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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
10.08.2026journal-article

Experimental Physiology

Clinical and biochemical factors associated with insulin therapy in gestational diabetes: The role of OGTT‐based groups

Libera Troìa, Martina Garassino, Riccardo Bertinato, Caroline Leitao Thomaz, Giulia Turatello, Chiara Airoldi, Alessandro Libretti, Daniela Surico, Valentino Remorgida

Abstract Gestational diabetes mellitus (GDM) represents one of the most common metabolic disorders of pregnancy. This study aimed to identify clinical and biochemical factors associated with antenatal insulin therapy, focusing on the association with oral glucose tolerance test (OGTT)‐based phenotypes. Retrospective observational study among GDM women, divided according to their treatment (nutritional therapy (NT) or insulin therapy). GDM was classified into three phenotypes based on OGTT results: isolated fasting …

10.08.2026journal-article

Physiotherapy Research International

Effect of Hamstring Stretching on Pain at Masseter Muscle and Mouth Opening: A Systematic Review

Nafisa Sarfaraz, Kalpana Zutshi, Ifra Aman, Heba Parwaiz

ABSTRACT Background Hamstring flexibility can potentially affect the mobility and function of remote musculoskeletal areas, including the cervical spine and temporomandibular joint (TMJ), thereby increasing tension along the myofascial chain and potentially reducing mouth opening, contributing to orofacial discomfort. This review aims to inform clinical practice by exploring the integrated impact of these interventions within the framework of neuro‐myofascial connectivity. Methods A comprehensive search was perform …

10.08.2026journal-article

P.A. Herzen Journal of Oncology

Efficacy of atezolizumab in combination with carboplatin and etoposide in first-line therapy for advanced small cell lung cancer in real clinical practice: a retrospective single-center study

D.M. Ponomarenko, K.S. Titov, D.Yu. Yukalchuk, S.S. Sidorova

Objective. To evaluate the efficacy and safety of atezolizumab in combination with carboplatin and etoposide in the first-line treatment of advanced small cell lung cancer (SCLC) in real-life clinical practice. Material and methods. A retrospective single-center cohort study was conducted. The analysis included 58 consecutive patients with advanced SCLC who received atezolizumab plus carboplatin and etoposide in the first-line treatment from SEP/2020 to SEP/2025 at the Irkutsk Regional Oncology Dispensary. Database …

10.08.2026journal-article

Advanced Science

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen

ABSTRACT The importance of fibrillarin (FBL), an established nucleolar methyltransferase, was identified in neoplastic growth of esophageal squamous cell carcinoma (ESCC), one of the most lethal malignancies worldwide. However, the underlying mechanism remains unclear. Here, by enrolling independent ESCC cohorts, we verified the negative correlation between intratumoral FBL expression and patient prognosis. Notably, comprehensive transcriptomic and metabolomic analyses indicated that FBL deletion elicited cell cycl …

10.08.2026journal-article

Physiotherapy Research International

Association Between Danish Guideline Treatments for Breast Cancer and Physiotherapy‐Relevant Late Effects: A Nationwide Cohort Study

Kim Michéle Feder, Lonny Stokholm, Hans Bjarke Rahr, Kim Gordon Ingwersen, Marianne Djernes Lautrup

ABSTRACT Background Breast cancer survival has improved substantially, yet many women continue to experience late effects that may require physiotherapy. Shoulder impairment, lymphedema, and fatigue are among the most common physiotherapy‐relevant late effects following primary breast cancer treatment. Understanding how guideline treatments for breast cancer influence these impairments is essential for the early identification of high‐risk patients and the development of targeted rehabilitation strategies. Purpose …

10.08.2026journal-article

Biological Research For Nursing

Continuous Positive Airway Pressure Therapy and Cardiovascular Outcomes in Adults with Obstructive Sleep Apnea: A Cohort Study Using the TriNetX Database

Vivi Leona Amelia, Septi Melisa, Jason C. Hsu, Min-Huey Chung

Background : Obstructive sleep apnea (OSA) is a common sleep disorder associated with increased cardiovascular morbidity. Continuous positive airway pressure (CPAP) therapy is the standard treatment; however, its long-term cardiovascular benefits remain uncertain. Aim : To evaluate 5-year associations between CPAP therapy and the risks of cardiovascular diseases in patients with OSA. Methods : This retrospective cohort study used the TriNetX global database, including adults diagnosed with OSA between 2014 and 2025 …

10.08.2026journal-article

Perfusion

ECMO as salvage therapy for severe ARDS complicating Crotalus atrox envenomation

Athanasios Papatriantafyllou, Vasileios Leivaditis, Daniela Prepelita, Florian Steinbach, Manfred Dahm

