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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
16.08.2026journal-article

Macromolecular Symposia

The Mammalian Target of Rapamycin(mTOR) Signaling Pathway and mTOR Inhibitors in Cancer Therapy

Sony Devassy, Mridula Sreedharan, Saju Joseph, Sulekha K M, Abhay Raju, Sabu Thomas

ABSTRACT The mammalian target of rapamycin (mTOR) serine/threonine protein kinase known to be an important regulator of cellular growth, protein translation, cell proliferation, cell survival, metabolism, and autophagy. It is known to be activated by intracellular as well as extracellular signals, such as nutrient availability, growth factors, and energy levels of cells. The frequent deregulation of mTOR signaling in over 30% of malignancies makes it a promising key target for cancer therapy. Many mTOR inhibitors h …

16.08.2026journal-article

Journal of Medical Rehabilitation

Evolution of quality of life concepts and changes in their assessment in medical rehabilitation

Т. V. Konchugova, V. V. Ivanova, L. N. Sandzhieva

The assessment of a patient’s quality of life (QoL) is an integral part of personalized treatment and rehabilitation programs. Although this method of assessing health status has been widely used, the past 10 years have seen prerequisites emerge for transforming this group of tools. This study reviews the evolution of concepts regarding patient QoL and changes in approaches to its assessment. Various methods are presented, ranging from questionnaires focused on social well-being to forms and scales used in routine …

16.08.2026journal-article

Journal of Medical Rehabilitation

Analysis of rehabilitation needs in patients with dementia in Russia

М. V. Ipatova, Yu. А. Pokrovsky, Т. А. Solokhina

Background. Dementia is one of the leading causes of disability among older adults that requires significant rehabilitation services. In Russia, the population aging is expected to increase the number of people with dementia and associated functional limitations. However, rehabilitation needs for this condition have not been quantitatively assessed. Objective: To estimate the magnitude and trends in rehabilitation need of people with Alzheimer's disease and other dementias in Russia. Material and methods. A seconda …

16.08.2026journal-article

Journal Of Babylon Center for Humanities Studies

أفعال الكلام وتجلياتها في ديوان (هكذا أُنَقِّبُ) للشاعر كرم الأعرجي _دراسة تداولية_

عمر خضر محيميد

الملخَّص: يهدف هذا البحث إلى الكشف عن أفعال الكلام التي مثَّلت مقاصد الشاعر وغاياته في ديوان (هكذا أنقِّب), فهي رسائل بثَّها الشاعر إلى المتلقي؛ ليجعله مشاركا له في تجاربه ومشاعره بلغة إبداعية تميل إلى الرمزية تارة وإلى كسر أفق التوقع تارة أخرى، ولما كانت نظرية أفعال الكلام تعنى بدراسة اللغة في استعمالاتها المختلفة مبدية عناية كبيرة بسياقي المقال والمقام والعرف الاجتماعي ومقاصد المتكلمين, فقد اخترت أن تكون وسيلتي للكشف عن مقاصد الشاعر وأفعال الكلام التي أنجزها في ديوانه. وقد اشتمل البحث على مبحثين يسبقهما تمهيد وتل …

16.08.2026journal-article

Journal of Drug Delivery and Therapeutics

An Overview of Mechanisms and Clinical Applications of Wet cupping therapy (Ḥijāma-bil-Sharṭ): A Comprehensive Review

Sadaf Nawaz, Mohd Anwar, Fatima Khan

Background: Wet cupping therapy (WCT), also known as Ḥijāma-bil-Sharṭ, is a traditional therapeutic modality widely practiced in complementary and alternative medicine. In recent years, increasing scientific interest has focused on elucidating its physiological mechanisms and evaluating its clinical efficacy across various health conditions. Objective: To provide a comprehensive review of the historical evolution, underlying mechanisms, and therapeutic applications of wet cupping therapy, integrating traditional co …

16.08.2026journal-article

Journal of Medical Rehabilitation

Multimodal approach to managing patients with myofascial pain syndrome

D. F. Khritinin

Myofascial pain syndrome (MPS) is a common disorder involving localized or referred pain that originates from trigger points in muscles and fascia. In many cases, its treatment is either inappropriate or delayed, leading to a reduced quality of life for patients. This is due to incomplete comprehension of the mechanisms underlying myofascial pain, the lack of uniform diagnostic criteria, and the absence of standard treatment protocols. This review aims to summarize, systematize, and evaluate the available data on t …

16.08.2026journal-article

Advanced Healthcare Materials

Spatial Transcriptomics‐Inspired Targeted Hydrogel for Dental Pulp Therapy via Strengthen Macrophage Communication

