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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of Personalized Medicine

Molecular Residual Disease in Non-Small Cell Lung Cancer: Technology or Patient Outcomes?

Paul R. Walker

Molecular residual disease (MRD) testing approaches with plasma next-generation sequencing (NGS) testing to identify circulating tumor DNA (ctDNA) in resectable-stage non-small cell lung cancer (NSCLC) are evolving. The MRD concept is to better guide perioperative systemic treatment and identify recurrent NSCLC before symptomatic radiographic recurrences. Multiple tumor-informed assays are available with technology driving lower levels of ctDNA detection. However, it remains unclear that individual patients derive …

29.08.2026journal-article

Cancer

Adjuvant CDK4/6 inhibitors in early‐stage breast cancer: Clinical evidence and considerations for risk stratification and treatment selection

Austin D. Williams, Anna Weiss

Abstract Hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer is the most common biologic subtype and carries a persistent risk of recurrence, particularly in patients with high‐risk, early‐stage disease. Cyclin‐dependent kinase 4 and 6 inhibitors, initially established as a standard component of first‐line therapy in the metastatic setting based on improvements in progression‐free and overall survival, have since been evaluated in the adjuvant setting. While adjuvant palbocicl …

29.08.2026journal-article

Journal of Psychology and Psychotherapy Research

Clinical Pharmacology of Bipolar Disorder: An Updated Review of Pharmacotherapeutic Strategies

Michel Bourin

Bipolar disorder (BD) is a chronic, recurrent psychiatric illness characterized by episodes of mania, hypomania, and depression that substantially impair psychosocial functioning and quality of life. Pharmacotherapy remains the cornerstone of both acute symptom management and long-term relapse prevention. Over the past decade, advances in clinical trials and international treatment guidelines have refined the role of mood stabilizers, second-generation antipsychotics, and adjunctive therapies across different phase …

29.08.2026journal-article

Veterinary Medicine and Science

The Estimation of Phenotypic and Genetic Parameters for Growth Rate Traits of Abergelle Goat Under the Community‐Based Breeding Programme in the North‐Eastern Parts of Ethiopia

Yeshiwas Walle Abebe, Wossenie Shibabaw Meberatie, Zeleke Tesema Wondie

ABSTRACT Background Understanding phenotypic performance and genetic parameter estimation is important for effective genetic progress in animal breeding and genetics. The data were collected for 6 years (2018–2023) from the established village of Abergelle goat community‐based breeding programme (CBBP) area in Sekota Dryland Agricultural Research Center. The investigated traits were birth weight (BWT), 3‐month weight (TMWT), 6‐month weight (SMWT), 9‐month weight (NMWT), yearling weight (YWT), average daily weight g …

29.08.2026journal-article

African Journal of Pharmacy and Alternative Medicine

Etiology, Prevalence, and Risk Factors of Bacterial Meningitis in Children Under Five at Nakuru County Referral Hospital, Kenya

Emily CHEWOREI, Titus SUGE

Bacterial meningitis remains a significant public health burden among young children in resource-limited settings. This study aimed to determine the etiology, prevalence, and associated risk factors of bacterial meningitis in children under five admitted to Nakuru County Referral Hospital, Kenya. A retrospective analysis was conducted on medical records of 105 children diagnosed with bacterial meningitis between 2017 and 2021. Streptococcus pneumoniae was the most prevalent pathogen, accounting for 42.9% of cases, …

29.08.2026journal-article

Surgery Today

Initial surgical results of subcostal uniportal robotic lung resection: a study of the perioperative outcomes and a CUSUM analysis of the learning curve

Teruhisa Kawaguchi, Fumiaki Watanabe, Shinji Kaneda, Daisuke Ito, Koji Kawaguchi

Abstract Purpose Anatomical lung resection using the da Vinci SP system was recently introduced in Japan. We retrospectively evaluated our initial experience and analyzed the learning curve for the first 53 consecutive cases. Methods Fifty-three patients with primary lung cancer underwent anatomical resection, including lobectomy and segmentectomy, using the da Vinci SP system. We reviewed the perioperative outcomes, including the operative time, console time, conversion rates, and complications. The learning curve …

29.08.2026journal-article

Revista Gênero e Interdisciplinaridade

WOMEN WHO HAVE UNDERGONE BARIATRIC SURGERY PERCEIVE THEIR BODIES AND EXCESS SKIN.

