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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
16.08.2026journal-article

Journal of Drug Delivery and Therapeutics

An Observational and Comparative Study of Cardiovascular Drug: Chlorthalidone and Hydrochlorothiazide the First Line Drug Therapy of Hypertension

Ishika Roy, Abhishek Prasad

Background: Hypertension is when the pressure in blood pressure vessels is too high. The heart has to work harder to pump blood. Hypertension also known as silent killer. There are 2 types of hypertensions each has a different cause. It causes complications such as heart attack or stroke heart failure, kidney problems, metabolic syndrome, etc. The risk of hypertension increases with age. Smoking and alcohol consumption also raises blood pressure. Objective: The present investigation to observe and compare cardiovas …

16.08.2026journal-article

Advanced Healthcare Materials

A Novel Drug‐Loaded Porous Parylene Electrode for Targeted Anti‐Inflammatory Therapy and Hearing Preservation in Cochlear Implantation

Chi‐Chieh Chang, Ying‐Chang Lu, Yu‐Ming Chang, Yen‐Hui Chan, Hong‐Yu Yan, Yi‐Shan Lee, Pei‐Hsuan Lin, Cheng‐Yu Hsieh, Chuan‐Jen Hsu, Tien‐Chen Liu, Hsien‐Yeh Chen, Chen‐Chi Wu

ABSTRACT This study investigates the feasibility and therapeutic effectiveness of a novel drug‑loaded parylene electrode prototype (PEP) designed to reduce inflammation and hearing loss associated with cochlear implantation (CI). The porous PEP was fabricated using vapor‑phase sublimation and deposition, producing an interconnected structure with 20–30 µm pores and mechanical flexibility suitable for intracochlear placement. Dexamethasone was incorporated into the device (Dex/PEP), and in vitro characterization usi …

16.08.2026journal-article

Physiotherapy Research International

Responsiveness, Smallest Detectable Change, and Minimal Important Change of the Turkish Pelvic Floor Distress Inventory‐20 Following Pelvic Floor Muscle Training

Seyda Toprak Celenay, Erhan Secer, Yasemin Karaaslan, Zehra Korkut, Derya Ozer Kaya

ABSTRACT Background and Purpose The Pelvic Floor Distress Inventory‐20 (PFDI‐20) is a widely recognized clinical tool designed to assess the severity of distress caused by pelvic floor symptoms. Within the context of conservative physiotherapy and pelvic floor rehabilitation, this study aimed to determine the responsiveness, smallest detectable change (SDC), and minimal important change (MIC) of the Turkish PFDI‐20 in women with pelvic floor dysfunction (PFD). Methods This multicenter, retrospective study consisted …

16.08.2026journal-article

Pharmaceutics

Mechanistic Artificial Intelligence for Personalized Drug Therapy: Integrating Pharmacokinetics, Pharmacodynamics, Therapeutic Drug Monitoring, and Multiomic Systems Biology

Ian Jenkins, Krista Casazza, Waldemar Lernhardt, Valentina Savich, Jayson Uffens, Vaishnavi Narayan, Jonathan R. T. Lakey

Interindividual variability in drug response remains a major challenge in clinical pharmacology despite substantial advances in therapeutic drug monitoring (TDM), pharmacogenomics, pharmacokinetics/pharmacodynamics (PK/PD), and model-informed precision dosing (MIPD). Although these approaches have improved individualized therapy, clinically important variability in efficacy and toxicity persists because drug response is determined not only by systemic exposure but also by target engagement, disease biology, compens …

16.08.2026journal-article

Advanced Healthcare Materials

Engineered Exosome‐Mediated FIH‐1 Delivery for Targeted Therapy of Hyperuricemic Nephropathy by Inhibiting NF‐κB/NLRP3 Inflammasome Signaling and Restoring Autophagic Homeostasis

Ting Xiao, Yu Liu, Zhe He, Ailing Yang, Jing Li, Li Zhou, Qingxiang Yang, Dunquan Xu, Lijia Yuan, Ming Chen, Sha Yang

ABSTRACT Renal tubular epithelial fibrosis is a key pathological process in the progression of hyperuricemia (HUA), and hyperuricemic nephropathy (HN). Targeted inhibition of renal tubular epithelial cell (RTEC) fibrosis represents a promising therapeutic strategy for HN. Extracellular vesicles derived from induced pluripotent stem cell‐derived mesenchymal stem cells (iPSC‐MSCs) were engineered as nanostructured delivery vehicles incorporating two functional modules: a kidney‐targeting module and a functional prote …

16.08.2026journal-article

Exploration of Targeted Anti-tumor Therapy

Response-adaptive breast cancer care in the grey zones: integrating ER and HER2 targeted PET, FDG PET/CT under immunotherapy, and ctDNA kinetics

