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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Contemporary Education and Community Engagement (CECE)

Influence of Rational Emotive Behavior Therapy on Sexual Abuse Education among Sampled Adolescents in Imo State, Nigeria

Mohamed Alusine Mansaray, Gilbert Madubuike

Adolescent sexual abuse remains a pervasive and deeply damaging issue globally, with significant psychological ramifications for its victims. In Nigeria, particularly within states like Imo, the prevalence of such abuse necessitates effective therapeutic interventions. This article explores the potential influence of Rational Emotive Behavior Therapy (REBT) as a therapeutic approach in addressing the psychological trauma experienced by adolescents who have endured sexual abuse in Imo State, Nigeria. Drawing upon ex …

17.08.2026journal-article

Scientific Reports

Immune responses elicited by rMV-SLAMblind oncolytic therapy exert a synergistic effect on cancer therapy

Kanako Moritoh, Tomoko Fujiyuki, Yosuke Amagai, Hiroki Sato, Misako Yoneda, Chieko Kai

Abstract Oncolytic virotherapy has emerged as a promising strategy for cancer therapy. rMV-SLAMblind is a recombinant measles virus that lacks the ability to interact with SLAM and specifically infects and lyses NECTIN4 + cancer cells. We previously reported that rMV-SLAMblind oncolytic virotherapy (rMV-OVT) exerts anti-tumor immunity through the activation of immune cells in virus-treated tumors. It is thought that oncolytic virotherapy promotes anti-tumor effects via two mechanisms: direct tumor cell lysis caused …

17.08.2026journal-article

Circulation: Population Health and Outcomes

Effectiveness of Multidomain Cardiac Rehabilitation After Myocardial Infarction by Patient Frailty: Prespecified Subgroup Analysis of the PIpELINe Trial

Beatrice Dal Passo, Elisabetta Tonet, Andrea Raisi, Silvia Zagnoni, Giorgio Chiaranda, Giovanni Pasanisi, Rita Pavasini, Paolo Cimaglia, Tommaso Piva, Gianni Casella, Serena Caglioni, Valentina Zerbini, Marta Cocco, Erica Menegatti, Simona Mandini, Gianni Mazzoni, Simone Biscaglia, Stefano Volpato, Giovanni Grazzi, Gianluca Campo

BACKGROUND: Frailty is common among older patients surviving myocardial infarction, is associated with adverse outcomes, and is often perceived as a barrier to cardiac rehabilitation (CR). The aim of this study is to determine whether frailty influences prognosis after myocardial infarction, and whether frailty modifies the clinical benefit of multidomain CR. METHODS: We performed a prespecified subgroup analysis of the PIpELINe (Physical Activity Intervention in Elderly Patients With Myocardial Infarction) randomi …

17.08.2026journal-article

South African Journal of Physiotherapy

Cystic fibrosis transmembrane conductance regulator modulator therapy and lived experiences in South Africa: A mixed-methods study

Brenda M. Morrow, Janine Verstraete, Sinead Thistlewhite, Carese Abrahams, Teboho N. Nkosi, Tyra Donnelly, Dalziel Kennedy, Marco Zampoli

Background: Cystic fibrosis transmembrane conductance regulator modulator (CFTRm) therapy has transformed cystic fibrosis (CF) outcomes in high-income settings, yet access remains severely limited in South Africa. Patient-reported outcomes of CFTRm are underexplored. Objectives: To describe the lived experiences of South African people living with cystic fibrosis (PLwCF) following CFTRm initiation, focusing on respiratory symptoms, treatment burden, physical activity, social and recreational participation, and well …

17.08.2026journal-article

RETINAL Cases & Brief Reports

Refractory Perifoveal Exudative Vascular Anomalous Complex (PEVAC)- Early Positive Response to Faricimab Therapy

Eduardo Cunha Souza

Purpose: To describe a case of refractory unilateral PEVAC macular edema initially treated with intravitreal faricimab injections. Methods: Medical and imaging records were evaluated. Tracked optical coherence tomography (OCT) B scans were reviewed to assess intra-retinal fluid and exudation. Results: A 79-year-old man with unilateral chronic macular edema secondary to PEVAC lesion underwent three monthly intravitreal faricimab injections with completely resolution of the fluid and visual recovery. A presumed throm …

17.08.2026journal-article

Small

Bidirectional ROS Modulation for Programmed Anti‐Infective and Anti‐Inflammatory Therapy With Au‐Cu 2 O/MXene Nanocomposite

