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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Frontiers in Oncology

Sertoli cell tumor in familial adenomatous polyposis: a case report

Chandra Kakarala, Katie Bussing, Reema Patel, Jessica Moss, Zin W. Myint

Familial adenomatous polyposis is known to progress into colorectal cancer, and extra-intestinal malignancies have also been reported. However, testicular sex cord stromal tumors are very rarely noted in association. In this study, we report the case of a 50-year-old man with genetically confirmed FAP and adenocarcinoma of the colon who was incidentally found to have a testicular lesion. Radial orchiectomy was performed, and histopathologic examination confirmed a Sertoli cell tumor without high-risk features. This …

24.08.2026journal-article

Frontiers in Oncology

Differential analysis of urinary stable downregulated proteins in male patients after colorectal cancer surgery

Lupeng Wang, Qian Meng, Mei Hu, Man Zhang

Background Colorectal cancer is a common malignant tumor that threatens men’s health, and there are currently ineffective biomarkers for noninvasive monitoring of postoperative tumor changes in clinical practice. Urine is an easily accessible sample that can reveal physiological and pathological changes in the body. To identify specific proteins stably downregulated postoperatively and thereby provide novel potential biomarkers for colorectal cancer following surgery monitoring, this study analyzed urinary proteomi …

24.08.2026journal-article

Frontiers in Oncology

Integrating clinical and economic outcomes in the elderly myeloma management: a comparative cost-effectiveness analysis

Antonio G. Solimando, Vanessa Desantis, Lucia Di Marzo, Giulia de Martino, Simona D’Amore, Leonardo Girardi, Giuseppe Dicuonzo, Alessandro Andriano, Franco Dammacco, Angelo Vacca, Massimo Bilancia, Roberto Ria

Introduction Multiple myeloma (MM) is a hematologic malignancy that predominantly affects older adults and poses substantial therapeutic challenges due to the high prevalence of comorbidities and limited treatment tolerability. This study evaluates the cost-effectiveness of four first-line treatment regimens for elderly MM patients, ineligible for autologous stem cell transplantation (ASCT): bortezomib, melphalan, and prednisone (VMP); daratumumab in combination with VMP (D-VMP); lenalidomide and dexamethasone (Rd) …

24.08.2026journal-article

Frontiers in Oncology

Prognostic nutritional index in evaluating the prognosis of ICIs in patients with advanced esophageal squamous carcinoma

Qingfang Shi, Man Li, Daqing Wang, Jun’e Yang, Jun Gao

Objective This study aimed to investigate the association between the Prognostic Nutritional Index (PNI) and the prognosis of advanced esophageal squamous cell carcinoma (ESCC) patients treated with immune checkpoint inhibitors (ICIs). Methods We retrospectively analyzed the clinical data of 157 advanced ESCC patients who received ICIs therapy at Hengshui People’s Hospital. The PNI was calculated based on serum albumin levels and lymphocyte counts. The predictive value of PNI for disease progression in advanced ESC …

24.08.2026journal-article

Frontiers in Cardiovascular Medicine

Editorial: Innovative modeling and simulation in thrombosis and hemostasis: enhancing diagnosis and treatment

Rodrigo Assar, Daria Hemmerling

Computational modeling has become an increasingly important component of thrombosis and hemostasis research, evolving from mechanistic simulations into multidisciplinary approaches that support diagnosis, risk stratification, and therapeutic decision-making. The fourteen contributions included in this Research Topic illustrate this evolution through complementary methodologies, including mechanistic modeling, computational fluid dynamics, machine learning, quantitative imaging, biomarker integration, real-world dat …

24.08.2026journal-article

Frontiers in Cell and Developmental Biology

Advances in understanding the mechanisms underlying acquired resistance to third-generation tyrosine kinase inhibitors in non-small cell lung cancer

Gu-Ha A-Lai, Lian Li, Guangzhi Ma, Yong-Sheng Zhao, Peng Yao, Yi-Dan Lin

Acquired resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) presents a formidable challenge in the treatment of non-small cell lung cancer (NSCLC). Despite the remarkable efficacy of these agents, resistance inevitably develops, typically within approximately 10 months of treatment initiation. This review elucidates the multifaceted mechanisms driving this resistance, broadly categorized into on-target EGFR-dependent alterations and off-target EGFR-independent b …

24.08.2026journal-article

World Journal of Clinical Oncology

Timing matters: Early vs late recurrence in nasopharyngeal carcinoma and its impact on survival

