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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Communications Medicine

Pooled two-cohort MRI body composition phenotyping with open-source deep learning

Christian J. Mertens, Hartmut Häntze, Sebastian Ziegelmayer, Jakob Nikolas Kather, Daniel Truhn, Su Hwan Kim, Felix Busch, Dominik Weller, Benedikt Wiestler, Markus Graf, Fabian Bamberg, Christopher L. Schlett, Jakob B. Weiss, Steffen Ringhof, Elif Can, Jeanette Schulz-Menger, Thoralf Niendorf, Jacqueline Lammert, Isabel Molwitz, Avan Kader, Alessa Hering, Aymen Meddeb, Jawed Nawabi, Matthias B. Schulze, Thomas Keil, Stefan N. Willich, Lilian Krist, Martin Hadamitzky, Anke Hannemann, Florian Bassermann, Daniel Rueckert, Tobias Pischon, Alexander Hapfelmeier, Marcus R. Makowski, Keno K. Bressem, Lisa C. Adams

Abstract Background Body mass index fails to capture variation in fat and muscle distribution that determines metabolic health and disease risk. MRI enables radiation-free quantification of regional body composition, yet scalable open-source tools applied in pooled cohorts with differing acquisition protocols have been lacking. Methods MRSegmentator, an open-source nnU-Net-based pipeline, was applied to quantify visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), gluteofemoral adipose tissu …

29.08.2026journal-article

BMC Medicine

Bladder cancer precision-cut tumor slices (PCTS) preserve functional immune microenvironment enabling ex vivo drug evaluation

Sarah Richtmann, Maja Radak, Viktor Sincic, Jenny Hugoson, Nadja Werner, Valeriia Skoryk, Darcy Wagner, Fredrik Liedberg, Kristina Lundberg

Abstract Background The development of effective cancer immunotherapies is hindered by the lack of preclinical models that faithfully preserve tumor-immune interactions. Current approaches provide limited representation of immune components, creating a critical translational gap between laboratory findings and clinical outcomes. Precision Cut Tumor Slices (PCTS) offer a promising solution by maintaining complete tumor architecture including native immune cell populations and spatial organization. Methods We establi …

29.08.2026journal-article

Diagnostics

AI-Assisted Multilabel Diagnosis of 12-Lead Electrocardiograms Using an Interpretable Stacked Deep Learning Model with External Validation

Asifa Tassaddiq, Aiman Albarakati, Rabab Alharbi, Carlo Cattani, Dalal Khalid Almutairi, Ruhaila Md Kasmani

Background: Automated interpretation of 12-lead electrocardiograms (ECGs) remains challenging because multiple abnormalities may coexist and appear in selected leads or brief waveform segments. We developed a compact and interpretable framework for five-superclass multi-label ECG diagnosis. Methods: We evaluated PTB-XL records using the official fold protocol, with folds 1–8 for training, fold 9 for validation monitoring and class-specific threshold selection, and fold 10 for independent internal testing. We then e …

29.08.2026journal-article

Foot & Ankle International

Outcomes of Iliac Crest Bone-Block Arthrodesis After Failed First MTP Joint Surgery With Bone Loss

Nurettin Mantı, Melih Atalay, Nuri Koray Ülgen, Mehmet Orçun Akkurt, Sadık Emre Erginoğlu, Ali Öznur

Background: Failed first metatarsophalangeal (MTP) joint surgery with bone loss is a challenging revision problem. This study aimed to evaluate the radiographic and clinical outcomes of iliac crest bone-block arthrodesis in this setting. Methods: This retrospective cohort included 72 patients who underwent revision first MTP arthrodesis with tricortical iliac crest autograft between 2018 and 2022. All patients had at least 2 years of clinical and radiographic follow-up, and 83.3% had at least 3 years of follow-up. …

29.08.2026journal-article

Polymers

Effects of Heat Treatment on the Mechanical Properties and Thermal Stability of Bamboo

Zilu Liang, Haiyun Jiang, Yimin Tan

Bamboo contains abundant hydrophilic components such as hemicellulose which result in poor interfacial compatibility with epoxy resin and, consequently, limit its application in bamboo–epoxy composite packaging materials. In this study, we subjected bamboo (aged 3–4 years) to vacuum heat treatment to investigate the effects of treatment temperature (140, 160, and 180 °C) and holding time (4 and 6 h) and systematically evaluated the resulting changes in density, surface color, microstructure, mechanical behavior, an …

29.08.2026journal-article

Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer)

From Screen to Care: Physician Approaches to Overcoming Communication Challenges in Telemedicine

