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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Clinical Dentistry and Research

Radiographic Evaluation Of The Success Of Root Canal Treatment In Mandibular Premolars: A Retrospective Cross-Sectional Study

Damla Erkal, Yunus Emre Çakmak, Maira Kopbayeva, Kürşat Er

Background and Aim: Radiographic assessment is essential forevaluating the technical quality of root canal fillings and periapicalstatus after root canal treatment (RCT). This retrospective crosssectionalstudy assessed the radiographic quality of RCT in mandibularpremolars using panoramic radiographs and investigated theassociation between root canal filling quality and periapical lesions.Materials and Methods: Archived digital panoramic radiographswere screened, and 205 radiographs (261 mandibular premolars:34, 35 …

24.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Seen, Heard, and Still Missing: Understanding Clinical Trial Nonparticipation Among Women of Color

Jasmine Dionne Souers, Marissa Thomas, Juliette Faughnan, Mary Fox, Nishtha Gupta, Gail Betz, Adishree Nayak, Nathaniel Laban, Christabel K. Cheung

Purpose: To examine structural, informational, and cultural barriers to clinical trial participation among women of color (WOC), with emphasis on adolescents and young adults (AYAs), through a community-partnered study to illuminate persistent challenges and generate actionable strategies through community-driven research. Methods: In partnership with For the Breast of Us , a national advocacy organization for WOC affected by breast cancer, we conducted a sequential exploratory mixed-methods study. In-depth intervi …

24.08.2026journal-article

Frontiers in Pharmacology

Pradefovir mesylate and tenofovir amibufenamide for chronic hepatitis B: a systematic review and pragmatic treatment algorithm

Shuqi Yang, Liting Zhan, Zimei Wan, Xueping Yu

Background Pradefovir mesylate (PDV; approved in China in 2024) and tenofovir amibufenamide (TMF; approved in China in 2021) are novel hepatocyte-targeted nucleotide prodrugs recently approved in China. Their clinical positioning relative to the guideline-endorsed benchmark tenofovir alafenamide (TAF) for chronic hepatitis B management remains undefined, particularly regarding renal/bone safety and drug-drug interaction profiles. Objective To synthesize available evidence and propose a pragmatic treatment selection …

24.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Improved healing and tissue regeneration for prevention and treatment of pelvic floor disorders: from reactive treatment to proactive prevention

Basak Akin, Sarah A. Sinclair, Jan Paul Roovers, Zeliha Guler

Pelvic floor disorders (PFDs), including pelvic organ prolapse (POP), stress urinary incontinence (SUI), and obstetric fistula, impose a major global health burden. Largely driven by birth-related trauma, they reduce quality of life and can cause physical, psychological, and social consequences. Current surgical and conservative treatments often fail to address underlying tissue damage and impaired healing, contributing to high recurrence; up to 30% of patients require repeat procedures. Tissue engineering and rege …

24.08.2026journal-article

World Journal of Clinical Oncology

Near-complete clinical response after neoadjuvant therapy in rectal cancer: Decision-making between organ preservation and surgery

Thanat Tantinam, Kullawat Bhatanaprabhabhan, Boonchai Ngamsirimas, Pawit Sutharat, Rangsima Thiengthiantham, Nataphon Santrakul, Suwan Sanmee, Ekkarin Supatrakul, Punnawat Chandrachamnong, Suradet Buakhrun

Near-complete clinical response (nCR) after neoadjuvant therapy in rectal cancer represents a clinically relevant but heterogeneous intermediate state between clinical complete response and incomplete clinical response. With the growing adoption of total neoadjuvant therapy, nCR is increasingly encountered; however, its optimal management remains controversial, particularly regarding its definition, timing of assessment, and the balance between organ preservation and oncologic safety. This mini-review synthesizes c …

24.08.2026journal-article

Discovery Medicine

Risk Factors for Persistent Atelectasis and Development of a Predictive Nomogram After Video-Assisted Thoracoscopic Lobectomy in Non-Small Cell Lung Cancer Patients: A Retrospective Cohort Study

Kai Su, Xiaohui Ding, Zhuhui Xu, Yi Yang, Rongrong Zhang, Dongliang Zhang

Background: On most postoperative imaging examinations, atelectasis after lobectomy is a transient finding. We focused on the more clinically consequential scenario: persistent collapse of at least one segment of the lung beyond the first postoperative week. These cases may delay mobilisation, impair secretion clearance, and increase the need for additional airway care after video-assisted thoracoscopic (VATS) lobectomy for non-small cell lung cancer (NSCLC). This study investigated perioperative predictors of this …

