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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Visualization in Medicine

Лучевая диагностика аневризмы верхней брыжеечной артерии. Клинический случай

Вероника Сергеевна Передереева, Борис Львович Севрюгов, Алексей Анатольевич Денисов, Дмитрий Леонидович Дубицкий, Кирилл Владимирович Игнашев

Аневризмы брюшного отдела аорты и ее висцеральных ветвей в детском возрасте — редкая патология, чаще всего ассоциированная с группой наследственных заболеваний (например, синдром Марфана, синдром Элерса–Данлоса, синдром Лоеса–Дитца), когда присутствуют мутации в генах, отвечающих за синтез коллагена или других белков, ответственных за формирование соединительной ткани. Клинические проявления долгое время могут оставаться незамеченными из за отсутствия характерных признаков и индивидуальных особенностей в каждом кон …

27.08.2026journal-article

Orphanet Journal of Rare Diseases

The undiagnosed rare disease clinic program of Indiana University School of Medicine: lessons learned from the first 100 cases enrolled (Phase-I pilot)

Khurram Liaqat, Rachel Hart, Marco Abreu, Kevin Booth, Amy Breman, Yann Gibert, Brett H. Graham, Benjamin M. Helm, Reynold C. Ly, Lili Mantcheva, Tae-Hwi L. Schwantes-An, Marwan K. Tayeh, Kayla Treat, Stephanie M. Ware, Leah Wetherill, Francesco Vetrini, Erin Conboy

Abstract Background The Undiagnosed Rare Disease Clinic (URDC) of Indiana University, established in January 2020, is a multidisciplinary collaborative clinic that focuses on providing genetic diagnoses for patients and families dealing with the uncertainty of an undiagnosed rare disease and/or diagnostic odyssey. Methods To identify rare disease-causing variants underlying the suspected undiagnosed genetic conditions in our patient cohort, the URDC team implemented the following procedure. After sequencing, each c …

27.08.2026journal-article

The Egyptian Journal of Internal Medicine

Clinicopathological evaluation of crescentic glomerulonephritis: a retrospective single-center study

Ahmet Dogukan Kansu, Murvet Yilmaz

Abstract Aim Crescentic glomerulonephritis (GN) represents a group of diseases characterized by rapid and severe kidney damage within weeks or months. This study aimed to evaluate the demographic, laboratory, histopathological features, treatment approaches, and renal survival of patients with crescentic GN followed in a nephrology clinic. Materials and methods Eighty patients with crescentic glomeruli identified on kidney biopsy were retrospectively analyzed. Five patients were excluded due to transplantation biop …

27.08.2026journal-article

Medicine Bulletin

Identification of Predictive Signatures for Osimertinib‐Associated Interstitial Lung Disease: Integrating Ensemble Machine Learning and Temporal Dynamics

Yilin Ye, Lianxin Zhu, Yunxiang Xie, Peng Sun, Cui Chen, Zhihua Zhu

ABSTRACT The shift toward chronic management of EGFR‐mutant lung cancer underscores the urgent need to identify molecular features potentially relevant to osimertinib‐associated interstitial lung disease (ILD). This study aimed to investigate candidate molecular mechanisms of this toxicity by integrating putative osimertinib target profiles with ILD‐associated transcriptomic networks. To prioritize high‐confidence candidate features and improve cross‐algorithm robustness, we implemented an ensemble machine learning …

27.08.2026journal-article

Frontiers in Surgery

Trauma-related postoperative redisplacement after tension-band fixation for patellar fracture in Parkinson's disease: a case report and focused literature review

Shaowei Sun, Zhixiang Gao, Longyun Li, Lifu Wang, Cong Xiao

Rationale Patellar fractures in patients with Parkinson's disease (PD) are rarely reported, and evidence regarding optimal fixation and postoperative management remains limited. In this population, recurrent falls, abnormal muscle tone, and impaired bone quality may increase the risk of treatment failure. Patient concerns A 78-year-old man with long-standing PD presented with a patellar fracture after a low-energy fall and subsequently developed trauma-related postoperative redisplacement after a recurrent fall fol …

27.08.2026journal-article

Frontiers in Oncology

Hypothermia and recovery outcomes before and after implementation of a multimodal perioperative temperature-management bundle in minimally invasive radical rectal cancer surgery

