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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Modern Rheumatology Journal

Current anti-inflammatory therapy for rheumatoid arthritis: efficacy issues (based on EULAR 2025 materials)

Yu. A. Olyunin, B. S. Belov, E. G. Zotkin, A. M. Lila

In modern rheumatology, the problem of rheumatoid arthritis (RA) treatment remains highly relevant. This is demonstrated by the numerous clinical trials of new drugs with an expanding range of mechanisms of action and studies of optimal treatment strategies using currently available medications conducted worldwide. This review analyzes materials prepared by EULAR experts on the efficacy of current disease-modifying antirheumatic drugs and glucocorticoids in the treatment of RA.

17.08.2026journal-article

Journal of Payavard Salamat

Investigating Occupational Conditions and Socioeconomic Support of Patients with Neuromyelitis Optica in Iran

Saeideh Ayoubi, Saman Salemi, Mohammad Ali Sahraian, Termeh Tarjoman, Sharareh Eskandarieh

Background and Aim: Noncommunicable diseases are one of the most important public health challenges in the 21st century. Neuromyelitis optica (NMO) is a rare autoimmune disease that affects the central nervous system and can lead to permanent disability in young people. This disease is important due to its economic impact and reduced quality of life, and it is essential to understand its economic and social factors on these subjects. Materials and Methods: This study is a cross-sectional study based on the populati …

17.08.2026journal-article

Sociology of Health & Illness

Interrogating the Effects of Technologies of Pregnancy Surveillance on Queer, Trans and Nonbinary Midwifery Service‐Users

Jennifer M. Goldberg, Amaya Perez‐Brumer, Lori E. Ross

ABSTRACT Queer, transgender and nonbinary (QTNB) people access midwifery services, yet little is known about their experiences of midwifery care. Our qualitative study used critical narrative inquiry to examine how QTNB midwifery service‐users in Ontario, Canada, experience cisheteronormativity in healthcare. Drawing on in‐depth interviews with 14 participants, our analysis examines the effects of biomedicalisation on QTNB people who navigate these systems. Our findings show that QTNB people access and participate …

17.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Effectiveness of a Personalized Robot-Assisted Trunk and Lower Limb Rehabilitation in Patients with Chronic Stroke

Justin Kim, Philbert Chen, Jacob Kim, Kyoung Tae Kim

Objective: To investigate the clinical effectiveness of a newly developed trunk–lower limb rehabilitation robot in patients with chronic stroke. Design: Randomized controlled trial conducted at a rehabilitation center. Forty patients with chronic stroke (mean age 59.48±7.63 years) were randomized to an intervention group (n=20) or a control group (n=20). The intervention group received individualized robotic trunk–lower limb training applying Jacob ® (LDS Co., Ltd, Daegu, Korea) once daily, 5 times per week for 3 m …

17.08.2026journal-article

Jurnal Ragam Pengabdian

From Podcasts to Comment Sections: An Analysis of Hate Speech and the Development of Netizens’ Language in Digital Spaces

Ulya Abidah, Nazla Maharani Umaya, Ika Septiana

The advancement of digital communication has transformed the way language is produced, shared, and interpreted in online spaces. This transformation has also contributed to the emergence of hate speech, particularly in digital content involving public figures with large audiences. This study aims to describe the forms of hate speech as illocutionary speech acts in Deddy Corbuzier's podcast and to analyze their implications for the development of netizens' language in digital spaces. Using a descriptive qualitative …

17.08.2026journal-article

Advanced Materials

Janus Nanozyme With Programmable Catalytic Switching for Adaptive Therapy of Diabetic Wounds

Xuelian Wei, Zhengxiang Gu, Yange Luan, Yongchao Wang, Yinggang Li, Zengxi Wei, Dan Jiang, Feng Ye, Qiyong Gong, Kui Luo