24.08.2026journal-article

Frontiers in Immunology

Research progress and clinical translation prospects of the urinary tract microbiome in prostate cancer

Ze-lin Li, Ruo-nan Qu, Shang-xuan Liu, Wei Wang

Prostate cancer (PCa) is one of the most common malignancies in men worldwide, and its development is influenced by multiple factors, including genetic susceptibility, hormonal dysregulation, chronic inflammation, immune dysregulation, and remodeling of the tumor microenvironment. In recent years, the urinary tract microbiome has emerged as an important component of the tumor ecosystem and has attracted increasing attention in PCa research. Accumulating evidence indicates that patients with PCa exhibit characterist …

24.08.2026journal-article

Pharmaceuticals

Pharmacological Mechanisms of Active Constituents from Traditional Chinese Medicine for Vitiligo Treatment

Adina Hamiti, Yingying Geng, Pengfei Huang, Jinghui Xie, Tingting Cui

Vitiligo is a chronic acquired depigmenting disorder characterized by progressive melanocyte loss. Its pathogenesis involves a multifactorial interplay among oxidative stress, impaired melanocyte regeneration, immune-mediated cytotoxicity, and neuroendocrine dysregulation. In recent years, traditional Chinese medicine (TCM)-derived active ingredients have attracted increasing research interest as potential interventions for vitiligo, although most isolated compounds remain at the preclinical stage. This review summ …

24.08.2026journal-article

Membranes

Nanomaterial-Modified Antibacterial Membranes for Water Treatment: From Dimensional Classification and Modification Strategies to Antimicrobial Mechanisms

Lu Pei, Bingrong Wang, Yutong Zheng, Yang Liu, Yang Zhou, Xiangdong Zeng

Membrane separation technology is extensively used in water treatment. However, during long-term operation, biofouling caused by bacteria and other microorganisms significantly limits the service life of membranes. Introducing antibacterial nanomaterials onto the membrane surface or into the internal structure is an effective way to combat biofouling. This review systematically summarizes recent progress in antibacterial membranes modified with different nanomaterials. First, we classify antibacterial nanomaterials …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Neuroimaging Evidence of Acupuncture Treatment for Depression Over the Past Decade: A Systematic Review

Jia Sun

This systematic review aims to synthesise evidence from neuroimaging studies to illustrate that acupuncture does have measurable multi-target central actions for major depressive disorder (MDD) treatment. The key mechanisms identified in studies over the past decade, using fMRI, PET and EEG, are: Acupuncture reduces hyperconnectivity of the default mode network (DMN) and increases its anti-correlation with the salience network. In task-based imaging, there is observed reduction in hyperactivity in the amygdala in c …

24.08.2026journal-article

Applied and Computational Engineering

Application of Semiconductor Nanomaterials in Water Pollution Treatment

Ruijie Li

Given the rapid advancement of industrialization and urbanization, multiple forms of water pollution have grown increasingly severe. Traditional water treatment technologies face challenges such as low treatment efficiency and secondary pollution. Semiconductor nanomaterial-based photocatalysis has emerged as a promising approach for green water pollution control. This paper adopts a literature review method to systematically explore the photocatalytic water purification mechanisms of semiconductor nanomaterials, s …

24.08.2026journal-article

Frontiers in Pharmacology

Integrated multi-omics analysis and functional experiments reveals PPAP2C as a potential prognostic biomarker and therapeutic target in breast cancer

Xiaoxi Lin, Lihang Cen, Sihui Yue, Liangsen Teng, Shuang Qin, Yipeng Cheng, Mingyue Qiu, Yonggang Lu, Jie Zhang, Shuguang Zuo

Background This study aims to systematically elucidate the clinical significance and biological function of the phospholipid phosphatase (PLPP) family member (PPAP2C) phosphatidic acid phosphatase type 2C in breast cancer, and to evaluate its potential as a prognostic biomarker and therapeutic target. Methods Gene expression data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Cancer Cell Line Encyclopedia (CCLE) databases were integrated to characterize the expression profile of PLPP fa …

24.08.2026journal-article

Journal of Healthcare Informatics Research

Toward Fairness in Machine Learning Models for Predicting Treatment Retention and Premature Discontinuation in Medication for Opioid Use Disorder

Tongnian Wang, Carolina Vivas-Valencia, Cici Bauer, Yanmin Gong, Kim-Kwang Raymond Choo, Yuanxiong Guo

