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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

BMC Public Health

Cumulative digital risk exposure and self-harm behavior among Indonesian adolescents

Triyana Harlia Putri, Fitri Ariyanti Abidin, Meita Dhamayanti, Popy, Fitri Fujiana, Aprida Manurung, Suryani Suryani

Abstract Background Self-harm behavior (SHB) among adolescents is a growing public health concern, particularly in the digital era. Exposure to digital risks such as online gaming addiction and cyberbullying victimization may increase vulnerability, especially when multiple risks co-occur. This study examined the association between cumulative digital risk exposure and SHB among Indonesian adolescents and identified associated psychosocial factors. Methods A cross-sectional study was conducted among 1,742 Indonesia …

27.08.2026journal-article

TEM Journal

Predictors of the Effective Implementation of Artificial Intelligence Tools in Mathematics Education of Pre-Service Primary Teachers

Dušana Babicová, Štefan Tkačik, Zlatica Huľová, Štefan Tkačik Jr, Peter Tokoš

Previous research suggests that math anxiety is common among prospective teachers, is associated with less positive attitudes toward math, and may later affect their students. At the same time, AI tools and educational podcasts appear promising for personalized support of self-study in mathematics education. The aim of this study is to establish a baseline profile of selected predictors prior to the planned implementation of an AI assistant for self-study in mathematics. Five research questions examined the relatio …

27.08.2026journal-article

Clinical and Translational Medicine

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin‐proteasome system

Xudong Wang, Tingyao Ma, Yixin Jing, Tianyi Li, Xi Zhao, Guohan Zhao, Ran Gao, Lu Kong, Xiaohong Chen

Abstract Background All‐trans retinoic acid (ATRA) exerts its biological functions primarily through nuclear receptors, but its therapeutic efficacy in solid tumours remains limited. This study aimed to elucidate the regulatory role of the cancer‐testis antigen PRAME in posttranslational modifications (PTMs) of the ATRA receptor RARα, and to assess its consequent impact on tumour progression in salivary adenoid cystic carcinoma (SACC). Methods Transcriptome sequencing was performed on public datasets from the Gene …

27.08.2026journal-article

BMC Medical Education

Impact of clinical case discussions in anatomy on national exam performance: a 10-year longitudinal cohort study

Fang Fang, Lan Yu, Yetao Ou, Si Zhou, Jun Ma, Yuntao Peng, Fang Liu, Junfeng Wang, Chunbo Xia, Houzhong Li, Weishan Zhang, Tan Cheng, Yu Chen, Yi Huang, Xin Li, Heng Guan

Abstract Background Traditional anatomy instruction often prioritizes structural memorization over clinical application. Although case-based learning is widely endorsed to bridge this theory-practice gap, longitudinal evidence regarding its sustained impact in foundational sciences remains limited, particularly concerning its performance over a decade amid massive enrollment expansion. Methods This 10-year longitudinal retrospective cohort study tracked seven clinical medicine cohorts (2015-2021). To maintain teach …

27.08.2026journal-article

Plant Health Progress

Current Status of Ceratobasidium theobromae Affecting Cacao and Cassava: Diagnosis and Management

Cansu Oksel, Fulya Baysal-Gurel

Ceratobasidium theobromae, the causal agent of vascular streak dieback in cacao, has recently been associated with cassava witches’ broom disease, expanding its known host range and increasing its importance in crop production systems. This review summarizes disease development, diagnosis, and management of C. theobromae in cacao and cassava. Diagnosis remains challenging due to difficulties in pathogen isolation and confirmation of pathogenicity, although molecular tools have improved detection and identification. …

27.08.2026journal-article

Journal of Clinical Medicine

Late-Course Lactate/Albumin Ratio and In-Hospital Mortality in CRRT-Treated Critically Ill Patients: A Retrospective Severity-Adjusted Analysis

Hasan Şenay, Mehmet Kürşad Orhan, Mahmut Sami Tutar, Munise Yıldız, Ece Ünüvar Şenay, Muhammed Halit Satıcı, Ahmet Erarkadaş, Betul Kozanhan