Amanda Gêa Gomes Gonçalves, Beatriz de Carvalho e Silva Cavalcante, Eduardo Alves Pimentel, Rogério José de Almeida

Obesity is a significant public health problem associated not only with physical comorbidities but also with psychosocial impacts such as low self-esteem, social stigma, and body image dissatisfaction. Therefore, this study aimed to understand the influence of excess skin on body perception in women undergoing bariatric surgery. This is a cross-sectional and descriptive study with a qualitative and exploratory approach, conducted through semi-structured interviews with eight women who underwent bariatric surgery an …

29.08.2026journal-article

Journal of Musculoskeletal Surgery and Research

Management of tuberculous hip ankylosis using dual-approach total hip arthroplasty and gluteal reconstruction: A case report

Shihab A. Bostaji, Khalid M. Alhomayani, Abdullah M. Alshanqiti, Abdulrahman M. Alshanqiti

Tuberculous hip ankylosis is an uncommon but disabling sequela of osteoarticular tuberculosis. We report a 34-year-old man with long-standing post-tuberculous complete osseous ankylosis of the right hip, severe deformity, and abductor deficiency. Magnetic resonance imaging showed complete fusion and advanced fatty degeneration of the gluteus medius and minimus without features of active infection. He underwent dual- approach total hip arthroplasty using a dual-mobility acetabular construct, cementless conical stem …

29.08.2026journal-article

Translational Medicine

Detection of latent tuberculosis infection in individuals before heart transplantation and heart transplant recipients

A. R. Sabirova, P. A. Fedotov, R. A. Sharipov, M. A. Simonenko, B. B. Musaeva, E. Yu. Vasilyeva, E. A. Stabrova, I. V. Kudryavtsev, D. A. Kudlay, A. A. Starshinova, D. M. Spelnikov

Background. The effective functioning of the immune system in solid organ recipients against M. tuberculosis may be compromised due to the intensive action of immunosuppressive drugs. Identifying latent tuberculosis infection (LTBI) in patients on the heart transplant waiting list, as well as in heart transplant recipients, may help improve the epidemic situation. Objective. To determent the level of latent tuberculosis infection in patients before and after heart transplantation. Materials and Methods. A comparati …

29.08.2026journal-article

Journal of the American Heart Association

Distribution and Clinical Utility of the Kidney Disease Improving Global Outcomes Chronic Kidney Disease Risk Classification in Patients Undergoing Atrial Fibrillation Ablation

Hironori Ishiguchi, Yasuhiro Yoshiga, Shintaro Hashimoto, Masakazu Fukuda, Goki Nakashima, Masafumi Fujinaka, Masaki Shibuya, Takuya Omuro, Shigeki Kobayashi, Motoaki Sano

Background Chronic kidney disease (CKD) is a key component of the cardiovascular–kidney–metabolic framework. However, in patients undergoing atrial fibrillation ablation, the distribution of CKD across Kidney Disease: Improving Global Outcomes risk categories and its prognostic value remain unclear. Methods Patients undergoing atrial fibrillation ablation with preprocedural urinalysis were studied. Patients were classified into Kidney Disease: Improving Global Outcomes CKD risk categories (low, moderate, high, very …

29.08.2026journal-article

Asian Journal of Advanced Research and Reports

Identification and Management of Myofascial Trigger Points in Shoulder Pain: A Critical Narrative Review with Particular Reference to the Indian Clinical Context

Himanshu Devki Nandan Sharma, Geetanjali Bhatnagar, Pallav Bhatnagar

Shoulder pain is a persistent and costly musculoskeletal complaint, and myofascial trigger points have been proposed as one of its principal peripheral contributors. The construct nevertheless remains contested. Palpation-based identification is imperfectly reproducible, instrumented alternatives remain investigational, and treatment trials frequently report short-lived analgesia obtained under conditions of incomplete blinding. These uncertainties acquire additional significance in India, where the occupational pr …

29.08.2026journal-article

Scientific Reports in Medicine

Co-Mutation Landscape of PIK3CA Across Multiple Adenocarcinomas: Insights from TCGA Data<b></b>

Perçin Pazarcı

Objective: PIK3CA is one of the most frequently mutated oncogenes across multiple cancer types, playing a crucial role in tumorigenesis via the PI3K/AKT/mTOR signaling pathway. Understanding its genuine co-mutation landscape is essential for identifying oncogenic interactions and refining targeted therapeutic strategies. In this study, we analyzed the true functional co-mutation patterns of PIK3CA in colorectal adenocarcinoma (COAD), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), stomach a …

