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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Magnetic Resonance in Medicine

Clinical Soma and Neurite Density Imaging ( SANDI ): Translational Microstructure Mapping on Clinical 3T MRI Scanners

Hansol Lee, Kwok‐Shing Chan, Yixin Ma, Dongsuk Sung, Sohyun Han, DongKyu Lee, Eva A. Krijnen, Laleh Eskandarian, Aneri Bhatt, Julianna Gerold, HyungJoon Cho, Susie Y. Huang, Hong‐Hsi Lee

ABSTRACT Purpose The Soma and Neurite Density Imaging (SANDI) model enables characterization of gray matter (GM) microstructure by estimating soma and neurite signal fractions, but its clinical applicability is limited by the need for multi‐shell acquisitions (at least five b ‐values up to 6000 s/mm 2 ), requiring high‐gradient MRI systems. We developed a clinically feasible SANDI model that reduces data requirements and model complexity while preserving sensitivity to cellular‐level microstructural features. Metho …

27.08.2026journal-article

Journal of Oncology Pharmacy Practice

Pharmaceutical care in patients with gastric cancer treated with capecitabine: A randomized clinical trial

Patrícia Kaiser Pedroso Cava, Camille Nigri Cursino, Larissa Dos Santos Sebould Marinho, Ana Clara Duarte Dos Santos, Ariela Dutra Norberto De Oliveira, Larissa Rodrigues Nascimento, Vanessa Cristiane Da Silva Ferreira, Dulce Helena Nunes Couto, Jessica Pronestino De Lima Moreira, Thaísa Amorim Nogueira, Selma Rodrigues De Castilho, Sabrina Calil-Elias

Introduction Cancer poses a major challenge to global health, impacting individuals, communities and societies worldwide. A significant proportion of global morbidity and mortality from neoplasms is accounted for by gastrointestinal tumors, due to their high incidence and lethality. Capecitabine, an oral antineoplastic agent, has brought advances in treatment, but requires caution regarding adherence and adverse events. In this context, it is believed that pharmaceutical care can significantly contribute to optimiz …

27.08.2026journal-article

JAMA Otolaryngology–Head & Neck Surgery

Necrotic Nasal Lesion in a Woman Without a History of Immunodeficiency

Jun Yun, Alice C. Yu, Chau T. Nguyen

A 51-year-old woman presented with a 2-month progressively enlarging right nasal lesion and 1 week of painful oral lesions limiting her oral intake. She also noted painful, erythematous nodules on her arms and hands. What is your diagnosis?

27.08.2026journal-article

Military Medicine

Upper Limb Disability in Men with Combat-Related Upper Limb Injury, 8 Years Post-Injury: The ADVANCE Cohort Study

Helena Macdonald, Fraje Watson, Susie Schofield, Alexander N Bennett, Christopher J Boos, Paul Cullinan, Harriet Kemp, Nicola T Fear, Anthony M J Bull

Abstract Introduction Upper limb (UL) injuries place a considerable economic and readiness burden on the military. Long-term outcomes of UL combat-related injuries have not been examined to the same extent as those of lower limb injuries. Specifically, a better understanding of long-term outcomes following non-amputation UL injuries is essential given the crucial role of the ULs in daily activities and quality of life. This study will compare UL disability in (1) participants with UL combat injury, non-UL combat in …

27.08.2026journal-article

Journal of Clinical Medicine

Mid to Long-Term Outcomes of Low-Energy Selective Laser Trabeculoplasty for Primary Open Angle Glaucoma

Hinako Ohtani, Yuri Fujino, Keigo Takagi, Yuto Yoshida, Chisako Ida, Kana Murakami, Mizuki Koike, Masaki Tanito

Background/Objectives: To evaluate the mid- to long-term outcomes of selective laser trabeculoplasty (SLT) performed with lower energy (≤0.5 millijoules (mJ)) than conventional settings (0.6–1.2 mJ). Methods: This retrospective chart-review study included patients who underwent low-energy SLT (0.34 ± 0.06 mJ) at Shimane University Hospital from April 2018 onward. A total of 54 patients (99 eyes) were analyzed, with a mean follow-up period of 57.5 months and a maximum follow-up period of 114 months. Treatment failur …

30.08.2026journal-article

European Heart Journal - Case Reports

Intravascular ultrasound-guided percutaneous treatment of late-presenting left anterior descending artery compression after penetrating cardiac trauma in a young adult: a case report

Hatice Özdamar, Duygu Melisa Hökerek, Burçin Abud, Burak Ayça, Mehmet Emre Özpelit

