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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
10.08.2026journal-article

RJNM

Institutional Strategies for Preventing and Mitigating Mental Exhaustion among Public Health Professionals: Proposals for Occupational Health Promotion and Workplace Well-Being

Oldair Donizete Galeni, Cassimar Dias Ferreira, Norton Martins Nunes, Sheila Érika Ferro Ramalho Nobre, Siglia Sousa de França, Mirela Galeni de Azevedo, Celia Fabricio de Souza Rezende, Nidia Helena Mareco Fernandes Dantas Amaral

Mental exhaustion among public health professionals represents a significant challenge for healthcare systems, affecting workers' quality of life, organizational performance, and the sustainability of health services. The increasing complexity of healthcare demands, combined with occupational pressures, emotional challenges, and organizational limitations, highlights the need for institutional strategies focused on prevention and mitigation of psychological suffering. This academic essay discusses approaches for pr …

10.08.2026journal-article

American Journal of Technology

A Conceptual Framework for Integrated Rehabilitation of Urban Sewer Networks Under Flood Risk Conditions

Hari Vamsi Krishna Nukala, Abhilash Srungarapati

Aim: The objective of this study is to develop an integrated rehabilitative framework for urban sewer systems (USS). The study addresses the systemic weaknesses associated with aging sewer systems in major cities, which can contribute to sewer overflows, urban flooding, environmental degradation, service disruptions, and economic losses. Methods: The study employs advanced hydraulic modeling, vulnerability assessment methods, sensor-based monitoring, multi-criteria decision analysis (MCDA), and resilience evaluatio …

10.08.2026journal-article

Frontiers in Molecular Biosciences

Combination treatment with intravesical interferon-alpha gene therapy and an oral pan-ErbB receptor family blocker improves survival in mice with bladder cancer

Akshay Sood, Alberto Martini, Paulo Genitiano, Mikael Rauf, Ganiraju Manyam, Jan K. Rudzinski, Come Tholomier, Roberto Contieri, I-Ling Lee, Nigel R. Parker, Seppo Yla-Herttuala, David J. McConkey, Colin P. N. Dinney, Sharada Mokkapati

Introduction Intravesical interferon-alpha (IFNα) gene therapy is approved by the FDA for BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). Identifying resistance mechanisms and deploying targeted combination treatment strategies is a rational approach to improving treatment responses. We identified the ErbB pathway as a resistance mechanism to IFNα gene therapy, and we hypothesized that combination treatment with an ErbB pathway blocker and IFN-α could improve outcomes in resistant tumors. Methods Murin …

10.08.2026journal-article

Biomacromolecules

Coordination-Driven Programming of MOF Stability via Targeting Protein Corona Engineering for Hypoxia-Relieving Sonodynamic Therapy

Youjung Sim, Gyeongseok Yang, Joohan Nam, Seungo Baek, Jung Heum Yoon, Jinhyu Lee, Hong Kyu Lee, Jaewoo Lee, Eunshil Choi, Gun Kim, Wonyoung Choe, Ja-Hyoung Ryu

Abstract Zr-based metal–organic frameworks (MOFs) are promising nanomedicine platforms, but their rapid degradation in phosphate-rich biological environments remains a critical barrier to clinical translation. Here, incorporating MnOx into the porphyrinic Zr-MOF PCN-224 modulates the coordination environment of Zr6 clusters, suppressing phosphate-induced linker displacement and extending structural integrity under physiological conditions. The optimized 1:1 MnOx@PCN-224 formulation resists phosphate-triggered disas …

10.08.2026journal-article

Journal of Forensic Sciences

EMBNet: Multi‐scale feature learning with efficient channel attention for deepfake speech detection

Haitao Yang, Fen Li, Xin Cai, Juanjuan Huang, Yifan Tang, Yingzhuo Xiong, Huapeng Wang

Abstract With the rapid advancement of generative artificial intelligence, deepfake speech has emerged as a significant threat to digital audio authenticity, posing challenges for forensic analysis and legal applications. In this study, we propose EMBNet, a task‐oriented deepfake speech detection framework that integrates efficient channel attention (ECA) with a multi‐scale bottleneck to enhance the representation of subtle acoustic anomalies. The ECA module adaptively emphasizes critical feature channels, while th …

10.08.2026journal-article

Journal of Translational Medicine

Efficacy and safety of AAV RPGR gene therapy in X-linked retinitis pigmentosa: a systematic review and meta-analysis

Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan

Abstract Background X-linked retinitis pigmentosa (XLRP) represents a severe inherited retinal dystrophy associated with pathogenic variants in the retinitis pigmentosa GTPase regulator (RPGR) gene. Adeno-associated virus (AAV)-mediated RPGR gene augmentation is designed to preserve photoreceptor structure and function. Objectives The purpose of this study was to critically appraise and quantitatively synthesize the efficacy and safety evidence for AAV-RPGR gene therapy in X-linked retinitis pigmentosa. Methods Sco …

