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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Fluctuation and Noise Letters

Numerical Treatment of Stochastic-Deterministic SIRS Epidemic Differential Model with Impact of Saturated Incidence Using Implicit/Stochastic RK and Euler–Maruyama Computing Paradigm

Nabeela Anwar, Iftikhar Ahmad, Hijab Javaid, Adiqa Kausar Kiani, Muhammad Shoaib, Muhammad Asif Zahoor Raja

This paper involves the numerical exploration of both stochastic and deterministic SIRS epidemic models with saturated incidence rates. The implicit Runge–Kutta method, Euler–Maruyama method and stochastic Runge–Kutta methods are employed to analyze the dynamic patterns of the epidemic. The deterministic model is formulated using an ordinary differential system and is deep-seated in the well-established classical SIRS epidemic framework. A stochastic model is formulated by incorporating the elements of white noise …

29.08.2026journal-article

International Journal of Research in Medical Sciences

A comparative analysis on safety and efficacy of telmisartan and ramipril in treatment of hypertension in a tertiary care hospital

Wajid Gulzar, Mudasir Manzoor Dar, Amritpal Singh, Peer Samiq Masoodi, Shah Samreen, Uma Jyoti

Background: Hypertension is a major global health challenge and an important risk factor for cardiovascular disease. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used first-line antihypertensive agents. This study evaluated the safety and efficacy of telmisartan and ramipril in patients with hypertension at a tertiary care hospital. Methods: This prospective observational study included 113 adult patients with hypertension who received either telmisartan (n= …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Practice Changes in the Diagnosis and Management of Bacterial Tracheitis in Ventilator-Dependent Children in the Outpatient Setting After Introduction of a Novel Pathway

Geneviève A Donahey, Glenn J Rapsinski

Abstract Background Diagnosis and management of bacterial tracheitis (BT) in tracheostomy- and ventilator-dependent children (VC) is highly variable among outpatient subspecialty providers (OP). Stewardship efforts are generally limited to the inpatient setting, thus further studies are needed to examine and improve outpatient practices. Many OP report desire for guidance in the diagnosis and management of BT and feel a decision support tool would be helpful in their daily practice, thus we developed a pathway for …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Characteristics and Outcomes of Respiratory Viral Infections in Pediatric Cancer Patients, Single center experience

Mona Mohammed, Yassin Taher, Maha Mohammed, Naiven Mohamed, Nehad Abd Elfatah, Marwa Jamal, Omnya Ahmed, Amira Sameh, Mohamed Kamal, Youssef Madney

Abstract Background Respiratory viral (RV) infections cause morbidity and mortality in immunocompromised pediatric patients undergoing cancer treatment. The burden of RV infections in pediatric oncology populations from low- and middle-income countries (LMICs) remain limited. We aimed to detect the prevalence of viruses causing respiratory infections among pediatric patients with cancer and guide empiric therapy and improve patient outcomes. Methods Retrospectively we collected nasopharyngeal swabs and clinical and …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

A Ten-Year Retrospective Study on the Clinical and Microbiological Characteristics of Early Onset Neonatal Sepsis at a Single Tertiary Care Institution

Vilma Antonette B Prado, Amanda Louise Du

Abstract Background Early-onset neonatal sepsis remains a significant cause of morbidity and mortality globally. Although Group B Streptococcus and Escherichia coli were commonly known to be the most common causes of Early-onset neonatal sepsis, this can vary per institution, thus creating a challenge in management. Understanding the clinical and microbiological profile of neonatal sepsis in a single-center study is crucial to improving diagnosis and treatment, strategies. Objectives This study aimed to characteriz …

29.08.2026journal-article

Journal of the Colleges of Medicine of South Africa

A novel approach to peritonitis

Tshepang A. Motsepe

Peritonitis is a deadly abdominal condition seen across many surgical disciplines, with causes including appendicitis, perforated peptic ulcers, and abdominal trauma. In the South African context, peritonitis is largely influenced by tuberculosis (TB), human immunodeficiency virus (HIV), and widespread malnutrition linked to socioeconomic challenges. Although peritonitis is traditionally classified into primary, secondary, and tertiary types, the addition of quaternary peritonitis could reflect the severe complicat …

29.08.2026journal-article

Risk Analysis

A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens

Jack F. Schijven, Peter F. M. Teunis, Walter Q. Betancourt

ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate suitability of the final wastewater effluent for potable reuse; (3) evaluate viruses or groups of viruses as indicators of wastewater treatment efficiency. Reduction …

