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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Livers

Metabolic Diversion from Geranylgeranoic Acid to 2,3-Dihydrogeranylgeranoic Acid in Hepatic Tumor Surveillance

Yuki Tabata

Geranylgeranoic acid (GGA) is an endogenous acyclic diterpenoid metabolite of the mevalonate pathway that has been implicated in programmed cell death in hepatoma cells and may contribute to the elimination of premalignant hepatocytes. Recent metabolomic studies have identified 2,3-dihydrogeranylgeranoic acid (2,3-diGGA), an α-saturated derivative of GGA with reduced cell-death-inducing activity compared with GGA. This concise review examines the hypothesis that diversion of bioactive GGA toward 2,3-diGGA formation …

24.08.2026journal-article

International Journal of Science, Strategic Management and Technology

Breast Cancer Classification in Ultrasound Images Using Two-Phase EfficientNetB7 Transfer Learning

Madishetti Kavya, Dr.G. Thirupati

Breast cancer is a leading cause of cancer morbidity and mortality among women globally, emphasizing the need for accurate and timely diagnostic methods. A systematic but innovative two phases transfer learning based deep learning classification framework is developed using popular EfficientNetB7 architecture architecture for breast cancer classification. Breast ultrasound imaging proves a high degree of complexity to extract features with limited available medical datasets to address it and the proposed methodolog …

24.08.2026journal-article

Natural and Life Sciences Communications

Expression-Guided Immunoinformatics Design of a Recombinant Multi-Epitope Vaccine Candidate for Triple-Negative Breast Cancer Incorporating a MyD88-Derived Immunomodulatory Domain

Moh Royhan Afnani, Volta Kellik Setiawan, Anwar Rovik

Triple-negative breast cancer (TNBC) remains a major therapeutic challenge because of its aggressive behavior, molecular heterogeneity, and limited subtype-specific targets. This study used an integrated immunoinformatics workflow to design a recombinant tumor-associated antigen-derived multi-epitope vaccine based on MMP1, CXorf61/CT83, and COL11A1, prioritized according to their tumor-to-normal transcript-expression ratios. Candidate cytotoxic T-lymphocyte, helper T-lymphocyte, and linear B-cell epitopes were scre …

24.08.2026journal-article

Discover Public Health

Current policies and practices for testing and treatment of chronic hepatitis B and C infection in high-burden countries in the WHO European region

Machiko Otani, Marcelo Contardo Moscoso Naveira, Stela Bivol

Abstract Chronic hepatitis B and C remain major public health concerns in the WHO European Region, with an estimated 10.6 million people living with HBV and 7.7 million with HCV in 2022. Despite this burden, diagnosis and treatment coverage remain low, challenging progress toward the 2030 elimination goal. To map national policies and reported service availability for hepatitis testing and treatment. , the WHO Regional Office for Europe surveyed nine high-burden countries, receiving responses from eight: Armenia, A …

24.08.2026journal-article

Healthcare

Effect of Mindfulness-Based Social–Emotional Learning Approach on Knowledge and Anxiety Levels Regarding Cervical Cancer Prevention

Nehal Shalaby Awad Mahmoud, Nourhan Essam Hendawi, Mahmoud Abdelwahab Khedr, Wafa Hamad Almegewly, Mazen Baazeem, Marwa Salah Abd Elgawad Abd Elhady

Background: Cervical cancer remains a major public health concern worldwide, particularly in low- and middle-income countries. Limited knowledge regarding cervical cancer prevention and elevated anxiety levels may hinder women’s participation in preventive measures. Mindfulness-Based Social–Emotional Learning integrates mindfulness practices with social–emotional learning strategies and may enhance health knowledge while reducing anxiety. Materials and Methods: A quasi-experimental pretest–posttest non-equivalent c …

24.08.2026journal-article

Frontiers in Oncology

UTROSCT: a case report and scoping review of ultrasound features, with exploratory serum proteomic findings

Davide Castelli, Ghergana Alexandrova Topouzova, Blendi Ura, Francesca Buonomo, Eduardo Maria Sommella, Alessandro Mangogna, Federico Romano, Giovanni Di Lorenzo, Stefania Cicogna, Andrea Romano, Giuseppe Ricci

Background and objectives UTROSCT is a rare uterine neoplasm with nonspecific imaging features. The aim of this study was to evaluate how UTROSCT is described on pelvic and transvaginal ultrasound in the published case-report literature and to report the clinicopathologic, immunophenotypic, and exploratory serum proteomic features of a new UTROSCT case. Case presentation Transvaginal ultrasound revealed an intracavitary uterine lesion in a 72-year-old asymptomatic postmenopausal woman. Histopathology and immunohist …

