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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale

18 | Active breaks for health promotion in the classroom: the experience of I.C. “Abba Alighieri”

A. Li Puma, A. Di Benedetto, E. Modica, G. Ripoli, D. Lipari, B. Ferrante, F. Di Marco, A. Firenze

Background. Physical activity represents one of the main determinants of health and contributes significantly to the psychophysical well-being of the individual. Data from the "OKKIO alla Salute" surveillance system highlight a high prevalence of excess weight among Sicilian children, which is also associated with the prolonged use of smartphones and devices. Active breaks are an educational strategy designed to reduce sedentary behavior and promote psychophysical and relational well-being, thereby improving health …

28.08.2026journal-article

Journal of Clinical Medicine

From Trial to Chronic Epidural Electrical Stimulation: A Single-Patient Feasibility Study in Motor-Complete Spinal Cord Injury

Alena Militskova, Elvira Mukhametova, Artur Biktimirov, Vyacheslav Andrianov, Elena Yakovleva, Dinara Silantyeva, Igor Lavrov

Background/Objectives: Epidural electrical stimulation (EES) is a valuable intervention for motor recovery after spinal cord injury (SCI). However, evaluating expected outcomes can be challenging due to the difficulty of assessing residual functional connectivity and other key factors underlying the effects of EES. This case study investigates EES with two 8-contact percutaneous electrodes (Perc-EESs) as a prognostic tool and therapeutic bridge for chronic neuromodulation with EES in an individual with clinically m …

28.08.2026journal-article

Journal of Clinical Medicine

Impact of Sugammadex on Clinical and Patient-Centered Outcomes: Beyond Neuromuscular Recovery

Ji-Yoon Jung, Tae-Yun Sung

Background: Residual neuromuscular blockade remains an important contributor to postoperative morbidity. Sugammadex provides rapid and predictable reversal of rocuronium- and vecuronium-induced blockade and reduces residual neuromuscular blockade more effectively than conventional anticholinesterase-based reversal. Methods: This structured narrative review was informed by searches of PubMed/MEDLINE and the Cochrane Library from database inception to 20 August 2026. Reference lists of relevant guidelines, systematic …

28.08.2026journal-article

Animal Health and Biosafety

<b>SHOTGUN METAGENOMIC SEQUENCING FOR THE CHARACTERIZATION OF BACTERIAL COMMUNITIES ASSOCIATED WITH GAMMARUS LACUSTRIS FROM FRESHWATER ECOSYSTEMS IN KAZAKHSTAN</b>

S. Suleymenova, M. Kumar, S. Nuralibekov, T. Sabyrzhan, Ye. Kassymbekov, M. Yessentureyeva, K. Isbekov, S. Assylbekova, V. Fefelov, B. Pangereyev, A. Kydyrmanov

Bacterial communities associated with the freshwater amphipod Gammarus lacustris collected from six inland lakes and a reservoir in Kazakhstan were characterized by shotgun metagenomic sequencing. Gammarus were obtained from lakes and reservoirs representing a range of salinity conditions, and bacterial community composition was compared at the family and genus levels. Community diversity was evaluated using the Shannon and Simpson indices, whereas differences among sampling sites were examined by principal coordin …

28.08.2026journal-article

Animal Health and Biosafety

<b>БИОФАРМАЦЕВТИЧЕСКИЕ СВОЙСТВА БАКТЕРИОФАГОВ, АКТИВНЫХ В ОТНОШЕНИИ SALMONELLA ENTERICA SEROVAR ABORTUSOVIS, ВЫДЕЛЕННЫХ В УСЛОВИЯХ КАЗАХСТАНА</b><b></b>

Р. Саттарова, Е. Оспанов, М. Маталипова, Ж. Тлегенова, А. Нурпейсова, М. Касенов, К. Боранбаева, Н. Пименов, Г. Спиридонов

Bacteriophage therapy for bacterial infections is based on the ability of lytic bacteriophages to selectively eliminate pathogenic microorganisms. The mechanism of action involves two key stages: the penetration of the phage into a susceptible bacterial cell followed by its destruction (lysis), accompanied by the release of newly formed viral particles. Understanding the interactions between bacteriophages, bacteria, and host tissues is of critical importance from both ecological and pharmacological perspectives. T …

28.08.2026journal-article

Frontiers in Pharmacology

Digital twin technology for HIV patient virtual modeling: a novel approach to treatment optimization

