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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

ACTA MEDICA IRANICA

Reducing Pain in the First Stage of Labour Using Counter-Pressure Therapy in the Indonesian Hospital

Sri Rejeki, Satriya Pranata, . Machmudah, Arief Yanto, Lalu Muhammad Irham, Tri Hartiti, Aric Vranada

Inadequately managed labor pain can negatively impact the birthing process. Potential adverse effects of labor pain include stress, fatigue, impaired breathing patterns, inhibited oxytocin production, psychological distress, and an increased risk of medical interventions. Counter-pressure is a safe nursing intervention used to alleviate labor pain. This study aimed to determine the effect of counter-pressure on intrapartum maternal pain. A pre-experimental, one-group pretest-posttest design was utilized, focusing o …

26.08.2026journal-article

Buildings

Artificial Intelligence for Structural Condition Assessment and Rehabilitation: Recent Advances and Future Directions

Shima Zare, Mohammad Najafi

The growing need to ensure the safety, resilience, and sustainability of existing building structures has accelerated the adoption of artificial intelligence (AI) for structural condition assessment and rehabilitation. This critical narrative review synthesizes 82 retained sources, including 33 application-oriented sources, through a transparent, structured literature search and study-selection process; it is not a formal systematic review or meta-analysis. To organize this fragmented evidence base, the review intr …

26.08.2026journal-article

Journal of Cancer Research and Therapeutics

Advances and future perspectives in the treatment of small cell lung cancer: From chemotherapy and radiotherapy to the era of targeted therapy and immunotherapy

Xiangwei Cheng, Weibin Lv, Linfeng Wu, Yifan Wang, Yiping Zhu

ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignant tumor that mainly originates from pulmonary neuroendocrine cells and is characterized by rapid proliferation, high metastatic potential, and acquired therapeutic resistance. The therapeutic landscape for SCLC is largely confined to traditional modalities, such as surgery and chemoradiotherapy. However, 80–85% of patients are diagnosed with extensive-stage SCLC at initial presentation; surgical intervention and radiotherapy are often not applicable fo …

26.08.2026journal-article

Frontiers in Medicine

ChatGPT-generated rehabilitation programs in sports physiotherapy: an expert evaluation and a mixed-methods study of clinical applicability

Adem Cali, Mehmet Erdem Yorukoglu, Gorkem Acar, Ertugrul Safran

Background Individualized rehabilitation supports safe return to sport, yet clinical workload may limit personalized program design. This study evaluated ChatGPT-4.1-generated programs for five sports injury scenarios using a structured rubric scored by two independent sports physiotherapy experts and examined inter-rater reliability and clinical applicability. Methods Mixed-methods design combining rubric scoring with deductive qualitative content analysis of expert commentary. Five cases covered muscle (hamstring …

26.08.2026journal-article

Journal of Clinical Oncology

Medical Therapy for Hormone Receptor-Positive, HER2-Negative Stage I-III Breast Cancer: ASCO Living Guideline, Version 2026.1.0

Jennifer L. Caswell-Jin, Mark R. Somerfield, Muhammad Ali Khan, Gretchen G. Kimmick, Shilpi Gupta, Kara Kenan, Namrata Peswani, Dawn L. Hershman, Brenda J. Ernst, Brittany E. Harvey, Gregor Krings, Nicholas P. McAndrew, Irbaz Bin Riaz, Ines Vaz-Luis, Cynthia Villarreal-Garza, Japneet Kaur Oberoi, Muhammad Hussnain Sadiq, Huan He, Ramaa Chitale, Michael J. Hassett

PURPOSE To provide recommendations on use of medical therapies for patients with stage I-III hormone receptor-positive, HER2-negative breast cancer. METHODS An Expert Panel including patient representation completed a systematic review of the evidence and formulated recommendations for practice. Eligible studies included patients with stage I-III hormone receptor-positive, HER2-negative breast cancer and evaluated neoadjuvant or adjuvant chemotherapy, endocrine therapy, immunotherapy, or targeted therapy. Outcomes …

26.08.2026journal-article

Linguistics Vanguard

Smiles can be conveyed to listeners via speech signals: a case study with Japanese labiodentalization

Shigeto Kawahara, Kimi Akita, Zen Nagatsuka, Julián Villegas

Abstract One long-standing question in speech communication research concerns the extent to which an emotional state is encoded in the acoustic signal and conveyed to the listeners. To address this question, we deployed a recent finding in Japanese, in which speakers replace bilabial sounds (e.g. [b]) with labiodental sounds (e.g. [v]) when speaking with a smile. Experiment 1 used stimuli recorded by two professional voice actors under four conditions crossing two factors, voice quality (smile vs. non-smile) and ar …

