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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Small

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

Jingmei Li, Jin Zhang, Xiayu Chen, Shan Wu, Jieping Wu, Xizi Fu, Yan Gao, Lixia Guo, Xingmei Duan, Ke Men

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumor immunogene therapy. Here reported the collaboration of two types of CMNPs using a double‐layered spherical scaffold. This scaffold was prepared by stacking photosensitive hydrogels with two concentrations. After implantation, the two laye …

22.08.2026journal-article

Water

Fuzzy Cognitive Maps for Wastewater Treatment Selection: Constructed Wetlands vs. Conventional Plants

Mohamad Azizipour, Narges Baahmadi, Amin E. Bakhshipour, Ulrich Ditmer

The Fuzzy Cognitive Map (FCM) framework provides a useful tool for representing the complex interdependencies involved in wastewater treatment selection, particularly when social, ecological, climatic, and economic criteria are considered simultaneously. In this study, the FCM approach was applied to compare two wastewater treatment approaches in Ahvaz, Iran: constructed wetlands (CWs) as a nature-based solution and energy-based wastewater treatment plants. The developed model included 30 components and 127 causal …

22.08.2026journal-article

Current Oncology

Preoperative Immunonutritional Indices in Colorectal Cancer: The Contribution of Albumin, Time-Dependence of Effect, and Threshold Transportability in a Saudi Cohort

Moaz W. Abulfaraj, Ali H. M. Farsi

Preoperative immunonutritional indices are widely reported to predict survival after colorectal cancer (CRC) resection, yet their independence varies across cohorts and no data exist from the Arab Gulf. In this retrospective cohort study we analyzed 316 patients undergoing curative resection for stage I–III colorectal adenocarcinoma at a Saudi tertiary center between 2013 and 2022, of whom 48 (15.2%) presented as emergencies. The prognostic nutritional index (PNI) and a composite albumin–neutrophil-to-lymphocyte ra …

22.08.2026journal-article

ACS Applied Polymer Materials

Natural Active Ingredient Nanomicelles for Synergistic Treatment of Wound Bacterial Infections

Qingru Wang, Ziliang Liu, Jindong Li, Wei Luo, Xinrui Yuan, Lei Hu

Abstract In this study, three natural antibacterial aldehydes, including cinnamaldehyde (CA), p-anisaldehyde (PA), and vanillin (VA), were grafted onto linear polyglycidol (LPG) via pH-responsive hydrazone bonds, yielding amphiphilic conjugates (CA-LPG, PA-LPG, VA-LPG) that self-assembled into stable micelles. Quercetin (Que)-loaded micelles (Que@CA-LPG, Que@PA-LPG, Que@VA-LPG) were prepared, with Que@CA-LPG showing superior antibacterial activity against Staphylococcus aureus (MIC: 32 μg/mL), a 3-fold enhancement …

22.08.2026journal-article

Genes

Alternative RNA Splicing in Cancer: Molecular Mechanisms, Functional Consequences, Biomarkers and Therapeutic Opportunities

Quanyou Wu, Kai Gui

Alternative pre-mRNA splicing is a central layer of gene regulation that enables a limited number of genes to generate a far larger and more context-dependent transcriptome and proteome. In cancer, splicing is disrupted by mutations in cis-regulatory sequences, recurrent lesions in spliceosome components, altered abundance or activity of RNA-binding proteins, and changes in transcription, chromatin, RNA modification, metabolism and stress signalling. These alterations are not merely by-products of malignant transfo …

22.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Reproducibility of overall survival in metastatic colorectal cancer randomized trials using ARCAD-Derived external control arms

Morteza Raeisi, Thierry André, Qian Shi, Takayuki Yoshino, Richard Adams, Chiara Cremolini, Jeffrey A Meyerhardt, Jeanne Tie, Romain Cohen, Jean-Baptiste Bachet, Hideaki Bando, Toshihiro Misumi, Carsten Bokemeyer, Leonard B Saltz, Miriam Koopman, Volker Heinemann, Marc Peeters, Eric Van Cutsem, Axel Grothey, Benoist Chibaudel, Aimery de Gramont

Abstract Background Synthetic control arms (SCAs) derived from historical trial data can complement randomized controlled trials (RCTs), particularly in oncology where feasibility, ethical, and cost constraints may limit conventional trial designs. However, their validity for overall survival (OS) remains uncertain. We evaluated the feasibility and limitations of constructing SCAs from the ARCAD metastatic colorectal cancer (mCRC) database across multiple treatment lines. Methods Seven landmark RCTs representing fi …

