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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
23.08.2026journal-article

Journal of Palliative Medicine

Early Palliative Debriefing to Mitigate Grief and Burnout in Hematology/Oncology Fellows: A Pilot Study

Cameron Oswalt, Richard F. Riedel, Andrea Sitlinger, Anthony Galanos

Background/Local Problem: Oncology providers are regularly exposed to grief, contributing to rising rates of burnout in practicing oncologists and trainees. Improved supportive interventions to combat grief are necessary. One solution is utilization of palliative care expertise to facilitate debriefing sessions, which provide protected time and space to discuss emotions related to oncology practice. Methods/Interventions: This pilot study aimed to evaluate how debriefing sessions led by a palliative care physician …

23.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

PGR expression as a pharmacogenomic companion biomarker to GENE70-derived genomic risk in ER-positive/HER2-negative breast cancer

Orcun Can

Abstract: Background: The biology of the estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancers is heterogeneous even when they are categorized by their risk via genomics. Transcriptomic PGR expression reflects endocrine pathway activity and may provide complementary biological information within established GENE70-derived genomic-risk categories. Whether this molecular marker improves the biological interpretation of genomic-risk stratification beyond conventi …

23.08.2026journal-article

Scientific Reports

Hierarchical grouped convolution and multi-scale vision transformer for uncertainty-aware early breast cancer detection using mammography

Praneeth K. R., Deepika Roy T. L., Lakshmi K., Divya Nimma, Sheeja Mary F.

Abstract Early breast cancer detection using mammography remains challenging because existing deep learning methods often emphasize either local lesion characteristics or global contextual information, while providing limited uncertainty quantification and clinically reliable prediction confidence. To address these limitations, this study proposes the Hierarchical Grouped Convolution and Multi-Scale Vision Transformer for Uncertainty-Aware Classification (HGCViT-UAC) framework. The proposed approach first applies a …

23.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Acute Kidney Injury During Vancomycin Treatment in Adult Patients With Haematologic Malignancies: A Multicentre Retrospective Study

Yuzhu Wang, Jie Li, Xingyun Hou, Ying Zhang, Chengchun Zuo, Xiaoqiang Ding, Xiaoyu Li, Qianzhou Lv, Hejin Lai, Kunming Pan

ABSTRACT Background Acute kidney injury (AKI) during vancomycin treatment remains a rare occurrence in adult patients with haematological malignancies (HMs). The objective of this multicentre study was to investigate the incidence and risk factors for AKI during vancomycin treatment in patients with HM. Methods The present study examined patients who were admitted to hospital and receiving vancomycin therapy between 2009 and 2024 at three tertiary hospitals. The primary outcome was the incidence of AKI during vanco …

23.08.2026journal-article

Journal of Clinical Nursing

Beyond Knowledge Transfer: Caregivers’ Evolving Medication Information Needs Across Paediatric Oncology Treatment

Micaella Sotera Hansen, Ronald Lynel Castelino, Raymond Li, Neevika Manoharan, Jacqueline Bloomfield, Connie Van

ABSTRACT Aim To identify and describe the medication information needs and preferences of caregivers of children with cancer, and the factors that support or impede those needs being met. Design Qualitative descriptive study guided by reflexive thematic analysis. Methods Between November 2024 and July 2025, semi‐structured interviews were conducted with 13 caregivers purposively recruited from a tertiary paediatric oncology centre in Australia. Data collection and analysis proceeded concurrently using reflexive the …

23.08.2026journal-article

Journal of Clinical Nursing

Longitudinal Trajectories and Predictors of Supportive Care Needs After Lung Cancer Surgery: A Prospective Cohort Study

Hui Yan, Jie Zhu, Xinyue Wu, Guihui Luo, Shurui Gao, Xuting Li, Hao Xu, Man Ye

ABSTRACT Aims To explore the trajectories of supportive care needs and identify influencing factors in lung cancer surgical patients. Design Prospective cohort study. Methods Data from 287 patients at a Chinese tertiary hospital were collected at admission (T0), 2 weeks post‐surgery (T1), 3 months (T2), 6 months (T3) and 1 year post‐surgery (T4). Latent class growth models were used to identify supportive care need trajectories, and logistic regression was used to analyse influencing factors. Results Three trajecto …

23.08.2026journal-article

Journal of Gastroenterology and Hepatology

Optimization of Minocycline‐Containing Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Randomized Controlled Trial

Yanan Gao, Yu Huang, Jinnan Chen, Shuhan Qiu, Yixian Guo, Meixuan Li, Xiao Liang, Hong Lu

