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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
23.08.2026journal-article

Molecular Carcinogenesis

RNF123 Inhibits the Proliferation, Migration, and Invasion of Thyroid Cancer by Inhibiting KAT5‐Mediated PSPC1 Histone Acetylation

Lin Guo, Senhe Jiang, Xuehan Wang, Yiren Feng, Gang Jin

ABSTRACT Thyroid cancer (THCA) is the most common endocrine malignancy worldwide, understanding the pathophysiological mechanism is vital for developing effective strategies for prevention, diagnosis, and treatment. In this study, paired tumor and adjacent noncancerous tissues were collected from THCA patients. Cell viability and proliferation were assessed using CCK‐8 and EdU assays. Cell migration and invasion were evaluated by wound healing and Transwell assays. Co‐immunoprecipitation was performed to examine RN …

23.08.2026journal-article

The Prostate

Stereotactic Prostate Cancer Ablative Re‐Irradiation: A Systematic Review and Meta‐Analysis (SPARE)

Andre G. Gouveia, Jody Tao, Gregory Pond, Kevin Dong, Allison Ye, Arthur A. Rosa, Daniel M. Palhares, Conrad J. Q. Villafuerte, Paola Anselmo, Fabio Y. Moraes, Fabio Arcidiacono, Robert Olson, Theodoros Tsakiridis

24 August 2026: This article published in Early View in error. The article is under embargo and will republish on September 30, 2026.

23.08.2026journal-article

MedComm – Oncology

Mitochondrial DNA in Tumor Evolution and Heterogeneity: Characteristics, Technological Advances, Applications and Challenges

Zifeng Ruan, Zihao Chen, Weicheng Yu, Maolei Zhang, Xingguo Liu

ABSTRACT Tumor heterogeneity and Darwinian evolution act as core drivers of therapeutic resistance. Deciphering the phylogenetic architecture of cancer demands high‐resolution lineage tracing. Nevertheless, exogenously introduced lineage markers possess inherent limitations. This review presents somatic mitochondrial DNA (mtDNA) mutations as a powerful, newly emerging endogenous lineage marker. It describes the unique characteristics of mtDNA, including high copy number, elevated mutation rate, and maternal inherit …

23.08.2026journal-article

International Journal of Molecular Sciences

The Crosstalk Between YAP/TAZ and Cancer Metabolism: From Mechanistic Insights to Drug Discovery

Yinhuang Gao, Minghong Chen, Songxia Lin, Min Huang, Jing Jin

As the core transcriptional co-activators of the Hippo signaling pathway, YAP and TAZ play essential roles in maintaining tissue homeostasis and in tumorigenesis. Their aberrant activation is frequently observed in human malignancies, and accumulating evidence has identified them as crucial drivers of tumor initiation and progression. YAP/TAZ have been recently recognized as key regulators of cellular metabolic reprogramming, a hallmark of cancer that fuels tumor cell proliferation by rewiring glucose, lipid, amino …

23.08.2026journal-article

Survey Practice

Methodology for exploring cross-cultural differences in quality of life among Asian American breast cancer survivors in California and Texas: Lessons learned from a convergent mixed-methods study

Annalyn Valdez-Dadia, Marjorie Kagawa-Singer, Lucy Young, Lei-Chun Fung, Beverly Gor, Becky Nguyen, Qian Lu

Studies investigating whether and how culture impacts social support and quality of life among diverse Asian American populations of breast cancer survivors often conflate race and ethnicity with culture, and investigate differences based on biological designations rather than understanding the unique ways beliefs and values contribute to health care practices. This article will be of relevance to researchers interested in identifying and recruiting underserved and made-to-be-vulnerable groups. This study applied a …

23.08.2026journal-article

Oral Science International

The Clinical Implications of the Inverse Correlation Between miR‐27b‐3p and EGFR in Oral Cancer

Taniya Michel, Bhuvaneswari Veeraswamy, Durairaj Sekar

ABSTRACT Aim This study aimed to investigate the role of miR‐27b‐3p in regulating epidermal growth factor receptor (EGFR) expression and its significance in the pathogenesis of oral squamous cell carcinoma (OSCC). Methods Potential miRNAs targeting EGFR were identified using TargetScan, miRDB, and miRTarBase, followed by literature screening. Expression patterns of miR‐27b‐3p and EGFR were analyzed using The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma (TCGA‐HNSC) and Gene Expression Omnibus (GEO) data …

23.08.2026journal-article

Annals of Surgical Oncology

Elevated Pre-Treatment Serum Interleukin-10 Levels Predict Poor Overall Survival in Esophageal Cancer

