Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 91

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Updates in Surgery

Role of liquid biopsy in the multimodal assessment and treatment of esophageal cancer: a surgical perspective

Alberto Aiolfi, Davide Bona, Emanuele Rausa, Vladimira Tichà, Antonio Biondi, Juana Riitano, Luigi Bonavina

Abstract Esophageal cancer (EC) remains a highly lethal malignancy, characterized by late diagnosis, early systemic dissemination, and high recurrence rates. Conventional diagnostic and surveillance strategies have limited sensitivity for early disease detection and minimal residual disease. Liquid biopsy technologies have emerged as promising minimally invasive tools for diagnosis, prognostication, and longitudinal monitoring. This scoping review summarizes current evidence on the clinical utilization of liquid bi …

24.08.2026journal-article

Frontiers in Oncology

Arylsulfatase D promotes malignant phenotypes in glioblastoma cells and is linked to altered Hippo pathway phosphorylation

Xuzhao Li, Qifan Hou, Yanli Tang, Nianhua Wang, Chen Zhong, Lixin Xu, Jun Wang

Introduction Glioblastoma (GBM) is a highly aggressive malignant brain tumor with persistently poor clinical outcomes and few effective treatment options. Arylsulfatase D (ARSD), a lysosomal sulfatase implicated in several cancers, has not been fully characterized in GBM. Methods ARSD expression in GBM was evaluated using bioinformatic analyses and immunohistochemical validation. ARSD was overexpressed or knocked down in U87MG, U251MG, and A172 cells, and proliferation, three-dimensional spheroid growth, apoptosis, …

24.08.2026journal-article

Frontiers in Medicine

Venetoclax plus azacitidine in higher-risk myelodysplastic syndromes: a treatment-purpose framework for interpreting response depth

Xinfu Zou, Jinyang Bu, Aojiao Chu, Ling Shi, Zheng Zhang, Qin Zheng, Meihong Luo

Venetoclax plus azacitidine has demonstrated substantial clinical activity in treatment-naïve higher-risk myelodysplastic syndromes (HR-MDS), including high rates of complete remission, marrow complete remission, and overall response. However, recent phase 3 experience indicates that greater response depth does not necessarily translate into improved overall survival. We propose a treatment-purpose framework for interpreting the clinical value of venetoclax plus azacitidine in HR-MDS. This framework first distingui …

24.08.2026journal-article

PLOS One

Metagenomic analysis of gut microbiota and its correlation with thyroid hormones in papillary thyroid cancer before and after operation

Wenyi Qin, Jiajun Huo, Xiongsheng Xiao, Siyi Li, Haiqing Luo, Yongkang Wu, Weijie Chen, Zhuoting Chen, Changwei Zheng, Muge Liu, Baibei Li, Guiping Zhou, Zhibin Huang, Xuemeng Li, Jinquan Li, Zhi Zhang, Jian Ye

Background The changes of intestinal flora and thyroid hormone levels before and after operation for papillary thyroid cancer (PTC) and their relationship are not clear. It may interfere with the intestinal thyroid axis, change the systemic thyroid hormone regulation and exogenous treatment response. It is recognized that this microbial involvement is clinically related to long-term metabolic outcomes, and future strategies for microbial targeted adjuvant therapy are suggested. This study aims to provide direct evi …

24.08.2026journal-article

Theoretical and Natural Science

Breast Cancer Risk Prediction and IDC Tumor Classification in Different Stages Based on Machine Learning Models

Yunze Li, Nor Samsiah Sani

Based on the medical statistical analyses of relevant information, in recent years, breast cancer is one of the leading causes of cancer-related deaths in women worldwide. Hence, the early detection and accurate diagnosis of breast cancer patients is significant to improve their prognosis. In this study, we propose a multi-modal, data-driven intelligent framework especially designed to breast cancer analysis the Multi-Dimensional Feature Refinement Cancer Network (MDFR-Cancer-Net) that can be used to analyse breast …

24.08.2026journal-article

Frontiers in Oncology

Pretransplant albumin-to-globulin ratio and long-term outcomes after liver transplantation for hepatocellular carcinoma: a two-center cohort study