Qian Liu, Ling Liu, Chenxi Han, Chunmei Cao, Jiefang Ji, Aihua Zhu

Background Inadvertent perioperative hypothermia is common during minimally invasive rectal cancer surgery. We assessed whether a five-component multimodal temperature-management bundle was associated with improved perioperative outcomes. Methods This single-center retrospective before-and-after study included 247 adults undergoing laparoscopic or robot-assisted radical rectal cancer surgery from 2021 to 2025 (pre-implementation, n = 123; post-implementation, n = 124). The primary outcome was any intraoperative nas …

27.08.2026journal-article

Pedagogical Review

Методологические аспекты диагностики взаимосвязи прокрастинации и стресса среди студентов: обоснование и использование комплексного подхода

Ксения Сергеевна Шалагинова, Арина Евгеньевна Бодрова, Александр Павлович Саратов

Исследуются методологические аспекты диагностики взаимосвязи прокрастинации и стресса у студентов. Обосновывается необходимость применения комплексного психодиагностического подхода, учитывающего многомерность данных феноменов. Прокрастинация рассматривается не только как поведенческий сбой, но и как дезадаптивная копинг-стратегия, связанная с эмоциональным избеганием. Стресс понимается в рамках когнитивно-транзакционной модели Р. Лазаруса. В исследовании использованы три стандартизированные методики: Шкала прокрас …

27.08.2026journal-article

Breastfeeding Medicine

Association Between Nipple Length and Early Breastfeeding Success in Postpartum Women: A Descriptive Correlational Study

Zeynem Yildirim Balkan, Serap Özdemir, Serap Balci

Background: Breastfeeding is essential for improving newborn health and maternal-infant bonding. Objectives: To examine the association between nipple length and early breastfeeding success assessed using the LATCH score in postpartum women. Methods: This descriptive correlational study was conducted in the delivery room and obstetric clinic of a university hospital. The researchers aimed to include the entire eligible population without performing sample size calculations. A total of 335 mother-infant pairs were e …

27.08.2026journal-article

Journal of Intensive Care Medicine

Modern Approaches to the Treatment of Respiratory Distress Syndrome in Children: The Role of Surfactant and Antenatal Prophylaxis

Aisuluu Omurzakova, Venera Azhikulova, Mairamkan Sharipova, Nargiza Kurbanova, Gulnura Zhunusbaeva

Background and Objective The aim of the study was to evaluate the multilevel impact of antenatal prophylaxis and modern non-invasive respiratory strategies on the course and outcomes of respiratory distress syndrome in new-borns. Methods A total of 4080 hospitalisations of preterm and full-term infants with confirmed respiratory failure, born between 1 January 2017 and 30 September 2024, who received care at the Osh Regional Clinical Maternity Hospital (Kyrgyzstan), were included in the retrospective cohort registr …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Meta-analysis of surgical quality-related factors associated with local recurrence rate after rectal cancer surgery

Jin-Kai Wang, Chang-Tao Yu, Bai-Xue Qin, Hua-Bin Cheng

BACKGROUND Despite treatment advances, rectal cancer continues to pose a considerable global health burden, and local recurrence remains an important driver of long-term outcomes. Despite the evolution of surgical technique and multimodal therapy, local recurrence rates (LRRs) remain heterogeneous across institutions, thought to be related to differences in surgical quality. Local recurrence risk has been associated with several surgical quality indicators such as circumferential resection margin (CRM) involvement, …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Implementing the IMB model combined with rehabilitation nursing to promote rehabilitation and self-management in coronary heart disease patients

Jinjin Gong, Xinmei Zhang

Objective To examine the association between routine Information-Motivation-Behavioral Skills (IMB) model-based rehabilitation nursing and rehabilitation-related outcomes and self-management behaviors in patients with coronary heart disease (CHD). Methods This single-center retrospective cohort study included 150 patients with CHD admitted to Shandong Provincial Third Hospital from January 2024 to February 2025. After ethics approval, data were extracted from existing clinical and nursing records. Patients were ret …

27.08.2026journal-article

International Journal of Population Data Science

The Need for Fully-Effective Federated Analytics of Data Sources for Clinical Trials