Background Snakebite envenomation is a global health problem, though rarely encountered in Europe outside captive settings. The Western diamondback rattlesnake ( Crotalus atrox ) is one of the most medically important North American pit vipers, with venom capable of provoking profound coagulation disorders and systemic toxicity. Respiratory complications are exceedingly rare, and the role of extracorporeal membrane oxygenation (ECMO) in this context has not been previously described. Case presentation We report the …

10.08.2026journal-article

Occupational Medicine

The seductive predator: navigating predatory publishing and conferences

Nerys Williams

Predatory journals and conferences exploit the open-access model of publishing threatening the professional reputations of researchers and the integrity of published scientific research. In occupational medicine, where research directly informs workplace health and safety and clinical guidelines, the risks are amplified. This article describes the tactics used by predatory publishers and conference organizers and provides a practical framework for researchers to protect themselves and their work.

10.08.2026journal-article

Scientific Reports

Phase II Non-Randomised Trial of Oral Chlorophyllin in Haemorrhagic Cystitis from Radiation Therapy (CLARITY Trial): clinical and quality-of-life outcomes with exploratory proteomics

Gagan Prakash, Vikram Gota, Deepak Sharma, Supriya Chopra, Mahendra Pal, Amandeep Arora, Ramya Nagarajan, Ankit Misra, Ganesh Bakshi, Vedang Murthy, Priyamvada Maitre, Lavanya Gurram, Prachi Mittal, Raghavendra S. Patwardhan, Rahul Checker, Mahendra Joshi, Shivkumar Madki, Saurabh Gupta, Sharath Kumar, Shraddha Bonkar Dethe, Priyal Gawad, Sanjana Ghadge, Santosh Menon, Tapan Ghanty, Sadhana Kannan, Rajendra Badwe, Pankaj Chaturvedi, Sudeep Gupta, Santosh K. Sandur

Abstract Chronic Haemorrhagic Cystitis (cHC) affects 5–15% of patients after pelvic radiotherapy. Sodium-copper-chlorophyllin, a semi-synthetic chlorophyll derivative, has shown promise in preclinical models. The phase II CLARITY trial evaluated oral chlorophyllin for radiation-induced cHC. This prospective, single-centre, single-arm phase II trial (NCT05348239) enrolled adults with grade 2–4 haematuria persisting ≥ 3 months after pelvic radiotherapy. Participants received chlorophyllin 750 mg orally daily for 12 w …

10.08.2026journal-article

RJNM

Institutional Strategies for Preventing and Mitigating Mental Exhaustion among Public Health Professionals: Proposals for Occupational Health Promotion and Workplace Well-Being

Oldair Donizete Galeni, Cassimar Dias Ferreira, Norton Martins Nunes, Sheila Érika Ferro Ramalho Nobre, Siglia Sousa de França, Mirela Galeni de Azevedo, Celia Fabricio de Souza Rezende, Nidia Helena Mareco Fernandes Dantas Amaral

Mental exhaustion among public health professionals represents a significant challenge for healthcare systems, affecting workers' quality of life, organizational performance, and the sustainability of health services. The increasing complexity of healthcare demands, combined with occupational pressures, emotional challenges, and organizational limitations, highlights the need for institutional strategies focused on prevention and mitigation of psychological suffering. This academic essay discusses approaches for pr …

10.08.2026journal-article

American Journal of Technology

A Conceptual Framework for Integrated Rehabilitation of Urban Sewer Networks Under Flood Risk Conditions

Hari Vamsi Krishna Nukala, Abhilash Srungarapati

Aim: The objective of this study is to develop an integrated rehabilitative framework for urban sewer systems (USS). The study addresses the systemic weaknesses associated with aging sewer systems in major cities, which can contribute to sewer overflows, urban flooding, environmental degradation, service disruptions, and economic losses. Methods: The study employs advanced hydraulic modeling, vulnerability assessment methods, sensor-based monitoring, multi-criteria decision analysis (MCDA), and resilience evaluatio …

10.08.2026journal-article

Frontiers in Molecular Biosciences

Combination treatment with intravesical interferon-alpha gene therapy and an oral pan-ErbB receptor family blocker improves survival in mice with bladder cancer

Akshay Sood, Alberto Martini, Paulo Genitiano, Mikael Rauf, Ganiraju Manyam, Jan K. Rudzinski, Come Tholomier, Roberto Contieri, I-Ling Lee, Nigel R. Parker, Seppo Yla-Herttuala, David J. McConkey, Colin P. N. Dinney, Sharada Mokkapati

