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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Frontiers in Oncology

Comorbidity patterns and risk of breast cancer: a case–control study exploring interaction with BMI using latent class analysis

Yaling Zhang, Bei Zhao, Xinchun Zhang, Na Cui, Lanhua Wu, Ling Chen

Background Most studies to date have examined individual comorbidities in relation to breast cancer risk but have largely ignored that these conditions often cluster in the same person. Looking at comorbidity patterns rather than isolated diseases may therefore offer a better understanding of breast cancer risk. Methods In this case–control study, latent class analysis (LCA) was performed in the pooled case–control sample based on 10 comorbidities/conditions, including diabetes mellitus, hypertension, coronary hear …

24.08.2026journal-article

Frontiers in Oncology

18F-FDG PET/CT metabolic network connectivity in clinical staging of diffuse large B-cell lymphoma

Jinhai Zou, Han Zou, Chang Liu, Chen Liang, Yufei Liang, Meiyu Zheng, Chunying Li

Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common and highly heterogeneous subtype of non-Hodgkin lymphoma, and accurate staging is essential for treatment planning and prognosis. This study explored the value of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic network connectivity for the clinical staging of DLBCL. Methods Forty-two previously untreated patients (23 males, 19 females; aged 30-82 years) diagnosed as de novo DLBCL, not ot …

24.08.2026journal-article

Frontiers in Pharmacology

Dual MAO A and HSP90 inhibitors enhance anti-PD-1 therapy and suppress colorectal cancer

Hui-Ju Tseng, Yueh-Lin Wu, Yan-Ling Chen, Chien-Hua Wang, Suddhasatwa Banerjee, Jing-Ping Liou

Introduction Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, yet their efficacy remains limited by tumor resistance, immune-related adverse events, and poor response in microsatellite stable colorectal cancer (CRC). To address these challenges, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitors, MPT1B098 and MPT1B099, were developed and evaluated for their therapeutic potential and immune-modulatory efficacy in CRC. Methods Human and murine CRC cell lines were trea …

24.08.2026journal-article

BMC Medicine

Associations of CLivD score with dementia, cardiovascular disease, cancer, and mortality in the general population from the UK biobank

Guozhe Sun, Jie Chen, Hongmei Yang, Caiyu Zhang, Chenhua He, Ying Zhou, Lin Guan, Shiyu Zhou, Yao Yu, Jun Wang, Xiangyu Tan, Yangzhi Yin, Ziyi Xie, Wei Miao, Wenhang Li, Yifei Chen, Xiaoxuan Tian, Tianhao Li, Xiaobing Zhou, Mengling Lu, Guangxiao Li, Xiaofan Guo

Abstract Background The Chronic Liver Disease (CLivD) score is a non-invasive marker of advanced liver disease risk. We evaluated its associations with dementia, cardiovascular disease (CVD), cancer, and all-cause mortality. Methods This prospective cohort study included UK Biobank participants with calculable CLivD scores at baseline (2006–2010). Two previously validated versions of the score were calculated: a laboratory-based CLivD (CLivD lab ), incorporating age, sex, waist-hip ratio, alcohol consumption, diabe …

24.08.2026journal-article

Discovery Medicine

Integrative Transcriptomic Analysis Identifies Glycolysis/Ferroptosis-Associated Candidate Genes in Gastric Cancer

Yongting Lan, Xin Zhou, Yongfen Ma, Jingmei Cao

Background: The crosstalk between glycolysis, ferroptosis and the gastric cancer (GC) immune microenvironment remains poorly defined. This study aims to uncover glycolysis/ferroptosis-related regulators of the GC immune microenvironment.Methods: Transcriptomic datasets from The Cancer Genome Atlas (TCGA)-Stomach adenocarcinoma (TCGA-STAD) and Gene Expression Omnibus (GEO) were integrated to screen glycolysis/ferroptosis-related differentially expressed genes (DEGs). We evaluated univariate prognostic associations o …

