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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
23.08.2026journal-article

International Journal of Molecular Sciences

Blood Plasma Analysis in Ovarian Cancer Patients Using an AFM/MS Approach: Effect of Sample Dilution on Proteome Depth

Arina I. Gordeeva, Anastasia A. Konstantinova, Tatiana A. Materova, Elizaveta E. Rybakova, Maria O. Ershova, Nikita E. Vavilov, Victor G. Zgoda, Tatyana O. Pleshakova, Alexander I. Archakov

Early detection of ovarian cancer remains challenging because of the lack of sensitive and reproducible blood-based biomarkers. A major challenge in plasma proteomics is the extremely wide dynamic range of protein concentrations, which prevents simultaneous detection of both high- and low abundance proteins and limits the identification of disease-associated signals. In this study, we applied a combined atomic force microscopy and mass spectrometry (AFM/MS) approach to investigate how sample dilution affects plasma …

23.08.2026journal-article

Cancers

Association Between Body Mass Index and Treatment Toxicity in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib or Pazopanib

Ahmet Kürşad Dişli, Ayşe Nuransoy Cengiz, Muhammet Cengiz, İrfan Buğday, Sinan Yıldırım, Rıdvan Gönül, Oktay Bozkurt, Mevlüde İnanç, Metin Özkan

Background/Objectives: Sunitinib and pazopanib are administered at fixed doses in patients with metastatic renal cell carcinoma (mRCC), without adjustment for body composition. This study aimed to investigate the association between body mass index (BMI) and treatment-related toxicity and treatment discontinuation in patients with mRCC receiving first-line sunitinib or pazopanib. Methods: A total of 136 patients with mRCC treated with sunitinib (n = 90) or pazopanib (n = 46) were retrospectively evaluated. BMI was …

23.08.2026journal-article

Smart Molecules

A photoimmune synergizing RNA interference technology for highly effective antitumor treatment

Xiang Xia, Bingbing Wu, Xueze Zhao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng

Abstract Photoimmunotherapy and RNA interference (RNAi) hold great potential for tumor therapy but exhibit limited efficacy as monotherapies. In this work, we report a red‐light‐activated combinatorial therapy that integrates photodynamic immunotherapy (PIT) with RNAi via a rationally designed photosensitizer, FNBS, developed on the basis of our previously reported advanced photosensitizer platform, HNBS. Upon cellular uptake and following red light irradiation, FNBS induces pyroptosis through the activation of nuc …

23.08.2026journal-article

Histopathology

AI for tumour proportion scoring of programmed death‐ligand 1 immunohistochemistry in non‐small cell lung cancer: a review of commercial and non‐commercial tools

Joachim Webers, Sandrina Martens, Pascal Gervois, Inge Mertens, Yuri Tolkach, Yves Sucaet, Esther Wolfs, Dirk Valkenborg

Programmed death‐ligand 1 (PD‐L1) expression, commonly quantified as tumour proportion score (TPS), is a key biomarker guiding immunotherapy in non‐small cell lung cancer (NSCLC). Manual scoring of PD‐L1 immunohistochemistry (IHC) is time‐consuming and challenged by preanalytical variability and interpretive subjectivity, which can hinder consistent treatment selection. Artificial intelligence (AI) tools aim to support more standardized PD‐L1 scoring. We compare publicly available evidence on PD‐L1 AI tools and ide …

23.08.2026journal-article

Cancers

EIF3H Modulates Glycolysis Through LDHA Stabilization in Triple-Negative Breast Cancer

Xuyu Cheng, Xinghai Liu, Ziyu Feng, Xiaoan Liu

Background: Triple-negative breast cancer (TNBC) lacks effective targeted therapies, and its dependence on glycolysis represents a potential metabolic vulnerability. EIF3H, the largest subunit of the eukaryotic translation initiation factor 3 complex and a putative deubiquitinase, has been implicated in tumor progression, but its role in TNBC metabolism remains unclear. Methods: EIF3H expression and prognostic value were evaluated in public datasets, clinical TNBC specimens, and cell lines. Functional roles were ex …

23.08.2026journal-article

Diagnostics

Diagnostic Performance of Post-Treatment F-18 FDG PET/CT for Detecting Recurrent Cervical Cancer

Choon-Young Kim, Sang-Woo Lee, Gun Oh Chong, Jong Mi Kim, Yoon Hee Lee, Chae Moon Hong, Shin Young Jeong

Background/Objectives: Cervical cancer recurrence after definitive treatment remains a major clinical challenge, and early detection may improve patient outcomes. This study evaluated the diagnostic performance of fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) for detecting recurrent cervical cancer according to clinical context. Methods: We retrospectively reviewed 1727 post-treatment PET/CT examinations obtained from 659 patients who achieved a complete respons …