24.08.2026journal-article

Cancers

Clinical Implications of Incorporating Molecular Profiles into the Staging of Endometrial Cancer: A Critical Review of the 2023 FIGO System on the Wave of 2025 ESGO/ESTRO/ESP Guidelines

Angela Santoro, Giuseppe Angelico, Antonio d’Amati, Livia Maccio, Emma Bragantini, Francesco Fanfani, Anna Fagotti, Gian Franco Zannoni

This review examines the clinical and practical implications of embedding molecular profiles directly into the 2023 FIGO staging system for endometrial carcinoma, in the context of the 2025 ESGO/ESTRO/ESP guidelines. The primary purpose is to navigate a central conflict in modern oncology: how to deliver increasingly personalized care while maintaining a globally accessible, equitable, and standardized cancer classification system. The 2023 FIGO update represents a paradigm shift from the traditional dualistic mode …

24.08.2026journal-article

Frontiers in Microbiology

Therapeutic regulation of gut microbiota in gastric cancer: mechanisms, strategies, and clinical prospects

Zicheng Liu, Mingyue Bai, lichao Han, Zeguang Li

Gastric cancer (GC) is a highly prevalent malignancy associated with substantial mortality worldwide. Dysbiosis of the gut microbiota is closely linked to the pathogenesis, clinical characteristics, and therapeutic responses of GC, making it a central focus of research in the field of tumor microecology. However, existing reviews mainly focus on microbial compositional features, individual mechanisms, or specific microbiota-based interventions, while lacking an integrated theoretical framework that incorporates Hel …

24.08.2026journal-article

BMC Health Services Research

Linking health literacy to malaria prevention and treatment behaviours: evidence from a community-based study in Gabon

Caroline Namubiru, Saidou Mahmoudou, Ynous Djida, Bertrand Lell

Abstract Background Health literacy (HL) affects how individuals engage in preventive behaviours, seek prompt treatment, select appropriate malaria prevention or treatment options, adhere to care and act on health information. Little is known about its role in malaria prevention and treatment behaviours. Therefore, this study investigated the extent to which HL relates to malaria health behaviours. Methods A cross-sectional household survey across urban and rural areas of Gabon using a sample of 504 respondents. HL …

24.08.2026journal-article

Clinical Nuclear Medicine

PSMA-Avid Metastatic Prostate Cancer With Intense Penile Uptake on PET/CT

Katarzyna Klappa, Witold Cholewinski, Mikolaj Kuta, Jakub Sarapata, Paulina Cegla

Penile metastasis from prostate adenocarcinoma is an exceptionally rare manifestation of advanced disease. We report the case of a 64-year-old man with biopsy-proven prostatic adenocarcinoma (cT3bN1M1, Gleason 4+4=8), diagnosed in 2020 with an initial PSA of 122.85 ng/mL. The most remarkable finding was intense, diffuse, and homogeneous PSMA uptake throughout the corpora cavernosa along the entire penile shaft (SUVmax=76.9). Histopathologic examination confirmed metastatic prostatic adenocarcinoma (Grade Group 3, G …

24.08.2026journal-article

Indian Journal of Medical Research

Unravelling the web of neglect in elderly cancer care in South India: A grounded theory approach

Viswanath Narendiran, Sonali Sarkar, Mahalakshmy Thulasingam, Gunaseelan Karunanithi

Background and objectives Elder neglect, characterised by unmet care needs, social isolation, and emotional distress, has been consistently reported in epidemiological studies, yet it continues to be insufficiently acknowledged as a major public health concern in India. Existing frameworks inadequately explain how factors interact to produce neglect and abandonment. This study aimed to explore the circumstances leading to neglect among elderly cancer patients in Puducherry and Tamil Nadu. Methods A qualitative grou …

24.08.2026journal-article

Methods and Protocols

Evaluating Cell-Free DNA Quantification and Integrity in Breast Cancer Using Fluorometric, Electrophoretic and PCR-Based Platforms

Gisha Rose Antony, Vidya P. Nimbalkar, Sowmya Nagaraj, Mahalakshmi Subramanya, Anupama C. Eshwara Rao, Ganapathi Bantwal, Belinda George, Akshay Ajoy, Nihal M. Ahamed, Rakesh S. Ramesh, Jyothi D. N, Jaya Kumari S, Jyothi S. Prabhu

Cell-free DNA (cfDNA) has emerged as a promising liquid biopsy biomarker; however, differences in analytical methods may influence cfDNA quantification and integrity assessment. This study compared plasma cfDNA concentration and integrity between treatment-naïve breast cancer (BC) patients (n = 100) and healthy controls (HC; n = 70) using complementary analytical platforms. cfDNA concentration was measured by Qubit fluorometry, TapeStation (TS) electrophoretic profiling, and ALU-based quantitative PCR (qPCR). An ex …