22.08.2026journal-article

Revista Acadêmica Online

ENDODONTIC TREATMENT OF TEETH AFFECTED BY IATROGENIC DENTAL TRAUMA: 3-YEAR FOLLOW-UP

Camila Silva de Carvalho, Pricilla Dantas Soares Moreira, Larissa Sousa Rangel, Rodrigo Gadelha Vasconcelos, Marcelo Gadelha Vasconcelos, Ernani Canuto Figueirêdo Júnior, Sandra Aparecida Marinho, Robeci Macedo Alves-Filho

Introduction: Orofacial procedures can cause dental trauma, including intubation-related injuries that may lead to pulp necrosis and resorption. Treatment options include monitoring, extraction, or bioceramic repair, but the prognosis remains uncertain. Objective: To describe the non-surgical endodontic approach in maxillary central incisors affected by iatrogenic trauma, as well as the surgical intervention performed on a left maxillary central incisor with invasive cervical resorption. Case report: A 20-year-old …

22.08.2026journal-article

Journal of Pharmaceutical and Sciences

Global Research Trends in Three-Dimensional Breast Cancer Models: A Bibliometric Analysis (2007–2025)

Amalia Amalia, Nur Ismiyati, Didi Nurhadi Illian, Agustina Setiawati, Adam Hermawan

Background: Three-dimensional (3D) culture models have emerged as a promising preclinical platform for breast cancer research because they better mimic the tumor microenvironment (TME) of conventional two-dimensional cultures. With advances in tissue engineering, research related to 3D models has grown rapidly, necessitating a comprehensive evaluation of global research trends. Methods: A bibliometric analysis was performed using the Scopus database covering publications from 2007 to 2025, and only original researc …

22.08.2026journal-article

Diseases of the Esophagus

PD09.04. Prophylactic Pyloric Dilatation and Its Impact on Early Delayed Conduit Emptying and Pneumonia Post-Oesophagectomy for Cancer: A Multi-Centre Cohort Study

Jonathan Sivakumar, Shaun Chew, Amass Zheng, Cuong P Duong, John Spillane, Ahmad Aly, David S Liu

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Early delayed conduit emptying and pneumonia are the most common complications following oesophagectomy, potentially resulting in significant morbidity and prolonged hospitalisation. Pyloroplasty or pyloromyotomy is challenging to perform with the increasing adoption of minimally invasive oesophagectomy. Here, we evaluate the therapeutic utility of prophylactic pyloric dilation in patients undergo …

22.08.2026journal-article

Diseases of the Esophagus

P1.101. Treatment Selection and Real-World Outcomes of First-Line ICI-Based Therapy for Unresectable or Recurrent Esophageal Cancer in a Regional Hospital

Tomonari Suetsugu, Narutoshi Nagao, Kazuo Yamamoto, Shinya Ohno, Shunya Kiriyama, Kakeru Tawada, Yoshinori Iwata, Chihiro Tanaka, Masahiko Kawai

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Based on pivotal clinical trials, immune checkpoint inhibitors (ICIs) have demonstrated efficacy in patients with unresectable advanced or recurrent esophageal cancer and are now incorporated as standard treatment in the Japanese clinical practice guidelines. Although expanded therapeutic options are expected to improve survival outcomes, real-world data remain limited. Our institution is a regional hospital where a large proportion of pat …

22.08.2026journal-article

Diseases of the Esophagus

P1.220. Totally Versus Hybrid Robot-Assisted Minimally Invasive Esophagectomy for Thoracic Esophageal Cancer: Similar Perioperative Safety and Oncologic Survival

Xinyu Yang, Chunguang Li, Zhigang Li

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background This study compared the perioperative safety, quality of life and oncologic outcomes of the totally robot-assisted minimally invasive esophagectomy (ToRaMIE) technique with hybrid robot-assisted thoracoscopic and laparoscopic esophagectomy with an abdominal mini-incision (HyRaMIE). Methods The ToRaMIE procedure is performed as follows (Figure 1A). The thoracic esophagus is mobilized via a right th …

22.08.2026journal-article

Diseases of the Esophagus

PD01.06. Dragon Study: Real-World Perioperative Treatment Patterns and Survival in Esophageal Squamous Cell Carcinoma Across Five High-Volume East Asian Centers

Xuefeng Leng, Hiroyuki Daiko

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background: Esophageal squamous cell carcinoma (ESCC) remains a major health burden in East Asia. However, perioperative management varies substantially across countries and institutions. We conducted the ISDE-supported Drgon Study to characterize real-world treatment patterns in high-volume East Asian centers and explore their association with survival outcomes, providing a foundation for future risk-adjusted subgroup analyses and collaborative …