ABSTRACT Background and Aim Minocycline‐containing bismuth quadruple therapy may provide a practical option for Helicobacter pylori ( H. pylori ) rescue treatment when tetracycline is unavailable, yet the optimal dosing remains unclear. We aimed to compare the efficacy and safety of different doses of minocycline‐containing regimens with classical tetracycline‐based bismuth quadruple therapy. Methods Refractory H. pylori –infected participants with multiple treatment‐failure were randomly (1:1:1:1) allocated to rec …

23.08.2026journal-article

Journal of Cosmetic Dermatology

Efficacy and Safety of Yellow Light Monotherapy Versus Yellow Light Combined With 20% Vitamin C for the Treatment of Melasma: A Single‐Center, Randomized, Double‐Blind, Placebo‐Controlled Clinical Study

Dan Du, Xu Liu, Yuwei Huang, Shuwei Wu, Xian Jiang

ABSTRACT Background Melasma treatment remains challenging due to limited effective and safe options. This study evaluated the efficacy and safety of yellow light phototherapy alone versus combined with 20% vitamin C in treating melasma. Methods Seventy‐one patients were randomly assigned to receive twice‐weekly yellow light phototherapy combined with either 20% vitamin C solution ( n = 35) or its corresponding vehicle ( n = 36). The primary outcome was the change from baseline in modified Melasma Area and Severity …

23.08.2026journal-article

Healthcare

Early Orthodontic Treatment in Children: A Qualitative Exploration of Orthodontists’ Perspectives and Practices in Saudi Arabia

Guna Shekhar Madiraju, Yousef Majed Almugla

Background and Objectives: The optimal timing of orthodontic intervention in children remains debated, particularly during the mixed dentition phase. Despite potential benefits, variability in clinical decision-making persists. This study explored orthodontists’ perceptions, clinical practices, and clinical decision-making regarding the timing of early orthodontic intervention in Saudi Arabia. Materials and Methods: An interpretive qualitative study was conducted using semi-structured interviews with nineteen licen …

23.08.2026journal-article

Interdisciplinary Medical Journal

Analysis of gene expression to explore the contribution of cancer-associated fibroblasts to breast cancer progression: a computational analysis

Nail Beşli, Nilufer Ercin, Bahar Sarikamis Johnson, Ulkan Celik

Objective: Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that greatly influence breast cancer progression. In this study, we used in silico analysis to determine the potential pathways and genes that could affect breast cancer progression associated with CAFs.Method: Data from breast cancer patients, collected through microarray and next-generation sequencing (NGS), were retrieved using the Gene Expression Omnibus (GEO) platform. The differentially expressed genes (DEGs) …

23.08.2026journal-article

Bioengineering

Research Progress on the Pre-Treatment of Chicken Feathers for Biogas Production

Isa Beatriz Conceição Oliveira-Alves, Hortência E. P. Santana, Ingrid Vieira Fernandes, Meirielly Jesus, Joana Santos, Fernando Mata, Samia Tássia Andrade Maciel, Denise Santos Ruzene, Daniel Pereira Silva

Keratin is an abundant, recalcitrant structural protein that constitutes the primary component of several animal wastes, particularly chicken feathers. Because of their potential and availability, various technologies, such as anaerobic biodigestion, have been used to degrade keratin and transform feathers into biogas and other value-added products. However, due to their fibrous architecture and rigid structure, keratinous materials are elastic, water-insoluble, and enzymatically resistant, which makes natural degr …

23.08.2026journal-article

BJU International

Diet and risk of bladder cancer: a systematic review of epidemiological evidence

Keiichiro Miyajima, Marcin Miszczyk, Navid Roessler, Shota Inoue, Paweł Rajwa, Akihiro Matsukawa, Fumihiko Urabe, Keiichiro Mori, Takafumi Yanagisawa, Pierre I. Karakiewicz, Jeremy Yuen‐Chun Teoh, Alberto Briganti, Lin Yang, Eva Schernhammer, Takahiro Kimura, Shahrokh F. Shariat

Purpose Although tobacco use and occupational exposures are established risk factors for urothelial cancer (UC), the influence of dietary factors remains uncertain. We conducted a systematic review to synthesize evidence from prospective cohort studies examining associations between dietary exposures and UC incidence. Methods A comprehensive literature search of MEDLINE, Embase, and Web of Science (May 2025) was performed to identify prospective studies evaluating dietary factors with UC incidence. The risk of bias …

23.08.2026journal-article

International Journal of Cancer

Assessing the Consistency of Genitourinary Cancer Estimates: A Comparison of Data From the Global Cancer Observatory and the Global Burden of Disease Study