Mingmei Yang, Houwang Lai, Fan Wu, Wenji Luo, Peimeng Zhan, Zhengmei Lin, Zongshan Shen, Lingling Chen

ABSTRACT Tissue repair depends on how inflammatory cues drive regenerative cell‐state transitions; a process poorly understood in human tissues. Human dental pulp provides an accessible, structurally well‐defined injury model with robust clinical responses, facilitating in situ investigations of inflammatory signaling and endogenous regeneration. Here, we integrated high‐resolution spatial transcriptomics with single‐cell RNA sequencing (scRNA‐seq) to chart its cellular ecosystem in health and caries. We resolved f …

16.08.2026journal-article

Psychology and Education: A Multidisciplinary Journal

Teaching Practices, Occupational Stress, and Coaching Competence of Teacher-Coaches in Western Visayas

Andrea Audine Bulquerin

This study determined the levels of teaching practices, occupational stress, and coaching competence of public secondary school teacher-coaches in Western Visayas during the School Year 2025–2026. It assessed teaching practices in instructional planning, classroom management, instructional strategies, and assessment and feedback; occupational stress in workload demands, role conflict, time pressure, and organizational support; and coaching competence in technical and tactical knowledge, training design and planning …

16.08.2026journal-article

International Journal For Multidisciplinary Research

Determinants of Sustained Antiretroviral Therapy Adherence and Behavioral Predictors Among Adults Living with HIV in Eastern Rwanda: Evidence from Kibungo Referral Hospital

Mukezamfura Phocas, Amos Habimana -

Consistent use of antiretroviral therapy (ART) is essential for achieving viral suppression, enhancing well-being, and lowering illness and death among individuals living with HIV. Although Rwanda has made significant strides toward meeting the UNAIDS 95-95-95 goals by providing universal access to free ART, gaps in adherence still hinder optimal treatment outcomes in certain groups. Exploring the behavioral, psychological, and health system-related factors that influence adherence is crucial for developing effecti …

16.08.2026journal-article

Human Gene Therapy

Durational Study of Persistent Transduction of Rhesus Macaque Lung and Other Organs Following Single Dosing with AAV1-CFTR

Prajita Paul, Tanvi Sharma, Masoud Afshani, Amanda Maxwell, Abhishek Sharma, William B. Guggino, Liudmila Cebotaru

Adeno-associated virus (AAV)–mediated gene transfer remains a promising strategy for cystic fibrosis (CF), but durability of expression and optimal dosing intervals are unresolved challenges. Here, we evaluated long-term gene transfer, transduction, and immunological responses following a single pulmonary administration of an AAV1 vector encoding Δ27–264 CFTR to juvenile rhesus macaques. Four animals received 1 × 10 1 ³ vector genomes via endotracheal spray. Two were untreated. All were analyzed 180 days post-deliv …

16.08.2026journal-article

Animals

Preparing Therapy Dogs for Animal-Assisted Services: Governance, Welfare-Centred Preparation, and a Lifecycle Research Agenda Across Selected European and United States Frameworks

Muhzina Shajid Pyari, Kun Guo, Niko Kargas

Dog-assisted services are employed in healthcare, educational, social-care, and community settings, yet systems for preparing and protecting therapy dogs remain unevenly developed. This narrative review synthesises empirical, conceptual, and governance literature on therapy dog preparation in selected European contexts and the United States. Searches were conducted across academic databases, specialist repositories, and grey-literature sources, with evidence organised thematically around governance, candidate selec …

16.08.2026journal-article

Acta Medica Alanya

The Effect of SGLT2 Inhibitors on Antianginal Therapy Dynamics in Diabetic CABG Patients

Fahri Çakan, Ali Çoner, Ertan Akbay, Can Öncel, Cemal Köseoğlu

Aim: Although SGLT2 inhibitors offer cardiovascular benefits in type 2 diabetes, their impact on antianginal therapy needs after CABG remains unclear. This study investigates the potential association between SGLT2i use and alterations in the frequency and intensity of antianginal regimens in these patients.Methods: This retrospective study included 125 diabetic patients ≥1 year post-CABG, divided into SGLT2i users (n=70) and non-users (n=55). Demographic characteristics, laboratory findings, comorbidities, and ant …

16.08.2026journal-article

Annals of General Psychiatry

Bidirectional association between thyroid dysfunction and depressive symptoms: the role of levothyroxine therapy and shared molecular mechanisms