Jovana Zivanovic, Jules Zhang-Yin

Breast cancer management increasingly hinges on decisions made in “grey zones” where tissue sampling is scarce, and tumour biology evolves under therapeutic pressure. This narrative review synthesises evidence on how whole-body imaging biomarkers and circulating tumour DNA (ctDNA) can support response-adaptive pathways at the interface of surgical and systemic care. Four clinically actionable domains are discussed. (a) 16α-[18F]fluoro-17β-estradiol ([18F]FES) positron emission tomography/computed tomography (PET/CT …

15.08.2026journal-article

Russian Journal of Cardiology

Potential for using speech patterns in cardiovascular disease diagnosis: a systematic review

A. A. Garanin, A. R. Khumorova, A. O. Rubanenko, O. Yu. Aidumova, A. V. Kolsanov

Aim . To determine the potential of using acoustic speech signal analysis parameters and speech biomarkers in the diagnosis and monitoring of cardiovascular diseases. Material and methods . A search was conducted in accordance with the requirements and guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in the PubMed, Google Scholar, ClinicalTrials, CyberLeninka, and eLibrary databases. The review included 14 original studies that analyzed the voice parameters of patients with …

15.08.2026journal-article

International Journal of Pharmaceutical and Bio Medical Science

Yoga Prana Vidya Healing as Alternative Therapy in the Resolution of Hemorrhoids And Dysmenorrhea: A Case Study

Venkata Satyanarayana Nanduri, Leelavathi Nayak

Background: Hemorrhoids and dysmenorrhea are common conditions that impair quality of life. Conventional treatments often provide partial relief and carry risks of recurrence. Yoga Prana Vidya (YPV), an integrative energy-based healing system, has shown promise in managing chronic conditions. Case Presentation: A 39-year-old female presented with chronic hemorrhoids, dysmenorrhea, headaches, and disturbed sleep. Symptoms persisted despite dietary modifications and self-practice of pranayama. She consulted a certifi …

15.08.2026journal-article

Medicine and ecology

Role of training classes for students in creating an individual human functioning profile and evaluating the effectiveness of rehabilitation

M. T. Koichumanova, I. A. Pekur, Sh. M. Gazalieva, O. V. Kazimirova

In the presented article, the role of the International Classification of Functioning, Limitations of Life and Health of a person is considered, which allows young specialists and interns to practice independently from the first days: 1) to conduct a comprehensive analysis of the patient’s existing life limitations; 2) to change the level and vector of building programs not only medical, but also social and environmental rehabilitation; 3) clarify the sequence of the complex of rehabilitation measures for supervise …

15.08.2026journal-article

Actas Españolas de Psiquiatría

Research Progress on Light Therapy to Improve Depressive Symptoms of Bipolar Depression

Yutong Cui

Bipolar depression is the predominant and most disabling phase of bipolar disorder, featured by recurrent depressive episodes that impair psychosocial function and quality of life. Conventional pharmacotherapy has limited efficacy and carries a risk of mood destabilization (e.g., affective switch). Light therapy, a nonpharmacological chronotherapeutic intervention, has shown potential to improve bipolar depression symptoms by regulating circadian rhythms and mood regulating neural circuits. This review synthesized …

15.08.2026journal-article

Advanced Healthcare Materials

Algae‐Integrated Optoelectronic Nanoplatform for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy

Gongcheng Ma, Nan Zhang, Hongrong Shi, Yaoqiang Li, Haoran Wang, Chaoyang Tang, Shengmei Wang, Hongli Chen, Qingzhi Wang, Zhaohui Wang, Guogang Liu, Ben Zhong Tang, Qihang Ding

ABSTRACT The clinical efficacy of photodynamic therapy (PDT) is fundamentally limited by the scarcity of efficient photosensitizers (PSs) and the oxygen dependence of singlet‐oxygen–mediated cytotoxicity. Here we report pentaperylene decaimide selenide (PPD‐Se), a nanographene‐derived photoelectronic material that functions as a high‐performance Type‐II photosensitizer. PPD‐Se exhibits broadband absorption (300–650 nm), enhanced intersystem crossing enabled by a selenium‐induced heavy‐atom effect, a small ΔE ST (0. …

15.08.2026journal-article

Journal of Dementia and Alzheimer's Disease

Fluid and Imaging Biomarkers in Lecanemab Therapy for Early Alzheimer’s Disease: Current Evidence, ARIA Risk Prediction, and Treatment Monitoring