23.08.2026journal-article

Diabetes, Obesity and Metabolism

Variation in Treatment Patterns of Type 2 Diabetes in Older Patients

Phuc Le, Ning Guo, Anita Misra‐Hebert, Christopher B. Boyer, Kevin M. Pantalone, Hamlet Gasoyan, Nicholas J. Casacchia, Michael B. Rothberg

ABSTRACT Aims To estimate the proportion of older patients with type 2 diabetes (T2D) and HbA1c above or below goal at provider level and explore factors associated with patients being above or below goal. Materials and Methods We used 2023 Cleveland Clinic electronic health records, including patients ≥ 65 years old with T2D, ≥ 1 diabetes medication and ≥ 1 HbA1c measurement. Patients were assigned to their listed primary care provider or the one they saw most frequently and stratified into good, intermediate, or …

23.08.2026journal-article

Public Health Reports®

Cardiovascular-Related Death Among Women With Breast Cancer in the United States: Do We Need a Better Approach for Estimating Rates?

Nguyen Le, Yan Liu, Chanhyun Park

Breast cancer is the most common cancer among women in the United States, and cardiovascular disease (CVD) is a leading cause of death in this population. Understanding CVD-related death among breast cancer survivors is critical to inform policies. Previous studies calculating CVD-related death rates in this population used data from the Centers for Disease Control and Prevention (CDC) Wide-ranging ONline Data for Epidemiologic Research (WONDER) with the general US female population as the denominator, which may ha …

23.08.2026journal-article

Arthroscopy Techniques

Fixation Treatment of Anterior Cruciate Ligament Avulsion Fracture via Suture‐Bridge Technique Through Transtibial Tunnels

Peisi Hou, Chenyang Meng, Jie Xu, WenQiang Zhao, Yuhang Wei, Changxu Han

Abstract Surgical intervention is usually required for type III/IV avulsion fractures of the inferior insertion of the anterior cruciate ligament. Arthroscopically assisted suture‐bridge technique with anchors and trans‐tibial tunnel pull‐out suture fixation using high‐strength sutures are currently common surgical methods. However, the biomechanical performance of anchor fixation and transosseous tunnel pull‐out fixation is suboptimal. For patients with high sports demands or those who need to return to competitiv …

23.08.2026journal-article

Molecules

Improved Lipophilicity Is Associated with the Cytotoxic Activity of Chlorogenic Acid Esters in In Vitro Colorectal Cancer Models

Ana María Castañeda-Cifuentes, Johanna Pedroza-Díaz, Gloria A. Santa-González, Isabel Cristina Henao-Castañeda, Andrea Johanna Andrea Báez, Jorge L. Jios, Ana Laura Di Virgilio

Chlorogenic acid (CGA) exhibits anticancer activity in colorectal cancer (CRC), but its clinical application is limited by low lipophilicity. To improve its physicochemical properties, four CGA esters (methyl, ethyl, n-propyl, and n-butyl chlorogenates) were synthesized and evaluated. Physicochemical properties were characterized in silico, and their biological activity was assessed in SW480, HT-29, and non-tumoral NCM460 cell lines using viability assays and flow cytometry. Molecular docking studies were performed …

22.08.2026journal-article

Diseases of the Esophagus

P1.239. Clinical Outcomes of Conversion Surgery for Locally Advanced Esophageal Cancer With Mediastinal M1b Lymph Node Metastasis

Tetsuya Abe, Takahiro Hosoi, Kosuke Inada, Kotaro Ozaki, Eiji Higaki

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The role of conversion surgery (CS) for locally advanced esophageal cancer with mediastinal M1b lymph node metastasis has not yet been clearly defined. Methods We evaluated the therapeutic outcomes of 27 patients who underwent conversion surgery (CS) for locally advanced esophageal cancer with mediastinal M1b lymph node metastasis, among 1,030 patients who underwent thoracic esophagectomy at our institution bet …

22.08.2026journal-article

Diseases of the Esophagus

P1.202. Management and Outcomes of Anastomotic Leak After Oesophagectomy in Patients With Oesophageal Cancer

Apurva Ashok, Soumyabrata Ghosh, Tarun Joseph, Gangireddy Sivasankar Reddy, Moses Arunsingh, Robin Thambudorai

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leak (AL) after oesophagectomy is a dreaded complication with significant implications on patient outcomes. Early detection of leak, advances in perioperative care and management techniques may improve long-term outcomes. This study was performed to assess the management patterns of anastomotic leak and its short-term and long-term consequences. Methods A retrospective study was conduc …

22.08.2026journal-article

Cancer Causes & Control

“I never thought to bring them up to the doctor”: examining symptom appraisal, help-seeking behaviors, and diagnostic delays among young adults with cancer