Introduction Intravesical interferon-alpha (IFNα) gene therapy is approved by the FDA for BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). Identifying resistance mechanisms and deploying targeted combination treatment strategies is a rational approach to improving treatment responses. We identified the ErbB pathway as a resistance mechanism to IFNα gene therapy, and we hypothesized that combination treatment with an ErbB pathway blocker and IFN-α could improve outcomes in resistant tumors. Methods Murin …

10.08.2026journal-article

Biomacromolecules

Coordination-Driven Programming of MOF Stability via Targeting Protein Corona Engineering for Hypoxia-Relieving Sonodynamic Therapy

Youjung Sim, Gyeongseok Yang, Joohan Nam, Seungo Baek, Jung Heum Yoon, Jinhyu Lee, Hong Kyu Lee, Jaewoo Lee, Eunshil Choi, Gun Kim, Wonyoung Choe, Ja-Hyoung Ryu

Abstract Zr-based metal–organic frameworks (MOFs) are promising nanomedicine platforms, but their rapid degradation in phosphate-rich biological environments remains a critical barrier to clinical translation. Here, incorporating MnOx into the porphyrinic Zr-MOF PCN-224 modulates the coordination environment of Zr6 clusters, suppressing phosphate-induced linker displacement and extending structural integrity under physiological conditions. The optimized 1:1 MnOx@PCN-224 formulation resists phosphate-triggered disas …

10.08.2026journal-article

Journal of Forensic Sciences

EMBNet: Multi‐scale feature learning with efficient channel attention for deepfake speech detection

Haitao Yang, Fen Li, Xin Cai, Juanjuan Huang, Yifan Tang, Yingzhuo Xiong, Huapeng Wang

Abstract With the rapid advancement of generative artificial intelligence, deepfake speech has emerged as a significant threat to digital audio authenticity, posing challenges for forensic analysis and legal applications. In this study, we propose EMBNet, a task‐oriented deepfake speech detection framework that integrates efficient channel attention (ECA) with a multi‐scale bottleneck to enhance the representation of subtle acoustic anomalies. The ECA module adaptively emphasizes critical feature channels, while th …

10.08.2026journal-article

Journal of Translational Medicine

Efficacy and safety of AAV RPGR gene therapy in X-linked retinitis pigmentosa: a systematic review and meta-analysis

Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan

Abstract Background X-linked retinitis pigmentosa (XLRP) represents a severe inherited retinal dystrophy associated with pathogenic variants in the retinitis pigmentosa GTPase regulator (RPGR) gene. Adeno-associated virus (AAV)-mediated RPGR gene augmentation is designed to preserve photoreceptor structure and function. Objectives The purpose of this study was to critically appraise and quantitatively synthesize the efficacy and safety evidence for AAV-RPGR gene therapy in X-linked retinitis pigmentosa. Methods Sco …

10.08.2026journal-article

Journal of Occupational & Environmental Medicine

A Comprehensive Obesity Benefit: Guidance for Occupational and Environmental Medicine Professionals

Faiyaz A. Bhojani, Tufail Shaikh, Annemieke De Wilde, Rupali Das, Nathan Jones, Laura Bayne, Lori Schwartz, Marygrace Hajec, Jessica Chuang, Ifeoma Ama, Muhammad Asif, Sumeet Batra, Julie Ording

Obesity is a prevalent, chronic disease that significantly affects employee health, safety, productivity, and healthcare costs across industries. Occupational and environmental medicine (OEM) physicians are uniquely positioned to influence workforce health strategies addressing obesity through clinical leadership and health benefit plan design. This guidance paper examines the burden of obesity in working populations, describes the role of OEM physicians across corporate and non-corporate practice settings, and pre …

10.08.2026journal-article

HERD: Health Environments Research & Design Journal

Exploring the Benefits and Challenges of Outdoor Therapy Environments: Integrating Perspectives From Rehabilitation and Design Professionals

Karen Joyce, Mardelle McCuskey Shepley

Objective This study examined perspectives of rehabilitation professionals and environmental designers to identify benefits, challenges, and design considerations for outdoor therapy spaces. Background The therapeutic potential of nature-based environments has gained recognition among researchers, healthcare practitioners, and designers, highlighting an opportunity to leverage outdoor environments in physical and occupational therapy. However, our understanding of the benefits, challenges, and considerations for im …

10.08.2026journal-article

Current Medicinal Chemistry

Breast Cancer Therapy with Quantum Dots: NIR-II Image-Guided Interventions, Multimodal Treatment, and Translation