Min Zhang, Kami Hu, Liuyuan Zhu, Rui Ding, Ying Hou, Junjie Mou, Haoming Xia, Yihe Lin, Purui Zheng, Lingnv Zhan, Haiping Fang, Hui He, Chunhua Zeng, Yingying Huang, Ruoyang Chen

ABSTRACT Chronic bacterial infections pose a therapeutic challenge in eliminating bacteria while suppressing inflammation. Conventional antibiotics are often limited by drug resistance and poor biofilm penetration, contributing to a global health threat of antibiotic misuse. Reactive oxygen species (ROS) modulation offers a promising alternative, yet requires precise balance: insufficient ROS compromises antibacterial efficacy, but excess exacerbates inflammation. Here, we present a bidirectional ROS‐regulation str …

17.08.2026journal-article

JAMA Neurology

Safety of Antiseizure Medications During Direct Oral Anticoagulant Therapy in Epilepsy

Kai Michael Schubert, Carolina Ferreira-Atuesta, Arunachalam Soma, Johan Zelano, David J. Seiffge, Francesco Brigo, Eugen Trinka, Nishant K. Mishra, Emilio Russo, Gregory Y. H. Lip, Gashirai K Mbizvo, Marian Galovic

Importance Concomitant use of antiseizure medications (ASMs) and direct oral anticoagulants (DOACs) is common in epilepsy, but comparative safety data remain limited. Objective To compare risks of thromboembolic events, major bleeding, and all-cause mortality across commonly used ASMs in adults with epilepsy receiving DOACs. Design, Setting, and Participants This was a retrospective cohort study emulating a target trial for each ASM group against an active comparator; 1:1 propensity score matching in 4 cohorts emul …

17.08.2026journal-article

Chinese Medical Journal

Advances in stroke-associated pneumonia in the era of revascularization therapy

Yiwen Xu, Yaqing Zhang, Yuesong Pan, Liping Liu, Ruijun Ji, Yilong Wang, Penglian Wang

Abstract In recent decades, the advent of revascularization treatments (RVTs), such as intravenous thrombolysis (IVT) and endovascular therapy, has significantly improved clinical outcomes in patients with acute ischemic stroke (AIS). However, stroke-associated pneumonia (SAP) remains a common complication that has a negative impact on the prognosis. This review addresses the mechanisms underlying the development of SAP in patients with AIS, evaluates risk factors, and discusses therapeutic and preventive measures …

17.08.2026journal-article

Exploration of Drug Science

Synergistic attack of “old drugs for new uses”: repositioning strategies in cancer combination therapy

Jingjing Yan, Xinran Wei, Xiangyi Zhang, Siqi Zhang, Dan Xia, Zi’an Tang, Zixuan Yang, Cuifeng Zhang

Cancer treatment faces severe challenges such as drug resistance, side effects, and high costs. The “repurposing old drugs” strategy, which involves repositioning approved drugs for non-oncology indications for cancer treatment, has opened up new avenues for developing efficient, low-toxicity, and rapidly translatable combination therapies. This strategy can not only accelerate clinical translation by leveraging known pharmacological and safety data but also generate synergistic effects with standard chemotherapy, …

17.08.2026journal-article

Discover Sensors

Next-generation nanobiosensors enable dynamic, real-time glucose monitoring for precision diabetes therapy

Riya Das, Monali Singh, Biswajeet Acharya, Amit Kundu, Ranjit Prasad Swain, Asha Deepthi Choppala

Abstract Diabetes mellitus is a rapidly growing global health challenge characterized by chronic hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Achieving optimal glycemic control requires continuous, accurate, and real-time glucose monitoring to minimize acute and long-term complications. Conventional glucose monitoring technologies, particularly enzyme-based electrochemical biosensors, have significantly improved diabetes management; however, their widespread clinical application …

17.08.2026journal-article

Biologic Orthopedics Journal

Standardizing Rehabilitation After Platelet-Rich Plasma (PRP) Injections for Soft-Tissue Injuries

Corbin Hedt, Derek Piszczek, Larry Balle

Purpose of Review: Platelet-rich plasma (PRP) is widely used for musculoskeletal soft‑tissue injuries, yet outcomes remain inconsistent and post‑injection rehabilitation is rarely standardized or well described. This review synthesizes clinical PRP trials across common soft‑tissue indications with specific attention to rehabilitation reporting and proposes a structured, criteria‑based post‑PRP rehabilitation framework.​ Recent Findings: A structured search identified 45 randomized or prospective comparative studies …

17.08.2026journal-article

Advanced Healthcare Materials

Proton Sponge‐Enabled Dual‐Driven Nanomotors for MRI‐Guided Tumor‐Penetrating Synergistic Therapy of Pancreatic Cancer

