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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
23.08.2026journal-article

iMetaMed

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

Yitong Pan, Zhou Yang, Junyuan Deng, Feng Liu, Guang Lei

ABSTRACT Bone metastases (BoMs) are a major clinical challenge across cancer types, yet mechanistic insights remain limited by small cohorts and insufficient profiling depth. Here, we present a single‐cell RNA sequencing atlas of 95 BoMs, 22 healthy bone marrows (hBMs) and 129 primary tumors (PTs) spanning 10 cancer types, comprising 895,475 high‐quality transcriptomes, to map cellular remodeling during bone metastatic colonization. Malignant cells in BoMs converged on chromosomal instability—high proliferative sta …

23.08.2026journal-article

Acta Anaesthesiologica Scandinavica

Anaesthetic Type and Survival in Metastatic Colorectal Cancer: A Nationwide Registry Study

Ahmed Tarfy, Anna Enlund, Erland Östberg, Hanna Vikman, Anders Berglund, Mats Enlund, Maziar Nikberg

ABSTRACT Background The impact of anaesthetic choice on survival following metastatic cancer surgery is uncertain. Inhalational anaesthetics, such as sevoflurane, may promote inflammation and tumour progression, while the intravenous agent propofol has been suggested to be anti‐inflammatory. This study aimed to evaluate the association between anaesthetic maintenance with inhalational anaesthesia versus propofol‐based total intravenous anaesthesia and overall survival in patients undergoing surgery for metastatic c …

23.08.2026journal-article

Cancers

Evaluating the Performance of Machine Learning Models for Predicting 5-Year Breast Cancer Survival: A Systematic Review and Meta-Analysis

Ashin Krishna Chalil, Bindu Therayangalath, Vikram Patil, Chaithra Nagaraju

Background: Breast cancer is the most common malignancy among women worldwide and a leading cause of cancer-related mortality. Despite advances in diagnosis and treatment, accurately predicting 5-year survival remains challenging because of disease heterogeneity. This study systematically evaluated the performance of machine learning (ML) models for predicting 5-year breast cancer survival and synthesised their overall discriminative performance. Methods: A systematic search of PubMed, Scopus, and Web of Science (2 …

23.08.2026journal-article

Biomedicines

Upfront Versus Deferred CDK4/6 Inhibitor Use in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Real-World Study

Pınar Kubilay Tolunay, Bediz Kurt İnci, Berkan Karabuğa, Ali Topkaç, Şura Usta, Ergin Aydemir, Nejat Emre Öksüz, Enes Erul, İrem Küçükşahin, Hatime Arzu Yaşar, Hakan Akbulut, Ülkü Yalçıntaş Arslan, Öztürk Ateş

Background/Objectives: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are commonly used as first-line treatment for hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. However, the optimal timing of CDK4/6i initiation remains uncertain. This study compared overall survival (OS) between upfront first-line and deferred second-line CDK4/6i use in routine clinical practice. Methods: This retrospective, two-center cohort study included 403 patients with hormone …

23.08.2026journal-article

Journal of Composites Science

Mechanical Properties of AZ91D Magnesium Alloy with Short Carbon Fibers Under Heat Treatment and Equal-Channel Angular Pressing

Song-Jeng Huang, Jun Yi Lin, William Li, Chuan Li, Sathiyalingam Kannaiyan

AZ91D is a lightweight, representative commercial magnesium alloy known for its excellent castability and specific strength. However, the mechanical properties of as-cast AZ91D remain limited by inherent brittleness, relatively low strength, and microstructural inhomogeneity caused by enrichment of secondary phases at grain boundaries. In this study, AZ91D/Csf (short carbon fiber at 0, 2.5, and 5 wt.%) composites were prepared by gravity casting with mechanical stirring, followed by post-casting T4 heat treatment a …

23.08.2026journal-article

Symmetry

SDFR-Net: A Stage-Asymmetric Spectral Diffusion and Frequency–Spatial Refinement Network for Brain Tumor MRI Segmentation

Jingshi Lei, Hongwei Deng, Xicheng Fu, Yi Lei, Lei Xu, Qiangfei Wang

Accurate brain tumor segmentation from multi-modal magnetic resonance imaging (MRI) is essential for clinical diagnosis and treatment planning. However, effectively capturing long-range contextual information and fine lesion boundaries under limited computational budgets remains challenging. In this work, we propose SDFR-Net, a lightweight stage-asymmetric Spectral Diffusion and Frequency–Spatial Refinement Network for efficient 2.5D brain tumor MRI segmentation. Instead of applying identical processing across all …

23.08.2026journal-article

Surgeries

Simultaneous Carotid Endarterectomy and Ipsilateral Parotidectomy for Asymptomatic Carotid Artery Stenosis and Concurrent Warthin’s Tumor: A Multicenter Retrospective Case Series