ABSTRACT Diabetic wound healing requires dynamic bidirectional regulation of reactive oxygen species (ROS). Herein, guided by density functional theory (DFT) calculations, we propose a programmable strategy to engineer catalytic pathways via an intimate heterointerface in Janus‐structured Cu‐Ag nanoparticles (CuAg‐J). Theoretical simulations reveal that the unique Cu‐Ag heterointerface induces a charge transfer to oxygen intermediates, enabling spontaneous formation of reactive species and pH‑switchable catalytic a …

17.08.2026journal-article

Modern Rheumatology Journal

Determining the optimal duration of treatment for antineutrophil cytoplasmic antibodyassociated systemic vasculitides. When can therapy be discontinued?

O. N. Egorova, G. Tarasova, M. V. Datsina

Antineutrophil cytoplasmic antibody-associated systemic vasculitides (AAV) are a group of severe, potentially fatal autoimmune diseases that include granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. The introduction of a modern therapeutic strategy based on the principles of remission induction and maintenance has fundamentally changed the prognosis of AAV, transforming them from fatal diseases into chronic relapsing disorders. A key unresolved issue is d …

17.08.2026journal-article

International Journal of Offender Therapy and Comparative Criminology

Narrative Complexity and Identity Formation in The Diary of Jack the Ripper

David Canter

The so-called Diary of Jack the Ripper purports to have been written by a Liverpool cotton merchant, James Maybrick, confessing to five infamous Victorian murders. However, researchers have rarely examined The Diary as a narrative in its own right. Debates about the diary’s authenticity have relied on comparison with well-known fraudulent diaries, forensic and historical information. These examinations overlook how the writer tells his story across its 63 pages. Structural, hermeneutic and thematic analysis, as wel …

17.08.2026journal-article

Adolescência e Saúde

Comparative Effectiveness Of Virtual Reality, Mirror Therapy, And Virtual Reality–Based Mirror Therapy For Upper-Extremity Motor Recovery After Stroke: A Systematic Review And Network Meta-Analysis

Tumuluri S S Chandra Sekharendra Swamy, Dr. Payal Sharma, PT, Dipika Balala, PT

Background. Upper-extremity motor impairment is a primary determinant of persistent disability following stroke. Conventional mirror therapy (MT), standalone virtual reality (VR), and digital or VR-based mirror therapy (VRMT/DMT) represent distinct visual and sensorimotor neurorehabilitation adjuncts. Their comparative effectiveness within a unified evidence framework remains uncertain. Objective. To systematically evaluate and compare the effectiveness of MT, standalone VR, and VRMT/DMT against conventional rehabi …

17.08.2026journal-article

ACS Applied Materials & Interfaces

A Non-Invasive Transtympanic Bioadhesive Hydrogel for Sustained Delivery of Dexamethasone in Otitis Media Effusion Therapy

Qian Wan, Hanwei Liu, Shizhe Sun, Ruotong Wang, Jingwei Lai, Wendi Shi, Yuanyuan Xu, Yumeng Jiang, Xianchuang Hu, Ziyuan Li, Minhui Zhu, Junji Zhang, Haibo Shi

Abstract Otitis media with effusion (OME) is a highly prevalent condition characterized by persistent inflammatory effusion in the middle ear cavity. The clinical management of OME remains challenging due to the anatomical inaccessibility of the middle ear, which limits drug efficacy and often necessitates invasive surgical interventions. To address this, we engineered a transtympanic hydrogel platform (Gel-HADA) that undergoes rapid, enzyme-mediated gelation on the tympanic membrane (TM), forming a “second membran …

17.08.2026journal-article

The Journal of Infectious Diseases

Low-Level Viremia and Spatial Heterogeneity Among Individuals on Dolutegravir-Based Antiretroviral Therapy in Botswana: A Nationwide Study (2016–2022)