Yuan Zhang, Tingting Li, Jie Chen, Huanhuan Ba, Jiajia Li, Jinling Yin, Kangxiao Ma, Huanqing Liu, Juan Jin

Background Human immunodeficiency virus (HIV) infection remains a global health challenge, necessitating personalized treatment strategies to optimize patient outcomes. Digital twin technology—synchronized with real-world entities—offers a pathway to precision medicine in HIV care. Methods We analyzed 5,436 HIV patients (2016–2024) with demographic, immunologic, and antiretroviral therapy (ART) information. Core algorithms comprised gradient boosting and random forest ensembles; deep architectures (LSTM and Transfo …

28.08.2026journal-article

Biochar

Application and prospect of artificial intelligence in biochar for acidic soil amelioration

Linyu Guo, Kewei Li, Ren-kou Xu

Abstract Effective amelioration of acidic soils with biochar is critical for mitigating soil degradation and promoting sustainable agriculture, yet this requires robust mechanistic understanding and predictive modeling. This review synthesizes the key biogeochemical pathways by which biochar neutralizes soil acidity and enhances soil pH buffering capacity. We identify critical data gaps—notably the overlooked relative contributions of organic and inorganic alkalis—that currently limit the predictive performance of …

28.08.2026journal-article

Mathematics Education Research Journal

Pre-service mathematics teachers’ perceptions of equity and interactive digital tasks: implications for initial teacher education

Kate Roscioli, Liza Bondurant

Abstract Interactive digital tasks have the potential to aid mathematics educators in providing equitable mathematics learning experiences. However, research indicates that mathematics educators may not be aware of how interactive digital tasks can promote equitable teaching practices. This study reports on a design-based research project exploring pre-service teachers’ perceptions of equity and interactive digital tasks. Over three cycles of design, implementation, evaluation, and revision, 57 pre-service teachers …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

University Students' Experiences During COVID-19: Insights from Online/Distance Education

Rabia Kıvanç, Çiğdem Aytekin

Objectives: The COVID-19 pandemic caused unprecedented disruptions in higher education, compelling a rapid transition to distance learning and altering students’ academic and psychosocial functioning. This study aimed to examine perceived stress levels among university students enrolled in Child Development departments and to identify the educational deprivations they experienced during pandemic-related remote instruction. Materials and Methods: A convergent mixed-methods design was employed. Data were collected fr …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

An Analysis of Graduate Theses Based on Watson’s Human Caring Model in Nursing

Cemal Özalp

Objectives: The aim of this review is to examine the postgraduate theses based on Watson's Human Care Model in the field of nursing in Türkiye.Materials and Methods: Within the scope of the review, theses registered in the National Thesis Centre were scanned with the keywords ‘Watson’ and ‘human care’ in Türkiye between 1-15 December 2024. The theses were analyzed in terms of application group, sample, method, research type and results.Results: It was determined that 28 theses in the field of nursing in Türkiye inc …

28.08.2026journal-article

Revista chilena de nutrición

Vitamin D fortification of dairy products: strategies, technologies, and health impacts

Macarena Ortiz, Andrés Bustamante, Francisco Perez-Bravo, Rodrigo Valenzuela, Catalina Espejo, Lissette Duarte

Vitamin D deficiency is a widespread global health concern driven by limited dietary sources, reduced sun exposure, and lifestyle changes. This narrative review synthesizes current evidence on the rationale, technologies, efficacy, and public health implications of vitamin D fortification of dairy products. A literature search was conducted in PubMed, Web of Science, and Scopus for English-language studies, including original research, randomized controlled trials, systematic reviews, meta-analyses, and relevant re …

28.08.2026journal-article

Clinical Cancer Research

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Xing Zhang, Bushu Xu, Qiuzhong Pan, Ruiqing Peng, Desheng Weng, Jingjing Zhao, Xizhi Wen, Qiyan Cai, Wei Li, Hongcheng Hu, Ruihua Xu

Abstract Purpose: Advanced sarcomas lack effective maintenance therapies after first-line chemotherapy. We present long-term phase I results evaluating multiantigen stimulated cell therapy I (MASCT-I), a novel immunotherapy integrating dendritic cell vaccination with adoptive T-cell transfer, as maintenance treatment (NCT03034304). Patients and Methods: Thirty-one patients with disease control after chemotherapy received MASCT-I alone (n = 17) or with ifosfamide (n = 14). The primary endpoint was safety. Secondary …

28.08.2026journal-article

BMJ Innovations

Digital-first postoperative follow-up after cataract surgery: real-world implementation of an integrated automated telephone and home vision-testing pathway in the NHS