29.08.2026journal-article

PKLI Journal of Health Sciences

Integrating AI and Multi-Omics for Predicting Transfusion Reactions: A Step Toward Safe and Personalized Transfusion Medicine

Muhammad Hashim

Background: Blood transfusion is a lifesaving process, but the risk of adverse reactions ranges from mild to life-threatening. Current detection methods with limited sensitivity lack predictive power. Aim: To explore how artificial intelligence with multi-omics data such as genomics, transcriptomics, proteomics, and metabolomics enhances early prediction of transfusion reactions. This study aims to highlight recent advances, AI methodologies, and challenges to implementing these technologies. Methods: This study is …

29.08.2026journal-article

Modern Rheumatology

Clinical Results of Unlinked-type Total Elbow Arthroplasty for Stiff Elbows in Patients with Rheumatoid Arthritis

Yasuhiro Kiyota, Takuji Iwamoto, Taku Suzuki, Noboru Matsumura, Kazuki Sato, Masaya Nakamura

Abstract Objectives Total elbow arthroplasty is a common treatment for elbow stiffness due to rheumatoid arthritis. Although linked prostheses are often preferred, unlinked implants may reduce prosthetic stress and loosening risk. This study evaluated the clinical outcomes of unlinked total elbow arthroplasty in patients with rheumatoid arthritis presenting with stiff elbows. Methods This retrospective study included 9 women with 10 stiff elbows due to rheumatoid arthritis who underwent primary total elbow arthropl …

29.08.2026journal-article

International Science Journal

Neuro-Ophthalmological Warning Signs in Intracranial Neoplasms: Clinical Patterns for Early Detection and Visual Preservation

Patricia Equilea Veizaga, Alejandra Mendoza Ortiz, Natalia Restrepo Hinestrosa, Patricio Sánchez de Ovando González, Mariana Lineth Orozco Ricardo, Mariana Ramírez García, Jorge Angel Velasco Espinal, Alexa Fernanda Uriostegui Navarro

Neuro-ophthalmological manifestations may represent the first clinically detectable sign of intracranial neoplasms, particularly when tumors involve the optic nerves, optic chiasm, sellar and parasellar regions, cranial nerves, skull base, brainstem, or structures associated with intracranial pressure. This study analyzed the main visual and ocular manifestations associated with intracranial tumors and their potential value for early diagnosis through a descriptive and analytical review of the scientific literature …

29.08.2026journal-article

Current Pharmacogenomics and Personalized Medicine

Neuropharmacological Interventions in Alzheimer’s Disease: Current and Emerging Approaches

Lalit Parihar, Ajay Pal Singh, Sanjar Alam

Introduction:: Alzheimer’s Disease (AD) is a neurodegenerative disorder with progressive cognitive decline, β-amyloid plaques, neurofibrillary tangles, oxidative stress, and neuroinflammatory responses. So far, the pathogenesis of AD has been explained by the cholinergic hypothesis, amyloid cascade hypothesis, and tau protein dysfunction. However, the current pharmacological treatment of AD with cholinesterase inhibitors and NMDA receptor antagonists provides only symptomatic relief and cannot prevent the progressi …

29.08.2026journal-article

Journal of the Royal Society of Medicine

The historical development of sample size estimation: from Huygens and Bernoulli to the present

Kristian Thorlund, Christian Gluud

This paper traces the historical development of frequentist sample size estimation from its philosophical origins to its present-day complexity. Preliminary concepts were identified by Christiaan Huygens’ work on expected value and Jacob Bernoulli’s law of large numbers , which first linked sample size and estimation accuracy. The 18th and 19th centuries brought major advances in probability theory through the work of Pierre-Simon de Laplace, Carl Friedrich Gauss and Siméon-Denis Poisson, yet explicit sample size p …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Leveraging ChatGPT to address patient queries on fever of unknown origin: opportunities and limitations

Prajwal Gundala

Fever of unknown origin (FUO) remains one of the most intriguing and diagnostically challenging syndromes in internal medicine. The term FUO itself implies a passive/negative approach to diagnosis, suggesting a state of uncertainty that may perpetuate medical inertia. FUO is defined as a temperature ≥38.3°C (101°F) on several occasions for at least three weeks without an established diagnosis despite appropriate evaluation.1 In resource-limited settings an active and pragmatic approach is essential to expedite diag …

29.08.2026journal-article

International Journal of Research in Medical Sciences

An interesting case of Contarini’s syndrome in a young patient

Abhishek Agarwal, Armaan Singh, Ambikesh Gupta, Anish Goyal

Pleural effusion is a common disease of the pleura. The pleural effusion is usually unilateral and bilateral pleural effusion is less commonly seen. In bilateral pleural effusions usually the same etiology is present on both the sides but bilateral pleural effusions due to the two different etiologies on the two sides is rare. Here we are describing an interesting case of Contarini’s syndrome where exudative pleural effusion was present on each side but due to the two different etiologies on the two sides.

