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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Transactions of The Royal Society of Tropical Medicine and Hygiene

Neglected arboviruses in South America: clinical manifestations and diagnostic challenges

Milagros Saavedra-Samillán, Sharon Díaz Velásquez, Marcos A Castillo Zuta, Julio Sandoval-Bances, Rafael Tapia-Limonchi, Stella M Chenet

Abstract In South America, the arboviruses that are most noted are those that lead to dengue, Zika, and chikungunya. Nevertheless, there are additional arboviruses that trigger outbreaks, yet do not receive adequate attention, including Oropouche virus (OROV), Mayaro virus (MAYV), Saint Louis Encephalitis virus, Madariaga virus (MADV), and Rocío virus (ROCV). A rapid review was conducted using the databases PubMed, LILACS, Scopus, and Google Scholar. This analysis focused on studies that outline the clinical signs …

27.08.2026journal-article

Diagnostics

Digital Patient-Reported Monitoring of Functional Recovery After Robot-Assisted Radical Prostatectomy in High-Risk Prostate Cancer Treated With or Without Perioperative Hormonal Therapy

Bogdan Adrian Buhas, Alessandro Uleri, Giorgio Calleris, Guilhem Roubaud, Marine Lesourd, Benjamin Pradère, Christophe Tollon, Damien Pouessel, Bernard Malavaud, Loïc Mourey, Guillaume Ploussard

Background/Objectives: Perioperative androgen-deprivation therapy (ADT) and androgen-receptor pathway inhibitors (ARPIs) are increasingly used in high-risk prostate cancer, yet patient-centred functional-recovery data after radical prostatectomy are scarce and rarely standardized. We assessed whether a smartphone-based digital monitoring pathway could characterize social-continence recovery and capture differences associated with a perioperative hormonal therapy (PHT) strategy after robot-assisted radical prostatec …

27.08.2026journal-article

Journal of Clinical Medicine

Cataract Surgery in Eyes with Congenital Iris–Choroidal Coloboma: Quantitative Assessment of Intraocular Lens Alignment and Optical Quality

Yuxuan Jia, Enjie Li, Zhenyu Wang, Xijin Wu, Xuefei Ding, Qi Zhang, Ting Chen, Peilin Yue, Xudong Song

Background/Objectives: Cataract surgery in eyes with congenital iris–choroidal coloboma is technically challenging, and postoperative intraocular lens (IOL) alignment and objective optical quality remain insufficiently characterized. This study evaluated short-term surgical outcomes, early postoperative IOL alignment, and objective optical quality after phacoemulsification with IOL implantation in eyes with congenital iris–choroidal coloboma and cataract. Methods: This retrospective comparative study included 36 ey …

27.08.2026journal-article

BMC Gastroenterology

Externally validated non-invasive diagnosis of obese MASH: CTL/S-serum biomarker integrated nomogram

Xiaohui Ma, Xin Wang, Li Ding, Yitong Han, Longhao Sun, Hua Meng, Qing He, Ming Liu

Abstract Context To develop and validate a non-invasive nomogram for predicting metabolic dysfunction-associated steatohepatitis (MASH) in obese patients, reducing reliance on liver biopsy. Methods This retrospective multicenter study included 387 severely obese patients undergoing laparoscopic sleeve gastrectomy with intraoperative liver biopsy at Tianjin Medical University General Hospital (training cohort: n = 272; internal validation: n = 115). Baseline demographics, laboratory tests including alanine aminotran …

27.08.2026journal-article

Blood Coagulation & Fibrinolysis

Clinical outcomes of peripartum fibrinogen replacement plus tranexamic acid in congenital hypofibrinogenemia: a single-centre case series of eight pregnancies

Jing Tian, Tianying Zhu, Terence T. Lao, Min Xie, Yunping Wu, Runmei Ma

Pregnancy in congenital hypofibrinogenemia is rare and hemorrhage-prone, with no reported use of tranexamic acid (TXA). We retrospectively reviewed eight pregnancies in six women (2015–2025). One intrauterine fetal death occurred. Seven live births were complicated by preterm membrane rupture, placental abruption, and postpartum hemorrhage (PPH; 4/8). All received peripartum fibrinogen replacement; seven also received intravenous TXA (1–3 g). Despite predelivery fibrinogen <0.8–1.89 g/l, no major maternal bleeding …

27.08.2026journal-article

Medical Sciences

Effects of Ramadan Fasting on Intradialytic Hypoglycemia and Clinical Outcomes in Patients with Diabetes on Maintenance Hemodialysis: A Multicenter Prospective Cohort Study in Southern Thailand

Ashari Saman, Jayanton Patumanond, Moragot Chatatikun, Atthaphong Phongphithakchai

