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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

International Journal of Biology and Life Sciences

The mechanism of action of alpha-lipoic acid in the treatment of type 2 diabetes and its complications

Yuli Wang

Type 2 diabetes mellitus is now one of the metabolic disorders in the world, Oxidative stress and chronic inflammation are the reasons for serious diseases such as insulin resistance and peripheral neuropathy, and the existing drugs are unable to prevent these diseases at the level of pathology. Alpha-lipoic acid is a very effective multi-functional antioxidant and has shown some good results in diabetes research, First, we will introduce the main mechanisms by which alpha-lipoic acid has antioxidant and anti-stres …

24.08.2026journal-article

Current Opinion in Neurology

Paradigm shift in the pathomechanisms and treatment of inclusion body myositis: at the crossroads of cell-autonomous muscle degeneration and immune activation

Naoki Suzuki, Rumiko Izumi, Kensuke Ikeda

Purpose of review Inclusion body myositis (IBM) is the most prevalent acquired myopathy in adults over 50 years of age, yet effective disease-modifying therapy has remained elusive. The longstanding debate over whether degeneration or inflammation is the primary driver has now given way to a model of bidirectional interplay. This review critically appraises advances published between January 2025 and June 2026, encompassing molecular pathomechanisms, early diagnostic strategies, disease-modifying therapies, and reh …

24.08.2026journal-article

Journal of Medicine, Nursing and Public health

Quality of Life of Caregivers of Pediatric Patients with Cancer at Kenyatta National Hospital, Kenya

Rhodah Auma Omondi, Lister Onsongo, Sarah Bett

Background: Family caregivers of children diagnosed with cancer play a critical supportive role in the care of these patients. The quality-of-life (QoL) challenges experienced by these caregivers have been shown to adversely affect their care for these children. The QoL of caregivers of children with cancer at Kenyatta National Hospital (KNH) and the experienced caregiving burden were unclear. Consequently, we assessed the QoL of caregivers of pediatric patients with cancer at KNH in Kenya and its relationship with …

24.08.2026journal-article

Clinics and Practice

Clinical Characteristics, Treatment Patterns, and Survival Outcomes of Right-Sided RAS/RAF Wild-Type Metastatic Colorectal Cancer: A Real-World Multicenter Cohort Study

Nur Deniz Yildiz, Çağatay Arslan, İlker Nihat Okten, Umut Kefeli, Mahmut Emre Yildirim, Nuri Karadurmus, Tuba Baydas, Bülent Karabulut, Irfan Cicin, Cemil Bilir, Melike Ozcelik, Timucin Cil, Sinemis Celik, Oktay Bozkurt, Hakan Harputluoglu, Bala Başak Oven, Mehmet Artaç, Hacı Mehmet Türk, Ahmet Alacacıoğlu, Mahmut Gumus, Şuayib Yalcin

Background: Right-sided metastatic colon cancer represents a clinically distinct subgroup with inferior outcomes and uncertain optimal biologic treatment selection, even among patients with RAS wild-type disease. Real-world data focusing specifically on right-sided RAS wild-type metastatic colon cancer remain limited. This study aimed to describe clinicopathologic characteristics, metastatic patterns, treatment approaches, and survival outcomes in this population using a national multicenter registry. Methods: This …

24.08.2026journal-article

Coatings

Regulating the Microstructure and Mechanical Properties of 22Cr12NiMoWV Martensitic Heat-Resistant Steel Through a Two-Step Heat Treatment

Jiaolong Huang, Changjun Qiu, Tiyun Xiao, Jia Gao, Yong Li, Ruiqing Li, Pinghu Chen

22Cr12NiMoWV martensitic heat-resistant steel serves as a candidate material for underground coiler sector plates, whereas the coupling relationship between partial austenitization, precipitate/carbide evolution, martensitic interfaces and mechanical response under medium-temperature quenching–tempering conditions is still ambiguous. This work systematically explores four key heat treatment variables to clarify the microstructure–property correlation and strengthening rebalance mechanism. In the 790–830 °C partial …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Pharmacogenetic variants in the molecular characterization initiative: a report from the children’s oncology group