24.08.2026journal-article

Cancer Immunology, Immunotherapy

A phase 1 study of VAC85135, a neoantigen vaccine regimen targeting calreticulin and JAK2 mutations, in combination with ipilimumab in patients with myeloproliferative neoplasms

Salman Otoukesh, Bethan Psaila, Andrew Kuykendall, Aaron T. Gerds, Ahmed Abdulgawad, Prithviraj Bose, Charlotte Van Bogaert, Jennifer Bishop, Patrick Wilkinson, Baolian Liu, Tianxiang Kevin Han, Busola Sanusi, Jaymala Patel, Katelyn D. Miller, Denis Smirnov, John T. Loffredo, M. Alejandro Sepulveda, Ricardo Attar, Kim Staquet, Charles G. Drake, Nikki Daskalakis, Claire Harrison

Abstract Disease-specific somatic mutations (mut) in calreticulin ( CALR ) and JAK2 ( JAK2V617F ) are drivers of myeloproliferative neoplasms (MPNs), causing generation of immunogenic peptide epitopes hypothesized to be vaccine-targetable neoantigens. VAC85135, a heterologous prime-boost vaccine regimen comprising adenoviral and vaccinia vectors encoding polypeptides specific to mutCALR and JAK2V617F , concurrent with anti-CTLA-4, ipilimumab, was investigated in a phase 1 study. Fourteen (myelofibrosis [MF], n = 10 …

24.08.2026journal-article

Hormone Research in Paediatrics

Failure to thrive (FTT) in infants with Prader-Willi syndrome and long-term effects of GH-treatment on FTT

Demi J. Trueba-Timmermans, Gerthe F. Kerkhof, Lionne N. Grootjen, Edmond H.H.M. Rings, Anita C.S. Hokken-Koelega

Context: Failure to thrive (FTT) with feeding difficulties and hypotonia are well-known features in infants with Prader-Willi syndrome (PWS). Limited studies reported the percentage of infants with FTT and it is unknown whether growth hormone (GH)-treatment affects body composition of infants with or without FTT differently. Objective: To evaluate the percentage of infants with PWS with FTT from birth to age 6 months and to investigate the 5-year GH effects on body composition in infants with or without FTT at GH-s …

24.08.2026journal-article

Endocrine-Related Cancer

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Carmen Ariño-Palao, Irene Carretero-Barrio, Sara Martos-Meléndez, Tamara Caniego-Casas, Marta Rosas, Noelia Martínez-Jañez, María Fernández-Abad, María Concepción Sánchez, Teresa Presa-Abos, Javier Zamora, Juan Martínez-Aedo Castro, María J Ledesma-Carbayo, José Palacios, Belén Pérez- Mies

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune infiltration and genomic risk within this framework remains incompletely characterised in luminal disease. We retrospectively analysed 492 luminal breast carcinomas with available MammaPrint® results. Clinicopathological variables (including …

24.08.2026journal-article

Frontiers in Medicine

Family history of cancer and risk of lung cancer: a retrospective cohort study in a Chinese population

Hongjun Song, Xinlu Men, Jun Cheng, Liangliang Zhang, Shuang Zhao

Background Family history of cancer is an established risk factor for lung cancer, but its association with the probability of malignancy among patients evaluated for pulmonary nodules—rather than with population-level lung cancer incidence—remains poorly characterized in Chinese populations. Methods We conducted a retrospective cohort study of 3,850 consecutive patients evaluated for pulmonary nodules at a tertiary teaching hospital between January 2018 and December 2021, of whom 1,257 (32.6%) underwent surgical r …

24.08.2026journal-article

Frontiers in Oncology

KRAS mutations as architects of the tumor immune microenvironment: implications for combination therapies