Stella Maris Fabiane, Sharon B. Love, David Fisher, Ian R. White, Jayne F. Tierney, Catherine Dampney, Folkert W. Asselbergs, Philip R. Quinlan, Macey L. Murray, Matthew R. Sydes

IntroductionClinical trials are usually analysed in a single environment allowing for flexible analysis including adjustment or stratification by subgroup: `one-stage' analysis of individual-level data. Health systems datasets, often distributed across geography and providers, can streamline clinical trials. Data are increasingly accessible in secure data environments (SDEs). Future trial analyses may involve working across multiple SDEs. Row-level data and identifiable data often cannot leave, requiring a `two-sta …

27.08.2026journal-article

American Journal of Veterinary Research

Clinical presentation, diagnosis, and treatment of caudal mediastinal paraesophageal abscesses in dogs: a multi-institutional retrospective study

Kathryn Biehl, Rachel W. Williams, Emily Orr, Kelley Thieman Mankin, Hunter Piegols, Jordyn Blew, David E. Holt, Francesca P. Solari, Federico R. Vilaplana Grosso

Abstract Objective To describe the clinical presentation, diagnostic findings, management, and short- and long-term outcomes of dogs with caudal mediastinal paraesophageal abscesses (CMPA) in a multi-institutional retrospective cohort. Animals 12 client-owned dogs with CMPA confirmed on CT and/or surgery. Clinical Presentation The most common presenting complaints were inappetence and lethargy. Tachypnea and dyspnea were frequent physical examination findings at presentation. Results All 12 dogs underwent CT. The C …

27.08.2026journal-article

JAMA Otolaryngology–Head & Neck Surgery

Unilateral and Bilateral Hearing Aids for Age-Related Hearing Loss

Sherri L. Smith, Todd A. Ricketts, Kayla W. Kilpatrick, Rebecca North, Janet P. Bettger, Theresa Coles, Shari Eberts, Sarah B. Peskoe, Howard W. Francis, Heather Toth, William Dillon, Laura Thompson, Kjersten Branscome, Amy Walker, Frank W. Rockhold

Importance Age-related hearing loss (ARHL) is ubiquitous and is characterized as bilateral symmetrical sensorineural and mild to moderate in degree. When left untreated, significant impacts arise in domains including communication, psychosocial, cognitive and physical health. Data demonstrating the effectiveness of unilateral or bilateral hearing aids (HAs) as the standard treatment are lacking. Objective To determine whether bilateral HAs provide more benefit compared with a unilateral HA. Design, Setting, and Par …

27.08.2026journal-article

Plastic & Reconstructive Surgery

Non-embolic complications of gluteal fat transfer: A systematic review of the literature.

Rodrigo Domínguez-Millán, Alfredo Hoyos, Lázaro Cárdenas-Camarena, Alexandra Condé Green, Jesús Cuenca-Pardo, Fabián A. Gutiérrez Valle, Mauricio E. Perez

Background: Gluteal fat grafting is a key component of aesthetic body contour surgery and ranks among the most frequently performed cosmetic procedures worldwide. While thromboembolic complications, such as fat embolism, dominate the literature due to their severe and often fatal outcomes, non-embolic complications have received less attention and standardization. These include infections, fat cysts, sciatic nerve injuries, and fat necrosis, which, despite being less severe, can significantly impact patient outcome …

27.08.2026journal-article

British Journal of Clinical Pharmacology

New therapeutic options for metabolic‐associated steatotic liver disease

Tessa Straatmijer, Midas Mulder

An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and malignancies. The pathogenesis of MASLD stems from a multifactorial interaction among genetic susceptibility, epigenetic modifications and environmental factors, which collecti …

27.08.2026journal-article

Neuro-Oncology

129 Electroactive drug delivery for local glioblastoma treatment

Joshua Killilea, Immi Van Der Auweraert, Gary Shaw, Harveena Padda, Holly Briggs, Une Kontrimaite, Leire Landeira Suquia, Rosalie De Ferm, Lucia Moreno Gimeno, Phoebe McCrorie, Estelle Cuttaz, Aaron Lee, Giovanni Carlo Miceli, Stuart Smith, Dong-Hyun Kim, Ruman Rahman, Juanita Lopez, Roberto Portillo Lara, Josef Goding, Heiko Wurdak, Ryan Mathew, Christopher Chapman, Rylie Green