26.08.2026journal-article

Frontiers in Neurology

Clinical presentation and engagement with a cognitive rehabilitation clinic in individuals reporting anomalous health incidents

Kelly Marshall, Katherine Sullivan, Louis M. French

Introduction The Department of Defense is working to establish effective rehabilitative management options for individuals who have experienced Anomalous Health Incidents (AHI). Methods This retrospective, observational study conducted at Walter Reed National Military Medical Center describes the clinical presentation of forty patients (21 female and 19 male; mean [SD] age, 43.3 [9.2] years) with reported AHI. It also describes the application of a cognitive training intervention, its utilization, patient satisfact …

26.08.2026journal-article

PLOS One

Implementation of objective structured clinical examination among midwifery and nursing educators at South and Central Region Universities in Ethiopia, 2023

Zerihun Demessie Dilebo, Bekana Fekecha Hurissa, Kebenesa Angasu Kitaba

Introduction The Objective Structured Clinical Examination (OSCE) is a well-known clinical skill evaluation tool that has been applied worldwide to teach and assess learners’ competencies in healthcare disciplines. Poor implementation of OSCE can lead to inaccurate assessments and ultimately result in the production of incompetent professionals. However, there is no evidence of the implementation status and factors that limit the much-needed OSCE practice in the study area. Objective To assess OSCE implementation a …

26.08.2026journal-article

Frontiers in Oncology

Minimal residual disease guides postoperative therapy in a patient with ALK-rearranged adenocarcinoma: a case report

Xinghong Xian, Ke Wang, Liwen Wang, Hua Ke

This case report explores the role of circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) monitoring in predicting tumor recurrence or metastasis after consolidative surgery in a patient with ALK-rearranged non-small cell lung cancer (NSCLC). We present a case of a 43-year-old female patient with stage IVA ALK-rearranged NSCLC who initially responded to six months of Alectinib targeted therapy, underwent consolidative surgery with postoperative pathology confirming complete response in the resected p …

26.08.2026journal-article

Frontiers in Immunology

Advancing precision tacrolimus therapy: a systems genetics dissection in BXD platform

Wei Zhou, Xin-Bo Wang, Yu-Wei Guo, Bing Hu, Zi-Xuan Wang, Yu Xiong, Xuan-Ming Chen, Bo-Yang Xu, Xiao-Xing Wang, Xiao-Xue Wang, Fei-Fei Han, Jun-Jie Wang, Hao-Jun Zhang, Liang Peng, Li-Li Gong, Lu Lu, Li-Hong Liu

Background Tacrolimus is a core immunosuppressant in organ transplantation, but its narrow therapeutic window and significant pharmacokinetic variability hinder precision dosing. Although CYP3A5-guided strategies have established clinical relevance for tacrolimus initial dose adjustment, they do not fully account for the marked interindividual variability in tacrolimus exposure, highlighting the need for complementary models to decode more complex genetic regulation. This study aimed to identify candidate genetic m …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

New import-substituting technology for obtaining cellular plasma therapy drugs

Iurii V. Parakhin, German V. Neustroev, Mikhail V. Parshikov, Nikolai V. Jarigin, Tatiana G. Kuzbaseva, Mikhail V. Govorov

In recent decades, autologous cellular plasma therapy (ACPT) has become a promising method for treating musculoskeletal diseases due to the ability of activated blood cells to secrete growth factors, anti-inflammatory and analgesic cytokines. However, the high cost of foreign consumables and equipment limits the availability of therapy. Study of a new domestic technology for obtaining plasma preparations (L-PE) and its comparison with the foreign RegenLab (RL) technology in terms of production methods, activation m …

26.08.2026journal-article

Frontiers in Endocrinology

Efficacy of endometrial microbiota testing-guided personalized therapy in infertile women stratified by CD138 status: a retrospective cohort study

Fang He, E’Nuo Peng, Jiao Lin, Zhuo Mao, Xiaowei Lu, Hui Xu, Lei Guo, Yangyun Zou, Jing Wang, Sijia Lu, Xianghong Huang

Background Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium associated with infertility. Current diagnosis relies on histopathological markers like CD138, which may not fully assess the functional state of the endometrial microenvironment. This study aimed to investigate whether the endometrial microbiome test (EMT) combined with personalized therapy could improve pregnancy outcomes in infertile women undergoing IVF, compared with standard management based on CD138 results. Method …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Effects of a neuromuscular exercise program on lower limb alignment and balance ability in individuals with genu varum and knee pain

Hyung-Hoon Moon, Sung-Ki Lee, Jeong-Ha Lee, Sang-Seo Park, Sang-Min Lee, Won-Moon Kim, Yong-Gon Seo