Shuai He, Fulin Li, Pan Yang, Yanying Sun, Jian Chen, Jingyi Gao, Mingdong Xu, Liguo Hao

ABSTRACT Dense stromal barriers and lysosomal sequestration severely restrict the extracellular transport and intracellular trafficking of nanomedicines in pancreatic cancer, while the robust glutathione (GSH)‐dependent antioxidant defense further compromises therapeutic efficacy. Here, we developed a proton sponge‐enabled dual‐driven nanomotor, HA/PEI‐DOX@MMSN@Pt (HPDMP), for MRI‐guided pancreatic cancer therapy. The asymmetric Pt domain generated near‐infrared (NIR)‐induced self‐thermophoretic motion as the princ …

17.08.2026journal-article

Modern Rheumatology Journal

Current anti-inflammatory therapy for rheumatoid arthritis: efficacy issues (based on EULAR 2025 materials)

Yu. A. Olyunin, B. S. Belov, E. G. Zotkin, A. M. Lila

In modern rheumatology, the problem of rheumatoid arthritis (RA) treatment remains highly relevant. This is demonstrated by the numerous clinical trials of new drugs with an expanding range of mechanisms of action and studies of optimal treatment strategies using currently available medications conducted worldwide. This review analyzes materials prepared by EULAR experts on the efficacy of current disease-modifying antirheumatic drugs and glucocorticoids in the treatment of RA.

17.08.2026journal-article

Journal of Payavard Salamat

Investigating Occupational Conditions and Socioeconomic Support of Patients with Neuromyelitis Optica in Iran

Saeideh Ayoubi, Saman Salemi, Mohammad Ali Sahraian, Termeh Tarjoman, Sharareh Eskandarieh

Background and Aim: Noncommunicable diseases are one of the most important public health challenges in the 21st century. Neuromyelitis optica (NMO) is a rare autoimmune disease that affects the central nervous system and can lead to permanent disability in young people. This disease is important due to its economic impact and reduced quality of life, and it is essential to understand its economic and social factors on these subjects. Materials and Methods: This study is a cross-sectional study based on the populati …

17.08.2026journal-article

Sociology of Health & Illness

Interrogating the Effects of Technologies of Pregnancy Surveillance on Queer, Trans and Nonbinary Midwifery Service‐Users

Jennifer M. Goldberg, Amaya Perez‐Brumer, Lori E. Ross

ABSTRACT Queer, transgender and nonbinary (QTNB) people access midwifery services, yet little is known about their experiences of midwifery care. Our qualitative study used critical narrative inquiry to examine how QTNB midwifery service‐users in Ontario, Canada, experience cisheteronormativity in healthcare. Drawing on in‐depth interviews with 14 participants, our analysis examines the effects of biomedicalisation on QTNB people who navigate these systems. Our findings show that QTNB people access and participate …

17.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Effectiveness of a Personalized Robot-Assisted Trunk and Lower Limb Rehabilitation in Patients with Chronic Stroke

Justin Kim, Philbert Chen, Jacob Kim, Kyoung Tae Kim

Objective: To investigate the clinical effectiveness of a newly developed trunk–lower limb rehabilitation robot in patients with chronic stroke. Design: Randomized controlled trial conducted at a rehabilitation center. Forty patients with chronic stroke (mean age 59.48±7.63 years) were randomized to an intervention group (n=20) or a control group (n=20). The intervention group received individualized robotic trunk–lower limb training applying Jacob ® (LDS Co., Ltd, Daegu, Korea) once daily, 5 times per week for 3 m …

17.08.2026journal-article

Jurnal Ragam Pengabdian

From Podcasts to Comment Sections: An Analysis of Hate Speech and the Development of Netizens’ Language in Digital Spaces

Ulya Abidah, Nazla Maharani Umaya, Ika Septiana

The advancement of digital communication has transformed the way language is produced, shared, and interpreted in online spaces. This transformation has also contributed to the emergence of hate speech, particularly in digital content involving public figures with large audiences. This study aims to describe the forms of hate speech as illocutionary speech acts in Deddy Corbuzier's podcast and to analyze their implications for the development of netizens' language in digital spaces. Using a descriptive qualitative …

17.08.2026journal-article

Advanced Materials

Janus Nanozyme With Programmable Catalytic Switching for Adaptive Therapy of Diabetic Wounds

Xuelian Wei, Zhengxiang Gu, Yange Luan, Yongchao Wang, Yinggang Li, Zengxi Wei, Dan Jiang, Feng Ye, Qiyong Gong, Kui Luo

ABSTRACT Diabetic wound healing requires dynamic bidirectional regulation of reactive oxygen species (ROS). Herein, guided by density functional theory (DFT) calculations, we propose a programmable strategy to engineer catalytic pathways via an intimate heterointerface in Janus‐structured Cu‐Ag nanoparticles (CuAg‐J). Theoretical simulations reveal that the unique Cu‐Ag heterointerface induces a charge transfer to oxygen intermediates, enabling spontaneous formation of reactive species and pH‑switchable catalytic a …

17.08.2026journal-article

Modern Rheumatology Journal

Determining the optimal duration of treatment for antineutrophil cytoplasmic antibodyassociated systemic vasculitides. When can therapy be discontinued?