Background/Objectives: The lactate/albumin ratio (LAR) integrates tissue hypoperfusion and nutritional reserve into a single dimensionless index. As a late-course measurement (last available value before the primary outcome), it may reflect terminal metabolic deterioration rather than early prognostic signal. We examined the association of the final LAR with in-hospital mortality after adjustment for validated severity scores (APACHE II, SOFA) in critically ill patients receiving CRRT, and evaluated its incremental …

27.08.2026journal-article

International Journal of Molecular Sciences

Beyond Swelling: Clinical Insights into the Diagnosis and Management of Hereditary Angioedema

Margarita Paulauskiene, Laura Tamasauskiene, Brigita Gradauskiene

Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of severe, non-pitting edema, most commonly caused by a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), resulting in excessive bradykinin production. HAE subtypes differ according to C1-INH levels, functional activity, underlying genetic variants, and increasingly recognized molecular mechanisms. Awareness of HAE outside specialized medical fields remains limited, and recurrent angioedema may arise through differ …

27.08.2026journal-article

Frontiers in Global Women's Health

Abdominopelvic hydatid disease during pregnancy: a systematic review of the literature

Evangelos Chinis, Kyriakos Tzanakis, George Lockett, Laura Burney Ellis, Stergios Bobotis, Georgios Geropoulos, Maria Kyrgiou, Konstantinos S. Kechagias

Objective To review the available literature on abdominopelvic cystic echinococcosis (CE) during pregnancy, focusing on clinical presentation, diagnostic approaches, management strategies, and maternal and foetal outcomes. Methods A systematic review was conducted in accordance with PRISMA guidelines. Studies reporting abdominopelvic hydatid disease in pregnant women were included without restrictions on study design or geography. Results Fifty-one studies (45 case reports and 6 case series) including 79 patients w …

27.08.2026journal-article

ICEETE Conference Series

Digital Platforms For Sustainability Education In Indonesia: A Systematic Review Of Usability And Equity

Cavin Agustinus Sitorus, Anggel Maria Savrila, Freddy Matius Herdia

Climate change and declining environmental awareness among youth have made sustainability education a national priority in Indonesia, and digital platforms are increasingly promoted as scalable enablers of this agenda. Their integration into formal education, however, remains uneven and is constrained by infrastructure gaps and disparities in digital literacy across the archipelago. While prior systematic reviews have examined digital tools for environmental education globally, and separate reviews have mapped envi …

27.08.2026journal-article

Big Data & Society

Commodifying compassion in the digital age: The promise and perils of tech for good

Maha Rafi Atal, Sofie Elbæk Henriksen, Lisa Ann Richey

Digital and data-driven technologies are transforming the humanitarian and development sectors. With the promise of faster, more efficient and accurate aid delivery, these technologies are often designed and implemented in partnerships between aid organizations and private technology firms. Consequently, “Tech for Good” has emerged as a significant humanitarian domain, where Big Tech companies aspire to create innovative technological solutions to humanitarian problems and link their business interests and strategi …

27.08.2026journal-article

Responsible Enterprise Pedagogy

Fair and equitable digital literacy and technology education: addressing the education gap through social entrepreneurship

Amy Abdou, Irene van Driel, Dadi Chen

Purpose This study examines two small social enterprises – a social business and a non-profit – founded by the same entrepreneur that provide digital literacy and technology education in the Netherlands. By comparing two distinct social enterprise models and their approaches to equitable supplemental education, the paper explores the relationships among entrepreneurial logics, organizational practices and external stakeholder involvement, including the role of government. Design/methodology/approach Drawing on thre …

27.08.2026journal-article

Journal of Fish Health

Growth Performance and Pathological Responses of Tissue Culture and Local <i>Kappaphycus alvarezii</i> Seedlings in Marine Waters of Punti Village, Bima Bay, Indonesia

Alis Mukhlis, Nadirah Karimatul Ilmi, Sanca Rahmatullah, Anita Prihatini Ilyas, Ardyen Saputra

Kappaphycus alvarezii is an economically important carrageenan-producing red alga, and tissue culture has been promoted as a means of improving seedling quality and field growth performance in Indonesian seaweed farming; however, field-based evidence comparing tissue-culture and conventional (local) seedlings under commercial cultivation conditions remains limited. This study therefore compared the growth performance and disease susceptibility of tissue-culture-derived and local Kappaphycus alvarezii seedlings cult …