Xun Liu, Xiao-An Liu, Di Wang, Jing Wang, Han-Xuan Wang, Ren Lang, Anshi Wu

Background Prognosis after liver transplantation for hepatocellular carcinoma (HCC) is driven mainly by tumor burden, vascular invasion, and alpha-fetoprotein. Routine pretransplant nutritional indices may add information on recipient condition, but direct comparisons are scarce and recurrence is not always analyzed with competing mortality. Methods The development cohort included 254 adults undergoing first liver transplantation for pathologically confirmed HCC. Overall survival (OS) was the primary outcome; time …

24.08.2026journal-article

Journal of Clinical Oncology

Omitting Bone Marrow Sampling in FDG-Avid Rhabdomyosarcoma With 2-[ 18 F]FDG PET-Negative Marrow: Results From an International Retrospective Study

Federico Mercolini, Marissa Just, Barry L. Shulkin, Natalie B. Collins, Jacquelyn Crane, Douglas Harrison, Maria C. Affinita, Wendy Allen-Rhoades, Alessandra Alessi, Sebastian D. Asaftei, Michael A. Arnold, Sonja Chen, Stefano Chiaravalli, Forrest FitzGerald, Martin T. Freitag, Jessica L. Iftner, Hedieh Khalatbari, Bart de Keizer, Irene von Luettichau, Christine Mauz-Körholz, Claudia Rossig, Guido Rovera, Stefan Rutkowski, Justin B. Sims, Stephan D. Voss, Ayami Yoshimi, Suzi Birz, Gianni Bisogno, Martin Ebinger, Johannes H.M. Merks, Monika Sparber-Sauer, Bernhard Haller, Aaron R. Weiss, Corinne M. Linardic, Reineke A. Schoot, Simone Hettmer, for the INSTRuCT Imaging/Pathology/Biology Network, Giorgio Baldari, Isabel Borrego-Dorado, Nicodemo Baffa

PURPOSE Detection of bone marrow disease has been a major component of rhabdomyosarcoma (RMS) staging with bilateral bone marrow aspirates/biopsies (BMAB) from the iliac crests considered the diagnostic gold standard. This study's goal was to determine if 2- 18 F-labeled fluorodeoxyglucose positron emission tomography/computed tomography ([ 18 F]FDG PET/CT) or PET/magnetic resonance imaging (MRI) may replace BMAB in RMS staging. METHODS Patients were recruited in Europe and North America. Medical records, FDG PET/C …

24.08.2026journal-article

Operative Neurosurgery

Toward 3-Dimensional Tumor Analysis for Planning Optimal Resection in Intradural Extramedullary Tumors: A Single-Institution Feasibility Study

Adhith Palla, Hammad A. Khan, Blake A. Perdikis, Nicolas K. Goff, Eric A. Grin, Roshni Patel, Jonathan T. Yang, J. Ricardo McFaline-Figueroa, Darryl Lau, Anthony Frempong-Boadu, Ilya Laufer

BACKGROUND AND OBJECTIVES: Intradural extramedullary spinal tumors (IDEMs) are ideally managed with gross total resection (GTR) for optimal local disease control in the absence of established adjuvant regimens. In this retrospective cohort study, we investigated the utility of morphology-based analysis of optimal IDEM resection quality compared with current linear measurement benchmarks. METHODS: Tumors were manually segmented from preoperative contrast-enhanced MRI. Morphological features of sphericity, elongation …

24.08.2026journal-article

Cancers

Can Contrast-Enhanced Ultrasound Reduce the False-Negative Rate of Metastatic Axillary Lymph Nodes After Neoadjuvant Therapy in Breast Cancer?

