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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Magnetic Resonance in Medicine

Ex Vivo Measurement of Human Blood T 1 at 5 T : Dependence on Hematocrit and Oxygenation

Shuwan Yu, Yuan Dong, Yuxiao Gu, Ne Yang, Lele Ma, Qingyu Xu, Ping Ma, Baoxin Zhou, Shuo Chen, Yonglin Chen, Dengrong Jiang, Xihai Zhao, Zixuan Lin

ABSTRACT Purpose To determine human blood longitudinal relaxation time (T 1 ) ex vivo at 5 T using modified Look‐Locker inversion recovery (MOLLI), and to evaluate its dependence on hematocrit (Hct) and oxygenation ( Y ). Methods A MOLLI 5(3)3 protocol was simulated across T 1 values of 1000–3000 ms to optimize the sampling interval. Aqueous gadolinium phantoms were scanned using optimized MOLLI and multi‐inversion‐time recovery spin echo (IR‐SE) acquisitions to derive a calibration equation. Arm venous blood from …

30.08.2026journal-article

International Journal of Pharmaceutical Sciences and Medicine

Recent Advances in Mouth Dissolving Films: Formulation Strategies, Evaluation and Therapeutic Applications

C. Pandian, Gowtham A, Gunaseelan M, Pooja B, Praveen Kumar D, Keerthana M, Dhanusiya V

Mouth dissolving films (MDFs) or oral dissolving films, are a novel and convenient method for drug delivery. They become even more useful by enhancing patient compliance and instant release of the drug. When thin and flexible polymer films come in contact with saliva, they break apart and release the drug without the aid of water. MDFs are particularly beneficial for patients who cannot swallow traditional dose forms, such as bedridden patients, those suffering from dysphagia, the elderly and children1. The product …

30.08.2026journal-article

Journal of Clinical Medicine

Renal Cell Carcinoma in the Geriatric Population: Toward a Frailty-Adapted Therapeutic Paradigm

Cemile Ozsurekci, Ufuk Yazar, Yusuf Acikgoz

Background: Renal Cell Carcinoma (RCC) primarily affects older adults, with incidence increasing with age. Older adults remain underrepresented in clinical trials, and treatment decisions are often extrapolated from younger populations. Age-related factors such as comorbidities, frailty, polypharmacy, and immunosenescence complicate management in the geriatric population. Methods: A narrative review of the literature was conducted, focusing on localized and metastatic RCC in older adults. The review comprehensively …

30.08.2026journal-article

Journal of Asian Medical Students' Association

Efficacy of Complementary Nutritional and Herbal Interventions on Peripheral Inflammatory Biomarkers and Clinical Outcomes in Parkinson’s Disease: A Systematic Review

Putu Ayu Anindita Maheswari Kusumaningtyas Nugraha Budha, Nicky Stevani Wijaya, Marcella Marcella, Alicia Priscila Estelle, Joyceline Chika Tanely

Background: Dopaminergic neuron loss, neuroinflammation, oxidative stress, and disruption of the gut microbiota are all linked to Parkinson's disease, a progressive neurodegenerative condition. Probiotics and synbiotics are examples of non-pharmacological adjuvant treatments that have shown potential advantages through modulation of neurotrophic and inflammatory pathways, while results are still mixed. Purpose of Study: The purpose of this systematic review was to evaluate the impact of non-pharmacological adjuvant …

30.08.2026journal-article

Frontiers on Healthcare Research

A Little of Everything, Just In Time: Multimodal Opioid-Sparing Anesthesia for a Twin Pregnancy in Decompensated Heart Failure Caused by Severe Mitral Stenosis

Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Muhammad Imam Mulia Muhammad Imam, Department of Anesthesiology and Intensive Therapy, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Arief Cahyadi Arief

<p style="font-weight: 400;"><strong>Background: </strong>Rheumatic heart disease remains a leading cause of valvular heart disease among women of reproductive age in low- and middle-income countries. Severe mitral stenosis complicating pregnancy substantially increases the risk of acute cardiac decompensation because of the hemodynamic load imposed by gestation, and anesthetic management becomes considerably more complex when it is combined with atrial fibrillation with a rapid ventricular response and a multifeta …

30.08.2026journal-article

IECCMEXICO

Beyond Preoperative Clearance: Integrated Cardiovascular Surveillance and Multiorgan Protection in Major Noncardiac Surgery

Daniel Fernando Camargo Medina, Beverly Denisse Jaramillo Jaramillo, Daniel Fernando Trejos Gartner, Dominique Magdalena Nathan Kreisberg, Ana Carla Naranjo González, Vicente Treviño Caballero, Justin Santiago Palacios Moreira, Diego Clemente Moreno