Abstract Background Penetrating cardiac trauma is rare in adolescents, and late acute coronary syndrome after surgical repair, which narrows left anterior descending artery, is even rarer. Managing ischaemia from late coronary stenosis without underlying atherosclerosis is challenging. Multimodal imaging, including coronary computed tomography and intracoronary imaging, is crucial for guiding treatment. Case summary An 18-year-old male presented with recurrent chest pain. Two years after surgical repair of a penetr …

27.08.2026journal-article

The Clinical Journal of Pain

The Role of Stress-related Biomarkers, Immune-inflammatory Pathways, and Genetic Polymorphisms in Cognitive-behavioral Therapies for Chronic Low Back Pain and Depression

Adrián Pérez-Aranda, Carla Rodríguez-Freire, Juan P. Sanabria-Mazo, Albert Feliu-Soler, Mar Grasa, Albert Carrillo, Montserrat Esteve, Oriana Filluelo, Araceli Rosa, Ariadna Colomer-Carbonell, Patricia Mas-Bermejo, Lance M. McCracken, Xavier Borràs, Juan V. Luciano

Objectives: This study aimed to (a) evaluate the effects of Acceptance and Commitment Therapy (ACT) and Behavioral Activation Therapy for Depression (BATD) on immune-inflammatory biomarkers in patients with chronic low back pain and comorbid depression, and (b) explore whether these biomarkers and genetic polymorphisms in BDNF and FKBP5 predict treatment response. Methods: A total of 114 female participants (mean age=57.5 y) were randomized to a group-based therapy delivered via videoconference (ACT or BATD, both a …

27.08.2026journal-article

International Journal of Clinical Oncology

Proteinuria as the cause of early dose modification in Japanese patients with metastatic colorectal cancer treated with fruquintinib: a multicenter real-world study

Shohei Udagawa, Chihiro Ishizuka, Hiroki Osumi, Toshiharu Hirose, Natsuko Okita, Hidekazu Hirano, Hirokazu Shoji, Ken Kato, Koichiro Yoshino, Keitaro Shimozaki, Shota Fukuoka, Takeru Wakatsuki, Mariko Ogura, Akira Ooki, Keisho Chin, Kensei Yamaguchi, Atsuo Takashima, Eiji Shinozaki

Abstract Background Fruquintinib has demonstrated survival benefits in patients with previously treated metastatic colorectal cancer (mCRC) in phase III trials. However, real-world data in Japanese patients remain limited. This study evaluated the effectiveness and safety of fruquintinib in routine clinical practice. Methods We conducted a retrospective observational study at two cancer centers. Patients treated with fruquintinib for mCRC between November 2024 and December 2025 were included. Clinical outcomes and …

27.08.2026journal-article

British Journal of Clinical Pharmacology

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi

Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered CBD+THC oil (12.5 mg + 12.5 mg), THC oil (12.5 mg) or placebo. Cardiovascular haemodynamics, respiratory muscle electromyography and peripheral tissue perfusion were ev …

27.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Reconceptualizing Cerebral Palsy as a Lifelong Condition Characterized by Systemic and Accelerated Biological Decline

Shannon R. Strader, Joline E. Brandenburg, Andrea A. Domenighetti

Cerebral palsy (CP), the most common childhood-onset disability worldwide, affects an estimated 50 million individuals globally. Although most individuals with CP are adults, CP education and training remain heavily concentrated within pediatric subspecialties, contributing to substantial gaps in adult care. At the same time, emerging evidence demonstrates that CP is associated with progressive multisystem, metabolic, musculoskeletal, and cellular changes across the lifespan, despite the original brain injury being …

27.08.2026journal-article

Clinical and Experimental Immunology

Prospective Association Between Leukocyte Telomere Length and Mortality: Findings from the Black Women’s Experiences Living with Lupus (BeWELL) Study

David H Chae, Connor D Martz, Amani M Nuru-Jeter, Tiffany Yip, Jue Lin, Eloisa Bonfá, Elissa S Epel, Kenneth Saag, Cristina Lanata, Sofia Nadgauda, Jesus Ramirez-Valles, Jinoos Yazdany

Abstract Leukocyte telomere length (LTL) is a biomarker of replicative history of cells and has been posited to be an indicator of biological aging. LTL may yield insight into immunomodulatory disorders, including systemic lupus erythematosus (SLE), an immune-mediated inflammatory disease that disproportionately affects Black/African American women. This study examined the association between LTL and mortality among 422 Black/African American women in the Black Women’s Experiences Living with Lupus (BeWELL) Study. …

