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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Frontiers in Nutrition

Effects of resistance training combined with creatine supplementation on muscle strength, physical function, and muscle mass in older adults: a systematic review and three-level meta-analysis

Lingzi Yao, Doudou Yang, Jiajia Gao

Objective To systematically evaluate the additional effects of creatine supplementation combined with resistance training, compared with resistance training alone, on muscle strength, muscle mass and physical function in older adults. Methods PubMed, Embase, the Cochrane Library and Web of Science were searched from inception to 20 May 2026. Randomized controlled trials enrolling older adults aged 60 years and older and comparing creatine supplementation plus resistance training with resistance training alone or pl …

25.08.2026journal-article

Geriatrics

Novel Hypothesis on Phase Angle as a Candidate Marker Associated with Physiological Reserve in Geriatric Patients in Long-Term Care

Alejandro Padilla Isassi, Rosalba Maya Hernández, María Elisa Otero Cerdeira, Ingrid Alejandra Abarca Salinas

Background: Physiological reserve reflects the capacity of the organism to maintain homeostasis under biological stress. We suggest the hypothesis that phase angle derived from bioelectrical impedance analysis could be a potential objective marker of Physiological reserve. Methods: An analytical cross-sectional study was conducted in 45 older adults residing in long-term care units at Hospital Español de México (2025). Frailty was assessed with the FRAIL index, sarcopenia using EWGSOP2 criteria, functionality with …

25.08.2026journal-article

BMC Geriatrics

Multidisciplinary prognostic accuracy in severe frailty: assessing short-term survival predictions in hospitalized older adults

Elena Pinardi, Simona Umidi, Beatrice Tonus, Jacopo Usai, Alice Margherita Ornago, Maria Cristina Ferrara, Alberto Finazzi, Chukwuma Okoye, Paolo Mazzola, Gianlorenzo Scaccabarozzi, Giuseppe Bellelli

Abstract Background The increasing number of hospitalized older adults with severe frailty and limited life expectancy highlights the need for accurate short-term prognosis to inform care planning, effective communication, and resource allocation. However, survival prediction in this population is underexplored. This study aimed to assess (i) agreement among healthcare professionals on short-term prognosis, (ii) predictive accuracy of multiprofessional survival estimates, and (iii) factors affecting prognostic accu …

25.08.2026journal-article

Frontiers in Medicine

Older adult patients with out-of-hospital pressure injuries: a single-center retrospective study in a tertiary hospital in China

Hongling Sun, Caiyun Xu, Yan Sun, Hui Wang, Shuyan Li, Jinping Xia

Background To investigate the prevalence and clinical characteristics of pressure injuries (PIs) present at hospital admission among older adult patients, and to identify factors influencing healing outcomes through a single-center retrospective analysis. The goal is to inform nursing strategies for PI management in older adults. Methods Data were retrieved from a self-developed pressure injury prevention and management platform at a tertiary hospital in Zhejiang Province. Patients aged ≥60 years admitted between J …

25.08.2026journal-article

Dementia

Studying What Matters: South Texas Community-Driven Dementia Research Priorities

Sara S. Masoud, Juana Escareño, Belinda Flores, Byeong Yeob Choi, Karla Daniela Lopez Lorenzo, Shanae L. Rhodes, Quetzaly Zenil, Carole L. White

South Texas has among the highest dementia prevalence rates in the United States, yet communities in the region remain consistently underrepresented in dementia research. Aligning research studies with what matters to communities most impacted by dementia is critical in addressing the crisis of research exclusion. This participatory study sought to identify community-driven dementia research priorities grounded in the experiences and needs of South Texas residents impacted by dementia. A two-year community-engaged …

25.08.2026journal-article

Advanced Science

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang

ABSTRACT Repairing peripheral nerve injury remains a clinical challenge due to its limited regenerative capacity and the situation is further compounded with age. In this study, we identified the dysregulated repair program of Schwann cells (SCs) as a key feature of the aging‐dependent impairment of nerve regeneration, mediated by dual influence of ferroptosis. The ferroptosis‐stressor‐rich microenvironment inhibits SC function in regenerating nerves. Moreover, the persistent intracellular ferroptosis stressor accu …

25.08.2026journal-article

JURNAL ILMIAH LIVING LAW

Assessing Local Elections in Indonesia by Regional Representative Councils and Local Elections by the People