10.08.2026journal-article

Journal of Occupational & Environmental Medicine

A Comprehensive Obesity Benefit: Guidance for Occupational and Environmental Medicine Professionals

Faiyaz A. Bhojani, Tufail Shaikh, Annemieke De Wilde, Rupali Das, Nathan Jones, Laura Bayne, Lori Schwartz, Marygrace Hajec, Jessica Chuang, Ifeoma Ama, Muhammad Asif, Sumeet Batra, Julie Ording

Obesity is a prevalent, chronic disease that significantly affects employee health, safety, productivity, and healthcare costs across industries. Occupational and environmental medicine (OEM) physicians are uniquely positioned to influence workforce health strategies addressing obesity through clinical leadership and health benefit plan design. This guidance paper examines the burden of obesity in working populations, describes the role of OEM physicians across corporate and non-corporate practice settings, and pre …

10.08.2026journal-article

HERD: Health Environments Research & Design Journal

Exploring the Benefits and Challenges of Outdoor Therapy Environments: Integrating Perspectives From Rehabilitation and Design Professionals

Karen Joyce, Mardelle McCuskey Shepley

Objective This study examined perspectives of rehabilitation professionals and environmental designers to identify benefits, challenges, and design considerations for outdoor therapy spaces. Background The therapeutic potential of nature-based environments has gained recognition among researchers, healthcare practitioners, and designers, highlighting an opportunity to leverage outdoor environments in physical and occupational therapy. However, our understanding of the benefits, challenges, and considerations for im …

10.08.2026journal-article

International Journal of Health and Pharmaceutical (IJHP)

The Effectiveness of Bay Leaf Water Boil Therapy in Reducing Hypertension in Pregnant Women in Ciseureuh Assisted Village, Purwakarta Regency

Ewith Widya Mareta

World Health Organization (WHO) of 70% of known hypertension sufferers only 25% received treatment and only 12.5% ​​were treated well (adequately treated cases) estimated that by 2025 the rate of high blood pressure will increase by 60% and will affect 1.56 billion people worldwide. The purpose of this study was to determine the Effectiveness of Bay Leaf Boiled Water (Syzygium Polyanthum) on Reducing Blood Pressure in Pregnant Women with Hypertension in the Taram Health Center Working Area, Limapuluh Kota Regency i …

10.08.2026journal-article

Current Medicinal Chemistry

Breast Cancer Therapy with Quantum Dots: NIR-II Image-Guided Interventions, Multimodal Treatment, and Translation

Senyang Guo, Jianhua Liu, Biao Huang, Hongmei Zheng, Xinhong Wu

Abstract: This systematic review evaluates quantum dots (QDs) as integrated theranostic platforms for breast cancer, combining second near-infrared (NIR-II) imaging with image-guided interventions and multimodal therapy. Literature was identified through a structured search of PubMed/MEDLINE, Web of Science, Scopus, CNKI, and Wan- Fang databases (January 2003-November 2025), followed by independent screening and quality appraisal by two authors using pre-defined inclusion/exclusion criteria. The review links QD com …

10.08.2026journal-article

Archives of Civil and Mechanical Engineering

Application of machine learning and deep learning methods for the prediction of near misses and occupational accidents in the construction industry

Katarzyna Topolska, Zuzanna Woźniak, Bożena Hoła

Abstract Occupational accidents remain one of the key challenges for modern work systems, both from the perspective of employee health and life, and in terms of economic, social, and organisational losses for society. Despite the significant diagnostic value of near misses, data on such events have not been incorporated as input variables in predictive models. This study aimed to develop, experimentally test, and empirically validate the effectiveness of various mathematical models in predicting occupational accide …

10.08.2026journal-article

Jurnal Indonesia Sosial Sains

The Influence of Occupational Safety and Health (OSH) Culture and Management Commitment on Occupational Safety and Health Management System (OSHMS) Performance through Employee Job Satisfaction at PT Aimtopindo Nuansa Kimia

Edward Alexander, Agus Triyono

The oil and gas industry is characterized by a high level of occupational accident risk, making the implementation of an OSHMS essential for improving workplace safety, productivity, and organizational sustainability. This research aims to examine the influence of Occupational Safety and Health culture and management commitment on OSHMS performance through employee job satisfaction at PT. Aimtopindo Nuansa Kimia. A quantitative research approach with a survey method was employed. Primary data were collected through …

10.08.2026journal-article

International Journal of Current Science Research and Review

Biological Characteristics, Innovative Isolation Methods, and Clinical Role of Exosomes in Cancer Therapy: Review

