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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

JNCI Cancer Spectrum

Prevalence of Patient-Reported and Clinician-Graded cognitive symptomatic adverse events in older patients with advanced cancer

Riham Alieldin, Mostafa Mohamed, Chin-Shang Li, Michelle C Janelsins, Rachael Tylock, Karen M Mustian, Luke Peppone, Charles Kamen, Po-Ju Lin, Kah Poh Loh, AnnaLynn M Williams, Brian J Altman, Paula M Vertino, Hongying Sun, Umang Gada, Supriya G Mohile, Judith O Hopkins, Bryan A Faller, Vincent Vinciguerra, Allison Magnuson

Abstract PURPOSE Cancer-related cognitive impairment is common in patients receiving cancer treatment but may be under detected by clinician-graded adverse events (AEs) alone. Patient-reported outcomes and cognitive screening may improve identification of cognitive symptoms. METHODS We conducted a secondary analysis of the nationwide, multicenter GAP70+ trial of adults aged ≥70 years with advanced cancer starting systemic therapy. Cognitive symptoms were assessed longitudinally using patient-reported and clinician- …

24.08.2026journal-article

Frontiers in Oncology

Risk-adapted neck dissection in salivary gland carcinoma: integrating occult nodal metastasis patterns with contemporary guidelines

Felix Johnson, Lea Stecher, Nora-Maria Burian, Marcel Kloppenburg, Rubens Thölken, Benjamin Freytag, Patrick Schuler, Benedikt Hofauer

Introduction Salivary gland carcinomas (SGCs) are rare and histologically diverse malignancies of the head and neck. They present significant challenges for standardized treatment due to varied metastatic behavior and limited high-level evidence. The extent of neck dissection remains controversial, influenced by tumor grade, histological subtype, and anatomical origin. This review evaluates current evidence and guideline recommendations to define an evidence-based, risk-adapted approach to neck dissection in SGC. M …

24.08.2026journal-article

Nutrients

Clinical Implications of Nutritional Consultations and Oral Nutritional Supplementation Refusal in Head and Neck Cancer Patients During Chemoradiotherapy

Aleksandra Krzywon, Anna Kotylak, Jolanta Mrochem-Kwarciak, Tomasz Rutkowski

Background/Objectives: Nutritional support may improve the tolerance and effectiveness of definitive treatment in patients with head and neck cancer (HNC). The aim of this study was to investigate the potential clinical deterioration in patients who refuse nutritional consultations and oral nutritional supplementation during chemoradiotherapy (CHRT) for HNC. Methods: The study included 52 patients undergoing CHRT for HNC. Among these patients, 22 (42.3%) received nutritional counseling with oral nutritional supplem …

24.08.2026journal-article

Diagnostics

Dynamic Oculomics for Diagnostic Monitoring: Personal Ocular Trends, Risk Stratification and Treatment Response

Alessandro Avitabile, Mario D. Toro, Roberta Amato, Dario Rusciano, Caterina Gagliano

Oculomics uses ocular images, ocular biofluids and functional ocular tests to extract diagnostic information on local or systemic biological states. Most current evidence is cross-sectional: one retinal photograph, OCT scan, OCTA examination or tear sample is compared with a reference population, or converted into a diagnostic or prognostic score. This approach is useful for screening and risk enrichment, but it does not show whether the same patient is changing over time. In this review, dynamic oculomics, or ocul …

24.08.2026journal-article

Current Cancer Therapy Reviews

Acteoside in Cancer Therapy: Integrating Ethnomedicinal Insights with Bibliometric Analysis

Tamim Ahmed, Deboja Ishita, Sibashish Kityania, Swaprakash Paul, Sutapa Dhar, Rajat Nath, Priyakshi Nath, Monjur Ahmed Laskar, Deepa Nath, Anupam Das Talukdar