Abstract Persistent low retention and completion rates in medications for opioid use disorder (MOUD) have driven the use of machine learning (ML) models to predict retention and identify patients at risk of premature discontinuation. However, the fairness of these models across patient populations remains largely unexplored, raising concerns about their application in treatment decision support. This study systematically assesses algorithmic fairness in ML models for predicting MOUD retention and premature disconti …

24.08.2026journal-article

JNCI Cancer Spectrum

Prevalence of Patient-Reported and Clinician-Graded cognitive symptomatic adverse events in older patients with advanced cancer

Riham Alieldin, Mostafa Mohamed, Chin-Shang Li, Michelle C Janelsins, Rachael Tylock, Karen M Mustian, Luke Peppone, Charles Kamen, Po-Ju Lin, Kah Poh Loh, AnnaLynn M Williams, Brian J Altman, Paula M Vertino, Hongying Sun, Umang Gada, Supriya G Mohile, Judith O Hopkins, Bryan A Faller, Vincent Vinciguerra, Allison Magnuson

Abstract PURPOSE Cancer-related cognitive impairment is common in patients receiving cancer treatment but may be under detected by clinician-graded adverse events (AEs) alone. Patient-reported outcomes and cognitive screening may improve identification of cognitive symptoms. METHODS We conducted a secondary analysis of the nationwide, multicenter GAP70+ trial of adults aged ≥70 years with advanced cancer starting systemic therapy. Cognitive symptoms were assessed longitudinally using patient-reported and clinician- …

24.08.2026journal-article

Discover Oncology

A single-center study of prognostic impact and treatment implications of cribriform pattern in prostate cancer

A. Handke, M. Dellino, C. Orf, N. Wang, C. Darr, P. Bach, F. Roghmann, K. H. Tully

Abstract Introduction Cribriform prostate cancer (cPCa) is increasingly recognized for its aggressive behavior and poor prognosis compared to conventional acinar adenocarcinoma. It is associated with adverse pathological features and excludes patients from active surveillance, highlighting the need for accurate identification. This study aimed to evaluate oncologic outcomes and characterize subsequent treatment patterns in a single-center cohort of patients with cribriform prostate cancer. Materials We retrospectiv …

24.08.2026journal-article

Frontiers in Oncology

Risk-adapted neck dissection in salivary gland carcinoma: integrating occult nodal metastasis patterns with contemporary guidelines

Felix Johnson, Lea Stecher, Nora-Maria Burian, Marcel Kloppenburg, Rubens Thölken, Benjamin Freytag, Patrick Schuler, Benedikt Hofauer

Introduction Salivary gland carcinomas (SGCs) are rare and histologically diverse malignancies of the head and neck. They present significant challenges for standardized treatment due to varied metastatic behavior and limited high-level evidence. The extent of neck dissection remains controversial, influenced by tumor grade, histological subtype, and anatomical origin. This review evaluates current evidence and guideline recommendations to define an evidence-based, risk-adapted approach to neck dissection in SGC. M …

24.08.2026journal-article

Nutrients

Clinical Implications of Nutritional Consultations and Oral Nutritional Supplementation Refusal in Head and Neck Cancer Patients During Chemoradiotherapy

Aleksandra Krzywon, Anna Kotylak, Jolanta Mrochem-Kwarciak, Tomasz Rutkowski

Background/Objectives: Nutritional support may improve the tolerance and effectiveness of definitive treatment in patients with head and neck cancer (HNC). The aim of this study was to investigate the potential clinical deterioration in patients who refuse nutritional consultations and oral nutritional supplementation during chemoradiotherapy (CHRT) for HNC. Methods: The study included 52 patients undergoing CHRT for HNC. Among these patients, 22 (42.3%) received nutritional counseling with oral nutritional supplem …

24.08.2026journal-article

Diagnostics

Dynamic Oculomics for Diagnostic Monitoring: Personal Ocular Trends, Risk Stratification and Treatment Response

Alessandro Avitabile, Mario D. Toro, Roberta Amato, Dario Rusciano, Caterina Gagliano

Oculomics uses ocular images, ocular biofluids and functional ocular tests to extract diagnostic information on local or systemic biological states. Most current evidence is cross-sectional: one retinal photograph, OCT scan, OCTA examination or tear sample is compared with a reference population, or converted into a diagnostic or prognostic score. This approach is useful for screening and risk enrichment, but it does not show whether the same patient is changing over time. In this review, dynamic oculomics, or ocul …

24.08.2026journal-article

International Journal of Environmental Science and Technology

Waste-to-resource valorization of babassu biomass: biochar integrated with ceramic microfiltration for oily water treatment

