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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
10.08.2026journal-article

Frontiers in Oncology

Oral selective estrogen receptor degraders and biomarker-driven therapy in ER-positive breast cancer: mechanisms, clinical evidence, and future directions

Anton Yu Alasheev, Raneem Hamama, Elena V. Petersen, Philipp Y. Maximov

Breast cancer (BC) remains one of the most prevalent malignancies worldwide, with approximately 70% of cases being estrogen receptor-positive (ER+). Endocrine therapy targeting the estrogen receptor has revolutionized BC treatment, evolving from surgical oophorectomy to selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs). Selective estrogen receptor degraders (SERDs) represent the latest advancement in hormonal therapy, offering complete receptor blockade and degradation. This review compr …

10.08.2026journal-article

Future Internet

Bimodal Speech Emotion Recognition Using a Hybrid CNN-LSTM Architecture with Sentiment Fusion

Tze-Syn Yap, Lee-Yeng Ong

Speech emotion recognition (SER) is a fundamental task in affective computing; however, traditional unimodal approaches often struggle to capture the complex emotional cues present in spontaneous conversational speech. Bimodal frameworks that integrate acoustic and textual information have therefore emerged to provide complementary semantic and acoustic representations. This study proposes a bimodal SER framework based on a hybrid convolutional neural network–long short-term memory (CNN–LSTM) architecture. Using th …

10.08.2026journal-article

Developmental Medicine & Child Neurology

Speech, language, social communication, and communication assessments in Rett syndrome: A systematic review

Lucas N. Raniolo, Ruth O. Braden, Jana von Hehn, John Christodoulou, David N. Lieberman, David J. Amor, Adam P. Vogel

Abstract Aim To provide a systematic overview of speech, language, and social abilities of people with Rett syndrome (RTT), and identify the most frequently used communication assessments in the literature. Method A systematic search of PubMed, CINAHL, ScienceDirect, ERIC, and speechBITE databases was conducted using terms synonymous with RTT, speech, language, social, and clinical assessment. Two independent reviewers screened abstracts; one reviewer conducted full‐text screening, communication‐related data extrac …

10.08.2026journal-article

P.A. Herzen Journal of Oncology

Ribociclib-based combination endocrine therapy in elderly and frail patients: key issues of efficacy, safety, and drug interactions requiring the attention of an oncologist

I.V. Kolyadina

This review presents the findings of the most consequential large-scale randomized controlled trials and real-world practice studies on combination endocrine therapy with ribociclib in elderly patients with advanced HR-positive, HER2-negative breast cancer. Phase 3 and 3b randomized clinical trials (MONALEESA-2, MONALEESA-3, and CompLEEment-1) have consistently demonstrated that endocrine therapy combined with ribociclib confers a significant advantage over endocrine monotherapy in reducing the risks of disease rec …

10.08.2026journal-article

Hospital Pharmacy

When the Law Changes Therapy: Interrupted Time-Series Analysis of the Regulatory Impact on Intravenous Analgesic Consumption in 2 Italian Orthopaedic Hospitals (2021-2024)

Barbara Crivelli, Luca Galassi, Beatrice Faitelli, Giorgio Oriani, Benedetta Angela Maurizio, Davide Picco, Carlo Banfi, Federica Pieri

Objectives: Tramadol is a centrally acting weak opioid widely used for moderate postoperative pain in orthopaedic surgery, so its regulatory status is directly relevant to hospital pharmacists. In November 2022 the Italian Ministry of Health reclassified tramadol as a controlled substance under Section A of Presidential Decree 309/1990. Its effect on surgical-hospital prescribing has not been systematically described. We quantified the change in consumption and expenditure of intravenous (IV) tramadol and of the IV …

10.08.2026journal-article

Asian Journal of Research in Biochemistry

Microbial Interventions in Cancer Therapy: Molecular Mechanisms, Engineering Strategies and Translational Constraints

Ummulkhairi Tukur, Imran Yahaya Umar, Aminat Oyiza Musa, Hassan Ibrahim Zogirma, Abdullahi Umar Muhammad, Ibrahim Sammani Auwal, Precious A. Idakwoji

Microbial interventions are being developed as anticancer agents, local drug factories, replicating immunotherapies and modifiers of treatment response. Their appeal arises from properties that conventional medicines do not readily reproduce: active replication, environmental sensing, penetration of poorly perfused tissue, programmable payload production and the capacity to engage innate and adaptive immunity. This critical narrative review evaluates tumour-targeting bacteria, engineered bacterial therapeutics, onc …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Сравнительный анализ тарифной политики санаторно-курортных организаций в системе обязательного и добровольного медицинского страхования как фактор финансовой доступности реабилитации