Vasudevan Ramachandran, Haily Liduin Koyou, Siddarth Raajasekar, Mohd Hazmi Bin Mohamed, Liyana Najwa Binti Inche Mat, Venkataramanan Swaminathan, Mohd Nazil Salleh, Muhammad Evy Prastiyanto, Nurul Aini Binti Ahmad

Oncogenic KRAS mutations rank among the most prevalent driver alterations in human malignancies, reaching near-universal frequency (~98%) in pancreatic ductal adenocarcinoma (PDAC) and high prevalence in colorectal cancer (CRC, ~52%) and lung adenocarcinoma (LAC, ~32%). Beyond their canonical roles in promoting cell-intrinsic proliferation and survival through the MAPK/ERK and PI3K/AKT cascades, KRAS mutations actively sculpt a profoundly immunosuppressive tumor microenvironment (TME), which constitutes a major bar …

24.08.2026journal-article

Gaceta Científica

Inequidades territoriales en la mortalidad por cáncer y gestión sanitaria en Huánuco, Perú

César López Godoy, Paulo César López Barrientos, Carmen Rosa Caballero Castillo, Karin Estacio Laguna, Nelly Adela Hilario Porras, David Chi-Hon León Chiang, Ana María Soto Rueda

Objective: To analyze territorial inequalities in mortality from cervical, gastric, and colorectal cancer in the provinces of the Department of Huanuco, Peru, and their relevance to territorial sanitary management. Materials and methods: A cross-sectional ecological study was conducted across the 11 provinces of Huanuco during the 2018–2023 period. Mortality records from the National Death Information System and population projections from the National Institute of Statistics and Informatics were used. Mortality ra …

24.08.2026journal-article

Selcuk Dental Journal

Multidisciplinary Management of Eagle Syndrome: From Diagnosis to Treatment

İremnur Sambur, Hilal Peker Öztürk

AbstractBackground:Eagle syndrome is a rare clinical entity characterized by a wide spectrum of symptoms, most commonly orofacial pain, dysphagia, and cervical discomfort. These symptoms result from compression and irritation of adjacent neurovascular and soft tissue structures caused by elongation and/or calcification of the styloid process. Despite the importance of a detailed medical history, careful clinical examination, and appropriate imaging modalities, the variability and nonspecific nature of clinical find …

24.08.2026journal-article

Frontiers in Microbiology

Therapeutic regulation of gut microbiota in gastric cancer: mechanisms, strategies, and clinical prospects

Zicheng Liu, Mingyue Bai, lichao Han, Zeguang Li

Gastric cancer (GC) is a highly prevalent malignancy associated with substantial mortality worldwide. Dysbiosis of the gut microbiota is closely linked to the pathogenesis, clinical characteristics, and therapeutic responses of GC, making it a central focus of research in the field of tumor microecology. However, existing reviews mainly focus on microbial compositional features, individual mechanisms, or specific microbiota-based interventions, while lacking an integrated theoretical framework that incorporates Hel …

24.08.2026journal-article

International Journal of Science, Strategic Management and Technology

Breast Cancer Classification in Ultrasound Images Using Two-Phase EfficientNetB7 Transfer Learning

Madishetti Kavya, Dr.G. Thirupati

Breast cancer is a leading cause of cancer morbidity and mortality among women globally, emphasizing the need for accurate and timely diagnostic methods. A systematic but innovative two phases transfer learning based deep learning classification framework is developed using popular EfficientNetB7 architecture architecture for breast cancer classification. Breast ultrasound imaging proves a high degree of complexity to extract features with limited available medical datasets to address it and the proposed methodolog …

24.08.2026journal-article

Discover Public Health

Current policies and practices for testing and treatment of chronic hepatitis B and C infection in high-burden countries in the WHO European region

Machiko Otani, Marcelo Contardo Moscoso Naveira, Stela Bivol

Abstract Chronic hepatitis B and C remain major public health concerns in the WHO European Region, with an estimated 10.6 million people living with HBV and 7.7 million with HCV in 2022. Despite this burden, diagnosis and treatment coverage remain low, challenging progress toward the 2030 elimination goal. To map national policies and reported service availability for hepatitis testing and treatment. , the WHO Regional Office for Europe surveyed nine high-burden countries, receiving responses from eight: Armenia, A …