Sijia Zhao, Jia Luo, Manying Li, Jiaping Li, Jiaqian Zhong, Peiwei Chen, Xiaoyan Xie, Ying Lin, Yanling Zheng

Background: Accurate assessment of axillary lymph node (ALN) status after neoadjuvant therapy (NAT) remains essential for surgical planning in patients with initially node-positive breast cancer. This study evaluated the potential value of contrast-enhanced ultrasound (CEUS) in conjunction with sentinel lymph node biopsy (SLNB) for post-NAT axillary assessment and explored clinicopathologic factors associated with lymph node (LN) status. Methods: In this retrospective study, 179 patients with cytologically confirme …

24.08.2026journal-article

Frontiers in Digital Health

High-technology telerehabilitation for the treatment of frail and pre-frail patients: the TeleRiab4FRA study design and protocol

Alessia Bramanti, Michele Ciccarelli, Albino Carrizzo, Placido Bramanti, Valeria Visco, Mariaconsiglia Calabrese, Marina Garofano, Maria Pia Di Palo, Colomba Pessolano, Simone Romano, Sabato Nocera, Giuseppe Scanniello, Carmine Vecchione

Introduction Chronic heart failure (CHF) in older adults is frequently associated with frailty, reduced functional capacity, cognitive vulnerability, poor quality of life, and recurrent healthcare needs. Despite the recognized benefits of cardiac rehabilitation, access and adherence to conventional center-based programs remain suboptimal in frail and pre-frail patients. The TeleRiab4FRA study investigates whether an 8-week high-technology telerehabilitation program combining sensorimotor and cognitive training can …

24.08.2026journal-article

Journal of Nephrology

Comparison of bortezomib with dexamethasone and thalidomide with dexamethasone in the treatment of patients with monoclonal immunoglobulin deposition disease

Jianan Jiang, Wencui Chen, Xiaomei Wu, Jinzhou Guo, Weiwei Xu, Xianghua Huang

ABSTRACT Background There is currently no standardized treatment strategy for monoclonal immunoglobulin deposition disease, and anti-plasma cell therapy is considered an effective method for treating patients with this pathology. Methods This retrospective study included 72 patients with biopsy-confirmed monoclonal immunoglobulin deposition ­disease from 2005 to 2025, divided by first-line therapy into bortezomib/dexamethasone (BD, n = 37) and thalidomide/­dexamethasone (TD, n = 35) groups. The bortezomib/dexametha …

24.08.2026journal-article

Biomolecules

Nitrogen-Doped Carbon Dot/TiO2 Hybrid Composites Induce Light-Dependent ROS-Mediated Cytotoxicity in Cancer Cells

Assia Azouaghe, Florence Back, Walid Daoudi, Abdelmalik El Aatiaoui, Céline Spack, Diana Potes Vecini, David Hoogewijs

Photodynamic therapy (PDT) exploits photoactivated materials that generate reactive oxygen species (ROS) to induce selective cancer cell death. Nitrogen-doped carbon dots (N-CDs) have emerged as promising photosensitizers owing to their favorable optical properties, while hybridization with titanium dioxide (TiO2) may further enhance photoinduced ROS generation through improved charge separation. Here, we synthesized a series of N-CD/TiO2 hybrid composites with varying TiO2 content using a hydrothermal approach and …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Role of Epidemic Tumor Vaccine in Cold Tumors to Hot Tumors

Chunqing Liu

Small cell lung cancer (SCLC) is a type of highly aggressive, prone to early metastasis and recurrence, neuroendocrine malignant tumor. The treatment effect of second-line therapy for patients with recurrence/refractory cases is limited, and new therapeutic targets and strategies are urgently needed. Delta-like ligand 3 (DLL3) is abnormally highly expressed on the surface of most SCLC cells, while its expression is limited in normal tissues, making it a promising therapeutic target. The DLL3/CD3 bispecific antibody …

24.08.2026journal-article

International Journal of Biology and Life Sciences

CRISPR/Cas9-Mediated PD-1 Engineered T Cells: New Strategy to Block Tumor Immune Escape

Weiyang Xu

At present, overexpression of immune-related genes is one of the key mechanisms of tumor immune evasion. As a tumor cell-mediated immune escape core checkpoint molecule, the PD-L1 (programmed death ligand 1) will recruit SHP-1/SHP-2 (Src homology phosphotyrosyl phosphatase 1/ Src homology phosphotyrosyl phosphatase 2) phosphatase by interacting with PD-1 (Programmed Death 1) on T cells' surface, dephosphorylation of key molecules of the downstream signaling pathway of T cell receptors (TCR) (such as CD3ζ, ZAP70, PI …