Chien-Ming Lo, David Kwan Ru Huang, Meng-Yun Tsai, Hsing-Hua Lai, Yu Chen, Hung-I Lu, Yen-Hao Chen, Shau-Hsuan Li

Abstract Objective Our objective was to evaluate whether pre-treatment serum interleukin (IL)-10 concentrations predicted overall survival (OS) in patients with esophageal squamous cell carcinoma. Methods This single-center retrospective analysis included 112 patients with esophageal cancer who were treated with definitive concurrent chemoradiotherapy. Pre-treatment serum samples were collected, and IL-10 levels were measured. Patients were dichotomized into “low” and “high” IL-10 groups. Baseline characteristics ( …

23.08.2026journal-article

The American Surgeon™

Preserving the Nipple-Areola Complex in Centrally Located Breast Cancer: Trade-offs Among Oncoplastic Techniques

Mehmet Furkan Sağdıç, Emre Tunç, Mahmut Onur Kültüroğlu, Lütfi Doğan

Background Centrally located breast tumors pose surgical challenges in achieving oncologic margin safety and acceptable aesthetic outcomes due to their proximity to the nipple-areola complex. Although mastectomy has traditionally been preferred, advances in oncoplastic breast-conserving surgery have enabled oncologically safe breast conservation with nipple-areola complex preservation. Methods We retrospectively analyzed 291 patients who underwent oncoplastic breast-conserving surgery with nipple-areola complex pre …

23.08.2026journal-article

Children

Atypical Case of Presumed Bartonella henselae Osteomyelitis in a Child with Cat-Scratch Disease Mimicking a Malignant Bone Tumor

Sinisa Ducic, Stefan Djordjevic, Mikan Lazovic, Polina Pavicevic, Milena Mihajlovic, Amela Kalac, Filip Milanovic

Background/Objective: Bartonella henselae, the causative agent of cat-scratch disease (CSD), usually causes a self-limiting zoonotic infection. Osteomyelitis is a rare but increasingly recognized manifestation, particularly in children, and may closely mimic malignant or other infectious bone diseases. We present a case of multifocal pediatric Bartonella henselae osteomyelitis and discuss the associated diagnostic and therapeutic challenges in the context of the current literature. Case presentation: We report the …

23.08.2026journal-article

Cancers

Targeting miR-10b in Breast Cancer Bone Colonization Model Using Image-Guided Nucleic Acid-Based Therapeutics

Sujan K. Mondal, Elizabeth Kenyon, Bryan Doyun Kim, Zdravka Medarova, Anna Moore

Background/Objectives: Breast cancer is the most frequently diagnosed cancer among women worldwide and a leading cause of cancer-related death. Despite the use of bisphosphonates, RANKL inhibitors, chemotherapy, and available endocrine therapies, the five-year survival rate for patients with bone metastases remains approximately 20–30%, underscoring the urgent need for novel, metastasis-specific therapeutic strategies. Recent studies demonstrated that miR-10b can serve as an attractive therapeutic target for the tr …

23.08.2026journal-article

Cancers

Shear Wave Elastography Adds to the Sensitivity of Cancer Diagnosis in AUS-Nuclear and AUS-Other Nodules > 1 cm, but It Cannot Replace TIRADS Assessment and Repeat FNA

Dorota Słowińska-Klencka, Bożena Popowicz, Joanna Duda-Szymańska, Mariusz Klencki

Background/Objectives: The aim of the study was to compare the effectiveness of SWE in AUS-nuclear and AUS-other nodules, including nodules with an unequivocal cytology (UC), taking into account the size of the nodules. Methods: We evaluated 100 AUS-nuclear and 131 AUS-other nodules with known results of EU-TIRADS, repeat FNA (rFNA), and histopathological examination, and 92 nodules with UC: 47 malignant and 45 benign. Two SWE measures were used: Ewhole—capturing the largest possible area of the nodule; and Estiffe …

23.08.2026journal-article

The Prostate

Comparison of Whole‐Gland and Transition Zone PSA Density in Predicting Clinically Significant Prostate Cancer in PI‐RADS 3 Lesions

Mehmet Akif Doğan, Hüseyin Saygın, Aydemir Asdemir, İbrahim Karaca, Adem Kır, Esat Korğalı

ABSTRACT Background PI‐RADS 3 lesions represent a clinical gray zone in prostate cancer diagnostics, often leading to unnecessary biopsies. Additional biomarkers are needed to improve risk stratification and safely exclude clinically significant prostate cancer (csPCa). This study aimed to compare the performance of whole‐gland prostate‐specific antigen density (PSAD) and transition zone PSA density (TZ‐PSAD) in predicting csPCa and to evaluate their clinical utility in biopsy decision‐making. Methods We conducted …