М. В. Деребизова, Н. Н. Мусинова, А. В. Мухачева, Н. С. Сергиенко, Х. Б. Монахова

Introduction: Sanatorium-resort rehabilitation is an integral component of the restorative treatment system in the Russian Federation. According to Rosstat data, in 2024 the sanatorium-resort services market volume reached 220.08 billion rubles with 7.3 million consumers; however, existing financing mechanisms through the compulsory (CHI) and voluntary (VHI) health insurance systems are characterized by significant tariff differentiation that reduces the financial accessibility of rehabilitation services for variou …

10.08.2026journal-article

International Journal Multidisciplinary (IJMI)

COMPLIANCE WITH OCCUPATIONAL HEALTH AND SAFETY PRACTICES AMONG HEALTHCARE WORKERS IN VACCINATION UNITS: A CROSS-SECTIONAL STUDY IN BASRA, IRAQ

Fatima A. Najem, Alaa K. Jasim, Majid A. Maatook

Objective: Healthcare workers (HCWs) in vaccination units are exposed to various occupational hazards, making adherence to occupational health and safety (OHS) measures essential. Therefore, this study aimed to assess OHS practices among HCWs in primary healthcare vaccination units in Basra Governorate, Iraq. Method: A descriptive cross-sectional study was conducted in 11 health sectors in Basra Governorate, Iraq, using a multistage stratified sampling approach with 228 HCWs. It depended on a questionnaire, which w …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Рентабельность санаторно-курортных организаций Республики Крым в условиях логистической изоляции и роста операционных издержек (2019–2025 гг.)

А. И. Кабалинский, Е. В. Разумова, М. А. Данилькевич, Л. В. Шубцова, Е. Г. Бунов

Introduction: The health resort sector of the Republic of Crimea operates under sustained logistic isolation driven by the closure of air services since 2022 and the limited capacity of road-rail corridors via the Crimean Bridge. Against a backdrop of industry-wide revenue growth, Crimean health resorts exhibit an accelerated rise in operational costs, producing a distinctive profitability model that warrants dedicated techno-economic analysis. Objective: To quantify the dynamics of operational profitability across …

10.08.2026journal-article

The Journal of International Advanced Otology

Pressure Therapy in Bilateral Ménière’s Disease: A Prospective Study

Edoardo Covelli, Piero Giuseppe Meliante, Chiara Filippi, Pietro Canzi, Sofia Pizzolante, Haitham Elfarargy, Maurizio Barbara

BACKGROUND: Ménière’s disease (MD) is an inner ear disorder characterized by unpredictable vertigo attacks, tinnitus, and aural fullness, ultimately leading to a decline in audiovestibular function. Linked to endolymphatic hydrops (EH), MD often progresses to bilateral involvement (BMD). When conservative therapies fail, MD requires destructive treatments. However, this is a high-risk choice in bilateral cases for hearing preservation. Pressure therapy (PT), a non-invasive treatment using low-pressure pulses to the …

10.08.2026journal-article

Exploration of Targeted Anti-tumor Therapy

Bioethical challenges in the implementation of targeted anti-tumor therapies in low-resource settings: a perspective from Latin America

Alcides Chaux

Precision oncology has revolutionized cancer care in high-income countries, but its implementation in Latin American low-resource settings faces profound bioethical dilemmas. This study analyzes these challenges through the lens of social justice and equity. An integrative review was conducted following the Whittemore and Knafl framework. A systematic search was performed across PubMed, Scopus, SciELO, and LILACS (2015–2025). Thematic synthesis was applied to integrate empirical data with normative bioethical theor …

10.08.2026journal-article

Jurnal Minfo Polgan

Indonesian Hate Speech Detection Across Diverse Domains Using Parameter-Efficient Fine-Tuning with IndoBERT and LoRA

Fergie Joanda Kaunang, Bhustomy Hakim, Angelina Pramana Thenata

The rapid proliferation of digital connectivity in Indonesia has catalyzed an unprecedented surge in harmful online content, necessitating robust automated systems for hate speech detection that can generalize across diverse digital platforms. Traditional models often struggle with domain shift and the linguistic complexities of Indonesian social media discourse, including informal slang and code-mixing. This research proposes a multi-domain detection framework leveraging the IndoBERT-base-p1 architecture integrate …

10.08.2026journal-article

Nordic Studies on Alcohol and Drugs

Acceptability of Internet-Based Therapy: Considerations Expressed by Individuals Struggling with Gambling