Perioperative cardiovascular complications remain an important cause of morbidity and mortality after major noncardiac surgery. This integrative review analyzed international evidence on cardiovascular event prediction, physiological and biochemical monitoring, and multiorgan-protection strategies, with particular attention to their applicability in Latin America. Twenty central publications were selected from PubMed/MEDLINE, Scopus, SciELO, LILACS, the Cochrane Library, and international guideline repositories. Th …

30.08.2026journal-article

Surgery

Предоперативната диагностика при пациенти с припокриващи се симптоми на гастроезофагеална рефлуксна болест и ахалазия – ролята на високорезолюционната езофагеална манометрия

Айсун Мехмед, Ангел Арабаджиев

Гастроезофагеалната рефлуксна болест (ГЕРБ) и ахалазията представляват две самостоятелни нозологични единици, характеризиращи се с различни патофизиологични механизми, но със значително припокриване на клиничната симптоматика. Прояви като киселини, ретростернална болка, регургитация и дисфагия могат да се наблюдават както при пациенти с ГЕРБ, така и в ранните стадии на ахалазията, което затруднява диференциалната диагноза и създава предпоставки за избор на неподходящ терапевтичен подход. Прецизното разграничаване м …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Modern scientific concepts of Zika fever

Viktor L. Melnikov, Larisa N. Aftaeva, Anastasia V. Sergeeva, Daria S. Bezmenova, Olesya S. Lebedeva

The review article presents epidemiological, etiopathogenetic, clinical, and diagnostic aspects of Zika fever, as well as possible measures for the prevention and treatment of this infectious disease. The Zika virus (ZIKA) is transmitted through various routes, including vector-borne, vertical, sexual, and hemato-transfusion, which determines the clinical presentation of patients, the high rate of fetal death, and the development of severe congenital malformations. Currently, there is no specific etiotropic therapy …

30.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Vanillin and its Derivatives: Therapeutic Strategies in Modern Medicine

Renu Verma, Uma Agarwal, Bhumika Chauhan, Harpreet Singh, Arun K Mishra, Nitin Kumar, Arvind Kumar

Introduction: Vanillin, a phenolic aldehyde, is the primary component of the vanilla bean's ethanolic extract. Synthetic vanillin is now more commonly used as a flavoring in foods, beverages, and pharmaceuticals. Natural vanilla extract consists of several hundred derivatives, while artificial vanilla flavoring is often a synthetic ethanol solution of pure vanillin. The first commercial synthesis of vanillin began with eugenol, and today, it is made from guaiacol or lignin. Methods: This narrative review aggregates …

30.08.2026journal-article

Interdisciplinary Medicine

3D printing of cell‐free implants: A promising avenue for cartilage regeneration and joint preservation

Liangbin Zhou, Shangsi Chen, Boguang Yang, Yiting Lei, Hegeng Li, Haoyue Luo, Xiaoshuai Wang, Qiongjiao Zeng, Jiahui Lai, Fei Jin, Rocky S. Tuan, Zhong Alan Li

Abstract Cartilage regeneration and joint preservation are confronted with tremendous challenges. Traditional cell‐based treatments, while effective in some cases, still encounter many limitations, including immunogenicity, high costs, and logistical problems concerning cell sourcing, in vitro expansion, and storage. Recent progress in 3D printing technologies offers a promising alternative: 3D‐printed cell‐free implants. By exploiting biomaterial‐driven activation and augmentation of the pro‐regenerative roles of …

30.08.2026journal-article

Clinical Infectious Diseases

Should valve leaflet thickening be considered a characteristic lesion of infective endocarditis?

Georgios Tzimas, Pierre Monney, Nicoleta Ianculescu, Panagiotis Antiochos, Benoit Guery, Lars Niclauss, Matthias Kirsch, Matthaios Papadimitriou-Olivgeris

Abstract Background Valve leaflet thickening was recently incorporated into the 2023 version of the Duke criteria by the European Society of Cardiology (ESC) as a potential imaging marker of infective endocarditis (IE). The study aimed to assess the impact of valve leaflet thickening on the diagnosis of IE among patients investigated for suspected IE. Methods This retrospective study included adults with suspected IE at Lausanne University Hospital (2014-2025). IE was diagnosed by the 2023 Duke-ISCVID based on the …

30.08.2026journal-article

Dermatitis®

Reasons for Upadacitinib Discontinuation and Risk of Recurrence in the Treatment of Atopic Dermatitis