Abstract Introduction Despite recent advances in cancer therapeutics, the prognosis for glioblastoma remains exceptionally poor, stemming from the limited ability of systemically administered chemotherapeutics to cross the blood brain barrier (BBB). Mechanically circumventing the BBB represents a promising avenue. However, biomaterials previously used for local delivery suffer from low control over drug release, further limiting their translation. To address this, an implantable bioelectronic drug delivery device w …

27.08.2026journal-article

Bioengineering

Post-MI Remodeling Mechanics of Left Ventricle: Microstructure-Informed Models, Identifiability, and Uncertainty for Patient-Specific Prediction

Thanyani Pandelani, Fulufhelo Nemavhola

Background: Myocardial infarction (MI) causes spatially heterogeneous loss of contractility and progressive extracellular matrix remodeling, altering left ventricular mechanics from the acute phase through chronic remodeling. This review integrates current understanding of infarct, border-zone, and remote-myocardial microstructure with organ-scale mechanics and patient-specific computational modeling. Methods: A narrative review and perspective were conducted using the literature identified through PubMed/MEDLINE, …

27.08.2026journal-article

Infection Control & Hospital Epidemiology

Impact of a single-set blood culture restriction during the 2024 national blood culture bottle shortage on patient outcomes: an interrupted time series analysis

Joseph B. Ladines-Lim, Bailey Van, Leigh Cressman, Warren B. Bilker, Laurel Glaser, Kathleen Degnan, Michael Z. David

Abstract Objective: To evaluate the clinical and stewardship consequences of a single-set blood culture restriction implemented during the 2024 national blood culture bottle shortage. Design: Interrupted time series analysis of hospitalizations from June 26, 2023, to June 25, 2025. Setting: Two tertiary hospitals in an urban academic health system. Patients: 116,341 inpatient hospitalizations, including 31,034 with ≥1 blood culture obtained. Intervention: A systemwide electronic health record order restriction from …

27.08.2026journal-article

Scientific Reports

Non-invasive detection of obstructive sleep apnea from speech in a limited clinical dataset

Martina Skapova, Pavol Partila, Jaromir Tovarek, Tereza Lubojacka, Jana Slonkova, Ondrej Hruby, Samuel Genzor, Jan Mizera, Petr Mooz

Abstract This study investigates non-invasive detection of obstructive sleep apnea (OSA) from daytime speech in a limited polysomnography-labeled clinical cohort. The objective was to evaluate whether speaker-verification-inspired representations can support robust speech-based OSA screening under constrained clinical data conditions. We compared conventional mel-frequency cepstral coefficient (MFCC)-based classifiers with i-vector systems using cosine-similarity, support vector machine (SVM), and neural-network (N …

27.08.2026journal-article

Frontiers in Immunology

Agonistic anti-CD40 antibodies in patients with solid tumors: a systematic review and evidence map of clinical safety, with exploratory proportional synthesis

Xinrui Yin, Shijia Du

Background Agonistic anti-CD40 antibodies and related CD40 agonist biologics are being developed across multiple solid tumors using diverse biologic formats, delivery routes, and combination regimens. Safety is central to their clinical development but remains difficult to interpret because high-grade adverse events in combination settings may reflect partner therapies, and safety outcomes are reported inconsistently. Methods We conducted a systematic review and evidence map of the clinical safety of CD40 agonists …

27.08.2026journal-article

Journal of Law, Medicine & Ethics

America First Bilateral Health Agreements Threaten to Undermine the Multilateral Global Health Order

Sharifah Sekalala, Shajoe J. Lake, Allan Maleche, Maria Birungi, Frank Ssekamwa

Abstract During the second Trump administration, the United States has signed bilateral health agreements with at least 27 states across Africa and Latin America, reshaping how signatory countries finance, regulate, and monitor their health systems. Grounded in the America First Global Health Strategy, these agreements are being signed as US withdrawal from WHO restructures global health. This column explores how this turn to bilateralism risks weakening multilateral legal obligations on capacity development, acces …