Introduction: Cancer remains a major global health challenge, accounting for nearly one in six deaths worldwide, with treatment often limited by drug resistance, tumour heterogeneity, and therapy-related side effects. Natural plant-derived compounds have gained attention as potential therapeutic leads owing to their structural diversity and multi-targeted mechanisms. Acteoside (Verbascoside), a phenylethanoid glycoside obtained from medicinal plants, exhibits diverse biological and promising anticancer effects. How …

24.08.2026journal-article

Ultrasound International Open

Tumor Size Discrepancies with Different Measurement Methods in Papillary Thyroid M​​​​​icrocarcinoma

Risa Kanematsu, Mitsuyoshi Hirokawa, Miyoko Higuchi, Ayana Suzuki, Makoto Kawakami, Rie Goryo, Makoto Fujishima, Akira Miyauchi, Takashi Akamizu

Abstract PurposeMeasurement of tumor size is critical for thyroid tumor management; however, optimal measurement methods and evaluation criteria remain unclear. This study aimed to quantitatively compare the papillary thyroid microcarcinoma tumor size measured by ultrasound, gross examination, and histological assessment and to determine how discrepancies between these different measurements may influence clinical decision making, such as indications for fine-needle aspiration, eligibility for active surveillance, …

24.08.2026journal-article

Journal of Immunotherapy and Precision Oncology

Colonic Polyp Regression After Nous-209 Cancer Immunotherapy: A Clinical Trial Case Report

Marina Crespo-Cruz, Manuel Rodriguez-Justo, Adam Humphries, Andrew Plumb, Anthony Antoniou, Kevin Monahan, Sarah Runswick, Alessia Capone, Laura Antonucci, Irene Garzia, Elisa Micarelli, Elisa Scarselli, Anna Morena D’Alise, Sven Gogov, Kai-Keen Shiu

ABSTRACT Immunotherapy is an established treatment for mismatch repair–deficient (dMMR) colorectal cancer (CRC), driven by increased neoantigen formation and enhanced responsiveness to immune checkpoint inhibitors. Nous-209 is a polyvalent viral vector immunotherapy under investigation in combination with pembrolizumab in the NOUS-209-01 clinical trial (ClinicalTrials.gov Identifier: NCT04041310) in patients with dMMR CRC. Here, we report on a participant of the NOUS-209-01 trial who achieved a complete pathologic …

24.08.2026journal-article

Frontiers in Medicine

Topical sirolimus for the treatment of verrucous epidermal nevus associated with an HRAS mosaic mutation: a case report

Qiu-ju Wei, Wan-yan Xiang, Wen-jun Zheng, Qiu-ju Li

Introduction Verrucous epidermal nevus is a benign epidermal hamartoma associated with somatic mosaic mutations, which shows poor response to conventional therapies and has a high risk of recurrence. To date, there are no standardized treatment guidelines for this condition. In recent years, targeted treatments for specific gene mutations have provided new directions for the clinical management of this disease. Case report We report a case of a 13-year-old child with verrucous epidermal nevus in whom genetic testin …

24.08.2026journal-article

Electronics

Robot-Based Hazard Detection for Wastewater Treatment Plants

Hui Liu, Zhenyan Ji, Bin Li, Haojie Feng, Wenqi Zhang, Zhipeng Zhang, Weiheng Kong, Guohao Ni

Wastewater treatment plants (WWTPs) are essential infrastructure for urban water management. Their stable operation is critical to effluent quality and public safety. However, wastewater treatment involves complex biochemical processes and extensive electromechanical equipment. Hazards such as sludge flotation in secondary clarifiers, fire, electric shock, and toxic gas poisoning may occur. These hazards can threaten worker safety and reduce treatment efficiency. Traditional inspection mainly relies on manual patro …

24.08.2026journal-article

Global Nursing Insights

Loneliness and Mental State in Cancer

Medine Koç, Havva Tel, Mustafa Başak, Hatice Tel Aydın, Çağdaş Akkaya, Özge Kısaoğlu