24.08.2026journal-article

Healthcare

Effect of Mindfulness-Based Social–Emotional Learning Approach on Knowledge and Anxiety Levels Regarding Cervical Cancer Prevention

Nehal Shalaby Awad Mahmoud, Nourhan Essam Hendawi, Mahmoud Abdelwahab Khedr, Wafa Hamad Almegewly, Mazen Baazeem, Marwa Salah Abd Elgawad Abd Elhady

Background: Cervical cancer remains a major public health concern worldwide, particularly in low- and middle-income countries. Limited knowledge regarding cervical cancer prevention and elevated anxiety levels may hinder women’s participation in preventive measures. Mindfulness-Based Social–Emotional Learning integrates mindfulness practices with social–emotional learning strategies and may enhance health knowledge while reducing anxiety. Materials and Methods: A quasi-experimental pretest–posttest non-equivalent c …

24.08.2026journal-article

Natural and Life Sciences Communications

Expression-Guided Immunoinformatics Design of a Recombinant Multi-Epitope Vaccine Candidate for Triple-Negative Breast Cancer Incorporating a MyD88-Derived Immunomodulatory Domain

Moh Royhan Afnani, Volta Kellik Setiawan, Anwar Rovik

Triple-negative breast cancer (TNBC) remains a major therapeutic challenge because of its aggressive behavior, molecular heterogeneity, and limited subtype-specific targets. This study used an integrated immunoinformatics workflow to design a recombinant tumor-associated antigen-derived multi-epitope vaccine based on MMP1, CXorf61/CT83, and COL11A1, prioritized according to their tumor-to-normal transcript-expression ratios. Candidate cytotoxic T-lymphocyte, helper T-lymphocyte, and linear B-cell epitopes were scre …

24.08.2026journal-article

Livers

Metabolic Diversion from Geranylgeranoic Acid to 2,3-Dihydrogeranylgeranoic Acid in Hepatic Tumor Surveillance

Yuki Tabata

Geranylgeranoic acid (GGA) is an endogenous acyclic diterpenoid metabolite of the mevalonate pathway that has been implicated in programmed cell death in hepatoma cells and may contribute to the elimination of premalignant hepatocytes. Recent metabolomic studies have identified 2,3-dihydrogeranylgeranoic acid (2,3-diGGA), an α-saturated derivative of GGA with reduced cell-death-inducing activity compared with GGA. This concise review examines the hypothesis that diversion of bioactive GGA toward 2,3-diGGA formation …

24.08.2026journal-article

BMC Health Services Research

Linking health literacy to malaria prevention and treatment behaviours: evidence from a community-based study in Gabon

Caroline Namubiru, Saidou Mahmoudou, Ynous Djida, Bertrand Lell

Abstract Background Health literacy (HL) affects how individuals engage in preventive behaviours, seek prompt treatment, select appropriate malaria prevention or treatment options, adhere to care and act on health information. Little is known about its role in malaria prevention and treatment behaviours. Therefore, this study investigated the extent to which HL relates to malaria health behaviours. Methods A cross-sectional household survey across urban and rural areas of Gabon using a sample of 504 respondents. HL …

24.08.2026journal-article

Clinical Nuclear Medicine

PSMA-Avid Metastatic Prostate Cancer With Intense Penile Uptake on PET/CT

Katarzyna Klappa, Witold Cholewinski, Mikolaj Kuta, Jakub Sarapata, Paulina Cegla