Xiaohan Li, Zhengju Ren, Yao Chen, Wei Fan, Guangping Zhao, Ying Huang, Qing Jiang

ABSTRACT The Global Cancer Observatory (GLOBOCAN) and the global burden of disease (GBD) are two key databases for cancer epidemiology. In this study, we aim to assess the consistency of genitourinary cancer incidence and mortality estimates from the same year across the two databases, analyze the association between observed discrepancies and levels of social development and available health resources, and explore the reasons underlying these differences. Age‐standardized incidence and mortality rates (ASIR and AS …

23.08.2026journal-article

Expert Systems

Systematic Literature Review of Deep Learning Techniques for Lung Cancer Segmentation

Muhammad Sufyan, Jun Qian, Jianqiang Li, Azhar Imran, Fahad Sabah

ABSTRACT Accurate lung nodule segmentation is essential for early lung cancer diagnosis and treatment planning. Although deep learning (DL) has significantly advanced automated segmentation, existing review studies often lack an integrated technical–clinical perspective and provide limited guidance for real‐world deployment. In this study, we conduct a systematic literature review following PRISMA 2020 guidelines, analysing 311 publications and synthesizing 113 high‐quality studies published between 2019 and 2026. …

23.08.2026journal-article

Cellular Physiology and Biochemistry

Effects of Mebendazole and Flutamide Combination in Prostate Cancer Cell Lines: a Comprehensive in Vitro Analysis

Mohammad Reza Fattahi Fattahi, Diana Taheri, Seyed Hassan Inanloo, Akram Mirzaei, Helia Azodian Ghajar, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir

Background/Aims: The aim of this research was to use Mebendazole as an anticancer candidate to reduce the dose of Flutamide and reduce its side effects. Method: In this in vitro study, we evaluated the effect of Mebendazole, Flutamide and Mebendazole-Flutamide combination therapy in LNCaP, DU145 and PC3 cell lines as representatives of human prostate cancer. The assessment includes scratch-wound assay, colony formation assay, flow cytometric analysis of apoptosis and DNA cell cycle, real-time PCR (BAX/BCL2, E-cadhe …

23.08.2026journal-article

Surgical Practice

Survival Analysis of Palliative Mastectomy for Patients With De Novo Stage IV Breast Cancer: A Single‐Centre Experience

Xiao Hong Su, Wai Fong Tsang, Ho Yan Yuen

ABSTRACT Objective To audit the impact of palliative mastectomy with axillary dissection (PMAD) on the prognosis of patients with de novo stage IV breast cancer in the Pok Oi Hospital (POH), Hong Kong. Methodology We retrospectively reviewed 5377 patients with breast cancer treated in POH between January 2010 and October 2025 and identified 68 patients with de novo stage IV disease who underwent PMAD after systemic therapy. Progression‐free survival (PFS) and overall survival (OS) were estimated by the Kaplan–Meier …

23.08.2026journal-article

iMetaMed

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

Yitong Pan, Zhou Yang, Junyuan Deng, Feng Liu, Guang Lei

ABSTRACT Bone metastases (BoMs) are a major clinical challenge across cancer types, yet mechanistic insights remain limited by small cohorts and insufficient profiling depth. Here, we present a single‐cell RNA sequencing atlas of 95 BoMs, 22 healthy bone marrows (hBMs) and 129 primary tumors (PTs) spanning 10 cancer types, comprising 895,475 high‐quality transcriptomes, to map cellular remodeling during bone metastatic colonization. Malignant cells in BoMs converged on chromosomal instability—high proliferative sta …

23.08.2026journal-article

Acta Anaesthesiologica Scandinavica

Anaesthetic Type and Survival in Metastatic Colorectal Cancer: A Nationwide Registry Study

Ahmed Tarfy, Anna Enlund, Erland Östberg, Hanna Vikman, Anders Berglund, Mats Enlund, Maziar Nikberg

ABSTRACT Background The impact of anaesthetic choice on survival following metastatic cancer surgery is uncertain. Inhalational anaesthetics, such as sevoflurane, may promote inflammation and tumour progression, while the intravenous agent propofol has been suggested to be anti‐inflammatory. This study aimed to evaluate the association between anaesthetic maintenance with inhalational anaesthesia versus propofol‐based total intravenous anaesthesia and overall survival in patients undergoing surgery for metastatic c …

23.08.2026journal-article

Cancers

Evaluating the Performance of Machine Learning Models for Predicting 5-Year Breast Cancer Survival: A Systematic Review and Meta-Analysis

