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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Indian Dermatology Online Journal

Role of Ultrasonography in the Diagnosis and Treatment of Hidradenitis Suppurativa: A Narrative Review

Apoorva Sharma, Hridya Karakkattil, Anindita Sinha, Nikita Verma, Sunil Dogra

Abstract Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disorder that predominantly affects the axillae, anogenital, and inguinal regions in the form of recurrent painful, suppurative abscesses, nodules, and fistulae. The major challenge in the management of HS lies not only in the difficulty of early diagnosis but also in the initial treatment decisions, which heavily rely on the stage of the disease. Multiple studies in the literature have concluded that clinical examination significan …

24.08.2026journal-article

Chinese Medical Journal

Tumor–host metabolic interactions in the microenvironment and macroenvironment: Mechanisms and targeting strategies

Yi Zhang, Caixia Suo, Linchong Sun

Abstract Tumor metabolic reprogramming is a hallmark of cancer and is driven not only by intrinsic mechanisms of tumor cells but also by dynamic interactions between the local tumor microenvironment (TME) and the host macroenvironment. This review systematically elaborates on the central role of “tumor–host” metabolic crosstalk in reshaping both the TME and the broader host macroenvironment. In the TME, hypoxia, nutrient deprivation, metabolic waste accumulation, and metabolic interactions among immune and stromal …

24.08.2026journal-article

Frontiers in Medicine

Comparative efficacy and safety of transarterial treatment strategies for hepatocellular carcinoma: a systematic review and network meta-analysis of randomized controlled trials

Jiajun Chen, Ganfa Huang, Fengyi Mo, Zijun Liao, Chang Zhao

Background Transarterial therapy is widely used for unresectable or intermediate-stage hepatocellular carcinoma (HCC), but the comparative efficacy and safety of available techniques remain uncertain. We compared the efficacy and safety of conventional TACE (cTACE), drug-eluting bead TACE (DEB-TACE), degradable starch microsphere TACE (DSM-TACE), balloon-occluded TACE (B-TACE), transarterial embolization (TAE), and transarterial radioembolization (TARE). Methods We performed a PROSPERO-registered systematic review …

24.08.2026journal-article

International Journal of Molecular Sciences

Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BRCA Multi-Gene Panel Testing and Cancer Surveillance

Ava Kwong, Cecilia Y. S. Ho, Sze Keong Tey, Chun Hang Au, Edmond S. K. Ma

Breast cancer remains highly prevalent, where the lifetime risk before age 75 is one in 13. However, known genetic factors were only identified in 14.7% of cases in our Hong Kong Hereditary Breast Cancer Family Registry. Our current local policy for genetic testing does not cover the detection of beyond BRCA1/2. Here we highlight the clinical value of extending testing to beyond BRCA susceptibility genes for improved prevention, diagnosis, and management. We recruited 6597 hereditary breast and ovarian cancer (HBOC …

24.08.2026journal-article

Indian Journal Of Science And Technology

Application of Artificial Intelligence in HPV Related Cervical Cancer Diagnosis: A Systematic Review

Tumpa Dey Barua

Objectives: This review aims to quantify AI diagnostic performance specifically for HPV-related cervical cancer detection, stratified by methodological category, and to evaluate the added value of HPV genotype integration. Methods: A systematic review was conducted following PRISMA 2020 guidelines. SciSpace, PubMed/MEDLINE, Google Scholar, and ArXiv were searched for records published between January 2015 and May 2025, yielding 647 records; after deduplication (n=450) and two-stage screening, 37 studies met inclusi …

24.08.2026journal-article

Journal of Clinical and Translational Research

The three-month referral threshold as an independent prognostic marker of cancer-specific survival in advanced oncological disease

Anda-Elena Crișan, Andrada Nemesis Crișan, Roxana Elena Sicoe, Liliana-Eleonora Semenescu, Oana Ciobănescu, Adina Mitrea

Background: Guidelines recommend the early integration of palliative care in advanced cancer; however, “earliness” remains heterogeneously defined, with no temporal consensus, and timing studies are vulnerable to immortal-time bias and do not model competing risks. Objective: To evaluate a pre-specified three-month threshold as a prognostic marker of cancer-specific survival (CSS) and as a potential auditable indicator of timely access to palliative care. Methods: A retrospective observational cohort st …

24.08.2026journal-article

Journal of Medicine, Nursing and Public health

Perceived Quality of Nursing Care Among Cancer Patients Attending Machakos Level Five Hospital, Machakos County, Kenya

