentially enhancing oncologic outcomes. In its current generation, robotically performed video-assisted thoracoscopic surgery (R-VATS) offers nume …

27.08.2026journal-article

The Egyptian Journal of Internal Medicine

Molecular interaction mechanisms of muscle fiber type transition in aging sarcopenia and the role of exercise intervention

ShaoHui Zhang, Jialin Zhang, Tao Fu, Linliang Zhao, Kexin Li, Sifan Yan

Abstract Muscle fiber type transition is a core pathophysiological process in aging sarcopenia; however, existing research has often analyzed its underlying mechanisms in isolation. This review systematically characterizes the features of muscle fiber type transition in sarcopenia at the neural, cellular, and microenvironmental levels, and dissects the multidimensional molecular interaction mechanisms, including disrupted neural input, aberrant intracellular protein metabolism, and inflammaging. Based on this mecha …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Relationship Between Water Scarcity, Climate Change, and Mental Health: A Systematic Review

İlknur Taşkıran, Hatice Sinem Şenli, Begüm Arıtan

The aim of this study is to examine the relationship between water scarcity, climate change, and mental health through a systematic review. Water scarcity is defined as the long-term inadequate management of available water resources and the failure to meet increasing demand; climate change, in turn, is a fundamental driver that both accelerates and deepens this scarcity through drought, heat waves, and disruptions to the water regime. In recent years, it has increasingly been emphasized that these environmental pr …

27.08.2026journal-article

Frontiers in Medicine

AI-driven diagnostic and prognostic models for metabolic dysfunction-associated steatotic liver disease: insights from clinical, imaging, and multi-omics studies—a scoping review

M. Sujana, G. N. Vivekananda

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most common chronic liver disease around the world, affecting 33.6% of the adult population (95% CI: 28.1%–39.5%; I 2 = 99.9%), or roughly one in three. The extent of the liver damage is variable, from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), cirrhosis and hepatocellular carcinoma (HCC). Early diagnosis is essential to prevent seriou …

27.08.2026journal-article

Journal of Eating Disorders

Mentalization-based treatment for eating disorders: a systematic review and narrative synthesis

Katie Gabrielle Salucci, Sela Scott, Amelia Austin

Abstract Background Mentalization-based treatment (MBT) targets difficulties in reflective functioning, emotion regulation and interpersonal relationships, which may contribute to the development and maintenance of eating disorders (EDs). This systematic review synthesised the available quantitative evidence on the outcomes of MBT or MBT-informed interventions for people with EDs. Methods A protocol was prospectively registered with PROSPERO (CRD42024421136) and the review was conducted in accordance with PRISMA gu …

27.08.2026journal-article

International Journal of Pharmacy Practice

Medicine shortages in an Austrian community pharmacy: quantification and pharmacist intervention—a prospective observational study on shortage extent, patient support, and associated predictive factors

Alexander Schmidt-Ilsinger, Thomas Arzt, Petra Riegler, Trudi McIntosh

Abstract Background Medicine shortages increasingly challenge community pharmacies, affecting patient safety, increasing pharmacist workload, and straining healthcare systems. Little is known about shortages in Austrian community pharmacy settings. Aim To estimate the prevalence of medicine shortages in a community pharmacy in Austria, and describe how frequently pharmaceutical interventions were provided to mitigate their impact on patients. Methods This prospective, single-centre study was conducted over 8 weeks …

27.08.2026journal-article

Journal of Bone and Joint Surgery

Distal Radial Fracture as an Early Marker of Bone Fragility

Ryutaro Shibata, Yoko Sato, Yoshihiro Tanaka

Background: Distal radial fractures (DRFs) are common fragility fractures in older adults and often indicate skeletal deterioration. However, whether DRFs reflect underlying systemic frailty or occur predominantly in relatively active individuals with preserved physical function remains unclear. Methods: This retrospective cohort study analyzed data from the Shizuoka Kokuho Database, which includes the health and long-term care (LTC) claims of 2.4 million residents. Individuals aged 65 to 89 years who were newly di …