Natasha C. Allard, Elizabeth G. Bouchard, Jennifer S. Ford, Thomas Hugh Feeley, Denise Rokitka, Heather Orom

Abstract Purpose Cancer incidence is rising among young adults (20–39 years), and it is one of the top five causes of death for this age group. Young adults often experience longer delays in diagnosis than children and older adults, which negatively impacts survival and quality of life. Communication interventions might help reduce these delays, but understanding the factors driving delays is crucial for developing effective strategies. Methods We conducted semi-structured interviews with 30 young adults diagnosed …

22.08.2026journal-article

Pain Medicine

Celiac Plexus Block with versus without Botulinum Toxin Type A for Pancreatic Cancer Pain: A Retrospective Comparative Study

Kaehong Lee, Seungpyo Nam, Seungcheol Yu, Jeongsoo Kim

Abstract Objective To evaluate whether the addition of botulinum toxin type A (BTX) to celiac plexus block (CPB) is associated with improved analgesic outcomes in patients with pancreatic cancer pain. Design Retrospective observational study. Setting Single-center tertiary hospital. Subjects A total of 60 patients with pancreatic cancer pain who underwent fluoroscopy-guided CPB between January 2022 and November 2025. Methods Patients were divided into CPB only (n = 34) and CPB with BTX (n = 26) groups. Pain intensi …

22.08.2026journal-article

Diseases of the Esophagus

P1.090. Innovative Push Percutaneous Endoscopic Gastrostomy Using Thread-Through-Trap and Alken Dilator in Advanced Esophageal and Head and Neck Cancer

Prasit Mahawongkajit, Worapong Anuponganan

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Percutaneous endoscopic gastrostomy (PEG) using the push technique is a minimally invasive alternative to surgical gastrostomy that reduces procedure-related morbidity and the risk of tumor seeding. This approach is particularly beneficial in patients with advanced esophageal and head and neck cancers. Methods An innovative push-PEG technique, termed Thread The Thread Though Trap and Alken Metal Dilator (5TAMeD) techniq …

22.08.2026journal-article

Diseases of the Esophagus

P1.086. Impact of Surgery Versus Non-Surgery on the Prognosis of Esophageal Cancer Patients With Clinically Identified Metastatic Supraclavicular Lymph Nodes

Yiheng Huang, Yuqin Cao, Hecheng Li

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The clinical significance of supraclavicular lymph node (SCLN) involvement in esophageal cancer remains controversial. The role of surgery in managing patients with SCLN metastases remains uncertain. This study evaluates the prognostic outcomes of patients with SCLN-positive esophageal cancer who received either surgical or nonsurgical treatment, aiming to develop evidence-based management strategies for this subgroup. Methods A retros …

22.08.2026journal-article

Diseases of the Esophagus

OA08.5. Incidence of Lymph Node Metastases in pT1 Chemo- and Radiotherapy Naïve Esophageal and Gastric Cancer in the Nordic Countries

David Edholm, Joonas H Kauppila, Michael P Achiam, Oliver Nørholm Kempf, Tobias Hauge, Mats Lindblad, Tom Mala

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background Although endoscopic resection is reported to be safe for early stage esophagogastric cancer, uncertainty remains regarding oncological efficacy, particularly for submucosal lesions. The aim of this study was to assess the frequency of lymph node metastasis (LNM) and survival in patients operated for chemo- and radiotherapy naïve pT1 esophagogastric cancer. Methods Patients who underwent surgical resectio …

22.08.2026journal-article

Cell Biochemistry and Biophysics

Host-Derived Proteomic Profiling of Human and Canine Mammary Tumor Xenografts Identifies Enrichment of Lipid Metabolism-Related Pathways

Elisa Díaz-Grijuela, Saioa Goñi, Alejandro Urdiciain, Miguel Barajas, Ileana B. Gonzalez-Valdes, Maider Espinal, Claudia Caballero-Mínguez, Enrique Santamaria, Agustín Hernández, Egoitz Astigarraga, Gabriel Barreda-Gómez, Raquel Urtasun, Joaquín Fernandez-Irigoyen

Abstract Breast cancer is the most frequently diagnosed cancer in women worldwide and one of the most common malignancies in dogs. Notable clinical, hormonal and molecular similarities between both species suggest that dogs may serve as a valuable comparative oncology model. Alterations in lipid homeostasis and metabolism are closely associated with the acquisition of cancer hallmarks. In this study, a comparative proteomic analysis of murine host-derived proteins was performed in cell line-derived xenograft (CDX) …

22.08.2026journal-article

Current Oncology Reports

Percutaneous Management of Desmoid Tumors

Gina P. Landinez, Shakthi Kumaran Ramasamy, Xiao Wu, Kiyon Naser-Tavakolian, Abin Sajan, Areeb Siddiqui, John Moody, Kirema Garcia-Reyes, Junaid Raja, Venkatesh P. Krishnasamy