27.08.2026journal-article

SN Comprehensive Clinical Medicine

Effects of Exercise Training on Muscle and Functional Outcomes in Adults with Liver Cirrhosis: A Systematic Review

Priscila Meireles Calil Fontana, Rafael dos Santos Souza, Manuella Franco Cerqueira da Silva, Anete da Costa Medeiros, Yamana Dias de Matos, Laisa Liane Paineiras-Domingos

Abstract Objective To evaluate the efficacy and safety of physical exercise on muscle mass, strength, and functional capacity in adult patients with pre-transplant liver cirrhosis. Methods This systematic review (PROSPERO: CRD420261279439) followed PRISMA guidelines. We searched six databases (PubMed, EMBASE, Cochrane, VHL, Scopus, SciELO) for randomized controlled trials (RCTs) evaluating exercise in cirrhotic patients. Risk of bias and certainty of evidence were assessed using RoB 2 and GRADE, respectively. Resul …

27.08.2026journal-article

Journal of Hospital Medicine

The association between sociodemographic and clinical factors and outcomes among inpatients with community‐acquired pneumonia

Farhana Islam, Surain B. Roberts, Sarah L. Malecki, Anne Loffler, Leo Hersi, Anthony D. Bai, Amol A. Verma, Fahad Razak, Peter J. Gill, Sanjay Mahant

Abstract Background Community‐acquired pneumonia (CAP) is a leading cause of hospitalization and mortality. The influence of sociodemographic characteristics on adverse outcomes in adults hospitalized with CAP remains poorly understood, particularly for patients younger than 65. Objectives To evaluate associations between baseline sociodemographic characteristics and a composite outcome of intensive care unit (ICU) admission or in‐hospital mortality, and whether these differed across age strata (18–39, 40–64, and ≥ …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

IL-18 in atherosclerosis: context-dependent biology, human evidence, and translational challenges

Dongshuai Zhang, Shuai Wang, Yang Li, Huijie Zhang, Bing Wang

Atherosclerosis is a chronic inflammatory disease shaped by interactions among vascular cells, innate immunity, adaptive immunity, and metabolic stress. Interleukin-18 (IL-18), an IL-1 superfamily cytokine activated predominantly downstream of inflammasomes, links vascular injury to type 1 immune responses. This structured narrative review integrates mechanistic, plaque-tissue, epidemiological, genetic, and therapeutic evidence for IL-18 in atherosclerosis. Experimental studies generally support pro-atherogenic act …

27.08.2026journal-article

Andrology

Penile Cutaneous Nerve Distribution Pattern: An Anatomical Study to Guide Penile Surgery

Junxi Wu, Fei Xu, Ji Zhang, Linhu Zhang, Shengbo Yang

ABSTRACT Background The overall distribution pattern of penile cutaneous nerves (PCNs) is critical for sexual function and penile surgeries but remains incompletely characterized. Objective To systematically elucidate the overall innervation pattern of PCNs and provide an anatomical basis for surgical practices. Methods PCNs origins were examined in 24 formalin‐fixed adult male cadavers (12 incompletely covered prepuces, 12 completely covered prepuces) through dissection. Modified Sihler's staining with clock‑point …

27.08.2026journal-article

Razi Medical Journal

Efficacy of Methotrexate Treatment in Women with Tubal Ectopic Pregnancy, University Hospital, Tripoli, Libya

Noura Elawam

The use of methotrexate for the treatment of women with tubal ectopic pregnancies is now common practice. However, the clinical and hormonal determinants of the success of this treatment are not known. Methods: We studied 120 women with tubal ectopic pregnancies who were treated with methotrexate intramuscularly according to a single-dose protocol. Pretreatment serum concentrations of human chorionic gonadotropin and progesterone, the size and volume of the gestational mass, fetal cardiac activity, and the presence …

27.08.2026journal-article

Neuro-Oncology

57 The role of the Clinical Nurse Specialist in neuro-oncology: Insights from a UK-wide review of adult brain tumour services (2020-2026)

Catharine James, Charlotte Robinson, Jillian Sokratous, Andrew Wright, Eloise Lines, Shona Floyd, Camille Goetz, Nicky Huskens

Abstract Introduction Clinical Nurse Specialists (CNSs) are central to coordinating complex neuro-oncology pathways, yet national data on capacity and roles are lacking. We aimed to examine variation in CNS capacity, team structure, responsibilities, and training across UK adult brain tumour services. Method Data were collected from 25 NHS neuro-oncology centres (covering more than 90% of the UK population) in 2020–2026 through the Tessa Jowell Centre of Excellence programme, supplemented by national patient experi …