H. L. Lira, L. P. S. Rosa, J. P. L. Santos, G. F. Silva

Abstract Produced water from oil production contains high levels of suspended solids, hydrocarbons, and salts, requiring efficient treatment before reuse or discharge. This study proposes a hybrid system integrating adsorption using babassu coconut biochar with ceramic microfiltration to treat real produced water from the Rabo Branco field in Brazil. A comprehensive characterization was performed for both the biochar (surface area, pore volume, TGA, SEM, FTIR, elemental composition, and true density) and the produc …

24.08.2026journal-article

Addiction Science & Clinical Practice

ACT now: a mixed-methods evaluation of a nurse-led tobacco treatment program in a safety-net hospital

Thye Peng Ngo, Sasha N. Skinner, Neal Benowitz, Marlene Martin, Maya Vijayaraghavan

Abstract Background Tobacco use remains prevalent among patients hospitalized in safety-net settings, where co-occurring psychosocial and structural needs complicate treatment and contribute to persistent health disparities. However, little is known about how nurse-led tobacco treatment programs within addiction consult services are implemented, prioritized, and sustained. This study estimated tobacco use prevalence and correlates and examined multilevel factors influencing the implementation and sustainability of …

24.08.2026journal-article

Cancer Discovery

A Pan-Cancer Single-Cell Analysis of Intratumoral Copy-Number Diversity and Evolution

Hanghui Ye, Thomas O. McDonald, Reem Elghaish, Emi Sei, Darlan Conterno Minussi, Min Hu, Shanshan Bai, Chenling Tang, Junke Wang, Kaile Wang, Robert J. Downey, Anna Casasent, Michael D. Nicholson, Hui Chen, Franziska Michor, Nicholas E. Navin

Abstract Aneuploidy is a hallmark of human tumors. Although patient-level copy-number alteration (CNA) differences have been investigated extensively in large cohorts, their intratumoral heterogeneity remains understudied. In this study, we conducted a pan-cancer analysis of 94 human tumors at single-cell resolution, representing seven cancer types: bladder, breast, colon, glioblastoma, kidney, lung, and ovarian. Single-cell copy-number profiling was used to analyze 62,646 aneuploid cells, in addition to bulk exome …

24.08.2026journal-article

Journal of Neonatal-Perinatal Medicine

Single-dose 40% buccal dextrose gel for treatment of neonatal hypoglycemia: A randomized controlled trial

Nagwa Mohamed Sabry Mahmoud, Aya Rabie Mohamed, Madeha Abdalla Sayed

Background Neonatal hypoglycemia is a common, potentially serious postnatal metabolic disorder. This study evaluated the efficacy and safety of a single dose of 40% buccal dextrose gel versus standard care for achieving early euglycemia in at-risk neonates with a documented low baseline blood glucose. Methods This prospective randomized controlled trial was conducted at the Neonatal Intensive Care Unit, Minia University Hospital, Egypt (March-November 2024). Clinically stable, asymptomatic at-risk neonates (gestati …

24.08.2026journal-article

Current Cancer Therapy Reviews

Acteoside in Cancer Therapy: Integrating Ethnomedicinal Insights with Bibliometric Analysis

Tamim Ahmed, Deboja Ishita, Sibashish Kityania, Swaprakash Paul, Sutapa Dhar, Rajat Nath, Priyakshi Nath, Monjur Ahmed Laskar, Deepa Nath, Anupam Das Talukdar

Introduction: Cancer remains a major global health challenge, accounting for nearly one in six deaths worldwide, with treatment often limited by drug resistance, tumour heterogeneity, and therapy-related side effects. Natural plant-derived compounds have gained attention as potential therapeutic leads owing to their structural diversity and multi-targeted mechanisms. Acteoside (Verbascoside), a phenylethanoid glycoside obtained from medicinal plants, exhibits diverse biological and promising anticancer effects. How …

24.08.2026journal-article

Frontiers in Medicine

Topical sirolimus for the treatment of verrucous epidermal nevus associated with an HRAS mosaic mutation: a case report

Qiu-ju Wei, Wan-yan Xiang, Wen-jun Zheng, Qiu-ju Li

Introduction Verrucous epidermal nevus is a benign epidermal hamartoma associated with somatic mosaic mutations, which shows poor response to conventional therapies and has a high risk of recurrence. To date, there are no standardized treatment guidelines for this condition. In recent years, targeted treatments for specific gene mutations have provided new directions for the clinical management of this disease. Case report We report a case of a 13-year-old child with verrucous epidermal nevus in whom genetic testin …