Ashin Krishna Chalil, Bindu Therayangalath, Vikram Patil, Chaithra Nagaraju

Background: Breast cancer is the most common malignancy among women worldwide and a leading cause of cancer-related mortality. Despite advances in diagnosis and treatment, accurately predicting 5-year survival remains challenging because of disease heterogeneity. This study systematically evaluated the performance of machine learning (ML) models for predicting 5-year breast cancer survival and synthesised their overall discriminative performance. Methods: A systematic search of PubMed, Scopus, and Web of Science (2 …

23.08.2026journal-article

Biomedicines

Upfront Versus Deferred CDK4/6 Inhibitor Use in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Real-World Study

Pınar Kubilay Tolunay, Bediz Kurt İnci, Berkan Karabuğa, Ali Topkaç, Şura Usta, Ergin Aydemir, Nejat Emre Öksüz, Enes Erul, İrem Küçükşahin, Hatime Arzu Yaşar, Hakan Akbulut, Ülkü Yalçıntaş Arslan, Öztürk Ateş

Background/Objectives: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are commonly used as first-line treatment for hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. However, the optimal timing of CDK4/6i initiation remains uncertain. This study compared overall survival (OS) between upfront first-line and deferred second-line CDK4/6i use in routine clinical practice. Methods: This retrospective, two-center cohort study included 403 patients with hormone …

23.08.2026journal-article

Journal of Composites Science

Mechanical Properties of AZ91D Magnesium Alloy with Short Carbon Fibers Under Heat Treatment and Equal-Channel Angular Pressing

Song-Jeng Huang, Jun Yi Lin, William Li, Chuan Li, Sathiyalingam Kannaiyan

AZ91D is a lightweight, representative commercial magnesium alloy known for its excellent castability and specific strength. However, the mechanical properties of as-cast AZ91D remain limited by inherent brittleness, relatively low strength, and microstructural inhomogeneity caused by enrichment of secondary phases at grain boundaries. In this study, AZ91D/Csf (short carbon fiber at 0, 2.5, and 5 wt.%) composites were prepared by gravity casting with mechanical stirring, followed by post-casting T4 heat treatment a …

23.08.2026journal-article

Symmetry

SDFR-Net: A Stage-Asymmetric Spectral Diffusion and Frequency–Spatial Refinement Network for Brain Tumor MRI Segmentation

Jingshi Lei, Hongwei Deng, Xicheng Fu, Yi Lei, Lei Xu, Qiangfei Wang

Accurate brain tumor segmentation from multi-modal magnetic resonance imaging (MRI) is essential for clinical diagnosis and treatment planning. However, effectively capturing long-range contextual information and fine lesion boundaries under limited computational budgets remains challenging. In this work, we propose SDFR-Net, a lightweight stage-asymmetric Spectral Diffusion and Frequency–Spatial Refinement Network for efficient 2.5D brain tumor MRI segmentation. Instead of applying identical processing across all …

23.08.2026journal-article

Surgeries

Simultaneous Carotid Endarterectomy and Ipsilateral Parotidectomy for Asymptomatic Carotid Artery Stenosis and Concurrent Warthin’s Tumor: A Multicenter Retrospective Case Series

Priscilla Nardi, Valerio Rinaldi, Greta D’Onofrio, Valeria Iacoucci, Sara Lembo, Lodovica Pepe, Marcella Vaglica, Roberta Zilli, Rocco Pasqua, Giulia Pizzardi, Massimo Ruggeri, Giampaolo Prezioso, Vito D’Andrea, Antonio Minni, Gianfrancesco Niccolini, Lorenzo Silvani, Marco De Vincentis, Giulio Illuminati

Background: Management of high-grade carotid artery stenosis with concomitant ipsilateral parotid gland tumor presents a rare and challenging surgical condition. Due to the rarity of this dual pathology, standardized guidelines are lacking. Material and Methods: A retrospective study was conducted between January 2020 and May 2025. Six asymptomatic patients with significant carotid stenosis and coexisting ipsilateral Warthin’s tumor underwent simultaneous eversion CEA (carotid endarterectomy) and partial superficia …

23.08.2026journal-article

International Journal of Molecular Sciences

Medical Cannabis and the Hallmarks of Cancer: A Critical Narrative Review

Diana Russo, Rute Fernandes, Valéria Tavares, Ana Agrelo, Rui Medeiros

Cancer remains a highly complex and heterogeneous disease, causing major morbidity and mortality worldwide despite advances in diagnosis and treatment. The hallmarks of cancer enlighten the biological mechanisms supporting tumourigenesis and malignant evolution, while helping to identify potential therapeutic targets. Medical cannabis has mostly been used in oncology for supportive care, but increasing preclinical evidence suggests interference with cancer-related signalling pathways. This narrative review summariz …