O. N. Egorova, G. Tarasova, M. V. Datsina

Antineutrophil cytoplasmic antibody-associated systemic vasculitides (AAV) are a group of severe, potentially fatal autoimmune diseases that include granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. The introduction of a modern therapeutic strategy based on the principles of remission induction and maintenance has fundamentally changed the prognosis of AAV, transforming them from fatal diseases into chronic relapsing disorders. A key unresolved issue is d …

17.08.2026journal-article

International Journal of Offender Therapy and Comparative Criminology

Narrative Complexity and Identity Formation in The Diary of Jack the Ripper

David Canter

The so-called Diary of Jack the Ripper purports to have been written by a Liverpool cotton merchant, James Maybrick, confessing to five infamous Victorian murders. However, researchers have rarely examined The Diary as a narrative in its own right. Debates about the diary’s authenticity have relied on comparison with well-known fraudulent diaries, forensic and historical information. These examinations overlook how the writer tells his story across its 63 pages. Structural, hermeneutic and thematic analysis, as wel …

17.08.2026journal-article

Adolescência e Saúde

Comparative Effectiveness Of Virtual Reality, Mirror Therapy, And Virtual Reality–Based Mirror Therapy For Upper-Extremity Motor Recovery After Stroke: A Systematic Review And Network Meta-Analysis

Tumuluri S S Chandra Sekharendra Swamy, Dr. Payal Sharma, PT, Dipika Balala, PT

Background. Upper-extremity motor impairment is a primary determinant of persistent disability following stroke. Conventional mirror therapy (MT), standalone virtual reality (VR), and digital or VR-based mirror therapy (VRMT/DMT) represent distinct visual and sensorimotor neurorehabilitation adjuncts. Their comparative effectiveness within a unified evidence framework remains uncertain. Objective. To systematically evaluate and compare the effectiveness of MT, standalone VR, and VRMT/DMT against conventional rehabi …

17.08.2026journal-article

ACS Applied Materials & Interfaces

A Non-Invasive Transtympanic Bioadhesive Hydrogel for Sustained Delivery of Dexamethasone in Otitis Media Effusion Therapy

Qian Wan, Hanwei Liu, Shizhe Sun, Ruotong Wang, Jingwei Lai, Wendi Shi, Yuanyuan Xu, Yumeng Jiang, Xianchuang Hu, Ziyuan Li, Minhui Zhu, Junji Zhang, Haibo Shi

Abstract Otitis media with effusion (OME) is a highly prevalent condition characterized by persistent inflammatory effusion in the middle ear cavity. The clinical management of OME remains challenging due to the anatomical inaccessibility of the middle ear, which limits drug efficacy and often necessitates invasive surgical interventions. To address this, we engineered a transtympanic hydrogel platform (Gel-HADA) that undergoes rapid, enzyme-mediated gelation on the tympanic membrane (TM), forming a “second membran …

17.08.2026journal-article

The Journal of Infectious Diseases

Low-Level Viremia and Spatial Heterogeneity Among Individuals on Dolutegravir-Based Antiretroviral Therapy in Botswana: A Nationwide Study (2016–2022)

Ontlametse T Choga, Zvifadzo Matsena-Zingoni, Wonderful T Choga, Goitseone M Lemogang, Catherine K Koofhethile, Thembinkosi M Shadreck, Ava Avalos, Bornapate Nkomo, Judith Nawa, Tony Chebani, Max Kapanda, Gaerolwe Masheto, Joseph Makhema, Sikhulile Moyo, Sally Blower, Simani Gaseitsiwe

Abstract Background The study uses spatial analysis to identify factors associated with human immunodeficiency virus (HIV) detectable viremia in dolutegravir (DTG)–based first-line antiretroviral therapy (ART), which is crucial for targeted interventions to sustain epidemic control in Botswana. Methods This was a longitudinal observational cohort utilizing a dataset of 42 546 people with HIV on DTG-based first-line ART from June 2016 to December 2022 enrolled in the Botswana National Treatment Program. Detectable v …