Abdul Rauf Samim, Mohammad Naser Sabawoon, Mohammad Aziz Khan Amirzai

Exosomes are a subset of nano-sized (30–150 nm) extracellular vehicles (EVs) released by cells through the endosomal route, you know like they get made inside and then pushed out. Objective: The primary objective of this scientific review is to give a broad and current appraisal of the intricate biological layout of exosomes, plus modern isolation technologies (for instance microfluidics and spectroscopy), and finally their clinical meaning for cancer detection and treatment. Methods: This article is arranged follo …

10.08.2026journal-article

The Family Journal

Where Is the Medical Family Therapist in Grey's Anatomy and The Pitt ? A Cinema Therapy Perspective

Afarin Rajaei, Danna Abraham, Katherine M. Hertlein

Medical television dramas significantly influence the public's understandings of healthcare systems, professional identities, emotional care, and relational dynamics in medical settings. Despite the deeply relational nature of these storylines, Medical Family Therapists (MedFTs) remain largely absent from these representations of healthcare. Drawing from systemic theory, narrative medicine, and Medical Family Therapy literature, in this article, we analyze themes including physician burnout, moral injury, family co …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Оценка результативности муниципальных программ поддержки санаторно-курортного комплекса города Сочи в постолимпийский период (2014–2024)

Н. Л. Красюкова, О. В. Панина, С. Г. Еремин, А. О. Кузьмина, Н. Г. Преснякова

Introduction: The sanatorium-resort complex of Sochi, which accounts for 75% of the municipal gross product, underwent a fundamental transformation following the 2014 Olympic Games. Cumulative tourist flow over the post-Olympic decade totaled 72.2 million visitors, while the municipal budget potential increased from 10.6 to 64.0 billion rubles. Despite massive public investment, a comprehensive assessment of the effectiveness of municipal support programs remains fragmented. Objective: To evaluate the effectiveness …

10.08.2026journal-article

Small

Injectable Optoelectronic Probe With In Situ Photoactivation and ROS Monitoring for Oxygen‐Dependent Metronomic Photodynamic Cancer Therapy

Jagyeong Goo, Gyan Raj Koirala, Taeyeon Lee, Hanhee Cho, Seong Ik Jeon, Wan Su Yun, Jeongrae Kim, Lili Guo, Suyoun Oh, Won‐Gun Koh, Jongho Lee, Tae‐il Kim, Kwangmeyung Kim

ABSTRACT Photodynamic therapy (PDT) offers an effective and minimally invasive approach to cancer treatment; however, its efficacy is intrinsically constrained by limited light penetration, which fails to target deep tumor tissues, and treatment‐induced hypoxia arising from the reduction in intratumoral oxygen levels. Here, we report an injectable optoelectronic probe integrating microscale light‐emitting diodes (microLEDs) to enable low‐frequency metronomic PDT (mPDT), together with a microLED–photodetector system …

10.08.2026journal-article

Frontiers in Pharmacology

Cost-effectiveness analysis of triplet therapy of encorafenib, binimetinib, and cetuximab for treatment of metastatic BRAF V600E-mutated colorectal cancer in China

Mengmeng Liu, Tong Liu

Background This study evaluates the cost-effectiveness of triplet therapy of encorafenib, binimetinib, and cetuximab in contrast to doublet therapy of encorafenib and cetuximab or a control group of cetuximab plus FOLFIRI as second-line or subsequent treatment for advanced or metastatic colorectal cancer (mCRC) patients with BRAF V600 E mutation-positive status in China. Methods An economic evaluation using a 3-state partitioned survival model assessed the cost-effectiveness of triplet therapy versus doublet therap …

10.08.2026journal-article

Jurnal Pendidikan Teknik Mesin

BIOMECHANICAL SENSITIVITY OF A THREE-IMPLANT MANDIBULAR REHABILITATION MODEL UNDER ORTHOTROPIC BONE PROPERTY VARIATIONS: A 3D FINITE ELEMENT STUDY

Alifian Bagas Saputra, Kriswanto, Septian Eko Cahyono, Jamari, Athanasius Priharyoto Bayuseno, Dhiaulhaque, Hastaka Juan Pratama Putra

Achieving clinical effectiveness depends on an awareness of the mechanical features of implanted supported mandibular prosthesis. This study used three-dimensional finite element analysis to assess how sensitive a three-implant mandibular arrangement is to changes in the properties of cortical and cancellous bone. Using Ti-6Al-4V material, implants were shown; the bone was defined with orthotropic linear-elastic properties. Young's modulus and shear modulus were systematically changed by 5–15%. Under a 100 N axial …

