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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.229. Prognostic Value of Tumor Length in Clinical T1–2N0M0 Esophageal Squamous Cell Carcinoma

YoHan Bae, JiYong Kim, Hyeong Ryul Kim, Yong-Hee Kim, Jae Kwang Yun

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The TNM staging system for esophageal cancer defines the T stage by depth of invasion rather than tumor size. However, prognosis may vary within the same T stage. This study aimed to evaluate the prognostic value of tumor length in clinical T1–2N0M0 esophageal squamous cell carcinoma (ESCC). Methods This retrospective single-center study included 923 patients who underwent upfront surgery for cT1–2N0M0 ESCC bet …

22.08.2026journal-article

Diseases of the Esophagus

P1.127. A Case of Unresectable Advanced Esophageal Cancer Successfully Treated With ICI Regimen and RIC

Yoshihiro Tanaka, Noya Masuda, Jyun Takada, Yuta Sato, Yuji Hatanaka, Itaru Yasufuku, Masahiro Fukada, Asai Ryuichi, Tajima Jesse Yu, Nobuhisa Matsuhashi, Masahito Shimizu

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Immune checkpoint inhibitors are used for unresectable, advanced, and recurrent esophageal cancer. Currently, the Japan Esophageal Society recommends a 5Fu/CDDP + ICI regimen as first-line treatment. Here, we present a suggestive case of a patient with dysphasia score 4 who had extensive infiltration of the aorta, trachea, and bronchi, in whom an ICI regimen and endoscopic treatment were effective. Methods Case presentation: A woman in her 60s …

22.08.2026journal-article

Diseases of the Esophagus

P1.195. A Machine Learning Model for Predicting Anastomotic Leak in Esophageal Cancer Patients Undergoing Esophagectomy: A Single-Center Retrospective Study

Chi Zhang, Yongde Liao

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leak (AL) is one of the most severe complications after esophagectomy. Early identification of high-risk patients may help optimize perioperative management and improve outcomes. Machine learning (ML) offers promising tools for clinical prediction, yet studies applying ML to predict AL risk after esophagectomy remain scarce. This study aimed to develop and compare ML-based models using …

22.08.2026journal-article

Annals of Surgical Oncology

Complete Resection of Simultaneous Hepatic and Pulmonary Metastases from Colorectal Cancer in the Era of Modern Systemic and Surgical Therapies: A Systematic Review and Meta-Analysis

Dominik Wróbel, Patryk Rogaczewski, Patryk Dąbrowski, Wojciech Olejek, Jędrzej Borowczak, Paweł Michał Potocki

Abstract Background Data suggest promising outcomes with resection of simultaneous hepato-pulmonary metastases (HPM) from metastatic colorectal cancer (mCRC). However, there is no consensus regarding the effectiveness of this approach. Therefore, we aimed to evaluate the feasibility and clinical benefit of metastasectomy of simultaneous HPM from mCRC. Methods A systematic review and meta-analysis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines …

22.08.2026journal-article

Current Medicinal Chemistry

CDC20B Dysregulation: Links to Tumor Prognosis and Immunity

Hongrong Wu, Liangli Hong

Objective: This study aimed to clarify the pan-cancer expression pattern, upstream regulatory mechanisms, prognostic relevance, and immune associations of CDC20B. Method: Using public databases (GTEx, GEO, and TCGA), we examined CDC20B expression and its associations with prognosis and tumor immunity across multiple cancers. Immunohistochemistry (IHC) on an independent clinical cohort was performed to validate CDC20B upregulation in tumor tissues. Promoter methylation, genetic alterations, and immune infiltration w …

22.08.2026journal-article

The Oncologist

Prognostic Significance of Positive Margin-Informed Tumor Status in Esophageal Squamous Cell Carcinoma Using Next-Generation Sequencing

Di Lu, Yu Tong, Chunhong He, Zhiming Chen, Zhizhi Wang, Jingwen Liu, Jiani C Yin, Shaobin Li, Shijie Mai, Xuguang Rao, Kaican Cai

Abstract Background Reliable prognostic biomarkers are urgently needed for operable esophageal squamous cell carcinoma (ESCC), as conventional histopathology often fails to detect minimal residual disease and accurately predict patient outcomes. Patients and Methods This study investigated the mutational patterns in ESCC and the prognostic value of shared mutations between tumors and margins (margin-informed tumor, MiT) using next-generation sequencing. We analyzed tumor, margin, and normal tissues from a total of …

22.08.2026journal-article

International Journal of Colorectal Disease

Minimally invasive surgery for locally advanced colon cancer (pT4): short-term outcomes from a consecutive real-world cohort