Hellen W. Wanjau, Lister Onsongo, Elizabeth Ambani

This study sought to determine the perceived quality of nursing care among cancer patients at Machakos Level 5 Hospital in Machakos County, Kenya. This was an analytical cross-sectional inquiry conducted among adult patients with cancer at Machakos Level 5 Hospital. A total of 161 patients receiving treatment for varied forms of cancer in the hospital’s oncology unit were targeted. The respondents were selected using a simple random sampling approach. They filled out a questionnaire that included the QONCS scale. I …

24.08.2026journal-article

BMC Cancer

Treatment outcomes and immuno-nutritional biomarkers in patients with cervical esophageal squamous cell carcinoma treated with induction chemotherapy

Takeharu Ono, Yasunori Nakata, Shun-ich Chitose, Shintaro Sueyoshi, Takashi Kurita, Fumihiko Sato, Kenta Murotani, Toshihiko Kawaguchi, Tsunehiro Oka, Toshiyuki Mitsuhashi, Naoki Mori, Kohei Saisho, Masashi Nakagawa, Hirohito Umeno

Abstract Background Cervical esophageal squamous cell carcinoma arises below the upper esophageal sphincter, often causing dysphagia due to tumor progression. Therefore, some patients with cervical esophageal squamous cell carcinoma become malnourished. Due to its low incidence, limited information is available on prognostic immune-nutritional biomarkers. Methods We retrospectively reviewed 47 patients with resectable cervical esophageal squamous cell carcinoma who underwent induction chemotherapy. Prognostic bioma …

24.08.2026journal-article

Frontiers in Medicine

Factors affecting women’s participation in cervical cancer screening through the theory of planned behavior: a cross- sectional study in Türkiye

Merve Taştan, Banu Ersoy Şen, Meltem Yılmaz

Introduction This study aimed to determine, within the framework of the theory of planned behavior (TPB), the psychosocial factors, such as attitude, subjective norms, perceived behavioral control, and intention, that affect participation in cervical cancer screening among women aged 30–65, as well as the mediating relationships among these factors. Methods This descriptive cross-sectional study was conducted with 511 women aged 30–65 who applied to four Healthy Life Centers in Amasya, Türkiye between 1 April and 3 …

24.08.2026journal-article

World Journal of Surgery

Per Protocol Analysis and Long‐Term Outcomes of Laparoscopic Radical Resection for Gallbladder Cancer Compared With Open Method

Tae Ho Hong, Kwang Yeol Paik, Yoon kyung Woo, Jae Hyun Han, Jung Woo Lee, Jong Woo Lee, Dong Do You

ABSTRACT Background Although laparoscopic radical resection for gallbladder (GB) cancer has been attempted, only a limited number of studies have evaluated its outcomes using a per‐protocol analytical approach. Methods Between January 2010 and December 2019, 213 patients underwent surgery for gallbladder (GB) cancer at three institutions, of whom 203 consecutive patients with T2 or T3 disease were retrospectively analyzed. Protocol‐adherent radical resection (per‐protocol) was defined as wedge liver resection or IV …

24.08.2026journal-article

Cell Communication and Signaling

Targeting NOX1/4 promotes macrophage phagocytosis and improves radiotherapy via YAP1/TEAD4-CD47 in non-small cell lung cancer

Yulan Kui, Fan Tong, Ruiguang Zhang, Jian Wang, Xiaorong Dong

Abstract Radiotherapy is a mainstay treatment option for non-small cell lung cancer (NSCLC). However, radiation remodels the tumor immune microenvironment by adaptively upregulating the immunoregulatory checkpoint CD47, leading to phagocytic evasion and radioresistance. Although targeting CD47 shows promising antitumor effects, severe hemolytic toxicity caused by CD47 antibodies greatly limits their clinical application. Therefore, strategies that specifically modulate the regulatory mechanism of CD47 expression in …

24.08.2026journal-article

Journal of Reconstructive Microsurgery

Efficacy of immediate lymphatic reconstruction after breast cancer surgery: A systematic review and time-course dynamics meta-analysis

Hong-Jie Chang, Kuan-Yu Chen, Wen-Kuan Chiu, Khanh Dinh Hoang, Tun-Wen Pai, Chin-Yu Sun, Chiehfeng 陳杰峰 Chen

Background: Immediate lymphatic reconstruction (ILR) is a prophylactic approach for breast cancer-related lymphedema (BCRL) following axillary lymph node dissection (ALND). This study assessed the preventive effect of ILR by evaluating data from prior studies, with a focus on time-course dynamics. Methods: A systematic review and meta-analysis was performed of 17 studies comparing ALND plus ILR with ALND alone. The primary outcome was BCRL incidence. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were …

24.08.2026journal-article

ACM Transactions on Intelligent Systems and Technology

Embryo Prediction Network: Determining Embryo Transfer Strategies with Time-Lapse Imaging for In Vitro Fertilization Treatment