Hanif Hardianto, Nina Farliana

This article examines the dynamics of the legal–political framework governing local elections in Indonesia by situating the debate between direct elections by the people and indirect elections through Regional People’s Representative Councils (DPRD) within the perspective of constitutional democracy. This study employs a qualitative juridical-normative research method with a descriptive-analytical approach, relying on the analysis of statutory regulations, Constitutional Court decisions, and relevant legal and poli …

25.08.2026journal-article

Frontiers in Medicine

Comparative effectiveness and dose–response relationship of exercise-based interventions for muscle mass in older women with sarcopenia: a systematic review and network meta-analysis

Xinyi Gou, Junhui Zhu, Xinmiao Feng, Dongze Li, Qi Gao, Bin Ruan

Background Exercise and nutrition are the principal non-pharmacological strategies for sarcopenia, but the relative effects of different exercise combinations and the dose required to improve muscle mass in older women remain uncertain. This study compared exercise-based interventions and examined the dose-response relationship. Methods PubMed, Web of Science, Embase, the Cochrane Library, and EBSCO were searched from inception to 1 July 2026. Eligible trials enrolled women aged ≥ 60 years female with sarcopenia. R …

25.08.2026journal-article

Journal of Social Science and Humanities

Uncertainty Regarding Access to Justice for Rural People: The Perspective of Salish and Village Courts

Sanjida Mostafiz

Rural people in Bangladesh face various obstacles in the justice system, from the primary justice system to the formal level, such as arbitration. Although the establishment of the rule of law is an expected aspect of a modern state system, the suffering of ordinary people at various stages of the legal process is endless. And the level of suffering is even greater among rural people. Ordinary people in villages are accustomed to the informal justice system in this country. The article highlights why people resort …

25.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

INTERFAITH COLLABORATION AND HUMAN RIGHTS IN WELCOMING VULNERABLE PEOPLE: FOUNDATIONS AND PERSPECTIVES OF THE TOCA PROJECT

Elizandro Poletto, Elson Santos Silva

This study analyzes interreligious cooperation as a strategy for welcoming, protecting, and promoting the human rights of people experiencing social vulnerability. It assumes that religious organizations and faith-based initiatives play an important role in building solidarity networks, particularly in contexts marked by poverty, exclusion, migration, lack of protection, and weakened social ties. The study discusses the legal and social foundations of such action, considering human dignity, equality, religious free …

25.08.2026journal-article

Indoor and Built Environment

The impact of the community life circle on the quality of life of older adults based on a structural equation model

Jingyu Yu, Nianzhang Mao, Guixia Ma, Mei-yung Leung

With the intensification of population aging in China, the community life circle (CLC), as an important planning model for enhancing the quality of life (QoL) of older adults, has garnered increasing attention. This study thus aims to investigate the complex impact of various CLC components on the QoL of older adults through a large-scale questionnaire survey. This study designed a structured questionnaire to investigate the complex relationships between CLC components and QoL domains from the perspective of older …

25.08.2026journal-article

Physiotherapy Quarterly

A randomized controlled trial assessing the impact of Pilates exercise on the static and dynamic balance ability and balance confidence of geriatric individuals aged 60–69 years: preliminary study

Li Jiang, Archrawadee Srijaroon, Yada Thadanatthaphak

Introduction This study aims to investigate the effect of Pilates exercise on static and dynamic balance abilities, as well as balance confidence, in elderly individuals aged 60 to 69 years following a 12-week Pilates exercise intervention. Methods The 43 participants were recruited from the Chongqing Hongshan Community Elderly Care Service Center, China. They were randomly assigned to the control group (22 persons) and the experimental group (21 persons). The experimental group spent 12 weeks performing specially …

25.08.2026journal-article

Psychology International

Contextual Adaptation of Psychological Interventions for Common Mental Health Conditions in Young People in Low- and Middle-Income Countries—A Systematic Review

Concilia Tarisai Bere, Melanie Amna Abas, Crick Lund, Claire van der Westhuizen

Adapting psychological interventions from High-Income Countries (HICs) to Low- and Middle-Income Countries (LMICs) is often needed because developing new treatments requires significant resources. Contextual adaptation improves acceptability, practicality, and effectiveness in diverse settings. However, few studies clearly describe the frameworks guiding these adaptations. Our review examined the literature on conceptual and procedural frameworks for culturally adapting psychological interventions aimed at youth de …

25.08.2026journal-article

Brain Sciences

Online Comprehensive Care Therapy Complementary Program Improves Quality of Life in People with Parkinson’s Disease