Ontlametse T Choga, Zvifadzo Matsena-Zingoni, Wonderful T Choga, Goitseone M Lemogang, Catherine K Koofhethile, Thembinkosi M Shadreck, Ava Avalos, Bornapate Nkomo, Judith Nawa, Tony Chebani, Max Kapanda, Gaerolwe Masheto, Joseph Makhema, Sikhulile Moyo, Sally Blower, Simani Gaseitsiwe

Abstract Background The study uses spatial analysis to identify factors associated with human immunodeficiency virus (HIV) detectable viremia in dolutegravir (DTG)–based first-line antiretroviral therapy (ART), which is crucial for targeted interventions to sustain epidemic control in Botswana. Methods This was a longitudinal observational cohort utilizing a dataset of 42 546 people with HIV on DTG-based first-line ART from June 2016 to December 2022 enrolled in the Botswana National Treatment Program. Detectable v …

17.08.2026journal-article

Bioethics

Reasonable Exceptions From Unreasonable Policies: Requiring Treatment Agreements for Long‐Term Opioid Therapy and Exemptions for Cancer and Terminal Illness

Larisa Svirsky, Martin Fried, Minseo Kim, Sarah R. MacEwan, Nathan Richards, Patricia Zettler, Dana Howard

ABSTRACT Since drug overdose deaths began increasing in the United States, policy makers and the medical community have developed tools to try to address the crisis. Opioid Treatment Agreements (OTAs) are one such tool which purportedly seek to promote shared decision‐making and informed consent with patients. OTAs are documents that clinicians present to patients when prescribing opioids for chronic pain that describe the risks of opioids and require patients to agree to certain conditions in order to receive thei …

17.08.2026journal-article

INTERNATIONAL JOURNAL OF EDUCATION AND EVALUATION

Influence of Cognitive Behavioral Therapy on Peer Influence and Academic Achievement Among Undergraduates in North-Central Nigeria

Mutong Cecilia Maren

This study examined the influence of Cognitive Behavioral Therapy (CBT) on peer influence and academic achievement among undergraduates in North-Central Nigeria. The study was motivated by the increasing rate of negative peer influence and declining academic achievement among undergraduate students in Nigerian universities. Negative peer pressure has been associated with behaviors such as truancy, examination malpractice, substance abuse, cultism, poor study habits, and other maladaptive behaviors that adversely af …

17.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

ESTRATÉGIAS NUTRICIONAIS PARA CONTROLE E PREVENÇÃO DA SÍNDROME DE REALIMENTAÇÃO EM PACIENTES COM ANOREXIA NERVOSA: UMA REVISÃO SISTEMÁTICA

Anna Clara Fialho da Paixão, Lívia Gallo Nieniskis, Lucas da Silva Saúde

Este estudo realiza uma revisão sistemática sobre estratégias nutricionais para controle e prevenção da síndrome de realimentação (SRS) em pacientes com anorexia nervosa (AN). A pesquisa seguiu as diretrizes PRISMA, com buscas nas bases PubMed, SciELO, BVS e LILACS, abrangendo artigos de 2015 a 2025 em português, inglês e espanhol, resultando na análise de 24 estudos variados, como ensaios clínicos, coortes e consensos. A literatura revela que protocolos conservadores iniciais (1.000-1.200 kcal/dia, progressão lent …

17.08.2026journal-article

Journal of Rehabilitation Medicine

Clinical factors associated with motor imagery ability in individuals with subacute stroke

Yuki Fukumoto, Tsubasa Kawasaki, Takanao Shirai, Tomomi Hase, Hinata Chiyo, Hiroyuki Hamada, Katsuya Sakai, Junpei Tanabe, Kota Sawa, Toshiaki Suzuki

Objective: To examine the associations of motor recovery stage, proprioceptive function, and working memory with motor imagery ability in patients with subacute stroke. Design: Multicentre cross-sectional study. Subjects/Patients: Forty patients with subacute stroke who had complete data. Methods: Motor imagery ability was assessed using mental chronometry during a Purdue Pegboard task. Associations with motor recovery stage, proprioceptive function, and working memory were examined using correlation and multiple r …

