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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Journal of Clinical Medicine

Biologic Therapy Is Associated with Reduced Pleural-Line Thickness in Severe Asthma: A Prospective Transthoracic Ultrasound Study

Müge Erbay, Selçuk Akkaya, Funda Öztuna, Hatice Tayar

Background/Objectives: Tissue-level markers of treatment response are lacking in severe asthma. Transthoracic ultrasound (TUS) non-invasively detects pleural-line and subpleural abnormalities that have been linked to small-airway disease, but it has not been evaluated as a marker of response to biologic therapy. The primary objective was to determine whether mean pleural-line thickness in the right and left hemithoraces changed between baseline and week 16 of biologic therapy. The secondary objectives were to descr …

17.08.2026journal-article

Wiener Medizinische Wochenschrift

Extracorporeal shockwave therapy as a key component of interdisciplinary wound management in diabetic foot syndrome

Richard Crevenna, Zoltan Vass, Michael Mickel, Michael Leutner, Shuren Li, Mohammad Keilani

Summary Background A 57-year-old male patient presented with the first manifestation of severe type 2 diabetes mellitus in the setting of diabetic foot syndrome complicated by osteomyelitis. Methods The patient was treated conservatively within a multimodal interdisciplinary approach. In addition, focused extracorporeal shockwave therapy (fESWT) was performed according to International Society for Medical Shockwave Treatment (ISMST)-oriented principles. Results After five sessions of fESWT, local wound management r …

17.08.2026journal-article

Frontiers in Oncology

Associations between pretreatment composite inflammatory indices and pathological response to neoadjuvant therapy in breast cancer: a retrospective cohort study

Yuhong Zhang, Cailing Tong

Background Pretreatment inflammatory indices may reflect the host immune-inflammatory status in breast cancer. Evidence comparing multiple composite indices across pathological response endpoints after neoadjuvant therapy remains limited. This study evaluated the associations between pretreatment composite inflammatory indices and pathological response in breast cancer. Methods This retrospective study included 280 patients with breast cancer who underwent neoadjuvant therapy followed by surgery. Baseline neutrophi …

17.08.2026journal-article

Biomolecules

Two Faces of the Right Ventricle in Fabry Cardiomyopathy: Septal-Coupled and Atrial-Coupled Strain Patterns and Their Differential Associations with Enzyme Replacement Therapy

Kuo-Tzu Sung, Dau-Ming Niu, Shu-Fen Hsu, Ming-En Liu, Po-Lin Lin, Yau-Huei Lai, Hsiang-Wei Yang, Yung-Hsiu Lu, Cheng-Ting Tsai, Ta-Chuan Hung, Po-Sheng Chen, Chung-Lieh Hung

Right ventricular global longitudinal strain (RVGLS) and right ventricular free-wall longitudinal strain (RVFWLS) are both used to assess right ventricular involvement, but they include different myocardial components. We examined their cross-sectional correlates and longitudinal changes associated with enzyme replacement therapy (ERT) in 100 patients with genetically confirmed Fabry disease, including 69 with serial echocardiography. RVGLS was independently associated with left ventricular global longitudinal stra …

17.08.2026journal-article

International Journal of Molecular Sciences

Recent Advances in Therapy for the Neurodegenerative Disorder Ataxia-Telangiectasia

Sam Nayler, Simon Foster, Martin Lavin, David Coman

At present, there is no cure for the human genetic disorder ataxia-telangiectasia (A-T), which is managed by supportive care. This disorder arises due to mutations in the ATM (ataxia-telangiectasia mutated) gene and is characterised by a defect in the response to DNA damage, oxidative stress, mitochondrial dysfunction and immune deficiency. The ATM protein is activated by DNA damage, reactive oxygen species (ROS), and a variety of other stimuli, which leads to the phosphorylation or altered cellular localisation of …

17.08.2026journal-article

Archivos en Medicina Familiar

Calidad de vida en pacientes con nefropatía diabética y terapia sustitutiva renal