24.08.2026journal-article

Clinical Epileptology

Strukturelle Barrieren in der Epilepsieversorgung

Sergio R. Pérez Rosal, Sonya C. Faber, Nils G. Margraf, Adam Strzelczyk, Andreas Schulze-Bonhage, Hans-Beatus Straub, Benedikt Greshake

Zusammenfassung Hintergrund Trotz erheblicher therapeutischer Fortschritte bestehen in Deutschland weiterhin Versorgungslücken in der Behandlung von Epilepsiepatienten, insbesondere bei therapieresistenten Verläufen. Nationale Daten deuten auf eine unzureichende Überweisungspraxis und verspätete Einbindung spezialisierter Epilepsiezentren hin. Ziel dieser Studie war es, die ambulante Versorgungssituation in Brandenburg, einem Bundesland mit in bestimmten Regionen besonders begrenztem Zugang zu neurologischer Expert …

24.08.2026journal-article

Gastric Cancer

Mesenchymal R-spondin 3 promotes an immunogenic tumor microenvironment with adaptive immune resistance in human gastric adenocarcinoma

Anne-Sophie Fischer, Alexander Arnold, Hilmar Berger, Stefanie Müllerke, Jonas Wizenty, Hans-Joachim Mollenkopf, David Horst, Frank Tacke, Christoph Treese, Michael Sigal

Abstract Background The main risk factor for gastric cancer (GC) is inflammation driven by Helicobacter pylori ( H. pylori ) infection. Despite growing use of immunotherapies targeting the tumor inflammatory microenvironment, responses remain suboptimal, highlighting the need to define inflammatory drivers and improve patient stratification. Methods We assessed the role of R-spondin 3 (RSPO3), a stroma-secreted Wnt potentiator, in a Caucasian tissue microarray of 277 chemotherapy-naïve GC patients by associating RS …

24.08.2026journal-article

Current Pain and Headache Reports

Predictors of Treatment Success Following Pulsed Radiofrequency of the Lumbar Dorsal Root Ganglion: A Multivariable Prediction Model with Clinical Nomogram

Matteo Luigi Giuseppe Leoni, Marco Mercieri, Sandra Magnoni, Giuliano Lo Bianco, Jamal Hasoon, Omar Viswanath, Giacomo Farì, Giuseppina Chelo, Giustino Varrassi

Abstract Background Pulsed radiofrequency of the lumbar dorsal root ganglion (DRG-PRF) is a minimally invasive treatment for chronic radicular pain, but outcomes vary substantially and validated prediction models to guide patient selection are lacking. The aim of this study was to develop and internally validate a multivariable prediction model identifying patients most likely to achieve treatment success following lumbar DRG-PRF. Methods This retrospective cohort study included 308 consecutive patients who underwe …

24.08.2026journal-article

JNCI Cancer Spectrum

Evaluating the impact of virtual oncology financial and legal navigation on cancer-related financial toxicity

Jean S Edward, Lynn J Andreae, Haafsah Fariduddin, Elizabeth Ruschman, Lori Eisele, Mackenzie Caldwell, Joanna Doran, Monica Bryant, Jordan Heflin, Brent Shelton, John D’Orazio, Kimberly D Northrip

Abstract Purpose To evaluate the impact of a virtual oncology financial and legal navigation (OFLN) intervention on cancer-related financial toxicity (FT) and health-related quality of life (QOL) in pediatric and adolescent and young adult (PAYA) cancer patients and caregivers, as well as assess the intervention’s acceptability and feasibility. Methods A single-arm trial was conducted in a PAYA oncology clinic between March 2024 and May 2025. Pre- and post-intervention surveys included the Comprehensive Score for F …

24.08.2026journal-article

Journal of The Society of Obstetricians and Gynaecologists of Pakistan

The Diagnostic Accuracy of International Ovarian Tumor Analysis Simple Rules (IOTA) to Discriminate Between Benign and Malignant Adnexal Masses