17.08.2026journal-article

Child Language Teaching and Therapy

Children's perspectives on structured literacy teaching and their emerging perceptions of themselves as readers and writers

Lisa Furlong, Sally Clendon, Gail Gillon, Brigid McNeill

This study focused on the methodological imperative of listening to children's voices in educational research, specifically in the context of structured literacy teaching. Adopting a qualitative, descriptive, multiple case study design, the research explored the experiences of five children (aged 5–6) engaged in structured literacy teaching through the Better Start Literacy Approach (BSLA) and their emerging perceptions of themselves as readers and writers. Aligning with a child-centred methodology, data collection …

17.08.2026journal-article

Journal of Clinical Oncology

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Living Guideline, Version 2026.1.2

Manish A. Shah, Jacob S. Marzalik, Erin B. Kennedy, Dana Deighton, Zahra Hamedi, Minaxi Jhawer, Kunal C. Kadakia, Paola Montenegro, Sarbajit Mukherjee, Christopher Nevala-Plagemann, Anwaar Saeed, Bryan J. Schneider, Thomas Semrad, Kohei Shitara, Melani Vincelli, Lakshmi Rajdev

This guideline has been updated. This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the online dynamic version for the latest updates. Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASC …

17.08.2026journal-article

Journal of Craniofacial Surgery

Speech Outcomes After Primary Palatoplasty With Intravelar Veloplasty and Extensive Muscle Dissection: A Single-Surgeon Cohort Study

Rodrigo D. Criado, Giovana R. Brandão, Daniela M.C.F. Ruiz, Barbara S. dos Santos, Ana P. Fukushiro, Renata P. Yamashita

This retrospective single-surgeon cohort study evaluated speech outcomes in 79 children with nonsyndromic cleft palate, with or without cleft lip, who underwent primary palatoplasty with intravelar veloplasty involving extensive palatal muscle dissection, performed by a single surgeon between 2015 and 2023. Hypernasality and velopharyngeal competence were assessed through auditory-perceptual evaluation using a 4-point ordinal scale and the Velopharyngeal Competence Rating (VPC-R). The mean age at surgery was 1 year …

17.08.2026journal-article

LUTS: Lower Urinary Tract Symptoms

Aquablation/ AquaBeam Waterjet Therapy for Benign Prostatic Hyperplasia: Three‐Year Functional and Ejaculatory Outcomes in a Multicenter Real‐World Italian Cohort

Angelo Porreca, Daniele D'Agostino, Davide De Marchi, Marco Giampaoli, Filippo Marino, Gian Maria Busetto, Antonio Amodeo, Paolo Corsi, Francesco Claps, Luca Di Gianfrancesco

ABSTRACT Objective To evaluate the 3‐year functional outcomes of Aquablation/AquaBeam waterjet therapy for bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH), with particular attention to urinary symptoms, quality of life, continence, ejaculatory function, and complications. Methods We performed a retrospective analysis of a prospectively maintained multicenter database including 218 consecutive men who underwent Aquablation/AquaBeam for symptomatic BPH between January 2019 and January 2022 …

17.08.2026journal-article

Central European Journal of Communication

Detecting and Categorizing Islamophobic Hate Speech on Spanish Twitter/X

William González-Baquero, Carlos Arcila Calderón, Javier Amores, Rocio Zamora, Pilar Garrido Clemente, Maria del Mar Grandio, Pedro Rojo

Islamophobic hate speech on social media includes overt toxicity and contextual frames that associate Muslims with invasion, criminality, cultural threat, or racialized exclusion. This study examines 21,326 Spanish-language tweets about Islam and Muslims posted in Spain between 2010 and 2022. We combine human annotation, exploratory discursive coding, Perspective API scores, and a multilingual BERT classifier. Human coders classified 28.2% of tweets as Islamophobic hate speech. Explicit hostility was the most frequ …