Yanet Flores Morales, Itzia I. Corona Candelas, Citlalli Orizaga de la Cruz, Anel Gómez García, María P. Rodríguez Correa

Objetivo: Comparar la calidad de vida en pacientes con nefropatía diabética sometidos a diálisis continúa ambulatoria y hemodiálisis. Métodos: Estudio observacional, transversal y prospectivo realizado en la Unidad Médica de Atención Ambulatoria 254 de Morelia Michoacán, México del Instituto Mexicano del Seguro Social. Se efectuó de diciembre 2023 a abril 2024, fueron incluidos 136 pacientes con nefropatía diabética en diálisis peritoneal continua ambulatoria y hemodiálisis. Para evaluar la calidad de vida se aplic …

17.08.2026journal-article

Journal of Clinical Medicine

Occupational Contact Dermatitis in the Post-COVID Era: From Barrier Dysfunction and Microbiome Dysbiosis to Prevention and Precision Management

Laura Maghiar, Andrada Iftode, Teodor-Andrei Maghiar, Raul Chioibas, Titus Grecu, Carmen Neamțu, Sandor Mircea Ioan, Cristina-Adriana Dehelean, Cristina Dumitrescu, Andreea-Adriana Neamțu

Background/Objectives: Occupational contact dermatitis (OCD) is the most common work-related skin disease, accounting for roughly 90–95% of occupational dermatoses and falling predominantly on the hands. It is rarely dangerous yet imposes a substantial burden through impaired quality of life, lost productivity, and premature exit from affected trades. The COVID-19 pandemic intensified this burden among healthcare workers, in whom the pooled one-year prevalence of self-reported hand eczema reaches around 27%; meta-a …

17.08.2026journal-article

Frontiers in Oncology

High dose IFN-α2b as post operative adjuvant therapy for acral melanoma: a multi-center real-world cohort study of 171 Chinese patients

Kaidi Yang, Shiji Lan, Yan Wang, Jin Wu, Xin Cai, Kui Jiang, Zhen Guo, Mei Xiang, Hongfeng Zhou, Jiwei Li, Fang Liu, Jianping Gui, Yuhuan Mao, Hongxue Meng, Xiang Ji, Janan Pang, Xinxin Yang, Lu Feng, Weizhen Zhang, Di Wu

Background This study aimed to investigate recurrence patterns and survival outcomes in Chinese patients with AM who received postoperative adjuvant High-dose interferon (HD-IFN), and to assess how treatment duration and the interval between surgery and therapy initiation relate to recurrence and survival. Methods A multi-center, retrospective cohort study involving 171 patients with AM who received postoperative adjuvant HD-IFN therapy between January 2012 and March 2025 was conducted at five melanoma diagnostic a …

17.08.2026journal-article

Frontiers in Neurology

Dose–response and recovery trajectories of fall prevention rehabilitation in older patients with vertigo: a retrospective cohort study based on vestibular and gait impairment phenotypes

Xiao-Qing Zhang, Jing Qin, Hong-Min Wang, Li Liu, Jie Zhang, Ya-Hui Wang, Wen-Ting Wang, Rui-Ting Zhu, Hong-Lei Guo

Background Vertigo and dizziness are common in older adults and are associated with a significantly increased risk of falls. Fall prevention rehabilitation therapy (FPRT) is recommended, but current prescriptions remain largely empirical and do not account for heterogeneity in baseline vestibular and gait impairments. The dose–response relationship between rehabilitation hours and functional improvement, and how baseline phenotypes are associated with recovery trajectories, are poorly understood. Methods This retro …

17.08.2026journal-article

Journal of Neurosurgery: Case Lessons

Primary denosumab therapy for a three-column pediatric cervical aneurysmal bone cyst: illustrative case

Mohammed Amin, Odette El Ghawi, Aya Mosleh, Louna Ftouni, Mohamad El Houshiemy, Marwan Najjar

