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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
15.08.2026journal-article

Cell Death & Disease

YAP delactylation enhances therapy resistance in renal cell carcinoma

Mingjie Lin, Xiaohan Jin, Minyu Chen, Liangmin Fu, Kun Ye, Yong Huang, Peixian Liang, Lei Tan, Xinwei Zhou, Jinchen Luo, Guannan Shu, Yuhang Chen, Gaosheng Yao, Hansen Lin, Zhu Wang, Qiong Deng, Wei Chen, Junhang Luo, Jiefeng Yang, Hui Liang, Jinhuan Wei

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla) is specifically downregulated in targeted therapy-resistant renal cancer cells and tissues. The lactylation status of YAP at lysine 90 (K90) regulates its nuclear translocation, which is critical for the expression of epithelial-mesenchymal …

15.08.2026journal-article

Genetics and Molecular Research

INTEGRATING QUANTITATIVE BONE IMAGING AND FUNCTIONAL PHYSIOTHERAPY ASSESSMENTS FOR EARLY DETECTION AND MANAGEMENT OF DEGENERATIVE SPINE DISORDERS

Dr. Katta praveen Kumar, Dr Debdeep Karak, Vijay Gujar, Ashish Kumar Shukla, S. Banumathi, Carlin Jersha Rachel J

Spine degeneration is one of the most common causes of musculoskeletal pain, disability, and decreased quality of life globally. The combination of spine degeneration, osteoporosis, and functional impairment creates diagnostic difficulties that require special attention to be paid to the development of appropriate assessment methods. The present study is devoted to the review of the existing scientific research on the use of quantitative bone imaging and functional physiotherapy tests to diagnose and manage spine d …

15.08.2026journal-article

Cardiovascular Therapy and Prevention

Reproducibility of ultrasound Doppler measurement of pulse wave velocity with different methods of assessing the superficial carotid-femoral distance

I. N. Posokhov, A. T. Betuganova

Aim . To calculate the reproducibility of the Doppler method for measuring carotid-femoral pulse wave velocity (cfPWV), taking into account various methods for establishing the surface distance between measurement points. Material and methods . Forty participants (men, 60%), aged 34,26±16,58 years, participated in this cross-sectional study. All patients underwent 2 sequential Doppler cfPWV measurements at intervals of 20 to 40 minutes, using the carotid-femoral distance obtained with a measuring tape, an electroni …

1 Zitationen
15.08.2026journal-article

Journal of Nonformal Education

Project-Based STEAM Learning in Non-Formal Vocational Education: Occupational Korean Proficiency and Delayed Work-Culture Understanding

Lutfi Ariefianto, Rody Putra Sartika, Nurul Faizah

Background - The high interest of Indonesian youth in pursuing international career pathways, particularly through the G-to-G placement program to South Korea, poses a major vocational training challenge in the non-formal education sector. Preparing Prospective Migrant Workers (CPMI) requires more than standard linguistic capabilities; it demands deep synchronization with real-world technological environments and the dynamic palli-palli industrial culture. This study is grounded in Law No. 20 of 2003 on the Nationa …

15.08.2026journal-article

Journal of Hospital Pharmacy and Health Services

Clinical implications of overbasalization in patients with diabetes mellitus under basal insulin therapy: a retrospective cohort study

Sarah Dias BORBA, Gabrielle Haque PEREIRA, Ananda Revoredo CAMPOS, Bianca Maria SOUZA, Luisa de Oliveira GURGEL, Mariana Carvalho OLIVEIRA, Déborah Dias MORAIS, Ana Luiza ROLIM, Gabriel Rodrigues FREITAS

Objective: To evaluate the prevalence of overbasalization and its association with hypoglycemia and inadequate glycemic control among patients with diabetes mellitus, as well as to assess its repercussions on public health resources. Methods: A retrospective cohort study was carried out at the endocrinology clinic of Hospital Universitário Lauro Wanderley (UFPB), João Pessoa, Brazil. Medical records of adult patients with a diagnosis of diabetes mellitus for ≥12 months, and at least two outpatient visits between De …

15.08.2026journal-article

British Journal of Occupational Therapy

The international application of the occupation-based community development framework: A pragmatist approach to knowledge translation

Liesl Peters, Donica Jacobs, Raeesah January, Silakhile Zote, Nureen Ebrahim, Lindelwe Mazibuko, Roshan Galvaan