Song-Po Pan, Yu-Cheng Lin, Shih-Chia Huang

In this article, we propose the Embryo Prediction Network, named EPNet, which aims to assist reproductive specialists in predicting blastocyst grades from day 3 embryo images, thereby optimizing embryo culture times and improving IVF success rates. EPNet comprises three subnetworks: Morula, Blastocyst, and Embryo Prediction, leveraging guided learning and a multi-loss function to address data imbalance and enhance prediction accuracy. The network was trained and evaluated on an internal testing set using 5,586 imag …

24.08.2026journal-article

Advances in Radiotherapy & Nuclear Medicine

Radiation therapy in head and neck with telecobalt beam quality: Tolerance to 70 Gy dose in a five-week overall treatment time

Ravi Kannan, Ramamoorthy Ravichandran, Kapil Malik, Tarani Mondal, Gopal Datta, Subramania Vijayakanth, Talagadadeevi V.S.S.K. Bharath, Abhishek Kesha, LamLynti Dkhar, Soumya Brata Deb

Head and neck malignancies are associated with accelerated tumor repopulation when overall treatment time (OTT) extends beyond 28 days, potentially compromising the effectiveness of radiotherapy. To address this limitation, a treatment strategy was developed to reduce OTT by delivering a total radiation dose of 70 Gy over five weeks. In a pilot study involving high-grade head and neck malignancies, a total dose of 70 Gy was delivered using cobalt radiotherapy with tissue compensation at 2 Gy per fraction, administe …

24.08.2026journal-article

Current Oncology

Development of a Clinicopathological Prognostic Model and Risk Classification to Predict Disease-Free Survival in Patients with Gastric Adenocarcinoma Following Neoadjuvant Chemotherapy and Curative Gastrectomy

Erdoğan Şeyran, Emre Hafızoğlu

Background: Prognostic assessment after neoadjuvant chemotherapy and curative gastrectomy remains challenging in patients with gastric adenocarcinoma because postoperative outcomes are influenced by both pretreatment disease burden and pathological response. We aimed to develop and internally validate a clinicopathological prognostic model and a simple postoperative risk classification for predicting disease-free survival (DFS). Methods: This single-center retrospective cohort study included patients with gastric a …

24.08.2026journal-article

Seeds

Effects of Electromagnetic Field and Nutri-Priming with Spirulina on Tomato Seed Germination Pre-Treatment NaCl and PEG-6000

Jared Osmar Avila-Arroyo, Claudia Hernández-Aguilar, Juana Isabel Méndez, Flavio Arturo Domínguez-Pacheco

Due to the degradation of agricultural soils due to saline stress and water stress, which affect 34.9% and 44.8% of the Mexican territory, respectively, tomato production is compromised. Consequently, there is a growing interest in strategies to mitigate the adverse effects of abiotic stress. The study aimed to evaluate the effects of electromagnetic fields (EMF) and nutri-priming with Spirulina on seed germination of Cherry and Roma tomato varieties. The seeds were pre-treated with either NaCl or PEG-6000 (an osmo …

24.08.2026journal-article

British Journal of Cancer

Cancer and Health Inequalities

Donna Wakefield, Clare Bambra

Abstract Cancer is subject to stark inequalities, with mortality rates 60% higher in the most deprived parts of the UK. Most research has focused on the role of behavioural risk factors or access to health care services. Insufficient attention has been paid to the influence of socio-economic factors across the whole cancer continuum. This essay argues that to reduce cancer inequalities and improve patient experience and clinical outcomes, we need to look more widely at inequalities in: (1) the risk of developing ca …

24.08.2026journal-article

Bioscience Reports

Proteomic Profiling reveals that DPP4 overexpression increases Cell Adhesion, inhibits cell migration, And Restores Androgen Sensitivity in Prostate Cancer

José María Mora-Rodríguez, Belén G. Sánchez, Alicia Bort, Alba Díaz-Yuste, Alicia Milla, Julie Courraud, Jerome Zoidakis, Ines Diaz-Laviada

Dipeptidyl peptidase-4 (DPP4), a serine protease with both enzymatic and non-enzymatic roles, has emerged as a context-dependent modulator of tumor progression. In this study, we investigated the expression and function of DPP4 in androgen-sensitive and androgen-resistant prostate cancer (CRPC) models. Proteomic analysis of androgen-resistant prostate cells overexpressing DPP4, identified the involvement of the cellular adhesion molecules pathway. In prostate cells, lentiviral-mediated DPP4 overexpression restored …