BACKGROUND Pediatric spinal aneurysmal bone cysts (ABCs) involving all three columns present significant surgical challenges due to high procedural morbidity and vertebral artery risks. While denosumab is utilized off-label for these aggressive lesions, its efficacy and safety in pediatric spinal cases remain insufficiently characterized. OBSERVATIONS A 12-year-old girl with a C6 ABC and progressive myelopathy (modified Japanese Orthopaedic Association [mJOA] score 14) underwent 12 months of primary denosumab thera …

17.08.2026journal-article

Adolescência e Saúde

Efficacy Of High Tone Power Therapy Combined With A Targeted Physical Therapy Program For Overactive Bladder In People With Multiple Sclerosis: A Randomized Controlled Trial

Mohamed H. Hussien, Eman S. Fayez, Salma H. Khalil, Amr M. Sayed, Jasmine M. Mahmoud, Mohamed H. Marzouk

Objective: Overactive bladder (OAB) is a predominant urinary tract disorder in people with multiple sclerosis (PwMS). We sought to assess the therapeutic effects for high tone therapy (HTT) in treatment of OAB symptoms and quality of life (QOL) in PwMS. Methods: A prospective, randomized controlled study included forty remitting relapsing MS patients of both sexes (RRMS) with moderate OAB symptoms were randomly allocated into 2 equal groups: The treatment group (GA) received HTT + targeted physical therapy program. …

17.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Psychosocial safety climate and emotional exhaustion among police officers in guangxi, China: The mediating role of surface acting

Mao Xueying, Fonny Dameaty Hutagalung, Rosila Bee Mohd Hussain

Background Emotional exhaustion is a central component of burnout and is highly prevalent among police officers due to the emotionally demanding nature of policing work. Psychosocial safety climate (PSC), as an organizational resource, may influence emotional exhaustion directly and through emotional regulation strategies such as surface acting. Objective This study aimed to examine the relationship between psychosocial safety climate, surface acting, and emotional exhaustion among police officers, and to investiga …

17.08.2026journal-article

Contemporary Education and Community Engagement (CECE)

Influence of Rational Emotive Behavior Therapy on Sexual Abuse Education among Sampled Adolescents in Imo State, Nigeria

Mohamed Alusine Mansaray, Gilbert Madubuike

Adolescent sexual abuse remains a pervasive and deeply damaging issue globally, with significant psychological ramifications for its victims. In Nigeria, particularly within states like Imo, the prevalence of such abuse necessitates effective therapeutic interventions. This article explores the potential influence of Rational Emotive Behavior Therapy (REBT) as a therapeutic approach in addressing the psychological trauma experienced by adolescents who have endured sexual abuse in Imo State, Nigeria. Drawing upon ex …

17.08.2026journal-article

Scientific Reports

Immune responses elicited by rMV-SLAMblind oncolytic therapy exert a synergistic effect on cancer therapy

Kanako Moritoh, Tomoko Fujiyuki, Yosuke Amagai, Hiroki Sato, Misako Yoneda, Chieko Kai

Abstract Oncolytic virotherapy has emerged as a promising strategy for cancer therapy. rMV-SLAMblind is a recombinant measles virus that lacks the ability to interact with SLAM and specifically infects and lyses NECTIN4 + cancer cells. We previously reported that rMV-SLAMblind oncolytic virotherapy (rMV-OVT) exerts anti-tumor immunity through the activation of immune cells in virus-treated tumors. It is thought that oncolytic virotherapy promotes anti-tumor effects via two mechanisms: direct tumor cell lysis caused …

17.08.2026journal-article

Circulation: Population Health and Outcomes

Effectiveness of Multidomain Cardiac Rehabilitation After Myocardial Infarction by Patient Frailty: Prespecified Subgroup Analysis of the PIpELINe Trial