Background: Patients with end-stage kidney disease (ESKD) and diabetes undergoing maintenance hemodialysis (HD) may be at increased risk of metabolic disturbances and intradialytic complications during Ramadan fasting. However, evidence regarding the safety of fasting in this population remains limited. This study evaluated the association between Ramadan fasting and intradialytic hypoglycemia and other clinical outcomes. Methods: This multicenter prospective cohort study included 153 patients with ESKD and diabete …

27.08.2026journal-article

European Journal of Clinical and Biomedical Sciences

AMAtt: Manifold Attention Network with Adaptive Log-Euclidean Metrics for Brain Signals

Syed Shaihan

In this paper, we discuss the recognition of electroencephalographic (EEG) signals, which is crucial in order to improve the performance of non-invasive brain-computer interfaces (BCIs). Although deep learning (DL) has achieved considerable advancements in the decoding of EEG signals, it frequently encounters difficulties related to noisy data and non-stationarity challenges. We discuss geometric learning which offers a more robust way to handle EEG signals by leveraging the mathematical structure of the data. We e …

27.08.2026journal-article

Applied Sciences

Dendrite-Network-Assisted Multi-Source Domain Generalization for Fault Diagnosis in Rotating Machinery

Pengcheng Liao, Xiaofei Bai, Rongzhang Cheng, Qun Chen

Intelligent fault diagnosis is crucial for the safe, efficient operation of rotating machinery. Domain adaptation models can mitigate distribution shifts from diverse operating conditions, but their over-reliance on annotated target domain data limits their use under unknown and dynamically changing conditions. To tackle this matter, DDDG, a dendrite-network-assisted multi-source domain generalization framework for fault diagnosis in rotating machinery, is proposed. First, a network integrating a dendrite module is …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Application of Traditional Chinese Medicine in Postoperative Rehabilitation for Anterior Talofibular Ligament Rupture

Xinxin Yang

The anterior talofibular ligament (ATFL) plays a critical role in ankle stability, yet it is the most commonly injured ankle ligament. Thus, its postoperative rehabilitation has become a crucial clinical issue. With the development of Traditional Chinese Medicine (TCM), TCM-based rehabilitation, in its turn, has been receiving more and more attention. This paper is a systematic review of the research studies on the use of TCM interventions in the rehabilitation of postoperative ATFL rupture. Findings indicate that …

27.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

The mediating role of social appearance anxiety in the relationship between instagram social comparison and cosmetic surgery acceptance: Implications for workplace wellbeing

Hatice Balci

Background Visually oriented social media use has increased social comparison processes and appearance-related concerns, potentially affecting psychosocial well-being, job burnout, and attitudes toward cosmetic surgery in professional settings. Objective This study examined the effects of Instagram-based social comparison, social media addiction, and social appearance anxiety on cosmetic surgery acceptance, with a focus on testing the mediating role of social appearance anxiety and investigating differences across …

27.08.2026journal-article

Journal of Pediatric Hematology/Oncology Nursing

Challenges of Treatment Decisions for Children With Hematological Malignancies Who Relapse After Hematopoietic Stem Cell Transplant: A Health Care Provider Perspective

Deborah Tomlinson, Sonia Lucchetta, Sarah Alexander, Sumit Gupta, Erilda Kapllani, Tal Schechter-Finkelstein, Jane Lowry, Joerg Krueger

Background When a child or adolescent's disease relapses following hematopoietic stem cell transplantation (HSCT), families are often presented with the complex decision to pursue further treatment with curative intent. This study aims to describe the experiences of health care professionals (HCPs) regarding choices after the first HSCT and factors influencing decision-making. Method This qualitative study included staff and trainee physicians, nurse practitioners, and nurse coordinators. All participants had exper …

27.08.2026journal-article

World Journal for Pediatric and Congenital Heart Surgery

Resection and Reimplantation of a Nearly Atretic Left Main Coronary Artery in an Adolescent

Robert McRae, Benjamin Hammond, Spencer Barfuss, Aaron Pennie, Collin Cowley, John Doty, Reilly Hobbs

Congenital coronary artery stenosis is a rare coronary anomaly with significant variability in presentation and management. We present a case of severe left main coronary artery stenosis in a young female. A 14-year-old female was referred to the Cardiology Clinic for multiple episodes of syncope and presyncope with activity that began in early childhood. Diagnostic imaging revealed near atresia of the proximal left main coronary artery. The patient underwent surgical repair with resection of the stenotic coronary …

27.08.2026journal-article

Cancers

Deconstructing Exceptional Responses to Immune Checkpoint Inhibition in Recurrent or Metastatic Head and Neck Carcinoma: A Site-Specific Clinical–Biological Synthesis

Giovanni Motta, Piero Giuseppe Meliante, Pasquale Capasso, Francesco Chiari, Giuseppe Tortoriello