27.08.2026journal-article

Al Qodiri : Jurnal Pendidikan, Sosial dan Keagamaan

Mental Health from the Perspective of Positive Psychology and the Concept of Patience and Gratitude in Islam

Rudi Herianto

Mental health is increasingly understood as a multidimensional condition involving psychological functioning, meaningful relationships, positive emotions, and the ability to respond constructively to life challenges. Positive psychology provides an important framework for understanding these dimensions through human strengths, flourishing, meaning, and well-being. However, psychological perspectives alone may not fully capture the spiritual dimensions of mental health within Muslim communities. This study examines …

27.08.2026journal-article

Pilot and Feasibility Studies

The Mother Nature Programme: a single-arm mixed-methods feasibility study of a group nature-based intervention for mothers experiencing postnatal mental health difficulties and their infants

Katherine Hall, Rosa Roberts, Katrina Turner, Lucinda Stanton, Sherien Elsheikh, Christopher Barnes, Beverly Shirkey, Lucy Duggan, Paul Moran, Jonathan Evans

Abstract Background Postnatal mental health difficulties are common and often under-treated. Nature-based interventions have potential mental health benefits, but little research has focussed on their applicability postnatally. This study examined the acceptability and feasibility of delivering a co-designed, 5-week group nature-based intervention, The Mother Nature Programme (MNP), for mothers experiencing postnatal mental health difficulties and their infants, in preparation for a future trial. Methods A single-a …

27.08.2026journal-article

BMC Oral Health

Oral findings and antiresorptive therapy exposure duration in postmenopausal women with osteoporosis: a cross-sectional cohort study

Safiyye Süslü, Håvard J Haugen, Tormod Bjartveit Krüger, Bente B. Herlofson, Janne Elin Reseland, Erik Fink Eriksen

Abstract Background Oral findings are common among older adults, but it is unclear whether they vary with the duration of antiresorptive therapy (ART) exposure or relate to the severity of osteoporosis in postmenopausal women. Methods In this cross-sectional cohort ( n = 129), postmenopausal women undergoing osteoporosis assessment/follow-up were stratified by ART exposure duration: no current ART control (G1, n = 50), short ART (G2, 3–5 years; n = 39), and long ART (G3, > 5 years; n = 40). The prespecified primary …

27.08.2026journal-article

Biosensors

Artificial Intelligence in Electrochemical Sensing: A Network Evidence Map of Translational Barriers and Pathways to Point-of-Care Deployment

Muhammad Saqib, Elena I. Korotkova, Kunquan Li, Neda Firoz, Mrinal Vashisth, Amrit L. Hui, Olga I. Lipskikh, Pradip Kumar Kar

The integration of artificial intelligence (AI) and machine learning (ML) with electrochemical sensing has revolutionized analytical diagnostics by overcoming traditional limitations such as signal drift, peak overlapping, and matrix interference. However, despite the exponential growth of this field, a unified framework evaluating translational feasibility remains absent. This review critically analyzes AI/ML architectures applied to electrochemical sensors and biosensors from 2016 to 2025. To the best of our know …

27.08.2026journal-article

Materials

Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application—A Scoping Review

Berta Furió-Alonso, Javier Gil, Danica Nikolic Jovanovic, Andreu Puigdollers-Pérez

Biofilm accumulation on orthodontic appliances is a recognized risk factor for white spot lesion formation and caries during treatment. Antibacterial surface modifications and coating strategies have been proposed as appliance-level preventive approaches. Studied interventions in the literature span true thin-film surface coatings, plasma-based and ion-implantation surface modifications, and bulk-incorporated antibacterial agents in appliance matrix materials. Yet the extent to which in vitro efficacy translates to …

27.08.2026journal-article

Journal of Plastic Surgery and Hand Surgery

Clinical outcomes of a defect-adapted strategy for free fibular great toe flaps in finger reconstruction: a retrospective series of 35 cases

Yangyang Liu, Huajian Zhou, Haoran Jiang, Jun Zhu, Renjie Li, Mingyu Jia

Background: To evaluate the clinical outcomes of a personalized surgical strategy for small-to-medium finger defects, utilizing either free dorsal toe or plantar proper digital artery flaps. Methods: We retrospectively analyzed 35 patients with finger defects (March 2021–January 2025). Patients were assigned by defect characteristics to Group A (pulp defects, n = 21; plantar proper digital artery flap) or Group B (dorsal/lateral defects, n = 14; modified dorsal toe artery flap preserving the plantar proper neurovas …