This study examined the effects of a neuromuscular exercise program on knee joint alignment, pain, and static and dynamic balance in pa-tients with genu varum. Forty female patients aged 40–60 years with ra-diographically confirmed genu varum and a Short-Form McGill Pain Questionnaire (SF-MPQ) score ≥18.0 were randomly assigned to either an exercise group (EG, n=20) or a control group (CG, n=20). The EG participated in a supervised neuromuscular exercise program 3 times per week for 12 weeks (60 min/session), while …

26.08.2026journal-article

The Kaohsiung Journal of Medical Sciences

Pretreatment Prediction of Tumor Recurrence in Breast Cancer After Neoadjuvant Systemic Therapy Using Machine Learning With Clinical and CT Radiomics Features

Huei‐Yi Tsai, Jo‐Ching Wang, Wei‐Shiuan Chung, Jui‐Sheng Hsu, Shu‐Yen Lin, Ming‐Feng Hou, Ming‐Chung Chou

ABSTRACT This study aimed to develop machine learning models for predicting tumor recurrence in breast cancer before neoadjuvant systemic therapy (NST) by integrating clinical and radiomic features derived from pretreatment computed tomography (CT). We retrospectively enrolled 235 patients with 237 breast tumors who underwent contrast‐enhanced CT before NST. Datasets were randomly divided into five‐fold training and testing sets using semi‐random partitioning to ensure similar clinical characteristics between the t …

26.08.2026journal-article

Acta Psychiatrica Scandinavica

Patients Receiving 100 or More Electroconvulsive Therapy Treatments in a Nationwide Cohort

Masahiro Hata, Yuki Miyazaki, Shun Takahashi

Key Points Significant outcomes In this nationwide cohort, 1% of electroconvulsive therapy recipients received 100 or more treatments, representing an identifiable subgroup of electroconvulsive therapy recipients. Patients receiving 100 or more treatments had treatment durations of several years and substantially more psychiatric hospitalizations and cumulative hospitalization days, indicating prolonged and recurrent psychiatric care. Clozapine use increased across cumulative electroconvulsive therapy exposure cate …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Analysis of professional football players’ sprint performance efficiency in matches

Jeong-Hyun Shim, Chang-Hwa Joo

The purpose of this study is to analyze the efficiency of the high-intensi-ty exercise performances of professional players during matches. Thirty professional players competed in a total of 38 matches throughout the season. 1,558 sprint efforts were recorded and subsequently analyzed. The sprint efficiency assessment tool ensured good interrater reliability (intraclass correlation coefficient, 0.892; 95% confidence interval, 0.883–0.901) and the validity of the analysis was confirmed by four experts with more than …

26.08.2026journal-article

JAMA Network Open

Maternal Engagement in HIV Care and Antiretroviral Therapy Uptake Among Children Living With HIV

Jiawei He, Bricia Gonzalez Trejo, Kemal Sherefa Oumer, Amanda Movo, Simon I. Hay, Christopher J. L. Murray, Peng Zheng, Aleksandr Y. Aravkin, Jeffrey W. Imai-Eaton, Hmwe H. Kyu

Importance Children living with HIV (CLHIV) in sub-Saharan Africa have lower rates of antiretroviral therapy (ART) uptake and viral load suppression (VLS) than adults with HIV. The association of maternal engagement in HIV care with child VLS remains underexplored. Objective To estimate the prevalence of ART uptake and VLS among CLHIV, and to examine the association between maternal engagement in HIV care and key steps in the pediatric HIV care cascade. Design, Setting, and Participants This cross-sectional study w …

26.08.2026journal-article

Children

Propranolol as Salvage Therapy for Refractory Congenital Chylous Ascites in a Preterm Neonate: A Case Report and Review of the Literature

Nicoletta Menzella, Francesca Riitano, Simonetta Costa, Francesca Paola Fusco, Simona Fattore, Chiara Tirone, Francesca Stollagli, Giovanni Vento

Background/Objectives: Congenital chylous ascites is a rare neonatal condition characterized by the accumulation of lymphatic fluid within the peritoneal cavity. The disorder can be difficult to manage, as many infants show limited response to standard conservative strategies such as dietary modification and supportive care. Currently, no universally accepted therapeutic guidelines exist. We report the successful use of propranolol in the management of refractory congenital chylous ascites. Methods: Clinical data w …

26.08.2026journal-article

Frontiers in Medicine

Real-time LC-OCT monitoring of scalp hypertrophic actinic keratosis clearance following cryotherapy, laser, and 5-fluorouracil therapy