Nicola Passuello, Sebastian Tiso, Enzo Mammano, Fabrizio Vittadello, Anna Sordo, Cinzia Anna Maria Papappicco, Dario Gregori, Giacomo Sarzo

Abstract Background The role of minimally invasive surgery (MIS) in pathological T4 colon cancer remains controversial because of the technical complexity of multivisceral resections and concerns regarding oncological adequacy. This study aimed to compare short-term postoperative outcomes following minimally invasive and open colectomy in patients with locally advanced (pT4) colon cancer. Methods We conducted a retrospective single-centre cohort study including consecutive patients who underwent surgical resection …

22.08.2026journal-article

Diseases of the Esophagus

P1.176. Cardiac Predictors of Esophageal Cancer Inoperability Using Coronary CT and Cardiac MRI

Tamás Vass, Miklós Vértes, Stephan Bennemann, András Herczeg, Ákos Balázs, Attila Szijártó, Zsófia Dóra Drobni

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Surgery remains a key part of multimodal esophageal cancer treatment but carries high morbidity and mortality. Early detection of patients unfit for major surgery is essential. We examined if thorough cardiac evaluation can predict surgical operability in esophageal tumor patients. Methods We prospectively included patients with esophageal tumors during pre-treatment workup. Coronary CT angiography assessed Agatston calcium score ( …

22.08.2026journal-article

Diseases of the Esophagus

PD07.02. Real-World Outcomes of Adjuvant Nivolumab After Surgery Following NAC/NACRT for Esophageal Cancer

Hayato Shimoyama, Ryo Shibayama, Kentoku Fujisawa, Yusuke Ogawa, Shusuke Haruta, Masaki Ueno

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The CheckMate 577 trial demonstrated the efficacy of adjuvant nivolumab in patients with esophageal cancer who did not achieve a pathological complete response after neoadjuvant chemoradiotherapy (NACRT). In Japan, however, adjuvant nivolumab is also administered to patients treated with neoadjuvant chemotherapy (NAC), although its real-world effectiveness in this population has not been fully validated. We evaluated the real-world out …

22.08.2026journal-article

Diseases of the Esophagus

P1.068. Design Features of PRO-Based Remote Symptom Monitoring Interventions With Alert-Triggered Clinical Response in Cancer RCTs: A Systematic Review

Simiao Lu, Yi Zhu, Yongtao Han, Qiuling Shi, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Patient-reported outcome (PRO)-based remote symptom monitoring with alert-triggered clinical response improves survival and quality of life in cancer patients. However, the design features constituting these complex interventions remain poorly characterised, limiting replication and optimisation. We conducted a systematic review to characterise the methodological architecture of such interventions …

22.08.2026journal-article

Diseases of the Esophagus

P1.110. Overexpression of DTL Relates to Tumor Cell Proliferation and Malignant Outcome of Esophageal Squamous Cell Carcinoma

Masateru Yamauchi, Shuhei Komatsu, Keiji Nishibeppu, Takuma Ohashi, Taisuke Imamura, Jun Kiuchi, Hiroshi Arakawa, Ryo Ishida, Satoshi Hamada, Hiroyuki Kanazawa, Tsutomu Kawaguchi, Hirotaka Konishi, Hitoshi Fujiwara, Hitoshi Tsuda, Issei Imoto, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Comparative genomic hybridization (CGH) method has contributed to the analysis of amplification and deletion of various genes. We detected Denticleless E3 ubiquitin protein ligase homolog (DTL) using the Agilent 244k oligo-array CGH and FISH analyses for 1q32 amplification among 22 genes in esophageal squamous cell carcinoma (ESCC) and investigated DTL as a cancer promoting gene. Methods We analyzed 43 ESCC cell lines and 113 primary ESCC samp …

22.08.2026journal-article

Scientific Journal of Technology

Research on the Treatment Technology of Sulfur-Containing Tail Gas Using Chelated Iron

Ye Sun, Peng Wang, Rui Liu, Xueri Nan, Nan Wang, Wei Wang, Yan Sun

This study investigates a chelated iron‑based process for H₂S removal from sulfur‑containing tail gas. Eight chelating agents were evaluated for iron complexation capacity at different pH values. The effects of pH, chelator mixing ratio, and Fe³⁺/Fe²⁺ molar ratio on desulfurization performance were examined through 42 complex systems using MATLAB regression analysis. Results show that pH 8–9 enables >90% H₂S absorption. HEDP exhibited the highest iron complexation capacity (30.8 g/L at pH 10) but poor stability; TE …