Beatrice Dal Passo, Elisabetta Tonet, Andrea Raisi, Silvia Zagnoni, Giorgio Chiaranda, Giovanni Pasanisi, Rita Pavasini, Paolo Cimaglia, Tommaso Piva, Gianni Casella, Serena Caglioni, Valentina Zerbini, Marta Cocco, Erica Menegatti, Simona Mandini, Gianni Mazzoni, Simone Biscaglia, Stefano Volpato, Giovanni Grazzi, Gianluca Campo

BACKGROUND: Frailty is common among older patients surviving myocardial infarction, is associated with adverse outcomes, and is often perceived as a barrier to cardiac rehabilitation (CR). The aim of this study is to determine whether frailty influences prognosis after myocardial infarction, and whether frailty modifies the clinical benefit of multidomain CR. METHODS: We performed a prespecified subgroup analysis of the PIpELINe (Physical Activity Intervention in Elderly Patients With Myocardial Infarction) randomi …

17.08.2026journal-article

South African Journal of Physiotherapy

Cystic fibrosis transmembrane conductance regulator modulator therapy and lived experiences in South Africa: A mixed-methods study

Brenda M. Morrow, Janine Verstraete, Sinead Thistlewhite, Carese Abrahams, Teboho N. Nkosi, Tyra Donnelly, Dalziel Kennedy, Marco Zampoli

Background: Cystic fibrosis transmembrane conductance regulator modulator (CFTRm) therapy has transformed cystic fibrosis (CF) outcomes in high-income settings, yet access remains severely limited in South Africa. Patient-reported outcomes of CFTRm are underexplored. Objectives: To describe the lived experiences of South African people living with cystic fibrosis (PLwCF) following CFTRm initiation, focusing on respiratory symptoms, treatment burden, physical activity, social and recreational participation, and well …

17.08.2026journal-article

RETINAL Cases & Brief Reports

Refractory Perifoveal Exudative Vascular Anomalous Complex (PEVAC)- Early Positive Response to Faricimab Therapy

Eduardo Cunha Souza

Purpose: To describe a case of refractory unilateral PEVAC macular edema initially treated with intravitreal faricimab injections. Methods: Medical and imaging records were evaluated. Tracked optical coherence tomography (OCT) B scans were reviewed to assess intra-retinal fluid and exudation. Results: A 79-year-old man with unilateral chronic macular edema secondary to PEVAC lesion underwent three monthly intravitreal faricimab injections with completely resolution of the fluid and visual recovery. A presumed throm …

17.08.2026journal-article

Small

Bidirectional ROS Modulation for Programmed Anti‐Infective and Anti‐Inflammatory Therapy With Au‐Cu 2 O/MXene Nanocomposite

Min Zhang, Kami Hu, Liuyuan Zhu, Rui Ding, Ying Hou, Junjie Mou, Haoming Xia, Yihe Lin, Purui Zheng, Lingnv Zhan, Haiping Fang, Hui He, Chunhua Zeng, Yingying Huang, Ruoyang Chen

ABSTRACT Chronic bacterial infections pose a therapeutic challenge in eliminating bacteria while suppressing inflammation. Conventional antibiotics are often limited by drug resistance and poor biofilm penetration, contributing to a global health threat of antibiotic misuse. Reactive oxygen species (ROS) modulation offers a promising alternative, yet requires precise balance: insufficient ROS compromises antibacterial efficacy, but excess exacerbates inflammation. Here, we present a bidirectional ROS‐regulation str …

17.08.2026journal-article

JAMA Neurology

Safety of Antiseizure Medications During Direct Oral Anticoagulant Therapy in Epilepsy

Kai Michael Schubert, Carolina Ferreira-Atuesta, Arunachalam Soma, Johan Zelano, David J. Seiffge, Francesco Brigo, Eugen Trinka, Nishant K. Mishra, Emilio Russo, Gregory Y. H. Lip, Gashirai K Mbizvo, Marian Galovic

Importance Concomitant use of antiseizure medications (ASMs) and direct oral anticoagulants (DOACs) is common in epilepsy, but comparative safety data remain limited. Objective To compare risks of thromboembolic events, major bleeding, and all-cause mortality across commonly used ASMs in adults with epilepsy receiving DOACs. Design, Setting, and Participants This was a retrospective cohort study emulating a target trial for each ASM group against an active comparator; 1:1 propensity score matching in 4 cohorts emul …