André Syvertsen, Bjørn Solberg-Hansen Fondenes, Ståle Pallesen

Aims Internet-based therapy (IBT) is effective in reducing symptoms of gambling disorder (GD), yet limited acceptability may constrain treatment uptake and engagement. This study explored perspectives on the expected acceptability (defined as perceiving the intervention as appropriate) of IBT for GD. Methods Twenty-eight individuals with current or lifetime gambling problems responded to open-ended questions in a qualitative survey, including reflections on a vignette describing a hypothetical patient receiving IBT …

10.08.2026journal-article

Viruses

Putting Evolution to Work: Host Range Alteration for Phage Therapy

Rachel Stanchek, Paul Hyman

Host range describes the hosts that a bacteriophage can and cannot infect. Throughout the history of phage use in various applications, phages with varying host ranges have been needed and techniques to alter a phage’s host range have been developed. These include techniques that rely on spontaneous mutations and others that use genetic engineering to make designed changes. Phages with altered host ranges have been used in personalized phage therapy cases and in cocktails in clinical trials. In this review, we prov …

10.08.2026journal-article

JAMA Network Open

Remote Multicomponent Rehabilitation and Cost-Effectiveness in Survivors of Critical Illness

Mandana Zanganeh, Brenda O’Neill, Judy M. Bradley, Bronwen Connolly, Julie Bruce, Martin Underwood, Mariam Ratna, Ranjit Lall, Chen Ji, Jill Costley, Rachel Clarke, Paul Dark, Orla Duffy, Penelope Firshman, Nigel D. Hart, Annette Henderson, Katherine Jones, Roger Kenyon, Darren Murphy, Gavin D. Perkins, Kerry Raynes, Ella Terblanche, Daniel F. McAuley, Jason Madan, iRehab Trial Investigators, Jane Snell, Sinead O'Kane, Jonathan Weblin, Denise McFarland, Jane Hedley, Kate Tantam, Sarah Varga, Catherine Donnison, Jennifer Davies, Samantha Coetzee, Keeleigh Champman, Amy Arnold, Hannah Hayter, Isabel Gonzales, Julie North

Importance The cost-effectiveness of remote rehabilitation for survivors following critical illness after intensive care unit (ICU) care is unknown. Objective To evaluate the cost-effectiveness of remote multicomponent rehabilitation compared with standard care following discharge from hospital after an ICU admission. Design, Setting, and Participants This economic evaluation was conducted within a pragmatic, multicenter, assessor-blinded trial comparing remote rehabilitation delivered online with standard care aft …

10.08.2026journal-article

Health, sport, rehabilitation

Associations between daily smartphone use duration and craniovertebral angle, cervical muscle endurance, and temporomandibular joint proprioception among high smartphone users

Mohamed Zidan, Maya Aly, Ahmed Ashraf, Khaled Olama

Background and purpose Smartphones are widely used by adolescents, and prolonged use may be associated with altered cervical posture, reduced neck muscle endurance, and temporomandibular dysfunction. This study aimed to examine the association between daily smartphone use duration and craniovertebral angle, cervical muscle endurance, and temporomandibular joint proprioception in adolescents with high smartphone use. Material and methods This cross-sectional study included 160 adolescents aged 17–19 years who used s …

10.08.2026journal-article

The Journal of International Advanced Otology

Delayed Detection of Bilateral High-Frequency Sensorineural Hearing Loss Following Childhood Cisplatin Therapy: A Case Report

Takeshi Tada, Tsunetaro Morino, Akihiro Oue, Kazuhisa Yamamoto

Cisplatin is a widely used chemotherapeutic agent in pediatric oncology; however, it is well known for its marked ototoxicity. While hearing impairment typically emerges during or soon after therapy, progressive or previously undetected auditory dysfunction may occasionally present years later. The reported case involves an 11-year-old boy who previously received cisplatin-based chemotherapy for hepatoblastoma and was first identified as having bilateral sensorineural hearing loss 9 years after completion of treatm …

10.08.2026journal-article

mBio

Deletion of the Salmonella pathogenicity island 2 gene, spiC , in attenuated Salmonella Typhimurium VNP20009 optimizes its potential for bacterial schwannoma therapy

Giulia Oliva, Sherif Ahmed, Manlin Shao, John J. Mekalanos, Gary J. Brenner

ABSTRACT Recent advances in systems biology and immunotherapy have spurred the investigation of bacteria as therapeutic vehicles for cancer treatment. Currently, Bacillus Calmette–Guérin remains the only FDA-approved bacterial cancer therapy; it is a live attenuated mycobacterium that is indicated for the treatment and prophylaxis of carcinoma in situ of the urinary bladder and for the prophylaxis of primary or recurrent papillary tumors following transurethral resection. Although safety concerns have been raised, …