Imelda Ritunga, Mora Claramita, Sandra Widaty, Hardyanto Soebono

Background: The growth of telemedicine has encouraged physicians to adapt their communication techniques for remote consultations. Even though telemedicine enhances access and continuity of care, it also presents barriers to effective doctor–patient interaction. Aims: This study explores the communication challenges faced by physicians in telemedicine consultations and identifies the strategies they use to ensure effective and high-quality virtual care. Methods: A qualitative descriptive study was conducted through …

29.08.2026journal-article

Current Tropical Medicine Reports

Rickettsial Diseases in the Mediterranean Basin: an Evolving Clinical and Epidemiological Challenge

Giulio D’Agati, Luca Pipitò, Chiara Iaria, Claudia Colomba, Antonio Cascio

Abstract Purpose of Review Rickettsial diseases represent a major cause of arthropod-borne febrile illness in the Mediterranean basin, where climatic conditions, vector ecology, and close human–animal interactions promote the circulation of a wide diversity of Rickettsia species. In recent years, advances in microbial genomics and molecular diagnostics have substantially refined rickettsial taxonomy, clarified phylogenetic relationships across the Spotted Fever, Typhus, and Transitional Groups, and enhanced recogni …

29.08.2026journal-article

Maltepe Tıp Dergisi

Long-Term Outcomes of Conservative Treatment in Traumatic Carotid Artery Dissection: A Case Report

Birol Özkal, Kadir Timuçin Turgutoğlu

Amaç: Travmatik karotis arter diseksiyonu (TCAD), künt servikal travma sonrası ortaya çıkabilen nadir ancak ciddi nörolojik sonuçlara yol açabilen bir vasküler yaralanmadır. Beş yılı aşan uzun dönem takip verilerinin sınırlı olması, doğal seyir ve konservatif tedavinin etkinliği hakkındaki bilgi eksikliğini sürdürmektedir. Bu çalışmanın amacı, konservatif tedavi altında altı yıl boyunca yaklaşık %90 düzeyinde stabil kalan sağ internal karotis arter TCAD olgusunu sunmak ve uzun dönem yönetim yaklaşımlarına katkıda b …

29.08.2026journal-article

The International Journal of Medical Robotics and Computer Assisted Surgery

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

Chao Jing, Kun Liu, Guowei Zhang, Hongwei Wu, Zhe Jia, Guoxin Li, Yaping Zhao, Zhongtao Zhang, Wei Guo

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port robot‐assisted cholecystectomy with MicroPort SA‐1000. The primary endpoint was the completion rate, while secondary endpoints included estimated blood loss, operating time, hospital length of stay and complications. Results From June 2023 to …

29.08.2026journal-article

Journal of Ayurvedic Herbal and Integrative Medicine

CARIES REMINERALIZATION THERAPY – AN IN VITRO EVALUATION OF THE EFFICACY OF THREE REMINERALIZING AGENTS BY SEM AND EDS ANALYSIS

Geeta IB, Pranjul Sharma, Rayala Lokesh, Urvashi Patel

Dental caries, by definition, is one of the most common diseases worldwide. It is dependent on biofilm, diet, and other factors. It causes mineral loss, disrupting the balance between demineralization and remineralization. This has led to the development of various treatment approaches for initial carious lesions. Remineralization requires a natural pathway to restore the mineral loss of hydroxyapatite (HAP) crystals. Many materials have been clinically evaluated and have demonstrated promising results.

29.08.2026journal-article

Healthcare

Artificial Intelligence in Prehospital Tele-Emergency Medicine: A Survey of Acceptance and Attitudes

Nadezhda Durdova, Mathias Schmidt, Hanna Schröder, Pia Thoma, Dominik Groß, Saskia Wilhelmy

Background/Objectives: Artificial intelligence (AI) is increasingly being used in medicine to improve the efficiency, accuracy, and timeliness of patient care. In prehospital tele-emergency medicine, AI also has the potential to address various challenges and support tele-emergency physicians. This study focuses on a specific AI-based decision support system being developed for use by practitioners. While technical feasibility is a prerequisite for the successful implementation of this system, social, ethical, and …

29.08.2026journal-article

The Nursing Scope

Occupational Stress and Nursing Performance in In-Patient Care: Organizational Determinants in a Nigerian Tertiary Hospital

Abiodun FATUKASI

Background: Occupational stress remains a major challenge in nursing practice, particularly in inpatient care settings characterized by demanding workloads, complex clinical responsibilities, and resource constraints. Persistent workplace stress can adversely affect nurses’ performance, clinical decision-making, communication, and patient safety. Despite growing concerns about occupational stress among nurses, evidence regarding its organizational determinants and impact on nursing performance in Nigerian tertiary …