Pan-Woo Ko

Background/Objectives: Lecanemab, a humanized anti-amyloid-β protofibril antibody, achieves substantial amyloid clearance and modest slowing of clinical decline in early Alzheimer’s disease (AD). Amyloid-related imaging abnormalities (ARIA) represent the most clinically important safety concern, yet no fluid biomarker has been prospectively validated for ARIA prediction in lecanemab-treated patients. This review critically synthesizes current evidence on fluid and imaging biomarkers for ARIA risk stratification and …

15.08.2026journal-article

American Journal of Human Psychology

Influence of Solution-Focused Therapy (SFT) in Inculcating Passion and Dedication to Counseling in Guidance Counselors in Imo State

Francisca Ngozi Okoro

This study examined the perceived influence of Solution-Focused Therapy (SFT) on passion and dedication to counseling among guidance counselors in Imo State. A descriptive survey design was adopted, involving 107 guidance counselors selected through purposive sampling. Data were collected using a structured online questionnaire and analyzed using descriptive statistics (mean and standard deviation). Findings revealed that counselors perceived SFT as having a strong influence on their passion (M = 4.02) and dedicati …

15.08.2026journal-article

Actas Españolas de Psiquiatría

Effect of Mobile Application-Based Cognitive Behavioural Therapy on Atopic Dermatitis Comorbid With Obsessive-Compulsive Disorder: A Retrospective Study

Dan Liang, Lihong Yang, Xian He

Background: This study aimed to evaluate the effect of mobile application-based cognitive behavioural therapy (MCBT) in patients with atopic dermatitis (AD) and comorbid obsessive-compulsive disorder (OCD). Methods: This retrospective study analysed 100 patients with AD and comorbid OCD treated at Chengdu First People’s Hospital from January 2024 to December 2025. Patients were divided into an MCBT group (n = 50) and a conventional group (n = 50) according to the treatment they received. All patients received routi …

15.08.2026journal-article

BMC Oral Health

Dentoalveolar and skeletal changes after customized elastodontic appliance therapy in mixed dentition children with maxillary transverse deficiency: a retrospective CBCT study

Jianhua Li, Xinran Fan, Qingyu Wang

Abstract Background This exploratory study aimed to evaluate the expansion effects of a customized elastodontic appliance (CEA) on maxillary and mandibular arches in mixed dentition children using cone-beam computed tomography (CBCT), and to clarify whether these effects are dental, dentoalveolar, or skeletal. Methods This retrospective study included 31 mixed dentition children (mean age 8.3 ± 1.2 years) who underwent CEA treatment for 8.2 ± 1.3 months. Pre- and post-treatment CBCT images were used to measure widt …

15.08.2026journal-article

Actas Españolas de Psiquiatría

Effects of Emotion-Focused Therapy on Weight Restoration and Emotion Regulation in Adolescents With Anorexia Nervosa

Linfeng Liu, Nongmei Cheng, Qing Feng

Background: To investigate the effects of emotionfocused therapy (EFT) on weight restoration and emotion regulation in adolescents with anorexia nervosa (AN). Methods: This retrospective study included 188 adolescents with AN treated at Chongqing Mental Health Center between January 2023 and December 2025. According to treatment methods, patients were divided into a control group and an EFT group. After screening based on inclusion and exclusion criteria, 60 patients in each group were included in the final analysi …

15.08.2026journal-article

JOEY: Journal of English Ibrahimy

The The Role of Drama in Improving Students' comprehension of Reported Speech

Rawend Sitorus, Chairuddin, Baihaqi

This study aims to examine the role of drama scripts implemented through role-play activities in improving students’ comprehension of reported speech at SMK Negeri 2 Langsa. This research employed a quantitative approach using a one-group pre-test and post-test design. The population of this study consisted of all eleventh-grade students of SMK Negeri 2 Langsa, while the sample was class XI RPL comprising 25 students selected through purposive sampling. The instrument used to collect the data was a grammar test in …

15.08.2026journal-article

Stem Cell Research & Therapy

Stem cell–based therapies in pediatric disorders: translational advances, unresolved challenges, and future horizons

Hany E. Marei

Abstract Pediatric disorders consist of genetic, hematologic, neurologic, autoimmune, and inflammatory diseases. These conditions impose long-term health challenges on children, despite many advancements with conventional medicine. Although conventional treatments increase life expectancy and provide better disease control, many present challenges such as toxicity, insufficient control of the disease, and adverse effects on normal growth, development, and quality of life. Many researchers have shown increased inter …

15.08.2026journal-article

Cancers

Exploring the Impact of T2-Weighted MRI Fat Saturation on Radiomics Stability for Brain Radionecrosis Prediction After Skull-Base Proton Therapy: A Pilot Study

Sithin Thulasi Seetha, Giulia Fontana, Sara Imparato, Sara Lillo, Lucia Pia Ciccone, Marina Francesca Achilli, Chiara Paganelli, Silvia Molinelli, Alberto Iannalfi, Guido Baroni, Lorenzo Preda, Ester Orlandi