Yuxin Luo, Ziyi Zhang, Shu Ding, Li Lei, Jing Chen

Background: Treatment discontinuation is common with Janus kinase inhibitors, such as upadacitinib, in moderate-to-severe atopic dermatitis (AD), and this often results in disease relapse and an increased patient burden. Objective: To explore reasons for discontinuation, risk factors, and willingness to reuse upadacitinib. Methods: This retrospective study enrolled 104 patients with AD (50 in the discontinuation, 54 in the non-discontinuation) from Xiangya Third Hospital (Feb–Mar 2026). Data on DLQI, pruritus NRS, …

30.08.2026journal-article

International Journal of Medical Sciences And Clinical Research

Detection of Danger Signs of Acute Respiratory Infections Among Under-Fives & Its Relation to Primary Case Management

Prof. Dr. Ilham Amin Jadoue

Acute respiratory infections form one of the most important health problems with high morbidity & mortality rate among under-fives, particularly in developing countries. ARIs, diarrhea & malnutrition are considered the main leading killers of children, their importance as a public health problem are of particular significance in developing countries where the associated mortality in children of (U5) is (30–50) times higher than million deaths a year. Children have about (4–6) ARIs episodes each year & make up a lar …

30.08.2026journal-article

Van Sağlık Bilimleri Dergisi

Evaluation of the effects of I-PRF and L-PRF on postoperative complications after impacted lower third molar surgery

Mehmet Güzel, Volkan Kaplan, Levent Ciğerim

Objective: The objective of this study was to ascertain the impact of L-PRF and I-PRF-impregnated type I collagen on postoperative complications (pain, edema, and trismus) following impacted third molar surgery.Material and Method: The study comprised two groups. The sequence of surgical interventions and the allocation of subjects to groups were determined through a randomization process. Subsequent to the surgical procedure, postoperative measurements were obtained from the patients. The first group received L-PR …

30.08.2026journal-article

International Journal of Molecular Sciences

Artificial Intelligence and Multi-Omics Approaches in the Precision Management of Pulmonary Hypertension: From Early Diagnosis to Therapeutic Stratification

Sergio Ferrantelli, Alessandro Del Cuore, Giuliano Cassataro, Luigi Dell’Ajra, Rosario Norrito, Giulio Geraci, Gabriella Carmina, Chiara Minà, Vincenzo Polizzi, Nicola Ciancio, Carlo Domenico Maida

Pulmonary hypertension (PH) is a heterogeneous clinical syndrome in which similar haemodynamic abnormalities may arise from distinct vascular, cardiac, pulmonary, thromboembolic, and molecular mechanisms. This complexity limits the ability of conventional classifications and risk scores to fully capture individual disease trajectories and treatment responses. Artificial intelligence (AI) offers a framework for integrating clinical data, electrocardiography, multimodal imaging, invasive haemodynamics, biomarkers, an …

30.08.2026journal-article

Journal of Wasit for Science and Medicine

<b>Corrosion of Mild Steel in Saline Environments: Mechanisms, Influencing Factors, and Recent Mitigation Strategies</b><b></b>

Thaqeef Murtada Jawad

Mild steel is prized because of its mechanical qualities and low prices but very vulnerable to corrosion in salty conditions such as in the marine areas. The paper examines its weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) corrosion behavior in 3.5 wt.% NaCl. Findings indicate that the rate of corrosion rises with the chloride concentration to a certain optimum and after that, the rate of oxygen diffusion begins to be limiting. High temperatures and acidic PH promote cor …

30.08.2026journal-article

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Assessing the agreement and reliability of Magene ® for heart rate monitoring

Mila Alves Matos Rodrigues, Thiago Danillo Silva, Jessika Teodoro Santos, Vinnycius Nunes de Oliveira, Nicolas Evangelista Marques, João Victor Rosa de Freitas, Marilia Santos Andrade, Rodrigo Luiz Vancini, Beat Knechtle, Katja Weiss, Ricardo Borges Viana, Claudio Andre Barbosa de Lira

To evaluate the accuracy and reliability of the Magene ® heart rate (HR) monitor compared to the Polar ® H7 (validated device) during rest, maximal graded exercise test, and active recovery. A within-group study was conducted with 68 healthy adults (21 women). Participants completed two laboratory sessions using both monitors in random order. HR values were collected at rest, during the Ellestad maximal treadmill stress testing protocol, and in active recovery. Relative reliability was assessed using the two-way ra …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Insulinoma