29.08.2026journal-article

African Journal of Pharmacy and Alternative Medicine

Gas Chromatography-Mass Spectrometry Analysis and Antidiabetic Effect of Fractionated Extract of Strophanthus hispidus

Muyiwa SAMUEL FAGEYINBO, Temitayo ESTHER ADEYEOLUWA, Abidemi JAMES AKINDELE, Esther OLUWATOYIN AGBAJE

Strophanthus hispidus DC (Apocynaceae) is a valued African plant that has been used as a remedy of various disease conditions. This study identified compounds present using GC-MS as well as the potential antidiabetic effects of the n-butanol, ethyl acetate, and aqueous fractions. Gas Chromatography Mass Spectrometry (GC-MS) was carried out using the Agilent 7890 A GC with a J&W HP-5MS column (30 m x 0.320 mm i.d. x 0.25 μm). The effects of the fractions (100 mg/kg each) on blood glucose levels, body weight, biochem …

29.08.2026journal-article

Journal of Gastrointestinal and Liver Diseases

C-reactive Protein Apheresis: A Novel Treatment Approach in Acute Necrotising Pancreatitis

Felix Götzinger, Michael Kunz, Felix Mahfoud, Michael Böhm, Andreas Link

Acute necrotizing pancreatitis is a severe condition associating with high morbidity and mortality. In most cases, supportive therapy is the only available therapeutic option. Herein, we report a case of a 29-year-old male who presented with severe acute necrotizing pancreatitis caused by hypertriglyceridemia, who consequently developed acute respiratory distress syndrome and multi-organ failure. We used an off-label C-reactive protein apheresis to target the sterile inflammatory reactions additional to optimal sup …

29.08.2026journal-article

Fluctuation and Noise Letters

Numerical Treatment of Stochastic-Deterministic SIRS Epidemic Differential Model with Impact of Saturated Incidence Using Implicit/Stochastic RK and Euler–Maruyama Computing Paradigm

Nabeela Anwar, Iftikhar Ahmad, Hijab Javaid, Adiqa Kausar Kiani, Muhammad Shoaib, Muhammad Asif Zahoor Raja

This paper involves the numerical exploration of both stochastic and deterministic SIRS epidemic models with saturated incidence rates. The implicit Runge–Kutta method, Euler–Maruyama method and stochastic Runge–Kutta methods are employed to analyze the dynamic patterns of the epidemic. The deterministic model is formulated using an ordinary differential system and is deep-seated in the well-established classical SIRS epidemic framework. A stochastic model is formulated by incorporating the elements of white noise …

29.08.2026journal-article

International Journal of Research in Medical Sciences

A comparative analysis on safety and efficacy of telmisartan and ramipril in treatment of hypertension in a tertiary care hospital

Wajid Gulzar, Mudasir Manzoor Dar, Amritpal Singh, Peer Samiq Masoodi, Shah Samreen, Uma Jyoti

Background: Hypertension is a major global health challenge and an important risk factor for cardiovascular disease. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used first-line antihypertensive agents. This study evaluated the safety and efficacy of telmisartan and ramipril in patients with hypertension at a tertiary care hospital. Methods: This prospective observational study included 113 adult patients with hypertension who received either telmisartan (n= …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Practice Changes in the Diagnosis and Management of Bacterial Tracheitis in Ventilator-Dependent Children in the Outpatient Setting After Introduction of a Novel Pathway

Geneviève A Donahey, Glenn J Rapsinski

Abstract Background Diagnosis and management of bacterial tracheitis (BT) in tracheostomy- and ventilator-dependent children (VC) is highly variable among outpatient subspecialty providers (OP). Stewardship efforts are generally limited to the inpatient setting, thus further studies are needed to examine and improve outpatient practices. Many OP report desire for guidance in the diagnosis and management of BT and feel a decision support tool would be helpful in their daily practice, thus we developed a pathway for …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Characteristics and Outcomes of Respiratory Viral Infections in Pediatric Cancer Patients, Single center experience

Mona Mohammed, Yassin Taher, Maha Mohammed, Naiven Mohamed, Nehad Abd Elfatah, Marwa Jamal, Omnya Ahmed, Amira Sameh, Mohamed Kamal, Youssef Madney