17.08.2026journal-article

Journal of Pharmaceutical Research and Integrated Medical Sciences

ML in Rare Facial Disorders: Hemifacial Microsomia, Parry-Romberg Syndrome, Moebius Syndrome, Treacher Collins Syndrome, Apert Syndrome, and Crouzon Syndrome-From Etiological Mapping and Pathology to AI-Driven Bio-Computational Gene Therapy

Yash Srivastav, Stuti Verma, Kamini Prajapati, Sandeep Prakash, Rajeev Kumar, Anubha Dhuriya, Anup Kumar Sirbaiya, Shivani Singh

These rare facial diseases, which include hemifacial microsomia, Parry-Romberg syndrome, Moebius syndrome, Treacher Collins syndrome, Apert syndrome, and Crouzon syndrome, among others, pose considerable difficulties in diagnosis and treatment due to their clinical variability, rare occurrence, and complex genetic etiology. This review highlights the increasing potential of artificial intelligence (AI) and machine learning (ML) technologies in the better diagnosis, phenotyping, genotyping, and clinical management o …

17.08.2026journal-article

Life

Stellate Ganglion Block Combined with Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss: A Retrospective Three-Arm Study

Geng-He Chang, Chung-Hang Wong, An-Ting Lee, Yu-Ching Cheng, Wen-Chun Liu

Sudden sensorineural hearing loss (SSNHL) carries unpredictable recovery, and adjunctive therapies beyond systemic corticosteroids are limited. Stellate ganglion block (SGB) and hyperbaric oxygen therapy (HBOT) have each been proposed as adjuncts, yet their combined effect remains poorly characterized. A retrospective three-arm cohort study (IRB No. 202401644B0) enrolled 75 SSNHL patients: Control (standard corticosteroid, n = 39), SGB (n = 21), and SGB+HBOT (n = 15). PTA4 improvement and Siegel recovery categories …

17.08.2026journal-article

Cancers

Functional Characterization of Myelodysplastic Syndrome by Multiparameter Flow Cytometry: The Clinical Synergy Between Ki-67 and Bcl-2 and Their Potential Role in Diagnostics and Personalized Therapy

Sixuan J. Wang, Rinaldo A. J. N. van Meel, Stefan G. C. Mestrum, Thomas H. P. M. Habets, Anton H. N. Hopman, Frans C. S. Ramaekers, Yvonne M. C. Henskens, Otto Bekers, Mathie P. G. Leers

The diagnosis and clinical management of myelodysplastic neoplasms are increasingly challenged by the disease’s inherent heterogeneity, particularly with respect to the diagnosis of low-grade variants. While standardized flow cytometric protocols traditionally rely on static biomarkers for lineage assignment, these often fail to capture the dynamic biological behavior of the malignant clone. This review synthesizes studies on the integration of functional biomarkers, specifically the nuclear proliferation marker Ki …

17.08.2026journal-article

ACS Applied Materials & Interfaces

Multifunctional MoO3− X Nanozyme-Hydrogel for Synergistic Photothermal Antibacterial Therapy and Enhanced Healing of Wounds Infected with Drug‑Resistant Bacteria

Weiwei Zhang, Lixiang Fan, Xuanjun Zhang, Hongyan Lu, Longbao Zhu, Ping Song, Fei Ge, Dongdong Sun, Wanzhen Li

Abstract Multidrug-resistant (MDR) bacterial infections and recalcitrant biofilms remain intractable barriers to wound healing, with traditional antibiotics offering limited efficacy due to resistance and poor biofilm penetration. To address this unmet clinical need, we innovatively engineered a multifunctional composite hydrogel (MoO3−X@CG-ODP) by integrating oxygen-vacancy-rich MoO3−X nanozymes into a dynamic cross-linking network formed by L-glutamine-grafted chitosan (CG) and 3-aminophenylboronic acid-mediated …