Han-xin Fu, Jia-xin Wang, Bin Qian, Xin Zhang, Lin-lin Hu

Abstract Background The association between thyroid dysfunction, thyroid hormone replacement therapy, and depression remains inconsistent. This study investigated the bidirectional risk association between thyroid dysfunction and depressive symptoms, focusing on the effect of thyroid hormone therapy on depressive symptoms, and exploring the shared molecular basis between hypothyroidism treated with levothyroxine and depression at the genetic level. Methods Part one utilized 2007–2012 National Health and Nutrition E …

16.08.2026journal-article

Lupus

Disseminated Nocardia pseudobrasiliensis infection in a case of juvenile systemic lupus erythematosus on immunosuppressive therapy

Kaustav Bhowmick, Angan Karmakar, Dipendranath Ghosh, Geetabali Sircar, Parasar Ghosh

Nocardiosis is an uncommon infection that presents as a chronic, debilitating illness with radiographic manifestations simulating lung cancer or tuberculosis. Immunocompromised hosts may develop a fulminant disease resembling acute bacterial pneumonia or disseminated disease. We report a case of a juvenile lupus who developed disseminated Nocardia pseudobrasilienisis infection in form of necrotizing pneumonia, subcutaneous nodules and central nervous system (CNS) lesion in the right parietal lobe, following inadver …

16.08.2026journal-article

Journal of Clinical Medicine

Patient-Reported Health-Related Quality of Life in Romanian Patients with Cystic Fibrosis in the Era of Highly Effective CFTR Modulator Therapy: A National Cross-Sectional Mixed-Methods Survey

Cristian Phillip Marinău, Cristian Sava, Alin Iuhas, Ioana Mihaiela Ciucă, Liviu Laurențiu Pop, Mihai Craiu, Zsolt Futaki, Ariana Szilagyi, Alexandru Jurca, Claudia Maria Jurca

Background/Objectives: Highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy has changed cystic fibrosis (CF) care, but Romanian patient-reported health-related quality of life (HRQoL) data remain limited. This national cross-sectional mixed-methods survey aimed to describe patient- and parent-reported HRQoL in Romanian people with CF (pwCF) aged ≥6 years using age-appropriate Cystic Fibrosis Questionnaire-Revised (CFQ-R) versions, with the respiratory domain as the primary o …

16.08.2026journal-article

International Journal of Education and Humanities

Research on Data Augmentation and Deep Learning Algorithms for Speech Emotion Computing

Kaiyu Guo, Yungang Wei

Speech is the most natural human interaction medium, which contains both linguistic semantic information and numerous non-semantic linguistic characteristics such as emotion, attitude and mood, making it a core research object in the fields of computational linguistics and human-computer interaction. Speech emotion computing aims to explore emotional features embedded in speech signals through computer algorithms to realize automatic recognition and classification of human emotions. It is an interdisciplinary resea …

16.08.2026journal-article

Journal of Medical Rehabilitation

Early postoperative complications after extensive surgery for pelvic malignant neoplasms: prevention and nonsurgical correction

V. А. Korotkov, L. S. Mkrtchian, I. N. Kuleshov, М. R. Kasymov, Е. А. Volicheva, G. Kh. Grigorian, Zh. V. Khailova, А. А. Nevolskikh, S. А. Ivanov, А. D. Kaprin

Contemporary surgical procedures are increasingly becoming more complicated and extensive, often requiring the removal of large volumes of tissue and resulting in significant changes to the patient's internal anatomy. Due to the advancements in anesthesia care, these operations can be performed successfully with a low risk of severe intraoperative complications. However, the postoperative period can pose some risks, including seromas, gastrointestinal motility disorders, wound suppuration and dehiscence. While not …

16.08.2026journal-article

Indonesian Journal of Health Science

Physiotherapy management and therapeutic exercise in drop hand due to radial nerve palsy after orif of humeral fracture: A case report

Yunita Andita Putri, Aleyda Asy Syifa, Ardhia Pramesti Amalia

Background: Postoperative radial nerve palsy after Open Reduction Internal Fixation (ORIF) of a humeral shaft fracture may cause wrist drop, sensory disturbance, weakness of the wrist extensors, and limitations in upper-extremity activities. Physiotherapy is intended to reduce secondary impairments, maintain joint mobility, and support function during nerve recovery. Objective: This case report aimed to evaluate clinical changes following physiotherapy management in a patient with wrist drop due to postoperative ra …

16.08.2026journal-article

Journal of Medical Rehabilitation

Сonceptual model and system of performance indicators for medical rehabilitation in the Russian Federation