10.08.2026journal-article

Cancers

The Influence of the Central Metal (Zn) in the Porphyrin Skeleton on the Mechanism Induced by Photodynamic Therapy

Rostyslav Marunych, Dorota Bartusik-Aebisher, Barbara Smolak, Klaudia Dynarowicz, David Aebisher

This review analyzes how Zinc(II) coordination alters the electronic configuration of porphyrin-based photosensitizers to optimize reactive oxygen species (ROS) generation and subcellular targeting in photodynamic therapy (PDT). By focusing on the structural design principles that govern excited-state behavior, the work moves beyond clinical descriptions to provide a mechanistic understanding of how engineered metalloporphyrins can achieve precise tumor destruction. When these engineered metal porphyrins are expose …

10.08.2026journal-article

Journal of College of Education

<b>تعرض المراهقين لمواقع التواصل الاجتماعي والاخبار الزائفة في مواقع التواصل الاجتماعي</b> <b>وتأثيرها على انتشار خطاب الكراهية والتطرف لدي المراهقين</b>

م.م. بسام كريم زيدان

هدفت هذه الدراسة إلى تحليل تأثير الأخبار الزائفة المنتشرة عبر مواقع التواصل الاجتماعي على انتشار خطاب الكراهية والتطرف لدى المراهقين. وتسعى إلى تحديد العوامل التي تسهم في انتشار الأخبار الزائفة بين هذه الفئة العمرية. وأعتمدت الدراسة على المنهج الوصفي التحليلي، حيث تم جمع البيانات باستخدام استبيان وُزّع على عينة عشوائية مكونة من 250 مراهقًا تتراوح أعمارهم بين 13 و18 سنة، ممن يعتمدون على مواقع التواصل الاجتماعي كمصدر رئيسي للمعلومات. واشتمل الاستبيان على أربعة محاور رئيسية: المعلومات الديموغرافية، مقياس التعرض للأخبا …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Финансовые последствия ухудшения качества рекреационных вод Черноморского побережья для санаториев климатобальнеологического профиля Большого Сочи

А. А. Бакулина, И. Ю. Ильина, Л. В. Адамская, В. Э. Комов, И. А. Бартошевич

Introduction: The Black Sea coast of Greater Sochi is the largest climate-balneological cluster in the Russian Federation, generating over 26 billion rubles in annual revenue from health resort organizations. The accident involving the tankers Volgoneft-212 and Volgoneft-239 in the Kerch Strait in December 2024, resulting in a spill of approximately 4,000 tonnes of fuel oil, highlighted the financial vulnerability of health resorts operating under conditions of systematically declining recreational water quality. M …

10.08.2026journal-article

Frontiers in Pharmacology

Cost-effectiveness of targeted therapy versus chemotherapy for patients with advanced or metastatic gastric cancer in China

Kehui Meng, Meiyu Wu, Andong Li, Zixuan Zhang, Yangke Yi, Chaohao Shi, Xiaomin Wan, Chongqing Tan, Hao He

Background Multi-biomarker testing increasingly guides first-line therapy for advanced or metastatic gastric cancer in China, but its economic value is uncertain. Methods We conducted a Chinese healthcare payer–perspective cost-effectiveness analysis comparing a testing-guided pathway with No-testing, using a hybrid decision tree plus three-state Markov model for a 1,000-patient cohort over 10 years. Results Testing-guided care increased costs by $64,242.13 and quality-adjusted life years (QALYs) by 0.63, yielding …

10.08.2026journal-article

Frontiers in Oncology

Rezvilutamide combined with ADT in an HIV-positive patient with high-volume mHSPC on efavirenz-based antiretroviral therapy: a case report

Heng Zhang, Tailin He, Zhiyuan Li, Yujie Gao, Yan Li, Yundie Zhou, Haifeng Wang

This case report describes a patient with metastatic hormone-sensitive prostate cancer (mHSPC), high tumor burden, and concurrent HIV infection receiving continuous efavirenz (a potent CYP3A4 inducer), who was treated with an intensified regimen based on androgen deprivation therapy (ADT) combined with the novel androgen receptor inhibitor rezvilutamide. Under rigorous multidisciplinary monitoring, this regimen achieved a rapid and profound response, characterized by a decline in prostate-specific antigen (PSA) lev …

10.08.2026journal-article

Gestión en Salud y Seguridad Social

Medicina laboral: una ciencia en el contexto actual

Laura Isabel Mata Jiménez

De acuerdo con la Organización Mundial de la Salud (OMS), el hospital forma parte de una organización médica y social, cuya misión consiste en proporcionar a la población asistencia sanitaria completa, tanto curativa como preventiva, con proyección hacia el ámbito familiar, además de contribuir con la formación del personal sanitario y la investigación biosocial.