29.08.2026journal-article

Cancers

Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia

Nihel Ammous-Boukhris, Rania Abdelmaksoud-Dammak, Wala Ben Kridis, Dorra Ben-Ayed-Guerfali, Souhir Guidara, Ameni Feki, Hassen Kamoun, Afef Khanfir, Jamel Daoud, Gérard-Hubert Lizard, Ali Gargouri, Raja Mokdad-Gargouri

Background/Objectives: This study aims to investigate the mutational spectrum of BRCA1 and BRCA2 genes in a cohort of breast cancer (BC) patients from southern Tunisia, and to evaluate their clinical and prognostic significance. Additionally, this study explores the contribution of other cancer predisposition genes and the prevalence of variants of uncertain significance (VUS). Results: Among the 165 patients included, pathogenic or likely pathogenic variants (P/LPVs) in BRCA1/BRCA2 were identified in 19 cases (11. …

29.08.2026journal-article

Journal of Separation Science

Bridging the Gap Between Chemiluminescence Immunoassay and Liquid Chromatography‐Tandem Mass Spectrometry for Infliximab Monitoring: Method Validation and Clinical Comparability Study

Ying Xia, Ming‐Mei Zhu, Meng‐Qing Xiao, Chen‐Chun Zhong, Yu‐Jun Zhou, Yi‐Hao Xue, Shi‐Wei Zheng, Li Li, Feng Chen

ABSTRACT Infliximab (IFX) is a cornerstone biologic for pediatric inflammatory bowel disease, where therapeutic drug monitoring (TDM) is essential but complicated by inter‐platform variability. Systematic comparison of automated immunoassays with reference methods is therefore warranted. This study aimed to validate an in‐house chemiluminescence immunoassay (CLIA) for IFX quantification and evaluate its agreement with liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). A CLIA kit was validated by assessing t …

29.08.2026journal-article

Journal of Clinical Medicine

Nocturnal Autonomic Dysregulation and Admission-Window Clinical Suicide-Risk Assessment in Hospitalized Children and Adolescents

Qiyuan Cao, Jiaqi Xu, Wenjing Li, Yan Zhang, Xuehua Huang, Kexin Zhou, Jinquan Zhang, Lijun Jiang

Background/Objectives: Suicide-risk assessment during child and adolescent psychiatric hospitalization draws on patient report, clinical history, and professional observation. Whether nocturnal autonomic physiology is concurrently associated with a structured admission-window assessment after accounting for depressive symptoms and self-reported suicidal ideation remains uncertain. Methods: We analyzed 212 hospitalized children and adolescents receiving inpatient care for a major depressive episode. All had a Nurses …

29.08.2026journal-article

Eurasian Journal of Anesthesiology and Intensive Care

Antibacterial effects of levobupivacaine against staphylococcus aureus in a patient-controlled epidural analgesia model: an in vitro experimental study

Gülay Akıncı

Aims: Catheter-related infections remain an important complication of epidural analgesia. Local anesthetics may contribute to infection prevention because of their antimicrobial properties. This study aimed to evaluate the antibacterial effects of clinically relevant concentrations of levobupivacaine against Staphylococcus aureus in a simulated patient-controlled epidural analgesia (PCEA) model. Methods: An in vitro experimental PCEA infusion system was established using epidural catheter tubing and 0.2-µm bacteria …

29.08.2026journal-article

Indian Journal of Radiology and Imaging

Prenatal Diagnosis of Thanatophoric Dysplasia Type I Based on Classical Ultrasound Findings During Anomaly Scan: A Case Report

Rajat Garg, Rashmi Singh

Abstract Thanatophoric dysplasia (TD), the most common lethal skeletal dysplasia, results from FGFR3 mutations causing impaired endochondral ossification. Where molecular testing is unavailable, ultrasound evaluation is the diagnostic cornerstone. We report a 24-year-old primigravida undergoing a routine anomaly scan at 22 weeks. Ultrasonography showed severe micromelia with femoral bowing (telephone-receiver appearance), a markedly narrow thoracic cage (thoracic circumference of 11.79 cm, falling below the fifth p …

29.08.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Surgical management of bilateral atypical tibial fractures associated with long-term bisphosphonate therapy in a cat

Justin Koh Wei Wong, Stephanie Colthurst

An eight-year-old, indoor, male neutered Oriental mix cat was presented with acute bilateral pelvic limb lameness without preceding trauma. The cat had received oral alendronate for 4.5 years for the management of idiopathic hypercalcaemia. Radiographs revealed bilateral, closed, comminuted proximal tibial and fibular fractures with cortical sclerosis. Staged bilateral open reduction and internal fixation were performed using orthogonal locking compression plates. Alendronate therapy was discontinued, and the cat r …