Moazana Fiaz, Nadia Ahmed Bokhari, Ambreen Fatima, Aiman Saeed, Ayesha Malik, Munnaza Akhtar, Aamir Afzal

Introduction: The most widely validated strategies for discrimination between malignant and benign adnexal masses are the methods established by the International Ovarian Tumor Analysis (IOTA) group. The IOTA group has formulated simple rules for ultrasound that differentiate malignant from benign adnexal masses. Objective: To determine the diagnostic accuracy of IOTA SR in predicting malignancy among patients presenting with adnexal mass taking histopathology as gold standard. Study Design: Validation study. Place …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Advances in Treatment Approaches for IDH Wild-Type Glioblastoma

Yunxi Yao

IDH-wild-type glioblastoma (WHO CNS Grade IV; known as glioblastoma multiforme, GBM) is the most malignant and recurrent brain tumor in the central nervous system. Research on GBM primarily focuses on its mechanisms and immunotherapy. However, due to cold tumor characteristics such as the immunosuppressive tumor microenvironment (TME), blood-brain barrier (BBB) obstruction, and tumor heterogeneity, immunotherapy regimens remain in the clinical trial phase. Overcoming core challenges including BBB barrier, TME, and …

24.08.2026journal-article

Selcuk Dental Journal

Temporomandibular Joint Disorders: A Contemporary Review of Anatomy, Biomechanics, Diagnosis, and Treatment Approaches

Ayşenur Uludağ, Ela Türmeli, Mevsim Yayman, Serhan Akman

Background: The temporomandibular joint (TMJ) is a complex anatomical structure responsible for essential functions such as mastication, speech, and swallowing. Disorders affecting this system are collectively referred to as temporomandibular disorders (TMDs) and represent one of the most common causes of non-dental orofacial pain. TMDs have a multifactorial etiology and may involve muscular, articular, and disc-related pathologies. Clinically, these disorders are characterized by pain, joint sounds, restricted man …

24.08.2026journal-article

Clinical Dentistry and Research

Radiographic Evaluation Of The Success Of Root Canal Treatment In Mandibular Premolars: A Retrospective Cross-Sectional Study

Damla Erkal, Yunus Emre Çakmak, Maira Kopbayeva, Kürşat Er

Background and Aim: Radiographic assessment is essential forevaluating the technical quality of root canal fillings and periapicalstatus after root canal treatment (RCT). This retrospective crosssectionalstudy assessed the radiographic quality of RCT in mandibularpremolars using panoramic radiographs and investigated theassociation between root canal filling quality and periapical lesions.Materials and Methods: Archived digital panoramic radiographswere screened, and 205 radiographs (261 mandibular premolars:34, 35 …

24.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Seen, Heard, and Still Missing: Understanding Clinical Trial Nonparticipation Among Women of Color

Jasmine Dionne Souers, Marissa Thomas, Juliette Faughnan, Mary Fox, Nishtha Gupta, Gail Betz, Adishree Nayak, Nathaniel Laban, Christabel K. Cheung

Purpose: To examine structural, informational, and cultural barriers to clinical trial participation among women of color (WOC), with emphasis on adolescents and young adults (AYAs), through a community-partnered study to illuminate persistent challenges and generate actionable strategies through community-driven research. Methods: In partnership with For the Breast of Us , a national advocacy organization for WOC affected by breast cancer, we conducted a sequential exploratory mixed-methods study. In-depth intervi …

24.08.2026journal-article

Frontiers in Pharmacology

Pradefovir mesylate and tenofovir amibufenamide for chronic hepatitis B: a systematic review and pragmatic treatment algorithm

Shuqi Yang, Liting Zhan, Zimei Wan, Xueping Yu

Background Pradefovir mesylate (PDV; approved in China in 2024) and tenofovir amibufenamide (TMF; approved in China in 2021) are novel hepatocyte-targeted nucleotide prodrugs recently approved in China. Their clinical positioning relative to the guideline-endorsed benchmark tenofovir alafenamide (TAF) for chronic hepatitis B management remains undefined, particularly regarding renal/bone safety and drug-drug interaction profiles. Objective To synthesize available evidence and propose a pragmatic treatment selection …