17.08.2026journal-article

Chinese Medical Journal

Advances in stroke-associated pneumonia in the era of revascularization therapy

Yiwen Xu, Yaqing Zhang, Yuesong Pan, Liping Liu, Ruijun Ji, Yilong Wang, Penglian Wang

Abstract In recent decades, the advent of revascularization treatments (RVTs), such as intravenous thrombolysis (IVT) and endovascular therapy, has significantly improved clinical outcomes in patients with acute ischemic stroke (AIS). However, stroke-associated pneumonia (SAP) remains a common complication that has a negative impact on the prognosis. This review addresses the mechanisms underlying the development of SAP in patients with AIS, evaluates risk factors, and discusses therapeutic and preventive measures …

17.08.2026journal-article

Exploration of Drug Science

Synergistic attack of “old drugs for new uses”: repositioning strategies in cancer combination therapy

Jingjing Yan, Xinran Wei, Xiangyi Zhang, Siqi Zhang, Dan Xia, Zi’an Tang, Zixuan Yang, Cuifeng Zhang

Cancer treatment faces severe challenges such as drug resistance, side effects, and high costs. The “repurposing old drugs” strategy, which involves repositioning approved drugs for non-oncology indications for cancer treatment, has opened up new avenues for developing efficient, low-toxicity, and rapidly translatable combination therapies. This strategy can not only accelerate clinical translation by leveraging known pharmacological and safety data but also generate synergistic effects with standard chemotherapy, …

17.08.2026journal-article

Discover Sensors

Next-generation nanobiosensors enable dynamic, real-time glucose monitoring for precision diabetes therapy

Riya Das, Monali Singh, Biswajeet Acharya, Amit Kundu, Ranjit Prasad Swain, Asha Deepthi Choppala

Abstract Diabetes mellitus is a rapidly growing global health challenge characterized by chronic hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Achieving optimal glycemic control requires continuous, accurate, and real-time glucose monitoring to minimize acute and long-term complications. Conventional glucose monitoring technologies, particularly enzyme-based electrochemical biosensors, have significantly improved diabetes management; however, their widespread clinical application …

17.08.2026journal-article

Biologic Orthopedics Journal

Standardizing Rehabilitation After Platelet-Rich Plasma (PRP) Injections for Soft-Tissue Injuries

Corbin Hedt, Derek Piszczek, Larry Balle

Purpose of Review: Platelet-rich plasma (PRP) is widely used for musculoskeletal soft‑tissue injuries, yet outcomes remain inconsistent and post‑injection rehabilitation is rarely standardized or well described. This review synthesizes clinical PRP trials across common soft‑tissue indications with specific attention to rehabilitation reporting and proposes a structured, criteria‑based post‑PRP rehabilitation framework.​ Recent Findings: A structured search identified 45 randomized or prospective comparative studies …

17.08.2026journal-article

Advanced Healthcare Materials

Proton Sponge‐Enabled Dual‐Driven Nanomotors for MRI‐Guided Tumor‐Penetrating Synergistic Therapy of Pancreatic Cancer

Shuai He, Fulin Li, Pan Yang, Yanying Sun, Jian Chen, Jingyi Gao, Mingdong Xu, Liguo Hao

ABSTRACT Dense stromal barriers and lysosomal sequestration severely restrict the extracellular transport and intracellular trafficking of nanomedicines in pancreatic cancer, while the robust glutathione (GSH)‐dependent antioxidant defense further compromises therapeutic efficacy. Here, we developed a proton sponge‐enabled dual‐driven nanomotor, HA/PEI‐DOX@MMSN@Pt (HPDMP), for MRI‐guided pancreatic cancer therapy. The asymmetric Pt domain generated near‐infrared (NIR)‐induced self‐thermophoretic motion as the princ …