Jing-Bo Wang, Yang Meng, Mei-Lin He, Si-Jia Zhang, Xiao-Dong Huang, Ye Zhang, Run-Ye Wu, Kai Wang, Xue-Song Chen, Yuan Qu, Jiang-Hu Zhang, Qing-Feng Liu, Jing-Wei Luo, Li Gao, Jian-Ping Xiao, Ye-Xiong Li, Li-Hua Luo, Jun-Lin Yi

BACKGROUND Despite the wide utilization of intensity-modulated radiation therapy and other advanced treatment modalities, approximately 10% of patients with nasopharyngeal carcinoma (NPC) still suffer from local or regional disease recurrence, leading to deteriorated survival outcome. Particularly, early recurrence is often associated with more aggressive biological behavior and greater resistance to initial treatments, subsequently resulting in poorer survival outcomes. AIM To investigate the temporal distribution …

24.08.2026journal-article

British Journal of Dermatology

Methodological discussion regarding the independent evaluation of a CE-marked AI smartphone application for skin cancer screening

Li Wan, Yongfei Hu, Fang Wang

This comment letter highlights methodological and analytical considerations in the evaluation of a CE-marked AI smartphone application for skin cancer screening, including failed image-capture cases, paired diagnostic comparisons, skin phototype-stratified performance and assessment of clinical utility.

24.08.2026journal-article

BMC Musculoskeletal Disorders

Comparison of lumbar interbody fusion with PEEK cage, titanium-coated PEEK cage and 3D-printed porous titanium cage for the treatment of lumbar degenerative disease: a systematic review and network meta-analysis

Ke Li, Yuchen Duan, Liangjuan Ren, Yao Shen, Runwen Liu, Yan Guo, Jie Zhang, Rigao Chen

Abstract Background As two classic representative materials, solid titanium cages and uncoated PEEK cage (UPC) each have distinct inherent advantages and limitations, and 3D-printed porous titanium cage (3DPPTC) and titanium-coated PEEK cage (TCPC) have been increasingly applied in clinical practice. Methods This study was in accordance with the NMA PRISMA Statement. A comprehensive search was conducted in the PubMed, Embase and Web of Science Core Collection databases from inception to January 26, 2026. The fusion …

24.08.2026journal-article

Frontiers in Cardiovascular Medicine

Understanding the distinct role of PI3K(p110α) in cancer and the heart to prevent chemotherapy-induced cardiotoxicity: mechanisms and therapeutic opportunities

Teleah G. Belkin, Yow Keat Tham, Amanda J. Edgley, Julie R. McMullen

The development of new cancer therapies with greater efficacy has reduced mortality for many cancers, as well as improving survivorship. However, for some cancer treatments, this has uncovered unintended cardiotoxicity during or after treatment, and cardiovascular disease has emerged as a leading cause of mortality in some cancer survivors. This may occur because many of the same growth factor signaling pathways that lead to tumor growth are also critical for maintaining normal heart function. A class IA phosphoino …

24.08.2026journal-article

Frontiers in Oncology

Potential of photoacoustic imaging for assessing tumor perfusion in intraocular tumors and high-resolution choroidal microvascular imaging: from technical advances to clinical translation

Huarong Wu, Cancan Huang, Shu Xu, Yanming Tian

Accurate diagnosis and treatment-response assessment for intraocular tumors, typified by choroidal melanoma and retinoblastoma, require characterization of tumor microvascular architecture and oxygenation. However, commonly used ophthalmic modalities—such as optical coherence tomography angiography (OCTA), contrast-enhanced ultrasound (CEUS), and magnetic resonance imaging (MRI)—are limited by penetration depth, reduced spatial resolution at depth, and/or insufficient functional specificity, which can hinder noninv …

24.08.2026journal-article

Advanced Functional Materials

Engineered MBene‐Based Materials for Water Treatment, Desalination, and Environmental Monitoring: Performance, Challenges, and Future Perspectives

I. Ihsanullah, Muataz Ali Atieh, Iftikhar Hussain, Kaili Zhang

ABSTRACT MBenes, a newly developed family of 2D transition‐metal boride materials, has gained considerable attention in recent years. MBenes have demonstrated encouraging potential in various fields, including energy storage, electrocatalysis, biomedical applications, environmental remediation, and sensing technologies. Despite rapid growth in MBene research, no comprehensive review has yet collectively evaluated their potential for pollutant adsorption from water, solar‐driven desalination, and environmental sensi …