23.08.2026journal-article

The Prostate

Prognostic Impact of the Addition of Prostate‐Directed Radiotherapy With or Without Metastasis‐Directed Radiotherapy Under Upfront Doublet Therapy for High‐Volume Metastatic Hormone‐Sensitive Prostate Cancer

Dai Koguchi, Hideyasu Tsumura, Ken‐ichi Tabata, Takefumi Satoh, Yutaka Shiono, Shuhei Hirano, Masaomi Ikeda, Yasufumi Yamada, Kazuki Matsushita, Rena Tanaka, Daisuke Ishii, Hiromichi Ishiyama, Kazumasa Matsumoto

ABSTRACT Background Radiotherapy is established as a standard treatment for low‐volume metastatic hormone‐sensitive prostate cancer (mHSPC), but its prognostic impact for high‐volume mHSPC under upfront therapy is unclear. This study investigates the effect of adding prostate‐directed radiotherapy (PDRT) with or without metastasis‐directed radiotherapy (MDRT) to upfront doublet therapy for high‐volume mHSPC. Methods We retrospectively assessed 239 patients who received upfront doublet therapy for synchronous high‐v …

23.08.2026journal-article

Flavour and Fragrance Journal

Elucidating Anti‐Breast Cancer Potential of Citrus medica Essential Oil: Targeting VEGFR2 and HER2 Receptors by In Silico Molecular Docking Analysis

A. R. Amala Dev, Sonia Mol Joseph, A. Shanitha

ABSTRACT Breast cancer is one of the most common cancers that affects women globally. The anti‐breast cancer potential of Citrus medica leaf essential oil (CMeLO) remains largely unknown, despite Citrus medica being a medicinally significant aromatic plant long used to treat a variety of illnesses. Consequently, this investigation assessed the antiproliferative activity of CMeLO against the human breast cancer cell line (MCF‐7). Gas chromatography–mass spectrometry (GC–MS) chemical profiling of CMeLO showed that ox …

23.08.2026journal-article

Biofuels, Bioproducts and Biorefining

Thermophilic anaerobic treatment and biogas generation from wastewater produced in an advanced biorefinery process

Jairo M. Carrillo‐Osorio, Germán Buitrón

Abstract Anaerobic digestion can be an alternative method for treating wastewater from second‐generation biorefineries while simultaneously producing biogas. However, the feasibility of the process and key operational parameters by which wastewater produced in lignocellulosic biorefineries affects reactor performance remain poorly understood. This study evaluated the thermophilic anaerobic treatment of wastewater from the hydrothermal biomass pretreatment stream of a lignocellulosic biorefinery. Reactor performance …

23.08.2026journal-article

Pharmaceutics

Targeted Delivery of Specialized Pro-Resolving Mediators (SPMs) for Improved Treatments of Inflammatory Diseases and Cancer

Adeola Aminu, Zhenjia Wang

Acute and chronic inflammation underlies the pathogenesis of numerous diseases, including autoimmune disorders, atherosclerosis, infections, and cancer. Although non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are widely used to control inflammation, their clinical utility is limited by adverse effects such as gastrointestinal toxicity and immunosuppression. Specialized pro-resolving mediators (SPMs), a family of endogenous lipid mediators derived from omega-3 fatty acids, have emerged as promisi …

23.08.2026journal-article

British Journal of Pharmacology

Resinous traditional Chinese medicine for cancer treatment: Mechanisms and therapeutic potential

Ruoxin Zhang, Fei Wang, Xuejiao Wei, Huiming Huang, Xinyu Qiu, Zhuguo Wang, Yufeng Gao, Wanying Xie, Xiaoxue Wang, Changhai Qu, Zhongdong Hu

Abstract Resinous traditional Chinese medicines are a ‘treasure trove of natural bioactive molecules’. Their unique hydrophobic components are an important source of antitumour agents. Resinous traditional Chinese medicines, including frankincense, myrrh, gamboge, Sanguis Draconis , Resina Draconis and asafoetida, strongly inhibit the progression of various malignant tumours, such as lung cancer, breast cancer, colorectal cancer, prostate cancer and gastric cancer, through multiple mechanisms. The core antitumour m …

23.08.2026journal-article

Eye & ENT Research

Proportion, Five‐Year Survival Rate of Laryngeal Cancer and Its Associated Factors Among Head and Neck Cancer Patients in Tanzania

Amenye Adili, Furaha Serventi, Baraka M. Musimu, Mica Magembe, Orest Tarimo, Geofrey Ikelesho, Salum Kalonge, Leonard Kiboko, Queen Godfrey Tarimo, Desderius C. Chussi