Background/Objectives: In skull-base proton therapy, T2-weighted brain magnetic resonance (MR) imaging may be acquired with or without fat saturation (FS). The present study investigated the impact of this protocol variation on radiomics feature stability and brain radionecrosis (BRN) prediction. Methods: Paired T2-weighted FS and non-FS follow-up MR scans of proton-treated skull-base chordoma patients (n = 52) were used to assess feature stability. For BRN prediction (CTCAEv5 grade ≥ 1), baseline planning scans of …

15.08.2026journal-article

Cardiovascular Therapy and Prevention

Oxidative stress severity and mitochondrial DNA polymorphisms in patients with heart failure at high risk of sudden cardiac death

T. Yu. Rebrova, V. A. Korepanov, M. V. Golubenko, E. F. Muslimova, T. A. Atabekov, S. V. Popov, S. S. Dorzhieva, A. A. Utusikova, S. A. Afanasyev

Aim. To assess the severity of oxidative stress and the presence of polymorphic variants of mitochondrial deoxyribonucleic acid (mtDNA) in patients with heart failure (HF) and a high risk of sudden cardiac death (SCD). Material and methods . The study included 198 patients (78,79% men) diagnosed with HF and implantable cardioverter-defibrillators (ICDs) for the prevention of life-threatening ventricular tachycardia (VT) and SCD. The control group consisted of 28 healthy volunteers (men, 64,29%). Clinical and paracl …

15.08.2026journal-article

International Journal of Digital Rehabilitation & Therapy

Syndrome Diagnosis in Traditional Chinese Medicine: Meridians, Eight Extraordinary Vessels and Five Element Theory

İpek Nurdan Dikmen, Dilek Öztaş, Salih Mollahaliloğlu

Syndrome diagnosis in Traditional Chinese Medicine (TCM) holistically evaluates functional and energetic imbalances in the body. This review aims to examine the fundamental principles of syndrome diagnosis in TCM by integrating meridian theory, the eight extraordinary vessels, and the five-element theory within a holistic diagnostic framework. The conceptual and theoretical foundations of syndrome diagnosis were examined by focusing on the functions of the meridian system, the regulatory roles of the eight extraord …

15.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Small-sided games in floorball: impact on technical actions in players aged 7–18

Mårten Storm, Taru Tervo, Jonas L. Markström

Abstract Background Small-sided games (SSGs; modified match play with fewer players and a smaller pitch) are widely used in team sports to develop adaptable movement skills and decision-making in game-like contexts. However, evidence is limited on how different SSG formats affect technical actions in youth floorball. This study examined how different SSG formats influence technical actions by outfield players in floorball, and whether these effects differ by age group and biological sex. Methods Twenty-four youth f …

15.08.2026journal-article

Cardiovascular Therapy and Prevention

Coronary Artery Ectasia prevalence and factors associated with ectasia in patients undergoing coronary angiography: An observational comparison analytic study

Hayder Abdulateef Zghair Nassir, Ahmed Qasim Ibrahim Mohammed, Hassan Abdulrazzaq Swaid

Aim . To determine the prevalence and risk factors of coronary artery ectasia (CAE), as well as the distribution of ectasia among the coronary vessels. Material and methods . An observational comparison analytic study was conducted in two cardiac centers in Iraq from February 2020 to February 2021, involving 263 patients who underwent coronary angiography. Clinical data and cardiovascular factors were analyzed to identify associations with CAE using logistic regression. Results . CAE was detected in 14.8% of the pa …

15.08.2026journal-article

Tạp chí Y học Dự phòng

Thực trạng căng thẳng nghề nghiệp của điều dưỡng tại các cơ sở y tế giai đoạn 2015-2025: Tổng quan luận điểm

Thị Thu Hà Nguyễn, Nguyễn Thị Mỹ Duyên, Nguyễn Thị Thu Hà, Phạm Diệu Linh

Căng thẳng nghề nghiệp ở điều dưỡng là một thách thức phổ biến trong bối cảnh môi trường y tế ngàycàng phức tạp. Nghiên cứu này nhằm mô tả thực trạng và nhận diện một số yếu tố liên quan đến căngthẳng nghề nghiệp của điều dưỡng trong giai đoạn 2015–2025. Nghiên cứu được thực hiện theo phươngpháp tổng quan luận điểm, thông qua rà soát và sàng lọc các tài liệu xuất bản từ năm 2015 đến năm 2025trên các cơ sở dữ liệu lớn, gồm PubMed, Cochrane Library, ScienceDirect, Google Scholar và hệ thốngdữ liệu y khoa Việt Nam. Kế …