22.08.2026journal-article

Diseases of the Esophagus

P1.073. The Evaluative Value of Quality of Life in Neoadjuvant Treatment for Esophageal Squamous Cell Carcinoma

Subinuer Maimaiti, Feng Su, Qi Yu, Yaxing Shen

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background While neoadjuvant therapy contribute to tumor downstaging and improves resectability rates, effective tools for predicting treatment response remain limited. This study investigated quality of life before and after neoadjuvant therapy, and examined whether changes in quality of life could predict treatment response. Methods This prospective single-center study enrolled patients with esophageal squamous cell carcinoma who received neoad …

22.08.2026journal-article

Diseases of the Esophagus

PD04.05. First-Line Treatment Strategies Considering Quality of Life in Unresectable or Recurrent Esophageal Cancer

Akiyuki Wakita, Yusuke Sato, Yushi Nagaki, Takatoshi Yoneya, Yusuke Minamizuka, Tsukasa Takahashi, Kazuhiro Imai

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Immune checkpoint inhibitors (ICIs) are established as standard treatments for unresectable or recurrent esophageal cancer. Nevertheless, a substantial proportion of patients experience severe dysphagia and malnutrition, which significantly impairs quality of life. The optimal first-line treatment strategy that addresses both therapeutic efficacy and symptom relief has yet to be determined. Methods From February 2022 to Decembe …

22.08.2026journal-article

Diseases of the Esophagus

P1.182. Development of Difficulty Prediction Method for Mediastinoscopic Esophagectomy in Esophageal Cancer

Hirotaka Konishi, Hitoshi Fujiwara, Hiroyuki Inoue, Keiji Nishibeppu, Toshiyuki Kosuga, Hiroki Shimizu, Tomohiro Arita, Yusuke Yamamoto, Ryo Morimura, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Mediastinoscopic esophagectomy is a minimally invasive procedure for esophageal cancer, but no established method exists to predict surgical difficulty. This study aimed to identify a difficulty factor of this technique and develop a novel scoring system to predict the difficulty of mediastinoscopic esophagectomy for esophageal cancer. Methods A total of 192 patients who underwent radical mediastinoscopic esophagectomy between 2019 …

22.08.2026journal-article

Diseases of the Esophagus

P1.170. Circulating Biomarkers of Angiogenesis in Esophageal Cancer Patients Undergoing Laparoscopic Gastric Ischemic Preconditioning: A Pilot Study

Stefan Marasligiller, Sumaya Ghaffar, Andrii Khomiak, Mythili Vigneshwar, Martin McCarter, Robert Meguid, John Mitchell, Elizabeth David, Sachin Wani, Mohammad Bilal, Sunnie Kim, Daysha Ferrer-Torres, Alison Mungo, Benedetto Mungo

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Laparoscopic gastric ischemic preconditioning (LGIP = ligation of the left gastric and short gastric vessels) aims to promote gastric conduit neovascularization and reduce anastomotic leak, a major complication following esophagectomy for esophageal cancer. The feasibility of measuring systemic peri-LGIP angiogenic biomarkers as a potential signal of preconditioning response was evaluated. Methods Twenty-three patients with resecta …

22.08.2026journal-article

Diseases of the Esophagus

P1.112. Low Circulating miR-5193 Promotes PD-L1–mediated Immune Evasion and Predicts Immune Checkpoint Inhibitor Response in Esophageal Cancer

Ryo Ishida, Shuhei Komatsu, Hajime Kamiya, Taisuke Imamura, Jun Kiuchi, Keiji Nishibeppu, Hiroshi Arakawa, Masateru Yamauchi, Satoshi Hamada, Hiroyuki Kanazawa, Hiroki Shimizu, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Hitoshi Fujiwara, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Low levels of circulating tumor-suppressor microRNAs are associated with cancer progression and poor prognosis. However, their role in immune evasion and response to immune checkpoint inhibitors (ICIs) remains unclear. Methods We aimed to identify a PD-L1–targeting tumor-suppressor microRNA downregulated in esophageal squamous cell carcinoma (ESCC). Four tumor-suppressor microRNAs (miR-5193, miR-3117-3p, miR-802, and miR-651-3p) predicted to t …

22.08.2026journal-article

Journal of Evolutionary Biology

Symbiotic cancer cell-stroma crosstalk in the acidic tumor microenvironment

Emma R Downey, Ana M Forero Pinto, Abigail L Booth, Joel Brown, Katarzyna A Rejniak, Mehdi Damaghi