Priscilla Nardi, Valerio Rinaldi, Greta D’Onofrio, Valeria Iacoucci, Sara Lembo, Lodovica Pepe, Marcella Vaglica, Roberta Zilli, Rocco Pasqua, Giulia Pizzardi, Massimo Ruggeri, Giampaolo Prezioso, Vito D’Andrea, Antonio Minni, Gianfrancesco Niccolini, Lorenzo Silvani, Marco De Vincentis, Giulio Illuminati

Background: Management of high-grade carotid artery stenosis with concomitant ipsilateral parotid gland tumor presents a rare and challenging surgical condition. Due to the rarity of this dual pathology, standardized guidelines are lacking. Material and Methods: A retrospective study was conducted between January 2020 and May 2025. Six asymptomatic patients with significant carotid stenosis and coexisting ipsilateral Warthin’s tumor underwent simultaneous eversion CEA (carotid endarterectomy) and partial superficia …

23.08.2026journal-article

International Journal of Molecular Sciences

Medical Cannabis and the Hallmarks of Cancer: A Critical Narrative Review

Diana Russo, Rute Fernandes, Valéria Tavares, Ana Agrelo, Rui Medeiros

Cancer remains a highly complex and heterogeneous disease, causing major morbidity and mortality worldwide despite advances in diagnosis and treatment. The hallmarks of cancer enlighten the biological mechanisms supporting tumourigenesis and malignant evolution, while helping to identify potential therapeutic targets. Medical cannabis has mostly been used in oncology for supportive care, but increasing preclinical evidence suggests interference with cancer-related signalling pathways. This narrative review summariz …

23.08.2026journal-article

Journal of Clinical Medicine

Safety and Efficacy of Brolucizumab in the Treatment of Patients with Diabetic Macular Edema and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Sharifa N. Bourisly, Fatmah S. Semairan, Yousef Mesaed Al-Shammari, Noor Alali, Lulwa Abbas Alfoudari, Abdulaziz F. Abdulkareem, Abdullah M. Alharran

Background: Brolucizumab is an intravitreal anti-vascular endothelial growth factor (anti-VEGF) agent developed to improve retinal drying and treatment durability in diabetic eye disease. However, its overall efficacy and safety in diabetic macular edema (DME) and diabetic retinopathy remain uncertain because available trials differ in population, comparator, dosing schedule, and follow-up. Methods: We searched PubMed, Cochrane Library, Scopus, and Web of Science from inception to 25 April 2026. Randomized controll …

23.08.2026journal-article

Biomedicines

Integrated Molecular Profiling of Endometrial Cancer: NGS Findings, MSI/MMR Status, Histopathological Features, and TCGA-Inspired Molecular Classification

Merve Cirak-Balta, Suleyman Erdogdu, Busra Ekinci, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci

Background/Objectives: Endometrial cancer is a heterogeneous malignancy that displays distinct molecular features and clinical behaviors. The molecular profile of endometrial cancer and its relationship with menopausal status, histological subtype, tumor grade, mismatch repair (MMR)/microsatellite instability (MSI) status, co-mutation patterns, and TCGA molecular classification were investigated in the current study. Methods: A total of 81 histopathologically confirmed endometrial cancer cases were retrospectively …

23.08.2026journal-article

Journal of Child and Adolescent Psychopharmacology

Families’ Neighborhood Resources Predict Treatment Response for Regulating Together, a Group Therapy for Emotion Dysregulation in Autistic Youth

Walker S. McKinney, Lauren M. Schmitt, Jennifer R. Ruberg, Marika Coffman, Debra Reisinger, Rebecca C. Shaffer

Introduction: Autistic youth often face difficulties with emotion dysregulation (ED) and associated challenging behaviors. The Regulating Together (RT) group therapy was developed to treat ED in autistic youth ages 8–18 years and has been shown to be feasible, acceptable, and efficacious at reducing ED. Results from other clinical trials suggest the efficacy of behavioral therapies may vary based on family- or neighborhood-level social determinants of health (SDOH: “the conditions in the environments where people a …

23.08.2026journal-article

International Journal of Molecular Sciences

Blood Plasma Analysis in Ovarian Cancer Patients Using an AFM/MS Approach: Effect of Sample Dilution on Proteome Depth

Arina I. Gordeeva, Anastasia A. Konstantinova, Tatiana A. Materova, Elizaveta E. Rybakova, Maria O. Ershova, Nikita E. Vavilov, Victor G. Zgoda, Tatyana O. Pleshakova, Alexander I. Archakov