Cyrine E Haidar, Wenjian Yang, Rachel D Harris, Andrew Ostrenga, Alberto Pappo, Douglas S Hawkins, Jun J Yang, Philip J Lupo, Melanie Brooke Bernhardt

Abstract Background The Childhood Cancer Data Initiative Molecular Characterization Initiative (MCI) provides molecular testing to patients with select tumors treated at Children’s Oncology Group (COG) sites, advancing our understanding of the genetic basis of pediatric cancers and their treatment. However, the frequency of actionable pharmacogenomic variants in this cohort has not yet been explored. Methods Germline exome sequencing data were generated by the Institute for Genomic Medicine at Nationwide Children’s …

24.08.2026journal-article

Die Dermatologie

Vitiligo in Deutschland

Markus Böhm, Lisa-Marie Müller, Alexa Benson, Alexander Heuck, Michael Sebastian

Zusammenfassung Hintergrund Vitiligo ist eine chronische immunvermittelte Erkrankung, charakterisiert durch depigmentierte Hautareale und assoziiert mit vielfältigen psychischen und somatischen Begleiterkrankungen. Für Deutschland existieren nur begrenzt aktuelle Daten zu Prävalenz, Komorbidität und Therapieverhalten. Methodik In dieser retrospektiven Analyse von Abrechnungsdaten der gesetzlichen Krankenversicherung (GKV) wurden Informationen von Versicherten (≥ 12 bzw. ≥ 18 Jahre) aus 2023 ausgewertet. Prävalenzfä …

24.08.2026journal-article

Current Oncology

Combining Radiation Therapy and Tumor-Infiltrating Lymphocyte Therapy: Biological Rationale, Clinical Synergies, and Future Directions

Sean Maroongroge, Heather M. McGee, Kelly Mahuron, Savita Dandapani, Terence M. Williams, Yan Xing, Myo Htut, Colton J. Ladbury, Yufei Liu, Arya Amini

Tumor-infiltrating lymphocyte (TIL) therapy is the first adoptive cellular therapy approved to treat solid tumors and has demonstrated durable responses in advanced melanoma. However, its clinical implementation is limited by the need for tumor harvesting, manufacturing delays, and lymphodepleting conditioning. These logistic challenges are also opportunities for physicians and scientists to consider combining TIL therapy with radiation therapy (RT), a modality with well-established roles in cancer care. RT exerts …

24.08.2026journal-article

Frontiers in Immunology

Immunosuppressive cells as barriers to cancer therapy: mechanisms and emerging solutions

Mengmeng Liu, Yichen Zhu, Hemiao Liang, Yu Li, Huaimin Liu, Jia Li

Tumor microenvironment-resident immunosuppressive cells-comprising myeloid-derived suppressor cells, regulatory T cells, and tumor-associated macrophages-constitute primary obstacles to effective cancer immunotherapy. Advances in single-cell and spatial multi-omics have uncovered their substantial functional heterogeneity, tissue-adaptive reprogramming, and organ-specific architectures distinguishing primary tumors from metastatic lesions. Beyond canonical immune checkpoint pathways, non-canonical regulatory layers …

24.08.2026journal-article

Molecular Cancer Therapeutics

PF-08046876, a Differentiated Integrin Beta-6 Antibody–Drug Conjugate Delivering a Potent Camptothecin Payload Optimized for Bystander Effect and Reduced Drug Efflux

Rebecca C. Mazahreh, Chuan Bian Lim, Nicolas H. Garcia, Devra J. Olson, Ryan Lyski, Gina M. LoMastro, Andrea Musa, Guadalupe Gutierrez, Samantha M. Sarrett, R. Greg Stacey, Li-Ya Huang, Kelly Hensley, Lori Westendorf, Sohinee Bhattacharyya, Narayana Yeddula, Vivian H. Trang