29.08.2026journal-article

Journal of Robotic Surgery

Robotic-assisted compartmental dissection for retroperitoneal sarcoma: a feasibility study on cadavers with the da Vinci Xi system

Jonas Wakker, Adrian Ohlde, Victoria van Rüth, Simone Schewe, Nathaniel Melling, Felix Nickel, Oliver Mann, Thilo Hackert, Volker Spindler, Sophie Kurmann, Rouven Berndt, Markus Albertsmeier, Jens Jakob, Anna Duprée

Abstract Retroperitoneal sarcomas (RPS) pose major technical challenges because of their size, anatomical complexity, and need for multivisceral resection. We evaluated the feasibility of a standardized robotic approach for right- and left-sided retroperitoneal sarcoma (RPS) compartmental resection using the da Vinci Xi system in tumour-free human cadavers. In a two-phase IDEAL-D Stage 0 cadaveric study, two sarcoma surgeons first compared four trocar configurations in two cadavers to identify optimal port template …

29.08.2026journal-article

Clinical Transplantation

Primary Language, Social Determinants of Health, and the Lived Patient Experience After Heart Transplantation: A Comparative Qualitative Study

Mansi K. Shah, Zara Latif, Carolina Lemos, Adi Hertz, Elena Donald, Byron Fuselier, Jordan Lindekens, Fabian Vargas, Afsana Rahman, Farhana Latif, Kevin J. Clerkin, Gabriel Sayer, Nir Uriel, Ersilia M. DeFilippis

ABSTRACT Background Over 4,500 individuals undergo heart transplantation (HT) in the United States every year. Limited qualitative data exist evaluating challenges and barriers in the evaluation and post‐transplant process and their association with primary language spoken. Methods We conducted semi‐structured interviews with individuals who received HT at a high‐volume urban academic medical center between 2015 and 2024. Primary English and Spanish speaking patients were included; interviews were conducted by a ce …

29.08.2026journal-article

Journal of Orthopaedic Science and Research

The Role of Biopsy Accuracy in the Treatment of Musculoskeletal Tumors

Hannah Werner, Bennie Lindeque

Background: The accurate treatment of Musculoskeletal (MSK) tumors necessitates appropriate timely biopsy of the mass of interest. With regards to malignant neoplasms biopsy plays a crucial role in the direction of treatment courses and patient outcome. Methods: This is a retrospective single-center chart review of 924 biopsies from 2013-2023. Patients included were between 18-85 with MSK tumors that necessitated biopsy and subsequent surgical treatment. Biopsy and final resection histopathology reports were compar …

29.08.2026journal-article

Veterinary Medicine and Science

Isolation and Antibiogram of Staphylococcus aureus Isolated From Bovine Mastitis in Bardaghat Municipality, Nepal

Biswash Ghimire, Shambhu Shah, Akash Adhikari, Sujan Adhikari, Asmita Regmi, Sirjan Bastola

ABSTRACT Background Mastitis in dairy animals is a major economic and public health concern in Nepal, exacerbated by the emergence of antimicrobial‐resistant pathogens. This study aimed to determine the prevalence and antibiotic resistance patterns of Staphylococcus aureus isolated from bovine milk in Bardaghat Municipality, Nepal. Results A cross‐sectional survey screened 196 milk samples from lactating cows and buffaloes using the California Mastitis Test (CMT). The overall prevalence of S. aureus was 39.79%. Str …

29.08.2026journal-article

Journal of Personalized Medicine

Personalizing Peri-Intubation Oxygenation in Patients at Risk of Acute Hypoxemic Respiratory Failure: A Phenotype-Driven Narrative Review of High-Flow Nasal Oxygen and Non-Invasive Ventilation

Daniele Salvatore Paternò, Luigi La Via, Rossella Moltisanti, Antonio Putaggio, Angela Maria Piccolo, Giorgia Maria Noce, Roberta Scuto, Gilberto Duarte-Medrano, Natalia Nuño-Lámbarri, Emilia Concetta Lo Giudice, Massimiliano Sorbello