Early detection of ovarian cancer remains challenging because of the lack of sensitive and reproducible blood-based biomarkers. A major challenge in plasma proteomics is the extremely wide dynamic range of protein concentrations, which prevents simultaneous detection of both high- and low abundance proteins and limits the identification of disease-associated signals. In this study, we applied a combined atomic force microscopy and mass spectrometry (AFM/MS) approach to investigate how sample dilution affects plasma …

23.08.2026journal-article

Cancers

Association Between Body Mass Index and Treatment Toxicity in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib or Pazopanib

Ahmet Kürşad Dişli, Ayşe Nuransoy Cengiz, Muhammet Cengiz, İrfan Buğday, Sinan Yıldırım, Rıdvan Gönül, Oktay Bozkurt, Mevlüde İnanç, Metin Özkan

Background/Objectives: Sunitinib and pazopanib are administered at fixed doses in patients with metastatic renal cell carcinoma (mRCC), without adjustment for body composition. This study aimed to investigate the association between body mass index (BMI) and treatment-related toxicity and treatment discontinuation in patients with mRCC receiving first-line sunitinib or pazopanib. Methods: A total of 136 patients with mRCC treated with sunitinib (n = 90) or pazopanib (n = 46) were retrospectively evaluated. BMI was …

23.08.2026journal-article

Cancers

EIF3H Modulates Glycolysis Through LDHA Stabilization in Triple-Negative Breast Cancer

Xuyu Cheng, Xinghai Liu, Ziyu Feng, Xiaoan Liu

Background: Triple-negative breast cancer (TNBC) lacks effective targeted therapies, and its dependence on glycolysis represents a potential metabolic vulnerability. EIF3H, the largest subunit of the eukaryotic translation initiation factor 3 complex and a putative deubiquitinase, has been implicated in tumor progression, but its role in TNBC metabolism remains unclear. Methods: EIF3H expression and prognostic value were evaluated in public datasets, clinical TNBC specimens, and cell lines. Functional roles were ex …

23.08.2026journal-article

Diagnostics

Diagnostic Performance of Post-Treatment F-18 FDG PET/CT for Detecting Recurrent Cervical Cancer

Choon-Young Kim, Sang-Woo Lee, Gun Oh Chong, Jong Mi Kim, Yoon Hee Lee, Chae Moon Hong, Shin Young Jeong

Background/Objectives: Cervical cancer recurrence after definitive treatment remains a major clinical challenge, and early detection may improve patient outcomes. This study evaluated the diagnostic performance of fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) for detecting recurrent cervical cancer according to clinical context. Methods: We retrospectively reviewed 1727 post-treatment PET/CT examinations obtained from 659 patients who achieved a complete respons …

23.08.2026journal-article

Histopathology

AI for tumour proportion scoring of programmed death‐ligand 1 immunohistochemistry in non‐small cell lung cancer: a review of commercial and non‐commercial tools

Joachim Webers, Sandrina Martens, Pascal Gervois, Inge Mertens, Yuri Tolkach, Yves Sucaet, Esther Wolfs, Dirk Valkenborg

Programmed death‐ligand 1 (PD‐L1) expression, commonly quantified as tumour proportion score (TPS), is a key biomarker guiding immunotherapy in non‐small cell lung cancer (NSCLC). Manual scoring of PD‐L1 immunohistochemistry (IHC) is time‐consuming and challenged by preanalytical variability and interpretive subjectivity, which can hinder consistent treatment selection. Artificial intelligence (AI) tools aim to support more standardized PD‐L1 scoring. We compare publicly available evidence on PD‐L1 AI tools and ide …

23.08.2026journal-article

Smart Molecules

A photoimmune synergizing RNA interference technology for highly effective antitumor treatment

Xiang Xia, Bingbing Wu, Xueze Zhao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng

Abstract Photoimmunotherapy and RNA interference (RNAi) hold great potential for tumor therapy but exhibit limited efficacy as monotherapies. In this work, we report a red‐light‐activated combinatorial therapy that integrates photodynamic immunotherapy (PIT) with RNAi via a rationally designed photosensitizer, FNBS, developed on the basis of our previously reported advanced photosensitizer platform, HNBS. Upon cellular uptake and following red light irradiation, FNBS induces pyroptosis through the activation of nuc …

23.08.2026journal-article

Diabetes, Obesity and Metabolism

Variation in Treatment Patterns of Type 2 Diabetes in Older Patients

Phuc Le, Ning Guo, Anita Misra‐Hebert, Christopher B. Boyer, Kevin M. Pantalone, Hamlet Gasoyan, Nicholas J. Casacchia, Michael B. Rothberg