Penile metastasis from prostate adenocarcinoma is an exceptionally rare manifestation of advanced disease. We report the case of a 64-year-old man with biopsy-proven prostatic adenocarcinoma (cT3bN1M1, Gleason 4+4=8), diagnosed in 2020 with an initial PSA of 122.85 ng/mL. The most remarkable finding was intense, diffuse, and homogeneous PSMA uptake throughout the corpora cavernosa along the entire penile shaft (SUVmax=76.9). Histopathologic examination confirmed metastatic prostatic adenocarcinoma (Grade Group 3, G …

24.08.2026journal-article

Frontiers in Oncology

UTROSCT: a case report and scoping review of ultrasound features, with exploratory serum proteomic findings

Davide Castelli, Ghergana Alexandrova Topouzova, Blendi Ura, Francesca Buonomo, Eduardo Maria Sommella, Alessandro Mangogna, Federico Romano, Giovanni Di Lorenzo, Stefania Cicogna, Andrea Romano, Giuseppe Ricci

Background and objectives UTROSCT is a rare uterine neoplasm with nonspecific imaging features. The aim of this study was to evaluate how UTROSCT is described on pelvic and transvaginal ultrasound in the published case-report literature and to report the clinicopathologic, immunophenotypic, and exploratory serum proteomic features of a new UTROSCT case. Case presentation Transvaginal ultrasound revealed an intracavitary uterine lesion in a 72-year-old asymptomatic postmenopausal woman. Histopathology and immunohist …

24.08.2026journal-article

Cancers

Clinical Implications of Incorporating Molecular Profiles into the Staging of Endometrial Cancer: A Critical Review of the 2023 FIGO System on the Wave of 2025 ESGO/ESTRO/ESP Guidelines

Angela Santoro, Giuseppe Angelico, Antonio d’Amati, Livia Maccio, Emma Bragantini, Francesco Fanfani, Anna Fagotti, Gian Franco Zannoni

This review examines the clinical and practical implications of embedding molecular profiles directly into the 2023 FIGO staging system for endometrial carcinoma, in the context of the 2025 ESGO/ESTRO/ESP guidelines. The primary purpose is to navigate a central conflict in modern oncology: how to deliver increasingly personalized care while maintaining a globally accessible, equitable, and standardized cancer classification system. The 2023 FIGO update represents a paradigm shift from the traditional dualistic mode …

24.08.2026journal-article

Indian Journal of Medical Research

Unravelling the web of neglect in elderly cancer care in South India: A grounded theory approach

Viswanath Narendiran, Sonali Sarkar, Mahalakshmy Thulasingam, Gunaseelan Karunanithi

Background and objectives Elder neglect, characterised by unmet care needs, social isolation, and emotional distress, has been consistently reported in epidemiological studies, yet it continues to be insufficiently acknowledged as a major public health concern in India. Existing frameworks inadequately explain how factors interact to produce neglect and abandonment. This study aimed to explore the circumstances leading to neglect among elderly cancer patients in Puducherry and Tamil Nadu. Methods A qualitative grou …

24.08.2026journal-article

Methods and Protocols

Evaluating Cell-Free DNA Quantification and Integrity in Breast Cancer Using Fluorometric, Electrophoretic and PCR-Based Platforms

Gisha Rose Antony, Vidya P. Nimbalkar, Sowmya Nagaraj, Mahalakshmi Subramanya, Anupama C. Eshwara Rao, Ganapathi Bantwal, Belinda George, Akshay Ajoy, Nihal M. Ahamed, Rakesh S. Ramesh, Jyothi D. N, Jaya Kumari S, Jyothi S. Prabhu

Cell-free DNA (cfDNA) has emerged as a promising liquid biopsy biomarker; however, differences in analytical methods may influence cfDNA quantification and integrity assessment. This study compared plasma cfDNA concentration and integrity between treatment-naïve breast cancer (BC) patients (n = 100) and healthy controls (HC; n = 70) using complementary analytical platforms. cfDNA concentration was measured by Qubit fluorometry, TapeStation (TS) electrophoretic profiling, and ALU-based quantitative PCR (qPCR). An ex …