Abstract Background Respiratory viral (RV) infections cause morbidity and mortality in immunocompromised pediatric patients undergoing cancer treatment. The burden of RV infections in pediatric oncology populations from low- and middle-income countries (LMICs) remain limited. We aimed to detect the prevalence of viruses causing respiratory infections among pediatric patients with cancer and guide empiric therapy and improve patient outcomes. Methods Retrospectively we collected nasopharyngeal swabs and clinical and …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

A Ten-Year Retrospective Study on the Clinical and Microbiological Characteristics of Early Onset Neonatal Sepsis at a Single Tertiary Care Institution

Vilma Antonette B Prado, Amanda Louise Du

Abstract Background Early-onset neonatal sepsis remains a significant cause of morbidity and mortality globally. Although Group B Streptococcus and Escherichia coli were commonly known to be the most common causes of Early-onset neonatal sepsis, this can vary per institution, thus creating a challenge in management. Understanding the clinical and microbiological profile of neonatal sepsis in a single-center study is crucial to improving diagnosis and treatment, strategies. Objectives This study aimed to characteriz …

29.08.2026journal-article

Journal of the Colleges of Medicine of South Africa

A novel approach to peritonitis

Tshepang A. Motsepe

Peritonitis is a deadly abdominal condition seen across many surgical disciplines, with causes including appendicitis, perforated peptic ulcers, and abdominal trauma. In the South African context, peritonitis is largely influenced by tuberculosis (TB), human immunodeficiency virus (HIV), and widespread malnutrition linked to socioeconomic challenges. Although peritonitis is traditionally classified into primary, secondary, and tertiary types, the addition of quaternary peritonitis could reflect the severe complicat …

29.08.2026journal-article

Risk Analysis

A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens

Jack F. Schijven, Peter F. M. Teunis, Walter Q. Betancourt

ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate suitability of the final wastewater effluent for potable reuse; (3) evaluate viruses or groups of viruses as indicators of wastewater treatment efficiency. Reduction …

29.08.2026journal-article

PKLI Journal of Health Sciences

Integrating AI and Multi-Omics for Predicting Transfusion Reactions: A Step Toward Safe and Personalized Transfusion Medicine

Muhammad Hashim

Background: Blood transfusion is a lifesaving process, but the risk of adverse reactions ranges from mild to life-threatening. Current detection methods with limited sensitivity lack predictive power. Aim: To explore how artificial intelligence with multi-omics data such as genomics, transcriptomics, proteomics, and metabolomics enhances early prediction of transfusion reactions. This study aims to highlight recent advances, AI methodologies, and challenges to implementing these technologies. Methods: This study is …

29.08.2026journal-article

Modern Rheumatology

Clinical Results of Unlinked-type Total Elbow Arthroplasty for Stiff Elbows in Patients with Rheumatoid Arthritis

Yasuhiro Kiyota, Takuji Iwamoto, Taku Suzuki, Noboru Matsumura, Kazuki Sato, Masaya Nakamura

Abstract Objectives Total elbow arthroplasty is a common treatment for elbow stiffness due to rheumatoid arthritis. Although linked prostheses are often preferred, unlinked implants may reduce prosthetic stress and loosening risk. This study evaluated the clinical outcomes of unlinked total elbow arthroplasty in patients with rheumatoid arthritis presenting with stiff elbows. Methods This retrospective study included 9 women with 10 stiff elbows due to rheumatoid arthritis who underwent primary total elbow arthropl …

29.08.2026journal-article

International Science Journal

Neuro-Ophthalmological Warning Signs in Intracranial Neoplasms: Clinical Patterns for Early Detection and Visual Preservation

Patricia Equilea Veizaga, Alejandra Mendoza Ortiz, Natalia Restrepo Hinestrosa, Patricio Sánchez de Ovando González, Mariana Lineth Orozco Ricardo, Mariana Ramírez García, Jorge Angel Velasco Espinal, Alexa Fernanda Uriostegui Navarro

Neuro-ophthalmological manifestations may represent the first clinically detectable sign of intracranial neoplasms, particularly when tumors involve the optic nerves, optic chiasm, sellar and parasellar regions, cranial nerves, skull base, brainstem, or structures associated with intracranial pressure. This study analyzed the main visual and ocular manifestations associated with intracranial tumors and their potential value for early diagnosis through a descriptive and analytical review of the scientific literature …