Aisling Higham, Louise Allen, Won Young Moon, Louisa Stacey, Ernest Lim, Nick de Pennington, Evgenia Anikina

Objectives Postoperative outcome data are essential for quality improvement and national audit after cataract surgery, the National Health Service’s (NHS) highest volume elective procedure, yet completion rates using traditional methods remain low. We evaluated whether an integrated digital-first pathway combining automated telephone follow-up and home-based distance visual acuity (DVA) testing could achieve high outcome-data capture with good patient acceptability in routine NHS care. Innovation The pathway integr …

28.08.2026journal-article

Journal of Comparative Social Work

Structural Barriers to Inclusive Education

Hirosha Lakmali Kalupe

Inclusive education is recognized in global and national frameworks as a fundamental right. However, students with disabilities in Sri Lankan higher education institutions continue to encounter structural barriers in their everyday life at the university. This qualitative case study examines how students with and without disabilities perceive accessibility across physical and digital environments at a Sri Lankan state university and how institutional policies conceptualize and operationalize accessibility within th …

28.08.2026journal-article

Jurnal Abdimas Universitas Insan Pembangunan Indonesia

EDUKASI LITERASI DIGITAL BERBASIS INVESTASI BAGI KELUARGA MUDA DI TK/PAUD PANDANWANGI

Aditya Wardhana, Mahendra Fakhri

Financial literacy, particularly regarding digital investment, has become an essential skill for young families navigating the modern economic landscape. However, the lack of foundational knowledge often exposes individuals to financial fraud and high-risk pitfalls. This community service activity aims to provide fundamental understanding and practical guidance on safe and wise digital investment for parents and teachers at TK/PAUD Pandanwangi, Bandung. The methods employed included interactive lectures by competen …

28.08.2026journal-article

Applied Artificial Intelligence Research

From Biomechanical Markers to Risk Prediction: Machine Learning Advances in Early Warning of Recurrent Acute Ankle Sprain

Yiming Wang, Siyu Chen, Zhendiao Lin

Acute lateral ankle sprain is among the most frequent injuries in sports medicine, and its high recurrence rate and propensity toward chronic ankle instability (CAI) constitute a persistent clinical challenge. Conventional risk assessment—relying on subjective questionnaires, physical examination, and clinical experience—captures only part of the complex biomechanical and neuromuscular adaptations that follow an initial sprain. Recent advances in objective biomechanical profiling and machine learning (ML) have open …

28.08.2026journal-article

IEEJ Transactions on Electrical and Electronic Engineering

Model Analysis of Deep Learning for Sound Image Direction Perception Using Explainable Artificial Intelligence

Koji Sakamoto

In recent years, deep learning models of human auditory perception have been researched for a super smart society. Deep learning has the potential to improve estimation accuracy; however, its internal structure becomes complex and difficult to explain, making improvements in explainability essential in the use of safety‐critical systems. In a previous study, deep learning binaural models of three‐dimensional sound image direction perception, which is an important factor of auditory perception, were constructed usin …

28.08.2026journal-article

Clinical and Translational Discovery

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Emmanuel Ifeanyi Obeagu, Yaregal Asres

Abstract Background Estrogen receptor‐positive (ER+) breast cancer represents the most common molecular subtype of breast cancer and remains highly responsive to endocrine therapy. However, therapeutic efficacy is frequently compromised by acquired or intrinsic endocrine resistance, particularly through ESR1 mutations, altered receptor conformation, co‐regulatory mechanisms, and activation of compensatory signaling pathways such as PI3K/AKT/mTOR. Conventional drug‐discovery approaches are often slow, resource‐inten …

28.08.2026journal-article

American Journal of Physical Education and Health Science

Effect of Maitland Mobilization Combined with Kendall Corrective Exercise on Pain and Postural Alignment of Patients with Upper Cross Syndrome: Pilot Study

Naeem Ullah, Fatima Amjad, Qamar Jan, Wagma Wajid, Aamir Niaz, Komal Hameed

Upper Cross Syndrome (UCS) is a prevalent postural dysfunction resulting from muscle imbalances that causes forward head posture, rounded shoulders and thoracic kyphosis. Although manual therapy and corrective exercises are frequently performed, studies comparing the two have not been conducted extensively.To determine the feasibility and effectiveness of Maitland mobilizations alongside Kendall exercises in patients with UCS.A pilot single-blinded randomized controlled trial was performed involving 28 subjects (14 …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Personalization of therapy for infections caused by N. gonorrhoeae, C. trachomatis, M. genitalium and T. vaginalis. Part II. Evaluation of the clinical effectiveness of personalized therapy