Diego Santos García, Pablo Campo Prieto, Carmen M. Breijo García, Lucía Dafonte Gil, Juan Pereiro Nogueira, Jessica Blanco López, Francisco Doblas

Objectives: Non-pharmacological therapies are a cornerstone of Parkinson’s disease (PD) treatment, but there is not enough evidence of their benefit when delivered altogether online. Our objective was to analyze the efficacy and safety of an online comprehensive care therapy program (OL-CCTP) in people with PD (PwP). Material and methods: This was a proof-of-concept experimental, prospective, 6-month interventional study comparing a PD treatment group (PwP-T) with a control group (PwP-C). The OL-CCTP included group …

25.08.2026journal-article

Alzheimer Disease & Associated Disorders

Discordance Between Cognitive Impairment Status and Claims-Based ADRD Diagnosis

Min Hee Kim, Lisandro D. Colantonio, M. Maria Glymour, Rita Hamad, Julia Adler-Milstein, Kiarri N. Kershaw, John Boscardin, Zhixin Wang, Ayse Sert Oti, Virginia J. Howard

Introduction: Understanding the concordance between incident cognitive impairment status and the diagnosis of Alzheimer disease and related dementias (ADRD) is clinically important, as a diagnosis serves as the gateway for treatment, care planning, and supportive services. Methods: Using the REGARDS cohort (2006 to 2021) linked to Medicare claims, we examined the discordance between incident cognitive impairment and claims-based ADRD diagnoses. Directly standardized diagnosis rates were estimated by year, overall, …

25.08.2026journal-article

Экономика и управление: научно-практический журнал

Прекаризация как сдерживающий фактор развития человекоориентированной экономики

Е.И. Янгирова

Актуальность темы исследования обусловлена развитием идеи человекоориентированной экономики. Целью статьи выступает выявление дихотомии между процессом прекаризации на российском рынке труда и целевым ориентиром экономической системы, в основу которой положен человеко-центричный принцип. Выявлено, что растущие масштабы российской прекаризации противоречат базовым принципам человеко-ориентированной экономики, что требует незамедлительного вмешательства государства по снижению данного явления. The relevance of the re …

25.08.2026journal-article

Aging Cell

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR /Ca 2+ Signaling

Han Li, Zhen Yang, Wukaiyang Liang, Jie Huang, Tianyi Ji, Hao Nie, Zixin Wan, Yuqi Qiu, Yi Huang, Le Zhang, Cuntai Zhang, Jinhua Yan

ABSTRACT DNA damage is considered one of the major contributors to aging. DHCR24, a multifunctional enzyme located within the endoplasmic reticulum (ER), is closely related to DNA damage. Our previous study showed that DHCR24 could delay vascular endothelial cells (ECs) senescence. The relationship between DHCR24 and DNA damage during ECs senescence requires further investigation. Here, we demonstrate that aging activates ATM‐mediated DNA damage response (DDR) in human umbilical vein endothelial cells (HUVECs) and …

25.08.2026journal-article

PLOS One

Career and education outcomes among people who acquired HIV perinatally and received care at two tertiary care hospitals in Bangkok, 2014–2020

Rangsima Lolekha, Piyarat Suntarattiwong, Vitharon Boon-yasidhi, Yossawadee Na-Nakorn, Yuitiang Durier, Warunee Punpanich Vandepitte, Sanny Chen Northbrook, Chuenkamol Sethaputra, Wanatpreeya Phongsamart, Vorapathu Thaineua, Kulkanya Chokephaibulkit, on behalf of the Happy Teen Working Group

Background People born with HIV who receive antiretroviral treatment (ART) are living longer. Data on long-term education and employment among people who acquired HIV perinatally (PAHP) remain limited. We report on the education, employment status, and health outcomes of PAHP attending two tertiary care centers in Bangkok. Methods PAHP ≥14 years of age attending two tertiary care centers in Bangkok were enrolled and participated in the Happy Teen 2 program (HT2), a long-term follow-up comprehensive hospital-based i …

25.08.2026journal-article

Geriatrics & Gerontology International

Impact of Frailty on Activities of Daily Living in Hospitalized Older Adults: A Systematic Review and Meta‐Analysis

Tomohiko Kamo, Ryoma Asahi, Yasuko Inaba, Isao Uno, Naoto Kamide, Masato Azami, Hirofumi Ogihara, Shota Hayashi, Takeshi Kera