10.08.2026journal-article

Current Cancer Therapy Reviews

Nanotechnology Advancements in Breast Cancer Therapy: A Comprehensive Review of Innovations in Drug Delivery, Diagnostics, and Personalized Treatment Strategies

Prerana Sahu, Gyanesh Sahu, Harish sharma, Mukesh Kumar Sharma

Abstract: Breast cancer is one of the most common cancers in women worldwide. Compared to its incidence, the cure rate remains relatively low. Various treatment methods, such as radiotherapy and chemotherapy, are available but often involve severe toxicity and limited curability. Recent research has shown that NDDS formulations can selectively target breast cancer cells without damaging surrounding tissues or organs. This comprehensive review provides details on nanocarriers and their loaded delivery systems as eff …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Инвестиционный потенциал санаторно-курортной отрасли Северо-Кавказского федерального округа в контексте Стратегии пространственного развития России до 2030 года

Л. Г. Руденко, Т. В. Алексашина, М. Ю. Маковецкий, А. В. Никонорова, А. В. Овсянникова

Introduction: The sanatorium and resort industry of the North Caucasus Federal District (NCFD) is undergoing accelerated transformation following the approval of the Spatial Development Strategy of the Russian Federation until 2030. Despite the growth of the tourist flow in the NCFD to 3.3 million people in 2024 (+8% compared to 2023) and the increase of the national sanatorium services market to 220.08 billion rubles (+18%), there remains a deficit of comprehensive assessments of the industry's investment potentia …

10.08.2026journal-article

International Journal of Health and Pharmaceutical (IJHP)

A Community-Based Holistic Midwifery Service Management Model To Optimize The Role Of Posyandu Cadres

Harmatuti, Dyan Oktaviany

This research on a community-based holistic midwifery service management model aims to develop and test a community-based holistic midwifery service management model to optimize the role of Posyandu (Integrated Health Post) cadres. Posyandu cadres serve as the frontline providers of community-based health services for mothers, children, adolescents, women of reproductive age, and the elderly in the community, integrating primary care (a basic health care system encompassing promotive, preventive, simple curative, a …

10.08.2026journal-article

Journal of Asian Pacific Society of Cardiology

Knowledge and Practice in Reversal of Oral Anticoagulation Therapy among Government Healthcare Professionals in Malaysia: A Nationwide Survey

Sze Ling Tan, Chelfi Zhi Fei Chua, Jagan Nirmala, Sim Mei Chuah, Mohamed Sahimi

Background: The rising use of oral anticoagulants (OACs) necessitates effective and timely reversal strategies. Despite established recommendations, variability remains in the prescribing and usage of OAC reversal agents. This study aimed to assess the availability of reversal agents and evaluate the practice and knowledge of healthcare professionals (HCPs) in managing OAC reversal within Ministry of Health Malaysia hospitals. Methods: A cross-sectional, self-administered questionnaire was distributed to prescriber …

10.08.2026journal-article

Frontiers in Virtual Reality

Next-generation movement-based physical rehabilitation through artificial intelligence-driven immersive virtual reality: a brief perspective

Martine Bordeleau, Hannah Derue, David R. Labbé, Samory Houzangbe, Maxime T. Robert, Anouk Lamontagne, Serge Marchand, Guillaume Léonard

This perspective article explores the current challenges and future potential of artificial intelligence (AI)-assisted immersive virtual reality (VR) for clinical applications in movement-based physical rehabilitation. It highlights the limitations of current immersive VR and introduces AI as a potential solution to improve the overall VR experience, particularly in the context of physical rehabilitation. AI’s role in content creation, personalizing clinical interventions, achieving the right balance between challe …

10.08.2026journal-article

Revista ft

O benefício do uso do laser de baixa intensidade em lesões por pressão.

Ludmilla Mattos Lino Schaeffer Ribeiro, Adriana Pitanga de Oliveira, Edinalva Helmer da Silva, Maria Celia Oliveira do Nascimento, Maria Luzia Leal, Julio Cesar Titol, Waltayr Rosa Rodrigues, Delcinéia Araujo Nascimento, Marcos Roberto Bernardino, Lucimara Alves do Rosario

Pressure injuries (PIs) constitute a significant public health problem, particularly among hospitalized individuals, the elderly, and people with reduced mobility. Given the complexity of the healing process and the challenges associated with treating these injuries, various therapeutic strategies have been developed and incorporated into clinical practice. Among these, the use of low-intensity laser also known as low-power laser stands out as an adjunct in the tissue repair process. This study is a literature revi …