24.08.2026journal-article

International Journal of Biology and Life Sciences

The mechanism of action of alpha-lipoic acid in the treatment of type 2 diabetes and its complications

Yuli Wang

Type 2 diabetes mellitus is now one of the metabolic disorders in the world, Oxidative stress and chronic inflammation are the reasons for serious diseases such as insulin resistance and peripheral neuropathy, and the existing drugs are unable to prevent these diseases at the level of pathology. Alpha-lipoic acid is a very effective multi-functional antioxidant and has shown some good results in diabetes research, First, we will introduce the main mechanisms by which alpha-lipoic acid has antioxidant and anti-stres …

24.08.2026journal-article

Current Opinion in Obstetrics & Gynecology

Postmenopausal endometriosis: current evidence and clinical challenges in diagnosis and treatment

Amber Trujillo Lalla, Jaden R Kohn, Dave Pasternak, Xiaoming Guan

Purpose of review Endometriosis was once thought to affect only reproductive-aged women. However, 2–5% of postmenopausal individuals remain affected. Guidance for this group is limited. This review outlines an updated approach to postmenopausal endometriosis, addressing pathophysiology, diagnostic challenges, and management in both natural and surgical menopause. Recent findings Postmenopausal endometriosis is underrecognized and has many diagnostic challenges. MRI is the preferred imaging modality for detecting le …

24.08.2026journal-article

Current Oncology

Combining Radiation Therapy and Tumor-Infiltrating Lymphocyte Therapy: Biological Rationale, Clinical Synergies, and Future Directions

Sean Maroongroge, Heather M. McGee, Kelly Mahuron, Savita Dandapani, Terence M. Williams, Yan Xing, Myo Htut, Colton J. Ladbury, Yufei Liu, Arya Amini

Tumor-infiltrating lymphocyte (TIL) therapy is the first adoptive cellular therapy approved to treat solid tumors and has demonstrated durable responses in advanced melanoma. However, its clinical implementation is limited by the need for tumor harvesting, manufacturing delays, and lymphodepleting conditioning. These logistic challenges are also opportunities for physicians and scientists to consider combining TIL therapy with radiation therapy (RT), a modality with well-established roles in cancer care. RT exerts …

24.08.2026journal-article

Frontiers in Immunology

Immunosuppressive cells as barriers to cancer therapy: mechanisms and emerging solutions

Mengmeng Liu, Yichen Zhu, Hemiao Liang, Yu Li, Huaimin Liu, Jia Li

Tumor microenvironment-resident immunosuppressive cells-comprising myeloid-derived suppressor cells, regulatory T cells, and tumor-associated macrophages-constitute primary obstacles to effective cancer immunotherapy. Advances in single-cell and spatial multi-omics have uncovered their substantial functional heterogeneity, tissue-adaptive reprogramming, and organ-specific architectures distinguishing primary tumors from metastatic lesions. Beyond canonical immune checkpoint pathways, non-canonical regulatory layers …

24.08.2026journal-article

Journal of Medicine, Nursing and Public health

Quality of Life of Caregivers of Pediatric Patients with Cancer at Kenyatta National Hospital, Kenya

Rhodah Auma Omondi, Lister Onsongo, Sarah Bett

Background: Family caregivers of children diagnosed with cancer play a critical supportive role in the care of these patients. The quality-of-life (QoL) challenges experienced by these caregivers have been shown to adversely affect their care for these children. The QoL of caregivers of children with cancer at Kenyatta National Hospital (KNH) and the experienced caregiving burden were unclear. Consequently, we assessed the QoL of caregivers of pediatric patients with cancer at KNH in Kenya and its relationship with …

24.08.2026journal-article

Clinical Nuclear Medicine

Radioiodine in Low-risk Differentiated Thyroid Cancer

Humayun Bashir, Aamna Hassan, Ahmad Qureshy, Hajira Ilyas, Sadaf Mufty, Mairah Razi, Sana Munir Gill

The management of differentiated thyroid cancer (DTC) has undergone a major paradigm shift over the past decade, with increasing emphasis on treatment de-escalation and avoidance of overtreatment in patients with low-risk disease. The 2015 American Thyroid Association guidelines marked a turning point by discouraging routine postoperative radioiodine (RAI) remnant ablation in low-risk patients, reflecting the excellent prognosis of most papillary thyroid carcinomas and concerns regarding unnecessary therapy-related …

24.08.2026journal-article

Current Opinion in Neurology

Paradigm shift in the pathomechanisms and treatment of inclusion body myositis: at the crossroads of cell-autonomous muscle degeneration and immune activation