ABSTRACT Background Laryngeal cancer carries a significant global burden, with substantial morbidity and mortality, and is increasing globally, with 95%–98% being squamous cell carcinoma. Males are more affected than females, with peak cases occurring between 60 and 80 years of age. A five‐year survival rate is poor for this disease as most of the patients are in the advanced stage of disease at the time of diagnosis. Purpose To determine the proportion, five‐year survival rate of laryngeal cancer and its associate …

23.08.2026journal-article

Interdisciplinary Medical Journal

Penile metastasis from rectal cancer: a case report

Canan Çolak, Teyfik Demir, Recep Türkel, Deniz Bayçelebi, Guzin Demirağ

Penile metastasis is extremely rare despite the rich vascularization of the organ. The majority of metastatic lesions originate from adjacent genitourinary and pelvic organs, particularly the bladder, prostate, and rectosigmoid colon (28.6%, 27.9%, and 12.2%, respectively). In addition, penile metastasis from other systemic malignancies has also been reported. Because the number of published cases in the literature is limited, each new case contributes to a better understanding of the diagnosis and management strat …

23.08.2026journal-article

Hematological Oncology

Metabolic Tumor Area: A Clinically Practical Prognostic Marker for Improved Risk Stratification in IPI Non‐High‐Risk DLBCL

Silu Cui, Qi Jiang, Faquan Ji, Panpan Luan, Yuxiao Hu, Yu Zhang

ABSTRACT Metabolic tumor volume (TMTV) is a core 18 F‐FDG PET/CT prognostic marker for diffuse large B‐cell lymphoma (DLBCL), but its complex measurement and limited standardization restrict clinical utility. Metabolic tumor area (MTA) features simple operation and good reproducibility, holding potential as a practical alternative to TMTV. This retrospective study aimed to validate MTA's substitutability and explore its prognostic value in DLBCL risk stratification. A total of 295 newly diagnosed DLBCL patients wer …

23.08.2026journal-article

Cancers

Cancer Cachexia Research and Drug Development: Lessons from Failures and the Promise of Immunomodulation

Lingbing Zhang, Jeffrey A. Norton

Cancer cachexia is a multifactorial systemic syndrome characterized by progressive muscle loss, with or without adipose tissue depletion, that cannot be reversed by conventional nutritional support. It affects cancer patients and is associated with reduced treatment tolerance, impaired physical function, poor quality of life, and increased mortality. The understanding of cachexia has evolved recently, from the perception of a simple nutritional disorder to a complex immune–metabolic syndrome, based on tumor–host in …

23.08.2026journal-article

Cancers

Hybrid Lexical–Semantic AI Architecture for Automated Cancer Registry Coding for the Vet-ICD-O-Canine-1 System from Free-Text Veterinary Pathology Reports

Vitória Souza de Oliveira Nascimento, Marcello Vannucci Tedardi, Guilherme da Silva Rogério, Katia Cristina Pinello, Maria Lúcia Zaidan Dagli

Background/Objectives: Free-text veterinary pathology diagnoses contain essential information for cancer registration but are difficult to convert into standardized ontology-based codes because of linguistic variability, contextual modifiers, and large ontology search spaces. This study evaluated a hybrid lexical–semantic architecture for the automated assignment of Vet-ICD-O-Canine-1 morphology codes. Methods: A retrospective single-registry benchmark included 211 diagnoses from the São Paulo Animal Cancer Registr …

23.08.2026journal-article

Journal of Palliative Medicine

Early Palliative Debriefing to Mitigate Grief and Burnout in Hematology/Oncology Fellows: A Pilot Study

Cameron Oswalt, Richard F. Riedel, Andrea Sitlinger, Anthony Galanos

Background/Local Problem: Oncology providers are regularly exposed to grief, contributing to rising rates of burnout in practicing oncologists and trainees. Improved supportive interventions to combat grief are necessary. One solution is utilization of palliative care expertise to facilitate debriefing sessions, which provide protected time and space to discuss emotions related to oncology practice. Methods/Interventions: This pilot study aimed to evaluate how debriefing sessions led by a palliative care physician …

23.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

PGR expression as a pharmacogenomic companion biomarker to GENE70-derived genomic risk in ER-positive/HER2-negative breast cancer

Orcun Can

Abstract: Background: The biology of the estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancers is heterogeneous even when they are categorized by their risk via genomics. Transcriptomic PGR expression reflects endocrine pathway activity and may provide complementary biological information within established GENE70-derived genomic-risk categories. Whether this molecular marker improves the biological interpretation of genomic-risk stratification beyond conventi …