Introduction: Originating in South Africa, the occupation-based community development (ObCD) framework offers a guide for practice that contributes through a critical, justice-oriented occupational therapy practice. Its translation into diverse global settings has been anecdotally noted, but has not been empirically studied. Method: This qualitative descriptive study examined the experiences of practitioners/scholars who utilised the ObCD framework in the United States, the United Kingdom, the Netherlands, India, a …

15.08.2026journal-article

Pharmacogenetics and Pharmacogenomics

Genetic markers of the effectiveness of anti-VEGF therapy in age-related macular degeneration

N. A. Bakunina, S. N. Tuchkova, V. P. Matyukhin, A. A. Anderganova, M. A. Frolov

Objective. To systematically review and critically appraise current evidence on genetic markers associated with the efficacy of anti-VEGF therapy in neovascular age-related macular degeneration (nvAMD). Methods. A literature analysis covering the period 2005–2025 was performed, including candidate gene studies, meta-analyses, and genome-wide association studies (GWAS). Genetic variants in CFH, ARMS2/HTRA1, VEGFA, KDR, IL8, and SIRT1 genes were examined. Results. The most reproducible associations with anti-VEGF res …

15.08.2026journal-article

Biomimetics

Biomaterial-Assisted Stem Cell Therapy and Exosome Delivery in Myocardial Infarction: A Narrative Review

Amanda-Ioana Răduţă, Andreea-Ramona Treteanu, Octavian Andronic, Ștefan Busnatu, Roxana Nicoleta Silişte, Elena Bălășescu

Myocardial infarction remains a leading cause of heart failure because current reperfusion therapies cannot prevent adverse ventricular remodeling or restore lost cardiomyocytes. Regenerative strategies based on stem cells and extracellular vesicles (EVs) have emerged as promising approaches; however, their clinical efficacy is limited by poor retention, rapid clearance, and the hostile post-infarction microenvironment. This narrative review critically examines the role of biomaterial-assisted delivery systems in e …

15.08.2026journal-article

Psychology and Education: A Multidisciplinary Journal

Narratives of Recovery from Peer Workers (Person Who Use Drugs-PWUDS) in Drug Rehabilitation Facilities

Rae Ann Feguracion, Aimee Rose Arguelles-Manda

Substance use disorder (SUD) is a chronic, relapsing condition that continues to affect individuals’ social functioning, psychological well-being, and employability even after treatment. While recovery is often measured through abstinence, less attention has been given to the roles of identity reconstruction and meaningful employment in sustaining long-term sobriety. This study explored the narratives of recovering persons who use drugs (PWUDs) who successfully maintained sobriety and reintegrated into the workforc …

14.08.2026journal-article

American Journal of Health Studies

Physical Attractiveness, Occupational Status, and Gender

Tina Penhollow, Michael Young

Sexual behavior and relationship preferences among emerging adults are shaped by sociocultural cues such as physical attractiveness and occupational status, which interact with gender norms to influence decision-making. This study examined how perceived partner attractiveness and occupational status affect college students’ willingness to engage in sexual behaviors and their relationship preferences, with attention to gender differences. A cross-sectional sample of 285 undergraduate students viewed standardized pho …

14.08.2026journal-article

Anesthesiology

A Multidepartment Investigation of Occupational Well-being, Systemic Features, and Organizational Outcomes in Anesthesiology Using the Well-Being Influencers Survey for Healthcare (WISH)

K. Elliott Higgins, Maxwell Mansolf, Elizabeth W. Duggan, Theodora Wingert, Amy E. Vinson, Jina L. Sinskey, Rebecca Margolis, Lynnie R. Correll, Helen Pappas, Jenna L. Swisher, Leelach Rothschild, Daniel Saddawi-Konefka, Tara Carey, Adam Was, Matthew J. Durand, Anna Budd, Jose Hernandez Carcamo, Christine Park

Background: High rates of distress and intention to leave threaten workforce stability and patient care in anesthesiology. Meaningful action is believed to require evidence-based insight into the systemic origins of occupational well-being shaping these risks. However, the field has lacked large-scale insights into these systemic features and their influence on well-being and its consequences using validated tools. The Well-Being Influencers Survey for Healthcare (WISH) was developed to provide a framework and metr …

1 Zitationen
14.08.2026journal-article

Journal of Health Economics and Outcomes Research

Cognitive Behavioral Therapy in Early Intervention for Psychosis: A Cost-Effectiveness Analysis