Aim: In many ways, the diagnosis of cancer affects the individual's mental health as well as their physical health. Cancer patients may experience a complex emotional state, loneliness, and isolation at different levels during the disease process. This study was conducted to determine the mental status and loneliness of patients diagnosed with cancer.Material and Methods: This descriptive study was conducted with 185 patients diagnosed with cancer. The research data were collected with the Brief Symptom Inventory a …

23.08.2026journal-article

ASIDE Oncology

National Trends in Pancreatic Cancer-Related Mortality: A Population-Based Analysis of Rural–Urban Disparities and the Distribution of Place of Death

Zuha Tariq, Alyaa Ahmed Ibrahim, Ahmed Khairy, Mohammad Rayyan Faisal, Abdelrahman Aly Mohamed, Rahemeen Goraya, Mahmoud Tablawy, Ibtissam ElGhazzani, Mohamed Ibrahim, Sihame ElGhazzani, Mahdi Ahmed, Ilhame ElGhazzani, Mohamed Zabady, Ahmed Atef Mohamed, Yara Refaii, Mohamed Fawzi Hemida

Background: Pancreatic Cancer is the sixth deadliest cancer across the world, and its incidence has more than doubled in recent decades. The literature lacks comprehensive evidence on rural-urban and place-of-death mortality trends over the last two decades. This retrospective analysis summarizes the mortality trends for deaths involving pancreatic cancer patients from 1999 to 2023, with urban and rural stratification to better direct interventional strategies. Methods: Data from death certificates were extracted u …

23.08.2026journal-article

Nutrients

Time-Dependent Multimechanistic Antitumor Effects of Olive Oil Phenolics in a Triple-Negative Breast Cancer Mouse Model

Nikoleta Anna Madelou, Marianna Kapetanou, Katerina Papakonstantinou, Olga Koutsoni, Zacharias Kakazanis, Eleni Melliou, Prokopios Magiatis, Vasilis Zoumbourlis, Efstathios S. Gonos, Haralabia Boleti

Background/Objectives: The health-protective properties of olive oil phenolics, including their potential chemopreventive and anticancer effects, have attracted considerable scientific interest. However, their in vivo efficacy and mechanisms of action remain insufficiently understood. Recent advances in extraction and purification technologies have enabled large-scale production of highly purified olive oil phenols and phenolic-rich extracts, facilitating translational research. Methods: Herein, the antitumor effic …

23.08.2026journal-article

Molecules

pH-Dependent Surface Charge Modulation of Peptide-Coated Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticle for Drug Delivery in Ovarian Cancer

Sylwia A. Dragulska, Mina Poursharifi, Benjamin Lesea-Pringle, Maxier Acosta Santiago, Caleb Mayes, Ying Chen, Maria Padron-Rhenals, Sandra Catalina Camacho, Kelsey Engelman, Olga Camacho-Vanegas, John A. Martignetti, Aneta J. Mieszawska

The development of nanoparticle (NP)-based drug delivery systems that combine passive tumor targeting, physiological stability, and therapeutic efficacy remains a key challenge in cancer nanomedicine. Here, we report a pH-responsive peptide-functionalized poly(lactic-co-glycolic acid) (PLGA) NP system designed for cancer targeting. The PLGA core is coated with a short glutamic acid–lysine–histidine–phenylalanine x3 (EKHFFF) peptide shell, enabling tunable surface charge modulation around its isoelectric point and p …

23.08.2026journal-article

Journal of Gastroenterology

Clonal evolution from primary to locally recurrent rectal cancer reveals recurrence-acquired potentially actionable alterations in treatment-naïve tumors

Mamoru Uemura, Yuta Kobayashi, Hisataka Ogawa, Yurika Nakamura, Masakatsu Paku, Nobuo Takiguchi, Chikako Kusunoki, Yuki Sekido, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Yoshinori Kagawa, Mitsuyoshi Tei, Yuichiro Doki, Hidetoshi Eguchi