ABSTRACT Aim To determine whether frailty is associated with activities of daily living (ADL) and other clinical outcomes in hospitalized older adults. Methods MEDLINE, Embase and CENTRAL were searched for English‐language cohort studies published from 1 January 2001 to 23 October 2025. Eligible studies included hospitalized adults aged ≥ 65 years (or samples with ≥ 80% aged ≥ 65 years), used a defined frailty measure and compared frail with non‐frail participants. Two reviewers independently selected studies, extr …

25.08.2026journal-article

International Journal of Environmental Research and Public Health

Functional Fitness and Objectively Measured Movement Behaviors in Relation to Arterial Stiffness in Older Adults: Age Emerges as the Only Independent Correlate After Multivariable Adjustment

Adjane Maria Pontes César, Edmar Lacerda Mendes, André Pereira dos Santos, Alynne Christian Ribeiro Andaki, Jessica Cordeiro, Jorge Mota, Paulo Farinatti, Joana Carvalho

Background: Central arterial stiffness assessed by carotid–femoral pulse wave velocity (PWVc-f) strongly predicts cardiovascular risk. We examined associations of objectively measured physical activity, sedentary behavior, and functional fitness with PWVc-f in community-dwelling older adults. Methods: The study included 170 older adults (124 women; 64–91 years). Moderate-to-vigorous physical activity (MVPA) and sedentary behavior were assessed by accelerometry, functional fitness by the Fullerton Functional Fitness …

25.08.2026journal-article

Journal of Applied Gerontology

Factors Associated With Caregiving Burden and Psychological Distress Among Family and Unpaid Caregivers With Cardiovascular Conditions Caring for Older Adults

Kyeung Mi Oh, Yeonsu Song

This study examined factors associated with caregiving burden and psychological distress among informal caregivers with cardiovascular conditions (CVC). A secondary analysis of the 2024–2025 National Health and Aging Trends Study and National Study of Caregiving included 792 community-dwelling older adults and their caregivers with CVC. In the regression on caregiver burden, higher burden was linked to female gender, younger age, leg strength and low energy limitations, sleep disruptions, greater negative emotion, …

25.08.2026journal-article

Nutrients

Effects of a Combined Vitamin D3 and Docosahexaenoic Acid Intervention on Cognitive Function and Blood Pyroptotic Biomarkers in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized, Double-Blind, Placebo-Controlled Trial

Jing Yuan, Ruifang Yang, Hui Chen, Huichao Zhao, Xuan Chen, Ziyan Lou, Xinze Han, Fei Ma

Background: This study aimed to assess the effects of a combined vitamin D3 (VD3) and docosahexaenoic acid (DHA) intervention on cognitive function and blood pyroptotic biomarkers in older adults with mild cognitive impairment (MCI). Methods: In total, 360 participants with MCI were recruited, and randomly assigned into four groups: VD3 (800 IU/day), DHA (1 g/day), VD3+DHA (VD3 800 IU/day+DHA 1 g/day), and placebo. Cognitive function was evaluated by the Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC), …

25.08.2026journal-article

PLOS One

Factors associated with death coping ability among geriatric nurses and development of culturally sensitive death education interventions

Shixiu Liu, Zhijing Li, Yujun Wang, Wenjing Xie

Background As population aging accelerates, the demand for high-quality end-of-life care for older adults continues to increase. Nurses’ death coping ability is essential to the delivery of compassionate end-of-life care and to the maintenance of nurses’ psychological well-being. However, in cultural contexts where death is often considered a taboo topic, limited evidence is available regarding geriatric nurses’ death coping ability, its associated factors, and appropriate strategies for death education. This study …

25.08.2026journal-article

JOURNAL OF COMPARATIVE RESEARCH IN ANTHROPOLOGY AND SOCIOLOGY

Book Review: Lareau, Annette. (2021). Listening to People: A Practical Guide to Interviewing, Participant Observation, Data Analysis, and Writing It All Up. Chicago: University of Chicago Press.

Gabriel Jderu

I discovered Annette Loreau’s book right at the University of Chicago Press booth at the 2025 Annual Meeting of the American Anthropological Association. This prestigious academic press has a renowned collection of textbooks on social science research methods aimed primarily at students, graduate students, and professors, which it continually expands with new titles. The book is written as a conversation between the author and a student, but without the off-putting style of a textbook. Written predominantly using t …