Abstract Integrins represent a large family of cell surface receptors that exist as heterodimers with essential roles in key biological processes such as cellular adhesion, motility, and cytokinesis. Among them, integrin beta-6 (IB6), which exclusively dimerizes with integrin alpha-v, has emerged as a clinically relevant target due to its restricted expression in normal adult epithelial tissues and elevated levels in solid tumors. High expression of IB6 is correlated with poor prognosis across multiple solid tumor …

24.08.2026journal-article

Clinical Nuclear Medicine

Radioiodine in Low-risk Differentiated Thyroid Cancer

Humayun Bashir, Aamna Hassan, Ahmad Qureshy, Hajira Ilyas, Sadaf Mufty, Mairah Razi, Sana Munir Gill

The management of differentiated thyroid cancer (DTC) has undergone a major paradigm shift over the past decade, with increasing emphasis on treatment de-escalation and avoidance of overtreatment in patients with low-risk disease. The 2015 American Thyroid Association guidelines marked a turning point by discouraging routine postoperative radioiodine (RAI) remnant ablation in low-risk patients, reflecting the excellent prognosis of most papillary thyroid carcinomas and concerns regarding unnecessary therapy-related …

24.08.2026journal-article

SDÜ SAĞLIK BİLİMLERİ DERGİSİ

Breast Cancer Worry and Associated Factors Among Female University Students: A Cross- Sectional Study

Filiz Salman Saraç, Altun Baksi, Şengül Horzum, Ümmü Sena Bilgiç

Aim: The study aimed to examine the level of breast cancer worry and the factors that might be associated with it among university students. Method: This cross-sectional descriptive research was conducted on 347 female university students. The data was collected using the Descriptive Characteristic Form and Breast Cancer Worry Scale and evaluated with descriptive statistics and binary logistic regression analysis. Results: The mean age of participants is 20.65±2.18 (min-max=18-35), and the mean score of the breast …

24.08.2026journal-article

Theoretical and Natural Science

Functional Mechanisms and Clinical Translation of Resveratrol for Lung Cancer Intervention

Chenxi Yang

Lung cancer patients commonly suffer from tumor immune escape and acquired chemotherapy resistance, and conventional comprehensive treatment schemes still have prominent clinical limitations. Resveratrol, a low-toxicity natural polyphenol, has become a key research focus for adjuvant lung cancer therapy. This paper systematically reviews the anti-lung-cancer mechanisms of resveratrol, relevant epidemiological evidence, and bottlenecks hindering its clinical translation. Resveratrol remodels macrophages to secrete i …

24.08.2026journal-article

Oncology Reviews

Brucea javanica oil emulsion as an adjunct to chemoradiotherapy in cervical cancer: a systematic review and meta-analysis of adverse effects reduction and immune enhancement

Buwei Han, Mingge Liang, Ding Qi, Yangfan Qu, Jinzhe Liu, Wenxia Ai, Yue Yang, Wenlan Li

Background Brucea javanica oil emulsion (BJOE) has been proposed as an adjuvant therapy to mitigate adverse reactions in cervical cancer patients receiving radiotherapy/chemotherapy, yet its efficacy remains understudied. This meta-analysis aimed to systematically evaluate the clinical benefits and safety of BJOE in this population. Methods We searched PubMed, Embase, Cochrane Library, and six other databases for Randomized controlled trials (RCTs) up to February 2025. Primary outcomes included adverse reactions (r …

24.08.2026journal-article

Cancer Research

Neutrophil Extracellular Trap-Derived DNA Activates the ITGB1/FAK Pathway to Promote Lung Adenocarcinoma Metastasis

Zhongpeng Xie, Fei Fang, Yanxia Wang, Lihong Wei, Xiaohua Situ, Qinru Zhan, Tongze Fu, Tian Tian, Shuhua Li, Jianwen Zhou, Qiong He, Yi-Yan Lei, Zunfu Ke