24.08.2026journal-article

Frontiers in Public Health

Reframing the starting point of shared decision-making under algorithmic short-form video exposure: bone tumor care as a sentinel context

Jia-Wen Wang, Ying-Fa Feng, Zi-Bo Zhang

Short-form video platforms have become a major component of the pre-consultation information environment for patients with cancer in China and may create new challenges for clinical communication. Contemporary shared decision-making (SDM) and patient decision aids (PtDAs) do not explicitly assess or calibrate beliefs formed before consultation. Algorithmic recommendation and emotionally charged narratives may therefore contribute to pre-consultation cognitive anchoring and alter the conditions under which SDM occur …

24.08.2026journal-article

Journal of Translational Medicine

Targeting the metabolic dependencies of tumor-associated macrophages for cancer immunotherapy

Weifeng Yuan, Yiran Zhu, Yuxin Zhang, Jinping Gu, Liqiong Xue, Wencan Zhang, Xu Cao

Abstract Tumor-associated macrophages (TAMs) play a pivotal role in tumor progression and immune evasion, with recent evidence indicating that metabolic reprogramming is crucial in determining their functional phenotype. Alterations in glucose, amino acid, and lipid metabolism are central to the regulation of TAMs plasticity, driving the shift between pro-inflammatory (M1) and anti-inflammatory (M2) states. M1 macrophages predominantly rely on glycolysis and aerobic metabolism to support their pro-inflammatory func …

24.08.2026journal-article

Clinical Nuclear Medicine

Two Cases of Solitary Corpus Cavernosum Metastasis From Prostate Cancer Detected by 68Ga-PSMA PET Imaging

Guannan Li, Lixiang Yang, Minggang Su, Fanglan Li, Yueqi Wang

Solitary corpus cavernosum metastasis from prostate cancer is extremely rare, particularly as an isolated nodular lesion. We report 2 patients who developed rapid prostate-specific antigen (PSA) elevation following radical prostatectomy without prior evidence of metastatic disease. 68 Ga-PSMA PET revealed isolated PSMA-avid nodules in the corpus cavernosum (SUV max : 4.46 and 22.46, respectively). Following salvage radiotherapy, both patients showed a marked decline in PSA levels. These cases highlight the utility …

24.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Genetic Markers of Early Skeletal Muscle Loss in Adolescent and Young Adult Cancer Patients Treated with Anthracyclines

Savannah V. Rauschendorfer, Amanda Brandt, Behrang Amini, J. Andrew Livingston, Michael E. Roth, Eugenie S. Kleinerman, Michelle A.T. Hildebrandt

Purpose: Skeletal muscle (SM) loss occurs during early anthracycline treatment in adolescent and young adult (AYA) cancer patients. Identifying those at greatest risk is critical for prevention. This study aimed to determine if genetic variants previously associated with SM loss in the general population are also associated with SM loss in AYA cancer patients receiving anthracycline chemotherapy. Methods: SM change was quantified via computed tomography for 138 AYA cancer patients. The genome-wide association studi …

24.08.2026journal-article

Biomedicines

Photodynamic Therapy in Cancer: Mechanisms, Photosensitizer Technology, Vitamin Modulation, and Rational Combination Design

Ilaf Naser, Dorota Bartusik-Aebisher, Barbara Smolak, Klaudia Dynarowicz, Edward Kowalczyk, Wiesław Guz, David Aebisher, Gabriela Henrykowska

Photodynamic therapy (PDT) is a minimally invasive anticancer modality based on the interaction of a photosensitizer, light of an appropriate wavelength, and molecular oxygen, resulting in reactive oxygen species (ROS)-mediated tumor injury. This review discusses PDT as a mechanism-dependent therapeutic platform and evaluates how photosensitizers, vitamin A, vitamin D, nanotechnology, and combination strategies may influence its efficacy. The article synthesizes mechanistic and translational evidence concerning pho …

24.08.2026journal-article

Journal of Transcultural Nursing

Use of Complementary and Alternative Medicine for Fatigue and Pain Among Gastrointestinal Cancer Patients in Türkiye: A Cross-Sectional Study

Ayşegül Çelik, Özlem Kardaş Kin

Introduction: Gastrointestinal cancers are associated with pain and fatigue that impair quality of life; use of complementary and alternative medicine (CAM) for symptom management is increasing, yet data from Türkiye remain limited. Method: A descriptive, cross-sectional design was employed with 167 gastrointestinal cancer patients receiving treatment at a university hospital in Türkiye. Results: Liver cancer (33.5%) and gastric cancer (31.7%) were the most common diagnoses. The total mean holistic complementary an …