Maximilian Duckworth, Sofia Venturini, Andres Roman-Urrestarazu

Background: Early intervention for psychosis (EIP) is a multidisciplinary service that treats individuals experiencing early psychosis. Treatment often consists of pharmacotherapy and cognitive behavioral therapy for psychosis (CBTp). While EIP demonstrates clinical efficacy and cost-effectiveness as a comprehensive package, the incremental contribution of its individual components remains unclear. With mental health services facing sustained funding pressures, understanding which EIP elements offer value for money …

14.08.2026journal-article

Frontiers in Public Health

When knowledge is not enough: infection prevention and control practices and occupational biological exposures among dental professionals in Zimbabwe

Tanusha Singh, Kundai Mavis Makozho

Background Dental professionals are routinely exposed to occupational biological hazards, yet evidence from low-resource settings remains limited. This study assessed infection prevention and control (IPC) knowledge and practices, quantified occupational biological exposures, and identified factors associated with sharps injuries and occupational infections. Methods A cross-sectional analytical study was conducted among 220 dental professionals in Bulawayo, Zimbabwe. Data were collected using a structured self-admi …

14.08.2026journal-article

DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan

Potential Benefits and Mechanisms of Yoga Therapy For Chronic Low Back Pain: A Narrative Review

Ni Made Rahajeng Ayu Narayani, Made Kurnia Widiastuti Giri, Made Pradnyandari Adiswarya Putri, Putu Elfira Pratiwi, Luh Putu Prema Sutayani, I Gede Satria Dharma Wijaya

Chronic low back pain (CLBP) is a common condition that can significantly impact physical function, psychological health, and overall quality of life, highlighting the need for effective non-pharmacological treatments. Yoga, which integrates physical postures, breathing techniques, and relaxation, may help address various aspects of chronic pain. This narrative review synthesizes potential clinical benefits and mechanisms of yoga therapy for CLBP, drawing from studies published between 2016 and 2025 sourced from Pu …

14.08.2026journal-article

Medicine

A study on the effect of posture-recognition-based mirror visual feedback therapy on balance function and activities of daily living in patients with poststroke neglect

Juan Jin, Hongji An, Juanxiu Cui, Long Piao

This study aimed to investigate the effects of posture-recognition-based mirror visual feedback therapy (MVFT) on the degree of neglect, balance function, and activities of daily living in patients with poststroke neglect. A retrospective cohort study design was employed. Patients with poststroke neglect admitted to the Department of Rehabilitation Medicine of our hospital from May 2023 to May 2025 were selected and divided into a feedback therapy group and a conventional rehabilitation group based on whether they …

14.08.2026journal-article

Journal of Modern Education and Culture

Developing Trends of Sports Rehabilitation Programs in New Zealand Higher Education Institutions in the Context of Population Aging

Xu Dai, Shan Jiang

As the world's population is ageing, so too has New Zealand's problem of an aging society. As the proportion of older people in society has been increasing, so too has the demand for health and medical services for older adults. As a scientific way to help people, exercise rehabilitation can boost the physical strength, bone density and other functions of older adults to slow down age-related decline and improve their quality of life. Research on the role of sports rehabilitation programs in New Zealand's universit …

14.08.2026journal-article

The BRICS Health Journal

Analysis of the CAR-T cell therapy landscape in Russia

Dmitry G. Shchurov, Igor N. Mizin

The objective of this study was to provide a comprehensive overview of the CAR-T (chimeric antigen receptor T-cells) therapy landscape in Russia, including the types of products used, their target antigens, indications, the role of CAR-T therapy in treatment pathways, clinical trials, marketing authorization, and production infrastructure data. A key feature of the Russian landscape is the emergence of a hybrid ecosystem in which academically developed products coexist with the first industrial CAR-T products. Mono …

14.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

The effect of SportsMetrics training program on functional performance, landing error, dynamic knee valgus and hamstrings/quadriceps strength in athletes: a systematic review and meta-analysis

Fereshteh Kazemi pakdel, Ahmad Kazemi pakdel, Elham Hajihoseini, Mohamad Mottaghitalab, Hamed Zarei

Abstract Objective The SportsMetrics training (SMT) program is a comprehensive injury prevention initiative designed for athletes, focusing on improving strength, flexibility, and overall performance through targeted exercises and assessments. Therefore, the purpose of this systematic review is to examine the effect of SMT program on functional performance, landing error, dynamic knee valgus and hamstrings/quadriceps strength ratio in athletes. Methods Primary sources were sourced from four databases: SCOPUS, PubMe …