Abstract The acidic microenvironment (AME) is a defining metabolic feature of solid tumors that fundamentally reshapes tumor–stroma interactions. Tumor acidosis arises from multiple metabolic processes, including hypoxia-driven glycolysis in poorly vascularized regions, the Warburg Effect (WE) in well-perfused areas, and carbon dioxide accumulation from tumor respiration. As a sustained ecological stress distinct from physiological pH (∼7.4), extracellular acidosis imposes powerful selective pressures within the tu …

22.08.2026journal-article

Urology Herald

Premature ejaculation: surgical treatment and its impact on reproductive function

M. Kh. Shaipov, T. V. Shatylko, S. I. Gamidov, D. E. Kalinkin, A. V. Beloborodova, I. V. Gulin, E. T. Zakaryaev

Introduction. Sexual dysfunctions, including erectile dysfunction and ejaculatory disorders, are highly prevalent among men and can adversely affect reproductive potential, making timely diagnosis and effective treatment essential. Objective. To evaluate the efficacy of surgical treatment for premature ejaculation and its impact on reproductive function. Materials & methods. The study included 116 men with premature ejaculation who expressed a strong desire to preserve and realise their reproductive potential. The …

22.08.2026journal-article

Techniques in Coloproctology

Salvage surgery after total neoadjuvant therapy and watch-and-wait in rectal cancer: a systematic review and proposed minimum outcome set

J. R. Burke, I. Samuel, R. Clifford, P. Sutton, C. Arthur, A. G. Renehan

Abstract Background Salvage surgery for local regrowth following watch-and-wait (W&W) after total neoadjuvant therapy (TNT) is perceived to be technically more difficult than immediate surgery after treatment. However, surgical difficulty lacks standardised definition and reporting. This methodological review proposes a structured minimum outcome set (MOS) to distinguish intra-operative technical complexity from surgery-related morbidity and evaluates current reporting against this framework. Methods A predefined f …

22.08.2026journal-article

Diseases of the Esophagus

P1.055. Combination of CAR-T Cell Therapy With Immune Checkpoint Inhibition Enhances Anti-Tumor Efficacy in Esophageal Squamous Cell Carcinoma

Ning Zhao

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Chimeric antigen receptor (CAR)-T cell therapy has limited efficacy in solid tumors like esophageal squamous cell carcinoma (ESCC). This study investigates whether combining CAR-T cells with an anti-PD-1 antibody can overcome immunosuppression and improve therapeutic outcomes by remodeling the tumor microenvironment (TME). Methods We constructed second-generation CAR-T cells targeting mesothelin, an antigen overexpressed in ESCC. Using …

22.08.2026journal-article

Diseases of the Esophagus

PD09.09. Post-Recurrence Survival After Esophagectomy for Esophageal Cancer: Impact of Timing and Anatomic Site

Ofek Zemer, Ran Orgad, Hila Merin, Moran Michaeli Rotshtein, Hila Shmilovich, Nikolai Menasherov, Idan Carmeli, Hanoch Kashtan, Daniel Solomon

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Recurrent disease remains the leading cause of mortality following esophagectomy for esophageal carcinoma. While patterns of recurrence have been previously described, the prognostic impact of recurrence timing and site on post-recurrence survival (PRS) remains unclear. This study evaluated the impact of disease-free survival (DFS) duration and first recurrence site on PRS. Methods A multicentric retrospective …

22.08.2026journal-article

Diseases of the Esophagus

P1.166. Preoperative Geriatric Nutritional Risk Index (GNRI) as a Predictor of Intraoperative Hypothermia in Esophageal Cancer Surgery

Weiming Chen, Xiamei Chen, Sufang Ye, Huangxiang Chen, Hui Jiang, Weimin Fang, Weikun Su

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophageal cancer is life-threatening, and esophagectomy patients have a high incidence of intraoperative hypothermia (linked to adverse postoperative outcomes), with no stable predictive indicator available. The Geriatric Nutritional Risk Index (GNRI), a validated tool for predicting cancer prognosis/complications, has not been studied for its association with intraoperative hypothermia in esopha …

22.08.2026journal-article

Diseases of the Esophagus

P1.212. Sarcopaenia in Gastrooesophageal Cancer Surgery: Application in Surgical Risk Calculators

Samuel Cathie, Indran Mukherjee, Ashwin Rajagopalan, Isabelle Vincenzion, Ashwin Subramaniam, Geraldine Ooi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Sarcopaenia is prevalent among gastrooesophageal patients and is associated with postoperative complications. Despite the association, no surgical risk calculators have incorporated sarcopaenia as a parameter. This study evaluates the prognostic significance of the preoperative skeletal muscle index (SMI) and assess whether adding SMI into risk calculators increases their accuracy. Methods The ret …