24.08.2026journal-article

INTERNATIONAL JOURNAL OF ENGINEERING AND MODERN TECHNOLOGY

Evaluate Operational Effectiveness of Waste Water Treatment Facility (WWTF) of a Petro - Chemical Plant in Port Harcourt

Dougha Preye

The aim of this study is to evaluate operational effectiveness of waste water treatment facility (WWTF) of a petro - chemical plant in Port Harcourt. In this study, the analysis is done in order to estimate waste water treatment facility operational effectiveness and reliability using operational and experimental data from the petro chemical plant. The volumetric efficiency, energy efficiency, sludge production rate, performance indices and removal efficiency of BOD, COD, TSS and TDS is gotten using effective and r …

24.08.2026journal-article

Galle Medical Journal

Breast cancer care in Sri Lanka: A review of breast clinic development, system gaps and future directions

C. T. R. Kasturi, K. P. V. R. De Silva, J. Saunders

One-Stop Breast Clinics (OSBCs) have emerged as a model of rapid diagnosis and streamlined care, enabling breast cancer patients to undergo assessment, diagnosis, and overview of treatment planning within a single day. This literature review examined the current implementation of breast clinics in Sri Lanka, analysing their growth, effectiveness, patient outcomes, and operational challenges. Well women clinics, cancer early detection centres, hospital based specialised breast clinics were identified as existing fac …

24.08.2026journal-article

Orphanet Journal of Rare Diseases

AAV-mediated genetic interventions in the treatment of rare kidney disease: a narrative review

Zhao Yafei, Zheng Qimin, Fang Zhengying, Xie Jingyuan

Abstract Chronic kidney disease (CKD) is one of the leading causes of global morbidity and mortality. As CKD progresses, it can lead to end-stage renal disease (ESRD), which requires treatment such as dialysis or kidney transplantation. Rare kidney diseases, a distinct subset of CKD, are primarily caused by genetic mutations. Due to the limited basic and clinical research on rare kidney diseases, treatment options remain limited, and the risk of progression to ESRD is higher compared to that of common CKD. As a res …

24.08.2026journal-article

Hereditas

Clinical validation of KIF11 overexpression in colorectal cancer and its potential association with the antitumor effects of nitidine chloride

Hui Li, Rui Lin, Ke-Jun Wu, Jin-Cheng Li, Long Wei, Kai Qin, Li-Min Liu, Xiao-Jue Huang, Liu-Hui Mo, Bin Li, Dong-Ming Li, Zong-Yu Li, Da-Tong Zeng, Wei Zhang, Lang-Ning Gan, Rong-Quan He, Gang Chen, Sen Zhang

Abstract Colorectal cancer (CRC) remains a leading cause of cancer mortality with few effective targeted therapies. Kinesin family member 11 (KIF11), a motor protein essential for mitotic spindle assembly, is frequently overexpressed in multiple cancers. We hypothesized that nitidine chloride (NC), a natural benzophenanthridine alkaloid with documented anti-tumor activity, might suppress CRC by targeting KIF11.Molecular docking predicted a strong interaction between NC and KIF11 (− 9.0 kcal/mol). RNA sequencing, qu …

24.08.2026journal-article

World Journal of Clinical Oncology

Neoadjuvant intra-arterial chemoembolization improves tumor pathological regression and survival in Borrmann type IV gastric cancer

Xiao-Xing Wu, Hou-Dun Yang, Jiang Min, Chao Yuan, Lian-Shuo Li, Wei Zhang, Yue Tong

BACKGROUND Gastric cancer (GC) is a significant global health challenge with high mortality rates. Borrmann type IV GC presents unique challenges owing to its aggressive biological characteristics and lack of specific clinical symptoms in the early stage, thus leading to advanced-stage diagnosis and poor prognosis. AIM To explore intra-arterial chemoembolization (IAC) as a novel treatment strategy for Borrmann type IV GC. METHODS We retrospectively analyzed 70 patients who underwent IAC followed by gastrectomy. The …

24.08.2026journal-article

International Journal of Molecular Sciences

The Role of Monoclonal Antibody Targeted Therapy (Panitumumab) in the Treatment of Metastatic Colorectal Cancer—A Narrative Review of Current Evidence and Emerging Therapeutic Strategies

Lidia Kwiatkowska, Małgorzata Szczuko

Metastatic colorectal cancer (mCRC) remains one of the leading causes of cancer deaths worldwide. Mutations of the RAS and BRAF genes and the location of the primary tumor determine the choice of systemic therapy. Panitumumab—a fully human anti-EGFR monoclonal antibody—is well-established in the treatment of patients with wild-type RAS and BRAF and left-sided tumor localization. The aim of this review is to summarize the role and potential of targeted therapies for colorectal cancer with monoclonal antibodies such …