14.08.2026journal-article

Acta Mechanica et Automatica

Method for Improving Muscular Activations during Exoskeleton-Aided Therapy with Intelligent Algorithms and VR-Based Teleoperation

Piotr FALKOWSKI, Kajetan JEZNACH, Tomasz OSIAK, Jan OLEKSIUK, Krzysztof ZAWALSKI, Piotr KOŁODZIEJSKI, Daniel ŚLIŻ, Zbigniew PILAT, Tomasz CHOMIUK

Population ageing, neurological and orthopaedical diseases, and shortages in medical staff result in the need to develop tools for minimally su-pervised therapy. To guarantee effective kinesiotherapy in high doses, rehabilitation robots are required. However, they require additional tech-nologies for automating treatment and monitoring patients' safety. This paper presents and assesses such technologies integrated with the SmartEx-Twin exoskeleton of a lower extremity and its digital twin in virtual reality (VR) fo …

14.08.2026journal-article

Archives of Mental Health

Acute dystonia following occupational inhalation of risperidone powder in a pharmaceutical trainee chemist

Anand Bhogaraju, Yasaswi Kadaru, Tabitha Jezreel, Kamma Vishnu Tulasi

Abstract Risperidone is an atypical antipsychotic whose occupational hazards, particularly via inhalation, are under-recognized. We report the case of a 22-year-old male trainee chemist in a pharmaceutical company who developed acute dystonia after unintentional inhalation of risperidone powder while working in a dryer room without adequate respiratory protection. Symptoms, including orofacial deviation, jaw clenching, torticollis, hand tremors, giddiness, tachycardia, and hypertension, began approximately 1 h post …

14.08.2026journal-article

Cerrahpaşa Medical Journal

Effect of Maintenance Anti-EGFR Therapy on Survival in RAS Wild-Type Metastatic Colorectal Cancer: Real-World Data

Simay Çokgezer, Selay Artan, Sevde Topuz, Muhammet Şenkal, Abdulmunir Azizy, Burak Şakar, Didem Taştekin, Senem Karabulut

Objective: This study aimed to evaluate the impact of anti-epidermal growth factor receptor (anti-EGFR)–based maintenance therapy administered after first-line chemotherapy combined with anti-EGFR treatment on progression-free survival (PFS) and overall survival (OS) in patients with RAS wild-type metastatic colorectal cancer (mCRC), using real-world data. Methods: Patients followed at a single center between 2015 and 2025 were retrospectively analyzed. A total of 37 RAS wild-type patients who achieved disease cont …

14.08.2026journal-article

Current Psychiatry Reports

Eating Disorder Focused Family Therapy with Autistic Children and Young People: A Narrative Review of Recent Developments

Amelia Austin, Rachel Loomes, Fiona Duffy

Abstract Purpose of review This review aims to report the recent advances for eating disorder focused family therapy (FT-ED) for Autistic children and young people, including outcomes, experiences, and suggested adaptations. Recent findings Quantitative studies suggest that Autistic children and young people (and those with high autistic traits) receiving outpatient FT-ED are more likely to require escalation to more intensive levels of care compared to non-autistic peers. Qualitative research shows that Autistic y …

14.08.2026journal-article

Advances in Translational Research

Novel biomarkers in breast cancer for precision therapy and adaptive treatment strategies

Dao-Fu Dai, Tamas Micsik

Abstract Breast cancer is a biologically heterogeneous disease in which clinical outcomes are strongly influenced by molecular characteristics that guide therapeutic decision-making. While the traditional framework based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) has enabled major advances in patient stratification, it provides only a limited and static representation of tumor biology. Increasing evidence indicates that breast cancer evolves dynamicall …

14.08.2026journal-article

International Forum of Allergy & Rhinology

Clinical Improvement and Immune Signatures Following Platelet‐Rich Plasma Therapy for Post‐Viral Olfactory Dysfunction

Vivienne M. Li, Jennifer S. Lee, Arwa Kurabi, Thomas Zhou, Farhoud Faraji, Carol H. Yan

ABSTRACT Background Platelet‐rich plasma (PRP) has emerged as a promising therapy for post‐viral olfactory dysfunction (PVOD) though its biological mechanisms remain unclear. This study evaluated clinical outcomes and targeted proteomic changes following PRP for refractory PVOD. Methods Adults with PVOD ≥ 6 months refractory to standard therapies underwent a single bilateral PRP injection into the olfactory clefts. Demographics, subjective olfactory ratings, and psychophysical assessment using the University of Pen …