Background: Recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is an aggressive malignancy with a historically poor prognosis. Although immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have established a new first-line standard of care, durable clinical benefit is restricted to a minority of patients, while primary or acquired resistance remains a major clinical challenge. This narrative review aims to provide a conceptual clinical–biological synthesis of immunotherapy in R/M …

27.08.2026journal-article

Revista Científica Saúde Global

Strategies in the Prevention and Treatment of Obesity

Ieda Carla Candido, Gisele Nicchio Rocha Buzzo, Matheus Rodrigues Dos Santos, Rafaela Crystina Vieira Bonfim, Fernanda Aparecida Vicente Magalhães, Karine Oltramari, Paulo Cesar Franzini, Angélica Sbrolini Marques Mincache, Greice Westphal-Nardo, Nelson Nardo Júnior Nardo Júnior

Objective: This study aims to present the most recent advances and the challenges encountered in the provision of pharmacological, surgical, and multidisciplinary programs for the treatment of obesity. Methods: This is a narrative literature review with a qualitative and exploratory approach, conducted in July 2025. The theoretical framework was based on studies published between 2020 and 2025, focusing on strategies for obesity prevention and treatment, particularly pharmacological therapies, bariatric surgery, an …

27.08.2026journal-article

Archivos Peruanos de Cardiología y Cirugía Cardiovascular

Trasplante cardiaco en paciente adulto con circulación de Fontan disfuncionante en un centro de alta complejidad cardiovascular en el Perú: reporte de caso

Roger Yoel Conde Moncada, Víctor Robles Velarde, Romel Zamudio Silva, Edwin Amado Masabel Chicoma, Sergio Martín Zavala Castillo, Franz Ronald Soplopuco Palacios

Fontan circulation failure represents a progressive condition associated with multiorgan dysfunction and increased morbidity and mortality. In this context, heart transplantation has become the definitive treatment for this subgroup of patients. Reported survival rates after heart transplantation in patients with Fontan circulation are approximately 80% at 1 year, 74% at 5 years, and 59% at 10 years. We present the case of a 46-year-old patient with a history of Ebstein anomaly who underwent intracardiac Fontan sur …

27.08.2026journal-article

Cancer Medicine

UTMD Suppresses CSF ‐1 to Drive Macrophage‐Mediated Ferroptosis in Papillary Thyroid Carcinoma

Yanqiang Niu, Zhenqiang Yao, Minghua Zhang, Jiayan Zhang, Yushan Li, Jinhui Xie, Zubang Zhou

ABSTRACT The tumor microenvironment (TME) of Papillary Thyroid Carcinoma (PTC), particularly the role of tumor‐associated macrophages (TAMs), contributes to therapeutic resistance. This study investigated whether ultrasound‐targeted microbubble destruction (UTMD), a non‐invasive physical modality, could reprogram the TME through modulation of TAMs and induction of ferroptosis. Transcriptomic profiling identified CSF‐1 as a top target suppressed by UTMD, which was validated by ELISA, Western blot, and qRT‐PCR. UTMD …

27.08.2026journal-article

Transactions of The Royal Society of Tropical Medicine and Hygiene

Out-of-pocket expenditure and catastrophic health expenditure in patients of leprosy at a tertiary care center in India

Kavita Kavita, Sukhdeep Singh, Kittu Malhi, Manisha Upreti, Sushma Saini, Arushi Ghai, Ritin Mohindra, Tarun Narang, Sunil Dogra

Abstract Objectives Leprosy continues to impose a significant clinical and socioeconomic burden. Despite free multidrug therapy, patients incur substantial out-of-pocket expenditure (OOPE), leading to catastrophic health expenditure (CHE). Evidence on the economic burden of leprosy in India remains limited. Methods A pilot prospective observational study was conducted at a tertiary care center in North India, enrolling 56 patients with leprosy. Data on sociodemographic characteristics, direct and indirect healthcar …

27.08.2026journal-article

Clinical Science

Resolvin D5 limits inflammatory lung injury and enhances antibacterial host defense in severe pneumococcal pneumonia

Henry H. Gong, Stephanie Pons, Jasmine Ji, Robert Nshimiyimana, Charles N. Serhan, Luciana P. Tavares, Bruce D. Levy

Abstract Streptococcus pneumoniae remains a leading cause of lower respiratory tract infections and pneumonia-related mortality worldwide. Although neutrophil recruitment is essential for pneumococcal containment, excessive and dysregulated neutrophilic inflammation can drive severe lung injury and acute respiratory distress syndrome. Specialized pro-resolving mediators, such as Resolvin D5 (7S,17S-dihydroxy-4Z,8E,10Z,13Z,15E,19Z-docosahexaenoic acid; RvD5), are produced in the lungs and have the potential to promo …

27.08.2026journal-article

Journal of Clinical Medicine

EZH2 Expression and Clinical Outcomes in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors: A Real-World Retrospective Cohort Study