27.08.2026journal-article

Clinical Journal of Health Sciences

Dialectical Behavior Therapy for Borderline Personality Disorder: A Systematic Review

Damla Rana Altunay, Meryem Karaaziz

There are numerous studies in the literature examining the effects of Dialectical Behavior Therapy (DBT) on patients with Borderline Personality Disorder (BPD). The aim of this systematic review is to synthesize studies on DBT and Borderline Personality Disorder to examine the effects of Dialectical Behavior Therapy on patients with BPD and to observe how differences in the treatment process and content influence patient outcomes. This study was conducted using a systematic review methodology and did not involve pr …

27.08.2026journal-article

Veterinary Sciences

Keyhole Limpet Hemocyanin-Based Multimodal Management in Two Dogs with Presumptive Urothelial Carcinoma: Long-Term Clinical and Imaging Follow-Up

Ji-hee Hong, Jihyun Kim, Kun-Ho Song

Canine urothelial carcinoma (UC) is commonly managed with non-steroidal anti-inflammatory drugs (NSAIDs), alone or combined with cytotoxic chemotherapy. Evidence supporting subcutaneous keyhole limpet hemocyanin (KLH) in canine UC is lacking. We describe two client-owned dogs with presumptive lower urinary tract UC managed with NSAIDs, KLH, and selenium after cytotoxic chemotherapy was declined. Case 1 was an 11-year-7-month-old castrated male Maltese with bladder-neck/proximal-urethral thickening. A positive veter …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Preoperative C-reactive protein and textbook outcome following pancreaticoduodenectomy for pancreatic head adenocarcinoma

Ugur Topal, Burak Aydogan, Yunus Kaycı, Ishak Aydin, Mevlut Harun Agca, Serdar Gumus, Ahmet Gökhan Saritas, Abdullah Ulku, Atilgan Tolga Akcam

BACKGROUND Textbook outcome (TO) captures an ideal postoperative course after pancreaticoduodenectomy (PD) and is increasingly used for surgical quality assessment. However, standardized TO-based data after PD from Türkiye remain limited, restricting comparison with international benchmarks. We hypothesized that preoperative systemic inflammation, reflected by C-reactive protein (CRP), would be associated with TO achievement after PD for pancreatic head adenocarcinoma. AIM To determine the TO achievement and preope …

27.08.2026journal-article

Journal of Clinical Immunology & Microbiology

Immune Memory Based Classification of Human Herd (IMCHH)

Ibrahim MS Shnawa

Individual and population/herd immunity are at most depend on the nature of effector cells on first encounter and immune memory cells on re-infection or boost vaccination. The present opinion paper tempts to suggest human herd classification on the bases of immune memory cell nature. The immune memory stratification starts as; baseline immune memory function, innate immune memory, infection induced memory, pre-existing and current immune memory and vaccine induced memory. Based on this stratification and in accorda …

27.08.2026journal-article

BMJ Supportive & Palliative Care

Cost-effectiveness analysis of fosaprepitant versus aprepitant-based antiemetic regimens in children receiving highly emetogenic chemotherapy: individual patient-level analysis of a randomised trial

Rahul Kumar, Manraj Singh Sra, Azgar Abdul Rasheed, Archana Sasi, Deepam Pushpam, Atul Batra, Shuvadeep Ganguly, Sameer Bakhshi

Objectives To assess the trial-based cost-effectiveness of an intravenous fosaprepitant-based antiemetic regimen compared with oral aprepitant, in combination with ondansetron and dexamethasone, among children receiving highly emetogenic chemotherapy in India and the USA using individual patient-level data. Methods Costs were estimated from a private payer perspective in India and the USA. Health outcomes were expressed as quality-adjusted life-years (QALYs). Incremental cost-utility ratio (ICUR) and incremental ne …

27.08.2026journal-article

Brain

Could NQO1 genotypes impact the results of clinical trials with idebenone?

Valerio Carelli, Martina Romagnoli, Filippo Fortuna, Claudio Fiorini, Leonardo Caporali, Thomas Klopstock, Chiara La Morgia, Anna Maria Ghelli

Carelli et al. argue that new insights into how NQO1 influences the response to idebenone warrant reevaluating the results of previous clinical trials, including those in Friedreich ataxia and Duchenne muscular dystrophy, using patient stratification by NQO1 genotype.