D. V. Blinov, A. G. Solopova, E. V. Gameeva, A. M. Stepanova, O. A. Obukhova, B. E. Gornyy

Background. Although regulatory requirements for assessing the efficiency of medical rehabilitation have been established in the Russian Federation, a unified, conceptually structured system of indicators consistent with international frameworks still needs to be developed. Due to the disparity of indicators across departments, regional data become difficult to compare and further integrate into international monitoring. Objective: To develop a conceptual model and matrix of basic indicators that evaluate the perfo …

16.08.2026journal-article

Psychogeriatrics

Efficacy and Safety of Electroconvulsive Therapy for Dementia With Lewy Bodies, Its Prodromal Phase, and Parkinson's Disease Dementia: Eight Cases Encountered at Our Institution

Takahide Fukatsu, Kouhei Fujita, Taro Yoshida, Mihoko Kawai, Jun Miyata

ABSTRACT Purpose This study aimed to assess the efficacy and safety of electroconvulsive therapy (ECT) for treating psychiatric symptoms and parkinsonism in patients affected by dementia with Lewy bodies (DLB), its prodromal phase, and Parkinson's disease dementia (PDD). Methods We retrospectively reviewed eight patients (four males, four females; mean age 71.5 ± 8.9 years) diagnosed with probable DLB or its prodromal phase, based on diagnostic criteria, who underwent ECT between January 2020 and December 2025. The …

16.08.2026journal-article

The International Journal of Medical Science and Health Research

A Comprehensive Systematic Review of the Role of Semaglutide Anti-Obesity Therapy in Multiple Metabolic Diseases: A Systematic Review of Randomized Controlled Trials and Primary Studies

Jeffy Marta

Introduction: Obesity constitutes the pathophysiological hub of interconnected metabolic diseases including type 2 diabetes mellitus (T2DM), atherosclerotic cardiovascular disease (ASCVD), heart failure with preserved ejection fraction (HFpEF), chronic kidney disease (CKD), metabolic dysfunction-associated steatohepatitis (MASH) and peripheral artery disease (PAD). Semaglutide, a long-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA), has been evaluated across all these domains. This systematic review synt …

16.08.2026journal-article

Journal Of Babylon Center for Humanities Studies

خطاب الكراهية في الفضاء الرقمي وأثره في السلم المجتمعي

رقيب محمد جاسم, فنار طارق ياسين

يَحمل خطاب الكراهية مدلولاتٍ سلبية، تمخّضت عنه رسائل محرّضة على العنف وبث التفرقة، والتمييز ضد عرقٍ معين أو مجموعةٍ ثقافية أو دينية. وقد تصاعدت لهجة هذا الخطاب في الفضاء الرقمي، من خلال ما تبثّه بعض الجهات والأفراد عبر المنصّات الرقمية من مضامين قائمة على التحّريض والتميّز. لقد أضحى خطاب الكراهية في الفضاء الرقمي ظاهرة تستدعي الدراسة، لأنها خلقت ثقافة تقبّل الكراهية والتشهير والتنمّر الذي يتطلب تضافر كل الجهود لمواجهتها، فضلاً عن عدم وجود تعريفٍ دولي موحّد لها، مما أدى الى ظهور تناقضاتٍ عدة في التطبيق القانوني له ن …

16.08.2026journal-article

Current Issues in Molecular Biology

Antiseizure Medications in Development: Novel Mechanisms, Precision Therapy, and the Move Towards Disease Modification

William Alves Martins

Background: Despite more than 30 licenced antiseizure medications (ASMs), approximately one third of people with epilepsy remain drug-resistant, and developmental and epileptic encephalopathies represent one of the greatest unmet needs in epilepsy therapeutics. The past decade has produced a substantial reorientation of ASM discovery, driven by epilepsy genetics, new disease models, advances in drug screening, and innovative therapeutic modalities. Objective: The objective of this study was to review the contempora …

16.08.2026journal-article

Journal of Drug Delivery and Therapeutics

An Observational and Comparative Study of Cardiovascular Drug: Chlorthalidone and Hydrochlorothiazide the First Line Drug Therapy of Hypertension

Ishika Roy, Abhishek Prasad

Background: Hypertension is when the pressure in blood pressure vessels is too high. The heart has to work harder to pump blood. Hypertension also known as silent killer. There are 2 types of hypertensions each has a different cause. It causes complications such as heart attack or stroke heart failure, kidney problems, metabolic syndrome, etc. The risk of hypertension increases with age. Smoking and alcohol consumption also raises blood pressure. Objective: The present investigation to observe and compare cardiovas …