Esra Asarkaya, Hatice Asoglu, Abdurrahman Aykut, Gunes Dorukhan Cavusoglu, Yasemin Aydınalp, Sendag Yaslıkaya, Suheda Atas Ipek, Fatma Calkan, Emine Kilic Bagir, Derya Gumurdulu, Hulya Binokay, Tolga Koseci, Ismail Oguz Kara, Berksoy Sahin, Ertugrul Bayram

Background: Lung cancer remains the leading cause of cancer-related mortality, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. Over the past decade, immune checkpoint inhibitors have become a core component of first-line treatment for advanced-stage NSCLC lacking driver mutations. Programmed death-ligand 1 (PD-L1) expression is currently used as the standard biomarker, yet its predictive value remains limited, and in most immunotherapy trials, treatment efficacy has been observed …

27.08.2026journal-article

Journal of Perinatal Medicine

Multidimensional compliance and outcomes in gestational diabetes

Weili Zhang, Qingqing Gong, Yan Zhu

Abstract Objectives To investigate the association between a composite multidimensional compliance score and glycemic control, maternal complications, and neonatal outcomes in women with gestational diabetes mellitus (GDM), and to evaluate these associations after adjusting for potential confounders. Methods This retrospective cohort study included 360 women with GDM, diagnosed between October 2023 and January 2026 at Guiyang Second People’s Hospital. A weighted compliance score (1–3) was calculated based on blood …

27.08.2026journal-article

Experimental Biology and Medicine

The interaction between oxidative stress and Schwann cells

Sihan Yang, Zijun Zhang, Qing Liao, Qipeng Ouyang, Yongyou Ye, Wei Lu, Zhendong Jiang

After peripheral nerve injury (PNI), a moderate increase in reactive oxygen species (ROS) levels can promote the proliferation and differentiation of Schwann cells (SCs) and participate in signal transduction. However, excessive ROS can trigger oxidative stress, and its harmful effects can overshadow the beneficial ones, such as inducing apoptosis, activating inflammation, disrupting environmental stability, and severely hindering neural processes. Therefore, if the damage caused by oxidative stress to SCs can be e …

27.08.2026journal-article

Frontiers in Endocrinology

Case Report: Development of a thyrotropinoma in a patient with thyroid hemiagenesis

Emil Bartosz Rozenek, Mark Gurnell, Jacek Kunicki, Maria Maksymowicz, Marta Korbonits, Wojciech Zgliczyński, Maria Stelmachowska-Banaś

Thyroid hemiagenesis (THA) is a relatively rare disorder in which one thyroid lobe fails to develop. Although most individuals remain clinically euthyroid, they typically exhibit higher thyrotropin (TSH) concentrations than those with a bilobed thyroid gland, possibly reflecting reduced thyroidal reserve and a chronic compensatory response by pituitary thyrotrophs. While pituitary hyperplasia has been reported in the setting of hypothyroidism in THA, a TSH-secreting pituitary neuroendocrine tumor (thyrotropinoma) h …

27.08.2026journal-article

Frontiers in Medicine

Rheumatoid arthritis and cardiovascular disease in relation to cytomegalovirus infection: a pilot cross-sectional study

Mohammed Ahmed Al-Kaif, Laith A. I. K. Al-Kaif, Zaid Saad Madhi, Dalya Talal Fathi Al-Azzawi, Wael Rasheed Obaead Alfatlawi, Sarah Kassab Shandaway Al-Zamali, Fatin Alaa Abdul Ameer Mahdi, Haibo Liu

Background Patients with rheumatoid arthritis (RA) face increased cardiovascular disease (CVD) risk not fully explained by traditional factors. Chronic cytomegalovirus (CMV) infection may contribute through immune activation and vascular inflammation. This pilot study investigated associations between CMV serostatus, vascular endothelial growth factor A (VEGF-A), and inflammatory markers in patients with RA and/or CVD. Methods This cross-sectional study enrolled 76 participants (CVD = 40, RA = 18, RA+CVD = 18). Ser …

27.08.2026journal-article

Frontiers in Medicine

Association between preprocedural information and anxiety in patients undergoing gastrointestinal endoscopy with sedation: a prospective observational study

Roberto Quirós-Zamorano, Raquel Romero-Tejedor, Miriam Álvarez-Villarreal, Francisco Javier García-Sánchez

Background Preprocedural anxiety is common among patients undergoing gastrointestinal endoscopy and may be influenced by the quality of information provided before the procedure. However, real-world evidence on the relationship between information delivery and anxiety levels remains limited. Methods A prospective observational cross-sectional study was conducted in the endoscopy unit of a tertiary hospital between June and September 2024. A total of 351 adult patients scheduled for elective gastroscopy or colonosco …