Giulio Bortone, Vincenzo Coppolelli, Luca Gargano, Francesca Svara, Mehdi Boostani, Steven Paul Nisticò, Giovanni Pellacani, Carmen Cantisani

Introduction Assessment of treatment response in hypertrophic actinic keratoses (hAKs) remains largely dependent on clinical examination and dermoscopy, although apparent clearance may not reflect complete resolution of imaging features associated with residual disease. Line-field confocal optical coherence tomography (LC-OCT) enables non-invasive, longitudinal visualization of epidermal, dermal-epidermal junction, and superficial dermal changes at near-cellular resolution. Objective To characterize LC-OCT response …

26.08.2026journal-article

Stem Cell Research & Therapy

GMP manufacturing, quality characterization, and GLP-based preclinical evaluation of human nasal turbinate–derived stem cells for the treatment of rheumatoid arthritis

Hyun Ji Lee, Jung Ho Jeon, Junwon Choi, Min Young Ahn, Ye Sol Park, Hyo Min Song, Seong Yeon Yoo, Youngjae Park, Seung-Ki Kwok, Sun Hwa Park, Sung Won Kim

Abstract Background Human nasal turbinate-derived stem cells (hNTSCs) are tissue-derived adult stem cells that are isolated from surgically discarded nasal turbinate tissue and exhibit robust proliferative capacity, and stable phenotypic properties. Unlike conventional MSCs, hNTSCs, although classified as tissue-derived adult stem cells, exhibit MSC-like phenotypes but display distinct gene expression patterns and functional properties that may be advantageous for indications of inflammatory and autoimmune disease. …

26.08.2026journal-article

International Journal of Laboratory Hematology

Myelodysplasia‐Related Gene Mutation Burden Is Associated With Complete Remission After Induction Therapy in Acute Myeloid Leukemia, Not Otherwise Specified: Reclassification According to the Updated Classifications

Taegeun Lee, Daehyun Chu, Miyoung Kim, Young‐Uk Cho, Sang‐Hyun Hwang, Je‐Hwan Lee, Yunsuk Choi, Eun‐Ji Choi, Ho Joon Im, Hyery Kim, Seongsoo Jang

ABSTRACT Introduction Updated classifications incorporating myelodysplasia‐related (MR) gene mutations reclassify many cases previously diagnosed as acute myeloid leukemia, not otherwise specified (AML, NOS). We evaluated the clinical significance of MR gene mutation burden, defined by mutation number and variant allele frequency (VAF), in AML, NOS. Methods We retrospectively reviewed adults diagnosed with AML, NOS who underwent next‐generation sequencing between 2018 and 2023. After excluding cases with KMT2A rear …

26.08.2026journal-article

Journal of Occupational & Environmental Medicine

VV-ECMO Support in Acute Respiratory Failure from Occupational Phosgene Gas Exposure: A Case Report

Mahmoud Elamin, Mays Tawayha, Wassim Mosleh, Harsh B. Jain, Xiao Jiantao, Stephen Downing, Craig Vitrano, Christopher J. Wilcox

A 56-year-old male with no antecedent respiratory disease developed acute respiratory failure following workplace exposure to phosgene gas (COCl₂), a toxic industrial compound known for its pulmonary toxicity. He developed refractory hypoxemia, was transferred to our facility, and was promptly placed on venovenous extracorporeal membrane oxygenation (VV-ECMO). The patient was successfully supported through the acute lung injury and recovery phase and was discharged from the hospital within 16 days without supplemen …

26.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Stimuli-responsive bioengineered platforms for precision cancer therapy

Hossein Omidian, Renae L. Wilson

Stimuli-responsive bioengineered platforms are redefining cancer therapy by shifting therapeutic design from systemic drug exposure toward context-dependent activation within malignant tissue. These systems are engineered to sense and respond to tumor-associated or externally applied cues, including acidic pH, redox imbalance, hypoxia, enzymatic activity, reactive oxygen species, temperature variation, light, ultrasound, and magnetic fields. Across the reviewed evidence, their principal value lies not merely in dru …

26.08.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Fu's Subcutaneous Needling Therapy Combined with Intra-Articular Injection of Hyaluronic Acid in Knee Osteoarthritis

Sujie Zhang, Xiaohong Mu

Objective This study investigated the effects of Fu's subcutaneous needling (FSN) combined with sodium hyaluronate (HA) intra-articular injection on knee function and inflammatory factor levels in patients with knee osteoarthritis (KOA). Materials and Methods A total of 122 patients with KOA were randomly assigned to an observation group (OG) or control group (CG). Outcomes included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), serum inflammatory cytokines, Lysholm Knee Scoring Scale (LKSS …