Abstract Purpose of Review To provide a comprehensive review of percutaneous image-guided techniques in the management of desmoid tumors including evolving thermal and non-thermal ablation options, as well as trans-arterial catheter options. Beyond each treatment modality, we aim to highlight considerations related to patient selection, technical components, and the growing interplay between percutaneous therapies and emerging systemic therapies. Recent Findings Percutaneous ablation, particularly cryoablation, has …

22.08.2026journal-article

Effective Pharmacotherapy

Justification for the Redundancy of Wide Axillary Llymphodissection in Patients with Early Breast Cancer who Developed Ttransformation from Iinitial cN1 to Complete Clinical Response after Neoadjuvant Chemotherapy

S.P. Botkin Moscow Multidisciplinary Scientific and Clinical Center, D.A. Karseladze, K.S. Titov, I.N. Lebedinsky, I.N. Kutz, D.D. Dolidze, S.S. Lebedev, A.A. Tatarova, E.Yu. Neretin, RUDN University, Moscow, Russian Medical Academy of Continuous Professional Education, Moscow

The aim of the study was to determine the feasibility of de-escalation of the volume of lymphodissection by performing selective target biopsy of the sentinel lymph node in patients with initial stage cN1 disease who progressed to cN0 after NACT and demonstrate that this approach does not result in worsening oncological outcomes or local recurrences. For this purpose, 345 patients with primary operable breast cancer were studied. In the first stage, the patients received NACT followed by radical surgery in the peri …

22.08.2026journal-article

BMC Microbiology

Effects of cephalexin treatment on DNA replication dynamics in Escherichia coli

Iren Grigoryan, Dominika Krawiel, Emma L. Dunbar, Stelinda Peros, Ronan R. McCarthy, Christian J. Rudolph

Abstract Background In bacteria, DNA replication and chromosome segregation are tightly coordinated with cell division. The replication run-out method, which combines inhibition of transcription initiation by rifampicin with inhibition of cell division by cephalexin, is widely used to analyse replication dynamics by allowing ongoing replication forks to complete in the absence of new initiations. While this approach is generally robust, the physiological consequences of the individual components of the method, part …

22.08.2026journal-article

Diseases of the Esophagus

P1.108. Molecular Determinants of Tumor Morphology in Esophageal Adenocarcinoma

Gavin Wilson, Jin-Soo Park, Frances Allison, Yvonne Bach, Jonathan Allen, Premalatha Shathasivam, Dahanny Aguilar, Razan Almohamedi, Sheng-Ben Liang, Elliot Wakeam, Gail Darling, Elena Elimova, Sangeetha Kalimuthu, Jonathan Yeung

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Esophageal adenocarcinoma (EAC) is histologically graded as well, moderately, or poorly differentiated. Poorly differentiated tumours are associated with worse prognosis compared to well and moderately differentiated tumours. However, the molecular mechanisms driving these differences are poorly understood and their delineation may lead to improved biologically-informed patient stratification and therapeutic development. Methods We primarily a …

22.08.2026journal-article

Diseases of the Esophagus

P1.075. Treatment Efficacy and Strategy in Immune Checkpoint Inhibitors Treatment for Stage IV Advanced Esophageal Cancer

Kosuke Narumiya, Yasuhiro Okumura, Shunsuke Yamagishi, Nao Yoshida, Hayato Abe, Yusuke Mitsuka, Ryo Muraishi, Yukiyasu Okamura

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The results of two trials, KeyNote590 and CheckMate648, have made it possible to use immune checkpoint inhibitors (ICIs) as first-line treatment for Stage IV esophageal cancer, and unprecedented therapeutic effects can now be expected, including multimodality therapy such as conversion surgery (CS) and chemo-radiation therapy. Treatment strategies have only just begun therefore the indications of using ICI to aim for a cure for it have …

22.08.2026journal-article

Diseases of the Esophagus

P1.042. Utility of a Fenestrated Surgical Drain for the Prevention and Treatment of Esophageal Leak

Nathan Yat Shun Mak, Michelle Lau, Edward Cheong, Jie qi Lim, Dulcena Yen, Koy Min Chue, Nan Guang Tan, Wai Keong Wong, Ya-Lyn Annalisa Ng, Daryl Chia, Jeremy Tian Hui Tan

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Esophageal transmural defects are associated with high morbidity and mortality. Sponge-based endoscopic vacuum therapy (EVT) is effective but costly and requires frequent exchanges under general anesthesia. We describe a modified, cost-effective EVT approach using a fenestrated, spongeless radio-opaque silicone drain for both prevention and treatment of esophageal leaks. Methods A retrospective case s …