Abstract Background Locally recurrent rectal cancer (LRRC) occurs in 6–10% of patients after curative surgery. It is often regarded as a simple residual disease, yet accumulating evidence suggests that LRRC is biologically distinct from primary tumors. Clonal evolution in matched primary–recurrence pairs not exposed to preoperative therapy has not been systematically investigated. Methods We analyzed formalin-fixed paraffin-embedded tumor specimens from 15 matched pairs of primary and locally recurrent rectal cance …

23.08.2026journal-article

Molecular Carcinogenesis

RNF123 Inhibits the Proliferation, Migration, and Invasion of Thyroid Cancer by Inhibiting KAT5‐Mediated PSPC1 Histone Acetylation

Lin Guo, Senhe Jiang, Xuehan Wang, Yiren Feng, Gang Jin

ABSTRACT Thyroid cancer (THCA) is the most common endocrine malignancy worldwide, understanding the pathophysiological mechanism is vital for developing effective strategies for prevention, diagnosis, and treatment. In this study, paired tumor and adjacent noncancerous tissues were collected from THCA patients. Cell viability and proliferation were assessed using CCK‐8 and EdU assays. Cell migration and invasion were evaluated by wound healing and Transwell assays. Co‐immunoprecipitation was performed to examine RN …

23.08.2026journal-article

The Prostate

Stereotactic Prostate Cancer Ablative Re‐Irradiation: A Systematic Review and Meta‐Analysis (SPARE)

Andre G. Gouveia, Jody Tao, Gregory Pond, Kevin Dong, Allison Ye, Arthur A. Rosa, Daniel M. Palhares, Conrad J. Q. Villafuerte, Paola Anselmo, Fabio Y. Moraes, Fabio Arcidiacono, Robert Olson, Theodoros Tsakiridis

24 August 2026: This article published in Early View in error. The article is under embargo and will republish on September 30, 2026.

23.08.2026journal-article

MedComm – Oncology

Mitochondrial DNA in Tumor Evolution and Heterogeneity: Characteristics, Technological Advances, Applications and Challenges

Zifeng Ruan, Zihao Chen, Weicheng Yu, Maolei Zhang, Xingguo Liu

ABSTRACT Tumor heterogeneity and Darwinian evolution act as core drivers of therapeutic resistance. Deciphering the phylogenetic architecture of cancer demands high‐resolution lineage tracing. Nevertheless, exogenously introduced lineage markers possess inherent limitations. This review presents somatic mitochondrial DNA (mtDNA) mutations as a powerful, newly emerging endogenous lineage marker. It describes the unique characteristics of mtDNA, including high copy number, elevated mutation rate, and maternal inherit …

23.08.2026journal-article

International Journal of Molecular Sciences

The Crosstalk Between YAP/TAZ and Cancer Metabolism: From Mechanistic Insights to Drug Discovery

Yinhuang Gao, Minghong Chen, Songxia Lin, Min Huang, Jing Jin

As the core transcriptional co-activators of the Hippo signaling pathway, YAP and TAZ play essential roles in maintaining tissue homeostasis and in tumorigenesis. Their aberrant activation is frequently observed in human malignancies, and accumulating evidence has identified them as crucial drivers of tumor initiation and progression. YAP/TAZ have been recently recognized as key regulators of cellular metabolic reprogramming, a hallmark of cancer that fuels tumor cell proliferation by rewiring glucose, lipid, amino …

23.08.2026journal-article

Survey Practice

Methodology for exploring cross-cultural differences in quality of life among Asian American breast cancer survivors in California and Texas: Lessons learned from a convergent mixed-methods study

Annalyn Valdez-Dadia, Marjorie Kagawa-Singer, Lucy Young, Lei-Chun Fung, Beverly Gor, Becky Nguyen, Qian Lu

Studies investigating whether and how culture impacts social support and quality of life among diverse Asian American populations of breast cancer survivors often conflate race and ethnicity with culture, and investigate differences based on biological designations rather than understanding the unique ways beliefs and values contribute to health care practices. This article will be of relevance to researchers interested in identifying and recruiting underserved and made-to-be-vulnerable groups. This study applied a …