22.08.2026journal-article

Small

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

Jingmei Li, Jin Zhang, Xiayu Chen, Shan Wu, Jieping Wu, Xizi Fu, Yan Gao, Lixia Guo, Xingmei Duan, Ke Men

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumor immunogene therapy. Here reported the collaboration of two types of CMNPs using a double‐layered spherical scaffold. This scaffold was prepared by stacking photosensitive hydrogels with two concentrations. After implantation, the two laye …

22.08.2026journal-article

Water

Fuzzy Cognitive Maps for Wastewater Treatment Selection: Constructed Wetlands vs. Conventional Plants

Mohamad Azizipour, Narges Baahmadi, Amin E. Bakhshipour, Ulrich Ditmer

The Fuzzy Cognitive Map (FCM) framework provides a useful tool for representing the complex interdependencies involved in wastewater treatment selection, particularly when social, ecological, climatic, and economic criteria are considered simultaneously. In this study, the FCM approach was applied to compare two wastewater treatment approaches in Ahvaz, Iran: constructed wetlands (CWs) as a nature-based solution and energy-based wastewater treatment plants. The developed model included 30 components and 127 causal …

22.08.2026journal-article

Current Oncology

Preoperative Immunonutritional Indices in Colorectal Cancer: The Contribution of Albumin, Time-Dependence of Effect, and Threshold Transportability in a Saudi Cohort

Moaz W. Abulfaraj, Ali H. M. Farsi

Preoperative immunonutritional indices are widely reported to predict survival after colorectal cancer (CRC) resection, yet their independence varies across cohorts and no data exist from the Arab Gulf. In this retrospective cohort study we analyzed 316 patients undergoing curative resection for stage I–III colorectal adenocarcinoma at a Saudi tertiary center between 2013 and 2022, of whom 48 (15.2%) presented as emergencies. The prognostic nutritional index (PNI) and a composite albumin–neutrophil-to-lymphocyte ra …

22.08.2026journal-article

ACS Applied Polymer Materials

Natural Active Ingredient Nanomicelles for Synergistic Treatment of Wound Bacterial Infections

Qingru Wang, Ziliang Liu, Jindong Li, Wei Luo, Xinrui Yuan, Lei Hu

Abstract In this study, three natural antibacterial aldehydes, including cinnamaldehyde (CA), p-anisaldehyde (PA), and vanillin (VA), were grafted onto linear polyglycidol (LPG) via pH-responsive hydrazone bonds, yielding amphiphilic conjugates (CA-LPG, PA-LPG, VA-LPG) that self-assembled into stable micelles. Quercetin (Que)-loaded micelles (Que@CA-LPG, Que@PA-LPG, Que@VA-LPG) were prepared, with Que@CA-LPG showing superior antibacterial activity against Staphylococcus aureus (MIC: 32 μg/mL), a 3-fold enhancement …

22.08.2026journal-article

Genes

Alternative RNA Splicing in Cancer: Molecular Mechanisms, Functional Consequences, Biomarkers and Therapeutic Opportunities

Quanyou Wu, Kai Gui

Alternative pre-mRNA splicing is a central layer of gene regulation that enables a limited number of genes to generate a far larger and more context-dependent transcriptome and proteome. In cancer, splicing is disrupted by mutations in cis-regulatory sequences, recurrent lesions in spliceosome components, altered abundance or activity of RNA-binding proteins, and changes in transcription, chromatin, RNA modification, metabolism and stress signalling. These alterations are not merely by-products of malignant transfo …

22.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Reproducibility of overall survival in metastatic colorectal cancer randomized trials using ARCAD-Derived external control arms

Morteza Raeisi, Thierry André, Qian Shi, Takayuki Yoshino, Richard Adams, Chiara Cremolini, Jeffrey A Meyerhardt, Jeanne Tie, Romain Cohen, Jean-Baptiste Bachet, Hideaki Bando, Toshihiro Misumi, Carsten Bokemeyer, Leonard B Saltz, Miriam Koopman, Volker Heinemann, Marc Peeters, Eric Van Cutsem, Axel Grothey, Benoist Chibaudel, Aimery de Gramont

Abstract Background Synthetic control arms (SCAs) derived from historical trial data can complement randomized controlled trials (RCTs), particularly in oncology where feasibility, ethical, and cost constraints may limit conventional trial designs. However, their validity for overall survival (OS) remains uncertain. We evaluated the feasibility and limitations of constructing SCAs from the ARCAD metastatic colorectal cancer (mCRC) database across multiple treatment lines. Methods Seven landmark RCTs representing fi …