Senyang Guo, Jianhua Liu, Biao Huang, Hongmei Zheng, Xinhong Wu

Abstract: This systematic review evaluates quantum dots (QDs) as integrated theranostic platforms for breast cancer, combining second near-infrared (NIR-II) imaging with image-guided interventions and multimodal therapy. Literature was identified through a structured search of PubMed/MEDLINE, Web of Science, Scopus, CNKI, and Wan- Fang databases (January 2003-November 2025), followed by independent screening and quality appraisal by two authors using pre-defined inclusion/exclusion criteria. The review links QD com …

10.08.2026journal-article

International Journal of Health and Pharmaceutical (IJHP)

The Effectiveness of Bay Leaf Water Boil Therapy in Reducing Hypertension in Pregnant Women in Ciseureuh Assisted Village, Purwakarta Regency

Ewith Widya Mareta

World Health Organization (WHO) of 70% of known hypertension sufferers only 25% received treatment and only 12.5% ​​were treated well (adequately treated cases) estimated that by 2025 the rate of high blood pressure will increase by 60% and will affect 1.56 billion people worldwide. The purpose of this study was to determine the Effectiveness of Bay Leaf Boiled Water (Syzygium Polyanthum) on Reducing Blood Pressure in Pregnant Women with Hypertension in the Taram Health Center Working Area, Limapuluh Kota Regency i …

10.08.2026journal-article

Archives of Civil and Mechanical Engineering

Application of machine learning and deep learning methods for the prediction of near misses and occupational accidents in the construction industry

Katarzyna Topolska, Zuzanna Woźniak, Bożena Hoła

Abstract Occupational accidents remain one of the key challenges for modern work systems, both from the perspective of employee health and life, and in terms of economic, social, and organisational losses for society. Despite the significant diagnostic value of near misses, data on such events have not been incorporated as input variables in predictive models. This study aimed to develop, experimentally test, and empirically validate the effectiveness of various mathematical models in predicting occupational accide …

10.08.2026journal-article

Jurnal Indonesia Sosial Sains

The Influence of Occupational Safety and Health (OSH) Culture and Management Commitment on Occupational Safety and Health Management System (OSHMS) Performance through Employee Job Satisfaction at PT Aimtopindo Nuansa Kimia

Edward Alexander, Agus Triyono

The oil and gas industry is characterized by a high level of occupational accident risk, making the implementation of an OSHMS essential for improving workplace safety, productivity, and organizational sustainability. This research aims to examine the influence of Occupational Safety and Health culture and management commitment on OSHMS performance through employee job satisfaction at PT. Aimtopindo Nuansa Kimia. A quantitative research approach with a survey method was employed. Primary data were collected through …

10.08.2026journal-article

International Journal of Current Science Research and Review

Biological Characteristics, Innovative Isolation Methods, and Clinical Role of Exosomes in Cancer Therapy: Review

Abdul Rauf Samim, Mohammad Naser Sabawoon, Mohammad Aziz Khan Amirzai

Exosomes are a subset of nano-sized (30–150 nm) extracellular vehicles (EVs) released by cells through the endosomal route, you know like they get made inside and then pushed out. Objective: The primary objective of this scientific review is to give a broad and current appraisal of the intricate biological layout of exosomes, plus modern isolation technologies (for instance microfluidics and spectroscopy), and finally their clinical meaning for cancer detection and treatment. Methods: This article is arranged follo …

10.08.2026journal-article

The Family Journal

Where Is the Medical Family Therapist in Grey's Anatomy and The Pitt ? A Cinema Therapy Perspective

Afarin Rajaei, Danna Abraham, Katherine M. Hertlein

Medical television dramas significantly influence the public's understandings of healthcare systems, professional identities, emotional care, and relational dynamics in medical settings. Despite the deeply relational nature of these storylines, Medical Family Therapists (MedFTs) remain largely absent from these representations of healthcare. Drawing from systemic theory, narrative medicine, and Medical Family Therapy literature, in this article, we analyze themes including physician burnout, moral injury, family co …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Оценка результативности муниципальных программ поддержки санаторно-курортного комплекса города Сочи в постолимпийский период (2014–2024)

Н. Л. Красюкова, О. В. Панина, С. Г. Еремин, А. О. Кузьмина, Н. Г. Преснякова

Introduction: The sanatorium-resort complex of Sochi, which accounts for 75% of the municipal gross product, underwent a fundamental transformation following the 2014 Olympic Games. Cumulative tourist flow over the post-Olympic decade totaled 72.2 million visitors, while the municipal budget potential increased from 10.6 to 64.0 billion rubles. Despite massive public investment, a comprehensive assessment of the effectiveness of municipal support programs remains fragmented. Objective: To evaluate the effectiveness …