29.08.2026journal-article

Journal of Clinical Medicine

The “Namaste Sign”—A Novel Coronal MRI Marker for the Evaluation of Anterior Cruciate Ligament Integrity

Shashank Chapala, Rajesh Botchu, Hasaam Uldin, Meili Jade Temsin Leung Chew, Kapil Shirodkar, Sang Bum Lee, Anoop Venkatapura Bylaswamy, Avneesh Chhabra

Magnetic resonance imaging (MRI) is universally recognized as the gold standard for evaluating anterior cruciate ligament (ACL) injuries. However, differentiating partial tears from complete ruptures using the standard sagittal plane remains a diagnostic challenge. The oblique coronal orientation of the ACL often leads to volume averaging artifacts and inaccurate interpretations. While axial imaging offers a favorable alternative, distal tears near the tibial attachment are frequently missed. This review synthesize …

29.08.2026journal-article

Journal of Clinical Medicine

Prospective Assessment of Carboxyhemoglobin and Methemoglobin Levels in Operating Room Personnel During HIPEC/Peritonectomy Compared with Standard Colorectal Surgery

Emil Kinda, Petar Matosevic, Sanda Smud Orehovec, Ivan Romic, Rudolf Radojkovic, Branko Bogdanic

Background/Objectives: In the operating room, surgical staff are exposed to inhalation of smoke from the combustion of tissues when using electrocautery. By introducing HIPEC/peritonectomy in the treatment of malignant neoplasms of the peritoneum, exposure to smoke is significantly increased. To adequately perform this procedure, high-power monopolar cautery is used. The aim of this study was to assess carbon monoxide exposure associated with surgical smoke generated during peritonectomy procedures and to compare i …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Neonatal Infectious Harm Reduction Benefits of Maternal Substance Use Treatment: A Dyad-Based Retrospective Review

Lindsey E Hastings, Ellen F Eaton, Rachel G Sinkey, Claudette L Poole

Abstract Background Substance use disorders (SUD) in pregnancy can disrupt routine prenatal care and have been linked to increased risk of congenital syphilis as well as perinatal exposure to hepatitis C (HCV) and human immunodeficiency virus (HIV). Moreover, inconsistent adherence to universal HCV maternal screening recommendations, fragmented care, and frequent removal of infants for child welfare often make timely identification of maternal HCV or syphilis infection challenging and follow-up screening of exposed …

29.08.2026journal-article

EJNMMI Physics

Development of a multifunctional anthropomorphic phantom for performance evaluation in nuclear medicine imaging: preliminary PET/CT validation

Xuesong Su, Zuowei Zou, Yingmao Chen, Hao Hong, Zhiwen Chen, Xuejuan Wang, Jianhua Geng

Abstract Purpose To develop an anthropomorphic phantom that enables the simultaneous evaluation of key performance metrics for nuclear medicine imaging systems and to preliminarily validate its application in PET/CT. Methods The anthropomorphic phantom replicates thoracic and abdominal anatomy, simulating human skeletal structures, lung tissue, soft tissue, and tumors. The phantom is divided into five functional regions: a lung tumor detection region (right lung with spheres), an attenuation and scatter correction …

29.08.2026journal-article

Psychiatry and Clinical Neurosciences

Brain Network Convergence of Abnormal Gray Matter and Functional Activity of Pathological Dissociative Symptoms

Xuhan Cui, Leyi Zhang, Yangpan Ou, Yong Liu, Bing Lang, Wenbin Guo

Aim Pathological dissociation is a complex clinical symptom widely observed across various psychiatric disorders. Dissociative symptoms prolong the duration of hospitalization and are associated with a poor clinical prognosis. Although several pathological models (e.g., the frontal‐limbic overmodulation model and the defense cascade model) have been proposed to interpret dissociative symptoms, heterogeneous regional‐level imaging findings impede our comprehension of the neural changes underlying dissociative sympto …

29.08.2026journal-article

ACR Open Rheumatology

Reduction of CXCR3 + CCR6 + CD4 + T Cells and IL ‐17+ RORγt + CD4 + T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

Addison Pacheco, Patricia Remalante‐Rayco, Nigil Haroon, Denis Poddubnyy, Robert D. Inman

Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic response. Methods At the clinician's discretion, 18 patients who did not respond to secukinumab were either switched to a tumor necrosis factor inhibitor (TNFi; n = 8) o …