22.08.2026journal-article

Revista Acadêmica Online

ENDODONTIC TREATMENT OF TEETH AFFECTED BY IATROGENIC DENTAL TRAUMA: 3-YEAR FOLLOW-UP

Camila Silva de Carvalho, Pricilla Dantas Soares Moreira, Larissa Sousa Rangel, Rodrigo Gadelha Vasconcelos, Marcelo Gadelha Vasconcelos, Ernani Canuto Figueirêdo Júnior, Sandra Aparecida Marinho, Robeci Macedo Alves-Filho

Introduction: Orofacial procedures can cause dental trauma, including intubation-related injuries that may lead to pulp necrosis and resorption. Treatment options include monitoring, extraction, or bioceramic repair, but the prognosis remains uncertain. Objective: To describe the non-surgical endodontic approach in maxillary central incisors affected by iatrogenic trauma, as well as the surgical intervention performed on a left maxillary central incisor with invasive cervical resorption. Case report: A 20-year-old …

22.08.2026journal-article

Journal of Pharmaceutical and Sciences

Global Research Trends in Three-Dimensional Breast Cancer Models: A Bibliometric Analysis (2007–2025)

Amalia Amalia, Nur Ismiyati, Didi Nurhadi Illian, Agustina Setiawati, Adam Hermawan

Background: Three-dimensional (3D) culture models have emerged as a promising preclinical platform for breast cancer research because they better mimic the tumor microenvironment (TME) of conventional two-dimensional cultures. With advances in tissue engineering, research related to 3D models has grown rapidly, necessitating a comprehensive evaluation of global research trends. Methods: A bibliometric analysis was performed using the Scopus database covering publications from 2007 to 2025, and only original researc …

22.08.2026journal-article

Diseases of the Esophagus

PD09.04. Prophylactic Pyloric Dilatation and Its Impact on Early Delayed Conduit Emptying and Pneumonia Post-Oesophagectomy for Cancer: A Multi-Centre Cohort Study

Jonathan Sivakumar, Shaun Chew, Amass Zheng, Cuong P Duong, John Spillane, Ahmad Aly, David S Liu

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Early delayed conduit emptying and pneumonia are the most common complications following oesophagectomy, potentially resulting in significant morbidity and prolonged hospitalisation. Pyloroplasty or pyloromyotomy is challenging to perform with the increasing adoption of minimally invasive oesophagectomy. Here, we evaluate the therapeutic utility of prophylactic pyloric dilation in patients undergo …

22.08.2026journal-article

Diseases of the Esophagus

P1.101. Treatment Selection and Real-World Outcomes of First-Line ICI-Based Therapy for Unresectable or Recurrent Esophageal Cancer in a Regional Hospital

Tomonari Suetsugu, Narutoshi Nagao, Kazuo Yamamoto, Shinya Ohno, Shunya Kiriyama, Kakeru Tawada, Yoshinori Iwata, Chihiro Tanaka, Masahiko Kawai

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Based on pivotal clinical trials, immune checkpoint inhibitors (ICIs) have demonstrated efficacy in patients with unresectable advanced or recurrent esophageal cancer and are now incorporated as standard treatment in the Japanese clinical practice guidelines. Although expanded therapeutic options are expected to improve survival outcomes, real-world data remain limited. Our institution is a regional hospital where a large proportion of pat …

22.08.2026journal-article

Diseases of the Esophagus

P1.220. Totally Versus Hybrid Robot-Assisted Minimally Invasive Esophagectomy for Thoracic Esophageal Cancer: Similar Perioperative Safety and Oncologic Survival

Xinyu Yang, Chunguang Li, Zhigang Li

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background This study compared the perioperative safety, quality of life and oncologic outcomes of the totally robot-assisted minimally invasive esophagectomy (ToRaMIE) technique with hybrid robot-assisted thoracoscopic and laparoscopic esophagectomy with an abdominal mini-incision (HyRaMIE). Methods The ToRaMIE procedure is performed as follows (Figure 1A). The thoracic esophagus is mobilized via a right th …

22.08.2026journal-article

Diseases of the Esophagus

PD01.06. Dragon Study: Real-World Perioperative Treatment Patterns and Survival in Esophageal Squamous Cell Carcinoma Across Five High-Volume East Asian Centers

Xuefeng Leng, Hiroyuki Daiko

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background: Esophageal squamous cell carcinoma (ESCC) remains a major health burden in East Asia. However, perioperative management varies substantially across countries and institutions. We conducted the ISDE-supported Drgon Study to characterize real-world treatment patterns in high-volume East Asian centers and explore their association with survival outcomes, providing a foundation for future risk-adjusted subgroup analyses and collaborative …