23.08.2026journal-article

Oral Science International

The Clinical Implications of the Inverse Correlation Between miR‐27b‐3p and EGFR in Oral Cancer

Taniya Michel, Bhuvaneswari Veeraswamy, Durairaj Sekar

ABSTRACT Aim This study aimed to investigate the role of miR‐27b‐3p in regulating epidermal growth factor receptor (EGFR) expression and its significance in the pathogenesis of oral squamous cell carcinoma (OSCC). Methods Potential miRNAs targeting EGFR were identified using TargetScan, miRDB, and miRTarBase, followed by literature screening. Expression patterns of miR‐27b‐3p and EGFR were analyzed using The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma (TCGA‐HNSC) and Gene Expression Omnibus (GEO) data …

23.08.2026journal-article

Annals of Surgical Oncology

Elevated Pre-Treatment Serum Interleukin-10 Levels Predict Poor Overall Survival in Esophageal Cancer

Chien-Ming Lo, David Kwan Ru Huang, Meng-Yun Tsai, Hsing-Hua Lai, Yu Chen, Hung-I Lu, Yen-Hao Chen, Shau-Hsuan Li

Abstract Objective Our objective was to evaluate whether pre-treatment serum interleukin (IL)-10 concentrations predicted overall survival (OS) in patients with esophageal squamous cell carcinoma. Methods This single-center retrospective analysis included 112 patients with esophageal cancer who were treated with definitive concurrent chemoradiotherapy. Pre-treatment serum samples were collected, and IL-10 levels were measured. Patients were dichotomized into “low” and “high” IL-10 groups. Baseline characteristics ( …

23.08.2026journal-article

The American Surgeon™

Preserving the Nipple-Areola Complex in Centrally Located Breast Cancer: Trade-offs Among Oncoplastic Techniques

Mehmet Furkan Sağdıç, Emre Tunç, Mahmut Onur Kültüroğlu, Lütfi Doğan

Background Centrally located breast tumors pose surgical challenges in achieving oncologic margin safety and acceptable aesthetic outcomes due to their proximity to the nipple-areola complex. Although mastectomy has traditionally been preferred, advances in oncoplastic breast-conserving surgery have enabled oncologically safe breast conservation with nipple-areola complex preservation. Methods We retrospectively analyzed 291 patients who underwent oncoplastic breast-conserving surgery with nipple-areola complex pre …

23.08.2026journal-article

Children

Atypical Case of Presumed Bartonella henselae Osteomyelitis in a Child with Cat-Scratch Disease Mimicking a Malignant Bone Tumor

Sinisa Ducic, Stefan Djordjevic, Mikan Lazovic, Polina Pavicevic, Milena Mihajlovic, Amela Kalac, Filip Milanovic

Background/Objective: Bartonella henselae, the causative agent of cat-scratch disease (CSD), usually causes a self-limiting zoonotic infection. Osteomyelitis is a rare but increasingly recognized manifestation, particularly in children, and may closely mimic malignant or other infectious bone diseases. We present a case of multifocal pediatric Bartonella henselae osteomyelitis and discuss the associated diagnostic and therapeutic challenges in the context of the current literature. Case presentation: We report the …

23.08.2026journal-article

Cancers

Targeting miR-10b in Breast Cancer Bone Colonization Model Using Image-Guided Nucleic Acid-Based Therapeutics

Sujan K. Mondal, Elizabeth Kenyon, Bryan Doyun Kim, Zdravka Medarova, Anna Moore

Background/Objectives: Breast cancer is the most frequently diagnosed cancer among women worldwide and a leading cause of cancer-related death. Despite the use of bisphosphonates, RANKL inhibitors, chemotherapy, and available endocrine therapies, the five-year survival rate for patients with bone metastases remains approximately 20–30%, underscoring the urgent need for novel, metastasis-specific therapeutic strategies. Recent studies demonstrated that miR-10b can serve as an attractive therapeutic target for the tr …