Tracheal intubation in patients at risk of acute hypoxemic respiratory failure (AHRF) carries a high risk of life-threatening desaturation, and the choice of peri-intubation oxygenation strategy critically influences patient safety. This narrative review synthesizes current evidence on non-invasive oxygenation techniques—high-flow nasal oxygen (HFNO), non-invasive ventilation (NIV), and their combination—across the pre-oxygenation, apneic, and awake-intubation phases of airway management. We examine the physiologic …

29.08.2026journal-article

Journal of Clinical Medicine

Total Pectoral Muscle Area and Prognostic Nutritional Index Provide Complementary Prognostic Information for Patients Hospitalized with HFmrEF/HFrEF

Çetin Alak, Hasan Emin Kaya, Fazıl Çağrı Hunutlu, Muhammed Batuhan Daştan, Zeynep Kumral, Tunay Şentürk

Background: Skeletal muscle depletion and malnutrition are common in heart failure (HF) and are associated with poor outcomes. Whether imaging-derived skeletal muscle reserve and laboratory-based nutritional indices provide complementary prognostic information remains unclear. We evaluated the prognostic value of total pectoral muscle area (TPMA), Prognostic Nutritional Index (PNI), and Controlling Nutritional Status (CONUT) scores in patients hospitalized with HFmrEF/HFrEF. Methods: In this retrospective single-ce …

29.08.2026journal-article

Journal of Clinical Medicine

CT-Based Peritumoral and Perirenal Fat Radiomics in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis of Grade, Stage, and Adherent Perinephric Fat Prediction

Abdulrahman Al Mopti, Ali H. D. Alshehri, Abdulsalam Alqahtani

Background/Objectives: Preoperative risk stratification in renal cell carcinoma (RCC) remains challenging for tumor aggressiveness and for adherent perinephric fat (APF) relevant to surgical planning. Although intratumoral radiomics are established, the peritumoral and perirenal fat microenvironment is biologically active and may encode imaging biomarkers. This systematic review and meta-analysis evaluated CT-based peritumoral and perirenal fat radiomics for preoperative grading, staging, and APF prediction and exa …

29.08.2026journal-article

Journal of Clinical Medicine

Self-Care Experiences of Individuals with Heart Failure: A Systematic Review and Metasynthesis

Israr Ahmad, Agata Bielecka-Dabrowa, Brunilda Subashi, Yi Chen

Background: Heart failure (HF) is a complex, life-threatening syndrome associated with substantial morbidity and mortality, reduced functional capacity, diminished quality of life, and considerable healthcare costs. Globally, HF affects more than 64 million individuals. Chronic heart failure (CHF) imposes a significant economic and personal burden on individuals, society, and the healthcare system, and places substantial demands on effective self-care. Objective: The purpose of this metasynthesis was to explore the …

29.08.2026journal-article

Advances in Respiratory Medicine

Morphological Analysis of the Flow–Volume Curve for Identifying Fixed Airflow Obstruction: A Scoping Review

Alirio Bastidas-Goyes, Luis F. Giraldo-Cadavid, Eduardo Tuta-Quintero, Diana Diaz-Quijano, Daniel Botero-Rosas, Adriana Maldonado-Franco, Alejandra Vargas, Paula Rincón, Lina López, Juan S. Hernández, Juan Castro, Isabella Criado, Charbel Faizal-Gómez, David Jiménez, Ingrid Mora, Juan León

Background/Objective: The morphology of the flow–volume curve has emerged as a potential source of additional functional information by enabling the analysis of concavity, slope-based metrics, area-derived measures, and mathematical models extracted from the expiratory tracing. Therefore, the aim of this study was to map and describe the available evidence on morphological analysis methods of the expiratory flow–volume curve for the identification and characterization of fixed airflow obstruction. Methods: A scopin …

29.08.2026journal-article

BMC Medical Education

Defining leadership competencies for rural community-based medicine: a Delphi study and field-based curriculum evaluation for undergraduate medical students

Koichi Hamabira, Marie Amitani, Hayato Sakiyama, Kimiko Mizuma, Rie Ibusuki, Tetsuhiro Owaki

Abstract Background Leadership is essential in community-based medicine, yet inconsistently taught in Japan’s undergraduate medical curricula. This study aimed to: (1) identify essential community-based leadership competencies using a Delphi approach, (2) develop and pilot a structured curriculum, and (3) evaluate outcomes through a multi-day interprofessional field programme. Methods We adopted Kern’s six-step approach to curriculum development. A literature review extracted preliminary competencies. A two-round D …