Abstract Neutrophil extracellular traps (NETs) have recently emerged as key modulators of cancer progression and metastasis. However, a more comprehensive understanding of the underlying mechanisms could help identify effective strategies to prevent and treat NET-mediated metastasis. Here, we observed a marked accumulation of intratumoral NETs in metastatic primary lung adenocarcinoma (LUAD). Tumor cells with elevated CXCL2 expression not only recruited neutrophils via interactions with CXCR2 but also facilitated N …

24.08.2026journal-article

Journal of Evidence-Based Medicine

Comparison and Selection of Network Meta‐Analysis Models for Fitting and Extrapolating Cancer Survival Data

Mingye Zhao, Qian Xing, Taihang Shao, Hanqiao Shao, Wenxi Tang

ABSTRACT Aim To assess network meta‐analysis (NMA) model biases under different proportional hazards (PHs) scenarios, compare fitting and extrapolation performance for hazard ratios (HRs) using cancer survival data, identify metrics guiding model selection, and compare extrapolation strategies using parametric versus constant‐tail HRs. Methods We conducted 30 NMAs (five three‐arm trials, with each arm anchoring pairwise comparisons for overall survival and progression‐free survival), subgroup analyses assessed the …

24.08.2026journal-article

World Journal of Clinical Oncology

Advancing perioperative care in breast oncology: The synergistic potential of electroacupuncture and nonsteroidal anti-inflammatory drugs analgesia

Lei Gao, Yan Liu, Tie-Jun Pan, Zhen-Yu Liu

This editorial examines the case control study by He et al recently published in World Journal of Clinical Oncology , which investigates the synergistic effects of perioperative electroacupuncture (EA) combined with flurbiprofen axetil (FA) on pain management and functional recovery following breast cancer surgery. In the study involving 130 patients, the EA group demonstrated a significant reduction in the incidence of moderate-to-severe movement-evoked pain and lower Visual Analog Scale scores at rest and during …

24.08.2026journal-article

BMC Cancer

Tocopherol-loaded niosomes: a promising nanocarrier for enhancing apoptotic and anti-metastatic effects in breast cancer cells

Ava Shamipak, Mahsa Kavousi, Faranak Jamshidian

Abstract Background Breast cancer is (BC) considered as one of the most common causes of morbidity and mortality among women worldwide. Tocopherol (Vitamin E) is a strong lipid soluble antioxidant, which has anticancer effects but its therapeutic application is limited due to poor water solubility. The aim of this study was to fabricate tocopherol-niosome nanoparticles (NPs) and determined their cytotoxic, apoptotic and anti-metastatic properties in human breast cancer MCF-7 cell line. Materials and methods The thi …

24.08.2026journal-article

American Journal of Clinical Oncology

Combining Statistical Modeling and Machine Learning for Prognostic Feature Selection in Cervical Cancer

Reyanguli Dawuti, Lili Yao, Mayila Wutikuer, Xiaoshan Liu, Dongrui Zhang, Tingting Qi

Objectives: Cervical cancer is a leading female malignancy with high global morbidity/mortality, and remains high recurrence risk after standard treatment. Accurate prognostic feature identification is critical for personalized therapy and patient survival improvement, while traditional indicators and single biomarkers lack sufficient accuracy in prognostic prediction. Methods: In this population-based retrospective study, we analyzed 5392 patients with cervical squamous cell carcinoma from the surveillance, epidem …

24.08.2026journal-article

Clinical Cancer Research

Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial

Hildur Helgadottir, Mariaelena Capone, Laura Ridolfi, Alberto Zambelli, Luisa Piccin, Helen Gogas, Marco Tucci, Pietro Quaglino, Michele Del Vecchio, Alessandro Marco Minisini, Francesco Spagnolo, Piotr Rutkowski, Virginia Ferraresi, Ana Arance, Michele Guida, Evaristo Maiello, Céleste Lebbé, Jenny Bulgarelli, Vanna Chiarion Sileni, Miriam Paone, Ignacio Melero, Claudia Trojaniello, Mattias Bergqvist, Reinhard Dummer, Diana Giannarelli, Giuseppe Palmieri, Paolo A. Ascierto