27.08.2026journal-article

Journal of the National Comprehensive Cancer Network

Fostering Improvements in Equitable Care Delivery: Insights From the Health Equity Report Card (HERC) Pilot in Academic Cancer Centers

Ashley Orr, Taneal D. Carter, Mallory Stubblebine, Heather McKee Hurwitz, Tiffany Go, Leticia Mercado, Darryl Outlaw, Elizabeth Bouchard, Levent Dumenci, Crystal S. Denlinger, Alyssa A. Schatz

Background: The Health Equity Report Card (HERC) was developed to support institutions in measuring equitable care practices and implementing improvement efforts. An objective of this study was to determine whether academic cancer centers can use their baseline HERC scores to identify institution-specific strategies to improve equitable care delivery. Methods: This quality improvement study collected quantitative and qualitative data from 5 NCCN Member Institutions about their quality improvement efforts in respons …

27.08.2026journal-article

Clinical Cancer Research

Focused Ultrasound-Enhanced Drug Delivery to Brain Tumors: Quantitative and Translational Insights from CNS Physiologically Based Pharmacokinetic Modeling

Andrew Wu, Charuka Wickramasinghe, Yuanyuan Jiang, Xun Bao, Jing Li

Abstract Purpose: Successful clinical translation of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening strategy to brain cancer therapy has been hindered by limited quantitative understanding of CNS pharmacokinetics. Using a physiologically based pharmacokinetic (PBPK) modeling framework, this study aimed to quantitatively characterize FUS-modulated CNS pharmacokinetics and identify key determinants of potential clinical benefits. Experimental Design: A previously validated 9-compartment CNS PBPK m …

27.08.2026journal-article

Ege Eğitim Dergisi

In-Service English Teachers' Attitudes toward Artificial Intelligence in Education

Pelin Derinalp

The rapid advancement of technology requires teachers to adapt to this change. Artificial intelligence (AI) is increasingly being used in education and is gaining influence. Therefore, examining teachers' attitudes toward AI is important for the effective integration of technology. This study investigates the attitudes of English teachers in Türkiye toward AI. Using qualitative descriptive research design, participants were first asked to provide written definitions of AI. Subsequently, four focus group discussions …

27.08.2026journal-article

JAMA Health Forum

Mental Health and Construction—Intervening to Prevent Collapse

Rosa M. Gonzalez-Guarda, Molly Hayes, Luke Smith

This JAMA Forum discusses mental health and substance abuse problems among US construction workers and proposes a national strategy to ensure that evidence-based prevention, early identification, and treatment reach this population.

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Artificial intelligence-empowered echocardiography: an updated review of clinical management in hypertrophic cardiomyopathy

Miao Zhang, Shanshan Yuan, Hongyan Dai, Guoan Wang

Hypertrophic cardiomyopathy (HCM) is a common and highly heterogeneous inherited cardiomyopathy characterized by complex clinical phenotypes and diverse disease trajectories, posing significant challenges for early diagnosis, precise phenotypic classification, and risk stratification. Owing to its noninvasive nature, repeatability, and wide availability, echocardiography remains the cornerstone imaging modality for the diagnosis and longitudinal management of HCM. However, conventional echocardiographic analysis re …

27.08.2026journal-article

International Journal of Molecular Sciences

Effect of Dupilumab on Allergen-Specific IgE Levels and Clinical Tolerance in Patients with Food Allergy: A Systematic Review

Magdalena Grześk-Kaczyńska, Szymon Kaczyński, Bernadetta Kosztulska, Magdalena Rydzyńska, Tomasz Rosada, Natalia Ukleja-Sokołowska

Food allergy is a growing global health concern associated with significant dietary restrictions, impaired quality of life, and risk of severe allergic reactions. Dupilumab, a monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), inhibits IL-4 and IL-13 signaling and has demonstrated efficacy across multiple type 2 inflammatory diseases. This systematic review aimed to evaluate the effects of dupilumab on food allergy outcomes in pediatric and adult patients. Across studies, dupilumab treatment w …