E.S. Negasheva, N.V. Frigo, A.E. Guschin, A.Yu. Khachaturyan, I.R. Baskakova, O.V. Zhukova

Background. Currently used antimicrobial agents, their doses, and treatment durations are clearly defined by standards and clinical guidelines. Nevertheless, treating patients with sexually transmitted infections presents significant challenges despite the availability of highly effective drugs. In this connection, the transition to personalized treatment is relevant, which is consistent with the provisions of the Strategy for Research and Technological Development of the Russian Federation adopted in 2024. Objecti …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Drug-induced sarcoid-like reaction during BRAF/MEK inhibitor therapy for metastatic melanoma

A.N. Khlebnikova, V.E. Shikina, A.V. Semenkov, A.I. Zotov, G.R. Setdikova

In recent years, targeted therapy with BRAF/MEK inhibitors has been successfully used for treating metastatic melanoma. Although generally well tolerated, it may lead to the development of both systemic and cutaneous side effects. The most frequently reported adverse events include nausea, vomiting, diarrhea, pyrexia, chills, and hypertension. Cutaneous side effects manifest as alopecia, acneiform rash, maculopapular rash, dry skin, and photosensitivity reactions. Cases of squamous cell carcinoma and keratoacanthom …

28.08.2026journal-article

Frontiers in Artificial Intelligence

AI inclusivity and the centrality of Africa: a systematic review of representation, innovation, and governance in global artificial intelligence

Ramadile Moletsane

Artificial Intelligence (AI) is reshaping global systems across education, healthcare, finance, and agriculture. Despite its transformative potential, concerns about inclusivity persist, particularly regarding the underrepresentation of African contexts in AI development. This study examines Africa’s role in achieving globally inclusive AI and explores the implications of its marginalization. A qualitative systematic review design was adopted, guided by PRISMA protocols, synthesizing peer-reviewed literature, polic …

28.08.2026journal-article

Modern Management Science & Engineering

Research on BIM Digital Collaborative Design System for Highway Tunnel Electromechanical

ZHAO Xin, CAO Hao, ZHAO Jingying, ZHANG Hao, Yang Xinyi, LI Yang

To address the issues of low efficiency in manual CAD drafting, labor-intensive BIM modeling, insufficient multi-disciplinary collaboration, and fragmented management of design deliverables that currently characterize highway tunnel electromechanical design, this study proposes a BIM-based digital collaborative design system that integrates CAD digital design, BIM automatic modeling, a collaborative design platform, and a core database. Built on AutoCAD and Revit secondary development technologies, the system enabl …

28.08.2026journal-article

JAMA

Cardiovascular Magnetic Resonance to Guide Defibrillator Implantation for LVEF of 36% to 50%

Joseph B. Selvanayagam, John G. F. Cleland, Graham S. Hillis, Sivabaskari Pasupathy, Laurent Billot, Katherine E. George, John J. Atherton, Colin Berry, Ivaylo Tonchev, Chris Gianacas, Werner Jung, Sanjay K. Prasad, Carmine G. De Pasquale, Johannes Brachmann, Anand Ganesan, Cardiovascular Magnetic Resonance–Guided Management of Mild to Moderate Left Ventricular Systolic Dysfunction Trial Investigators, Rajiv Ananthakrishna, Margaret Arstall, Niall Campbell, Derek T Connelly, David Ferreira, Daniel Garofalo, Jemima Gore, Suchi Grover, John Hill, Nicola Johnston, Alamgir Kabir, David Kaye, Sau Lee, Tina Lin, Scott Lorensini, Jakob Lüker, Paul D MacIntyre, Christian Mahnkopf, Andrew Martin, Gerry P McCann, Ashley Nisbet, Gaetano Nucifora, Bhupesh Pathik, Andreas Pflaumer

Importance Current guidelines do not recommend primary prevention implantable cardioverter-defibrillators (ICDs) unless a patient’s left ventricular ejection fraction (LVEF) is 35% or less. Many sudden cardiac deaths (SCD) occur when LVEF is 36% to 50%. Myocardial scar (a key arrhythmic substrate) can be assessed by late gadolinium enhancement on cardiovascular magnetic resonance (CMR), but robust evidence is lacking regarding a scar-based approach to ICD insertion. Objective To determine whether implantation of IC …