Elsa S. Gaisina, Renata I. Karimova, Olga V. Malyshkina, Tatyana V. Nikiforova

The article presents a description of a clinical case of insulinoma in a 69-year-old female patient. Insulinoma is a rare neuroendocrine tumor originating from the β-cells of the pancreas, the clinical manifestations of which are associated with hyperproduction of insulin/insulin-like factors, leading to the development of a hypoglycemic symptom complex. The presented case highlights the prolonged course and diagnostic difficulty of this disease due to its rare occurrence. The “gold standard” of diagnosis is the 72 …

30.08.2026journal-article

Jurnal Kejuruteraan

Effect of Hot Water Treatment on Physical and Mechanical Properties of Oil Palm Empty Fruit Bunch Fibre Cement Boards

Nurul Huda Azmi, Mohammad Soffi Md Noh, Nik Mohd Zaini Nik Soh

The growing demand for sustainable construction materials has increased interest in fibre–cement composites reinforced with natural fibres. Oil palm empty fruit bunch (OPEFB) is an abundant agricultural by-product with strong potential for fibre cement boards. However, its hydrophilic nature and weak fibre–matrix adhesion limit dimensional stability and mechanical performance. While hot water treatment has been shown to improve fibre compatibility, most studies have focused only on untreated, 60°C, and 100°C condit …

30.08.2026journal-article

Aggregate

Dual‐Acceptor Engineered Multimodal Phototheranostic NIR‐II AIEgens for Orthotopic Breast Cancer Treatment

Miaomiao Kang, Yu Pei, Zengming Yang, Yinzhen Pan, Zhijun Zhang, Xue Li, Dong Wang, Ben Zhong Tang

ABSTRACT “One‑for‑all” phototheranostics has emerged as a promising alternative to conventional cancer therapies. Aggregation‑induced emission luminogens (AIEgens) are exemplary templates for constructing such versatile systems. However, developing robust NIR‑II (1000–1700 nm)‐emitting “one‑for‑all” phototheranostic AIEgens remains challenging, due to the drastically lowered reactive oxygen species (ROS) generation capability and strong intermolecular π‐π stacking in the NIR‑II range. To address this, an ingenious …

30.08.2026journal-article

Journal of Personalized Medicine

Optimising Autologous Breast Reconstruction: Pneumothorax and Pneumomediastinum—A Literature Review and First Reported Case of Pneumomediastinum Following Bilateral DIEP Flap Reconstruction

Akshay Soni, Ishith Seth, Kaiyang Lim, Alexander Phan, Richard J. Ross, Mathew Lee, Warren M. Rozen

Background: Thoracic air complications after autologous breast reconstruction (ABR) are uncommon and incompletely characterised. A personalised perioperative approach requires integration of patient anatomy, reconstructive technique, anaesthetic exposures and the postoperative clinical trajectory rather than reliance on population-level estimates alone. Methods: We report a 41-year-old woman in whom pneumomediastinum was identified after bilateral DIEP flap reconstruction and performed a focused literature review r …

30.08.2026journal-article

Genes

Expanding the Phenotypic Spectrum of PRKD1 Gain-of-Function Syndrome: Congenital Heart Disease, Bilateral Carotid Dissections, and Ectodermal Dysplasia in an Adult Patient

Pedram Kharaziha, Klara Junker, Josefine Åhsberg, Antheia Kissopoulou

Background: PRKD1-related congenital heart defects and ectodermal dysplasia syndrome (CHDED) is a rare multisystem developmental disorder caused by heterozygous gain-of-function variants in PRKD1. Reported phenotypes include congenital heart defects, ectodermal abnormalities, limb anomalies, and neurodevelopmental impairment, while vascular manifestations remain poorly characterized. We report an adult patient with a de novo PRKD1 variant and bilateral carotid artery dissections. Methods: Clinical, cardiovascular, …

30.08.2026journal-article

Clinical Case Reports

Rapid Diagnosis and Surgical Management of Catastrophic Stanford Type A Acute Aortic Dissection Resulting in Successful Lung Donation: A Case Report

Koki Yokawa, Ryota Abe, Tomonori Higuma, Kazunori Yoshida, Hidefumi Obo, Makoto Kadotani, Hidetaka Wakiyama

ABSTRACT This case highlights that rapid diagnosis and emergency surgical repair for catastrophic Stanford Type A acute aortic dissection may preserve the opportunity for successful lung donation even when neurological recovery is impossible. Transthoracic echocardiography played a critical role in establishing the diagnosis when computed tomography could not be performed.