Abstract Purpose: Although immune checkpoint inhibitors (ICI) are generally the preferred first-line treatment for metastatic BRAF V600–mutated melanoma, a subgroup that remains incompletely defined requires initial tumor control with BRAF/MEK-targeted therapy (TT). The purpose of this study was to evaluate circulating thymidine kinase activity (TKa), a blood-based marker of cellular proliferation, as a biomarker of outcome and treatment sequencing in patients enrolled in the randomized phase II SECOMBIT trial (NCT …

24.08.2026journal-article

Holistic Integrative Oncology

CACA Guidelines for holistic integrative assessment (2025)

Hongyan Zhang, Qiuling Shi, Xiaomei Li, Qian Li, Yong Liu, Hongmei Zhang, Rongbo Lin, Wenli Zhou, Qian Chu, Jie Min, Jin Zheng, Bo Liu, Xiaobing Chen, Yi He, Lei Ni, Min Li, Minghua Cong, Feng Liang, Xiaowen Wang, Zhi Guo, Guibin Qiao, Jinghui Bai, Hongxia Li, Beibei Chen, Fei Wang, Jizong Jiang, Duanqi Liu

Abstract The complexity and heterogeneity of malignant tumors necessitate a paradigm shift from a disease-centric to a patient-centric model of care. Cancer holistic integrative assessment (CHIA) is a multidimensional evaluation process that forms the cornerstone of personalized oncology. CHIA is characterized by four core principles: integrative philosophy, multidimensionality, dynamic individualization, and multidisciplinary collaboration. Key assessment domains include: 1) General status (performance status, phy …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Periductal myxoid stroma identifies ductal carcinoma in situ at risk of invasive recurrence

Aglaia Schiza, Viktoria Thurfjell, Erik Holmberg, Troy Bremer, Patrick Micke, Per Karlsson, Fredrik Wärnberg, Carina Strell

Abstract Overtreatment of breast ductal carcinoma in situ (DCIS) remains a major clinical problem because clinicopathologic criteria are insufficient to define the invasive potential. We evaluated whether periductal stromal morphology in diagnostic hematoxylin-eosin sections predicts invasive recurrence among 711 DCIS patients from the randomized SweDCIS trial, who underwent breast-conserving surgery with or without radiotherapy. Two raters scored the proportion of DCIS ducts surrounded by myxoid stroma. Eighty pat …

24.08.2026journal-article

Frontiers in Oncology

Global pattern and evolution of PPARγ in breast cancer: a 25-Year bibliometric and visualized knowledge map analysis

Xiaotian Zhang, Juan Jin, Yuan Cai, Xiaohui Luo, Qing She

Bibliometric methods were employed to visually examine the global trends and progression of PPARγ in the breast with the aim of clarifying the evolution of significant academic contributions, collaborative networks, foundational disciplines, and key terms. A comprehensive search was conducted on publications related to PPARγ in breast cancer research using the Web of Science Core Collection database (WOSCC) and PubMed. The reference types for the WOSCC database were restricted to articles and reviews published in E …

24.08.2026journal-article

Frontiers in Oncology

Adenosine signaling in tumor immune escape: metabolic checkpoints, myeloid suppression, and combination immunotherapy

Rui Li, Shengbiao Li, Tongtong Zhang

Adenosine is a central metabolic regulator of tumor immune escape, shaping the tumor microenvironment (TME) through suppression of effector lymphocytes and reprogramming of myeloid populations. Extracellular adenosine is generated primarily via the ectonucleotidases CD39 and CD73 and signals through A2A (A2AR) and A2B (A2BR) receptors on T cells, NK cells, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and dendritic cells. This pathway promotes T-cell exhaustion, inhibits cytotoxicit …