ABSTRACT Aims To estimate the proportion of older patients with type 2 diabetes (T2D) and HbA1c above or below goal at provider level and explore factors associated with patients being above or below goal. Materials and Methods We used 2023 Cleveland Clinic electronic health records, including patients ≥ 65 years old with T2D, ≥ 1 diabetes medication and ≥ 1 HbA1c measurement. Patients were assigned to their listed primary care provider or the one they saw most frequently and stratified into good, intermediate, or …

23.08.2026journal-article

Arthroscopy Techniques

Fixation Treatment of Anterior Cruciate Ligament Avulsion Fracture via Suture‐Bridge Technique Through Transtibial Tunnels

Peisi Hou, Chenyang Meng, Jie Xu, WenQiang Zhao, Yuhang Wei, Changxu Han

Abstract Surgical intervention is usually required for type III/IV avulsion fractures of the inferior insertion of the anterior cruciate ligament. Arthroscopically assisted suture‐bridge technique with anchors and trans‐tibial tunnel pull‐out suture fixation using high‐strength sutures are currently common surgical methods. However, the biomechanical performance of anchor fixation and transosseous tunnel pull‐out fixation is suboptimal. For patients with high sports demands or those who need to return to competitiv …

23.08.2026journal-article

Molecules

Improved Lipophilicity Is Associated with the Cytotoxic Activity of Chlorogenic Acid Esters in In Vitro Colorectal Cancer Models

Ana María Castañeda-Cifuentes, Johanna Pedroza-Díaz, Gloria A. Santa-González, Isabel Cristina Henao-Castañeda, Andrea Johanna Andrea Báez, Jorge L. Jios, Ana Laura Di Virgilio

Chlorogenic acid (CGA) exhibits anticancer activity in colorectal cancer (CRC), but its clinical application is limited by low lipophilicity. To improve its physicochemical properties, four CGA esters (methyl, ethyl, n-propyl, and n-butyl chlorogenates) were synthesized and evaluated. Physicochemical properties were characterized in silico, and their biological activity was assessed in SW480, HT-29, and non-tumoral NCM460 cell lines using viability assays and flow cytometry. Molecular docking studies were performed …

23.08.2026journal-article

Public Health Reports®

Cardiovascular-Related Death Among Women With Breast Cancer in the United States: Do We Need a Better Approach for Estimating Rates?

Nguyen Le, Yan Liu, Chanhyun Park

Breast cancer is the most common cancer among women in the United States, and cardiovascular disease (CVD) is a leading cause of death in this population. Understanding CVD-related death among breast cancer survivors is critical to inform policies. Previous studies calculating CVD-related death rates in this population used data from the Centers for Disease Control and Prevention (CDC) Wide-ranging ONline Data for Epidemiologic Research (WONDER) with the general US female population as the denominator, which may ha …

22.08.2026journal-article

Diseases of the Esophagus

P1.239. Clinical Outcomes of Conversion Surgery for Locally Advanced Esophageal Cancer With Mediastinal M1b Lymph Node Metastasis

Tetsuya Abe, Takahiro Hosoi, Kosuke Inada, Kotaro Ozaki, Eiji Higaki

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The role of conversion surgery (CS) for locally advanced esophageal cancer with mediastinal M1b lymph node metastasis has not yet been clearly defined. Methods We evaluated the therapeutic outcomes of 27 patients who underwent conversion surgery (CS) for locally advanced esophageal cancer with mediastinal M1b lymph node metastasis, among 1,030 patients who underwent thoracic esophagectomy at our institution bet …

22.08.2026journal-article

Diseases of the Esophagus

P1.202. Management and Outcomes of Anastomotic Leak After Oesophagectomy in Patients With Oesophageal Cancer

Apurva Ashok, Soumyabrata Ghosh, Tarun Joseph, Gangireddy Sivasankar Reddy, Moses Arunsingh, Robin Thambudorai

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leak (AL) after oesophagectomy is a dreaded complication with significant implications on patient outcomes. Early detection of leak, advances in perioperative care and management techniques may improve long-term outcomes. This study was performed to assess the management patterns of anastomotic leak and its short-term and long-term consequences. Methods A retrospective study was conduc …

22.08.2026journal-article

Cancer Causes & Control

“I never thought to bring them up to the doctor”: examining symptom appraisal, help-seeking behaviors, and diagnostic delays among young adults with cancer

Natasha C. Allard, Elizabeth G. Bouchard, Jennifer S. Ford, Thomas Hugh Feeley, Denise Rokitka, Heather Orom

Abstract Purpose Cancer incidence is rising among young adults (20–39 years), and it is one of the top five causes of death for this age group. Young adults often experience longer delays in diagnosis than children and older adults, which negatively impacts survival and quality of life. Communication interventions might help reduce these delays, but understanding the factors driving delays is crucial for developing effective strategies. Methods We conducted semi-structured interviews with 30 young adults diagnosed …