Naoki Suzuki, Rumiko Izumi, Kensuke Ikeda

Purpose of review Inclusion body myositis (IBM) is the most prevalent acquired myopathy in adults over 50 years of age, yet effective disease-modifying therapy has remained elusive. The longstanding debate over whether degeneration or inflammation is the primary driver has now given way to a model of bidirectional interplay. This review critically appraises advances published between January 2025 and June 2026, encompassing molecular pathomechanisms, early diagnostic strategies, disease-modifying therapies, and reh …

24.08.2026journal-article

Die Dermatologie

Vitiligo in Deutschland

Markus Böhm, Lisa-Marie Müller, Alexa Benson, Alexander Heuck, Michael Sebastian

Zusammenfassung Hintergrund Vitiligo ist eine chronische immunvermittelte Erkrankung, charakterisiert durch depigmentierte Hautareale und assoziiert mit vielfältigen psychischen und somatischen Begleiterkrankungen. Für Deutschland existieren nur begrenzt aktuelle Daten zu Prävalenz, Komorbidität und Therapieverhalten. Methodik In dieser retrospektiven Analyse von Abrechnungsdaten der gesetzlichen Krankenversicherung (GKV) wurden Informationen von Versicherten (≥ 12 bzw. ≥ 18 Jahre) aus 2023 ausgewertet. Prävalenzfä …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Pharmacogenetic variants in the molecular characterization initiative: a report from the children’s oncology group

Cyrine E Haidar, Wenjian Yang, Rachel D Harris, Andrew Ostrenga, Alberto Pappo, Douglas S Hawkins, Jun J Yang, Philip J Lupo, Melanie Brooke Bernhardt

Abstract Background The Childhood Cancer Data Initiative Molecular Characterization Initiative (MCI) provides molecular testing to patients with select tumors treated at Children’s Oncology Group (COG) sites, advancing our understanding of the genetic basis of pediatric cancers and their treatment. However, the frequency of actionable pharmacogenomic variants in this cohort has not yet been explored. Methods Germline exome sequencing data were generated by the Institute for Genomic Medicine at Nationwide Children’s …

24.08.2026journal-article

Molecular Cancer Therapeutics

PF-08046876, a Differentiated Integrin Beta-6 Antibody–Drug Conjugate Delivering a Potent Camptothecin Payload Optimized for Bystander Effect and Reduced Drug Efflux

Rebecca C. Mazahreh, Chuan Bian Lim, Nicolas H. Garcia, Devra J. Olson, Ryan Lyski, Gina M. LoMastro, Andrea Musa, Guadalupe Gutierrez, Samantha M. Sarrett, R. Greg Stacey, Li-Ya Huang, Kelly Hensley, Lori Westendorf, Sohinee Bhattacharyya, Narayana Yeddula, Vivian H. Trang

Abstract Integrins represent a large family of cell surface receptors that exist as heterodimers with essential roles in key biological processes such as cellular adhesion, motility, and cytokinesis. Among them, integrin beta-6 (IB6), which exclusively dimerizes with integrin alpha-v, has emerged as a clinically relevant target due to its restricted expression in normal adult epithelial tissues and elevated levels in solid tumors. High expression of IB6 is correlated with poor prognosis across multiple solid tumor …

24.08.2026journal-article

Clinics and Practice

Clinical Characteristics, Treatment Patterns, and Survival Outcomes of Right-Sided RAS/RAF Wild-Type Metastatic Colorectal Cancer: A Real-World Multicenter Cohort Study

Nur Deniz Yildiz, Çağatay Arslan, İlker Nihat Okten, Umut Kefeli, Mahmut Emre Yildirim, Nuri Karadurmus, Tuba Baydas, Bülent Karabulut, Irfan Cicin, Cemil Bilir, Melike Ozcelik, Timucin Cil, Sinemis Celik, Oktay Bozkurt, Hakan Harputluoglu, Bala Başak Oven, Mehmet Artaç, Hacı Mehmet Türk, Ahmet Alacacıoğlu, Mahmut Gumus, Şuayib Yalcin

Background: Right-sided metastatic colon cancer represents a clinically distinct subgroup with inferior outcomes and uncertain optimal biologic treatment selection, even among patients with RAS wild-type disease. Real-world data focusing specifically on right-sided RAS wild-type metastatic colon cancer remain limited. This study aimed to describe clinicopathologic characteristics, metastatic patterns, treatment approaches, and survival outcomes in this population using a national multicenter registry. Methods: This …