24.08.2026journal-article

Frontiers in Oncology

HAIC combined with atezolizumab and bevacizumab versus lenvatinib in advanced hepatocellular carcinoma: a multicenter propensity score matching analysis

Lei Zhao, Dan Liu, Chao Ma, Yue Hu, Shu Liu

Purpose This study aimed to evaluate the clinical efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with atezolizumab and bevacizumab (HTA) versus HAIC combined with lenvatinib (HL) in the treatment of advanced hepatocellular carcinoma (HCC). Methods A multicenter retrospective study was conducted between June 2021 and June 2025, reviewing advanced HCC patients treated with either HTA or HL. To mitigate initial differences between the two groups, propensity score matching (PSM) was appli …

24.08.2026journal-article

Pharmaceuticals

Transcriptional Regulation of Receptor-Mediated Mitophagy in Sunitinib-Resistant Renal Cancer Cells: Response to Succinic Acid

Goksu Kasarci-Kavsara, Sinem Bireller, Baris Ertugrul, Bedia Cakmakoglu

Background/Objectives: Drug resistance is a major challenge in cancer therapy, and mitochondria contribute to this process by controlling both metabolic adaptability and cell survival signaling. Mitophagy, the selective lysosomal removal of dysfunctional mitochondria, has been implicated in therapy resistance, yet its role in sunitinib-resistant renal cancer remains poorly defined. Methods: In this study, acquired sunitinib resistance was established in ACHN renal cancer cells through eight months of stepwise dose …

24.08.2026journal-article

IJEDO

Is a 20-Session Treatment Sufficient for Adult Anorexia Nervosa? A Critical Comparison of CBT-AN-20 with CBT-E

Simona Calugi, Riccardo Dalle Grave

The aim of this article is to describe the key theoretical differences between CBT-AN-20 and enhanced cognitive behaviour therapy (CBT-E), to compare briefly the findings from CBT-AN-20 with those of the principal outpatient CBT-E studies in adults with anorexia nervosa, and to examine the conceptual and clinical implications of the two approaches. The treatments differ in their theoretical foundations and strategies. CBT-AN-20, based on an anxiety model, promotes rapid behavioural change, exposure to feared foods, …

24.08.2026journal-article

Cancers

Quality of Outcome Reporting for Older Subgroups in FDA Registration Gastroesophageal Cancer Trials (2010–2024): A Systematic Review

Ilse Trip, Martha Kormi, Elizabeth Smyth, Russell D. Petty, Mark A. Baxter

Background: Gastroesophageal adenocarcinoma is predominantly a disease of older adults. However, older adults are underrepresented in randomised controlled trials (RCTs), and outcomes specific to this subgroup are underreported. Clinicians therefore extrapolate data from younger, fitter trial populations, which can lead to over- and undertreatment of older cancer patients. This study examines the inclusion and completeness of outcome reporting for older patients in practice-changing trials in gastroesophageal cance …

24.08.2026journal-article

Veterinary Dermatology

A Randomised Placebo‐Controlled Study to Evaluate the Efficacy and Safety of a Two‐Dose Topical Terbinafine and Betamethasone Gel for the Treatment of Yeast ( Malassezia pachydermatis ) Otitis Externa in Dogs

Zorica Zivkovic Baks, Hope Baird Heinz, Stephan Grundke, Caryn Thompson, Roberto Garcia

ABSTRACT Background Otitis externa (OE) with Malassezia pachydermatis overgrowth with limited bacterial involvement is common in dogs. Treatment with products containing antibiotics is unnecessary and not consistent with judicious use of antimicrobials. Objectives To evaluate the efficacy and safety of an otic gel containing 1% terbinafine and 0.1% betamethasone acetate for the treatment of yeast‐predominant canine OE. Animals 239 privately owned dogs were enrolled. Materials and Methods Inclusion criteria were an …

24.08.2026journal-article

British Journal of Pharmacology

Single‐atom Pt‐N‐C nanozyme targets Rara/Wnt/β‐catenin axis for diabetic cardiomyopathy treatment

Lina Hao, Xiufen Qu

Abstract Background and Purpose Diabetic cardiomyopathy (DCM) lacks effective therapies because of complex mechanisms. This study aims to develop a single‐atom nanozyme for integrated antioxidant and signalling regulation in DCM. Experimental Approach A graphene quantum dot‐templated single‐atom Pt‐N‐C nanozyme (PtsaN‐C) was synthesised for all‐trans retinoic acid (ATRA) delivery (PtsaN‐C@ATRA). In vitro antioxidant activity and in vivo efficacy were evaluated in DCM mice, combined with scRNA‐seq for mechanistic an …