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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Medicine

Research progress of cerebroplacental ratio in obstetric complications

Xinran Bi, Ruotong Qi, Haiying Chen

Cerebroplacental ratio (CPR), defined as fetal middle cerebral artery pulsatility index (MCA-PI)/umbilical artery pulsatility index (UA-PI), quantifies intrauterine hemodynamic redistribution driven by the fetal brain-sparing response to placental insufficiency. With the advancement of ultrasonic technology and in-depth clinical research, CPR has been widely applied in early screening, condition assessment, prognosis evaluation and intervention guidance of various obstetric complications, especially showing unique …

27.08.2026journal-article

Frontiers in Medicine

Real-world safety profile of alectinib: a 10-year pharmacovigilance study based on the FDA adverse event reporting system

Le Zhang, DanDan Li, ChenJing Luo, Li Fan, Min Hu, Fei Ye, Peng Gu

Objective Alectinib is the standard first-line therapy for treatment-naïve ALK-positive non-small cell lung cancer (NSCLC). Given its increasing clinical utilization, a comprehensive pharmacovigilance evaluation of its adverse events (AEs) is warranted. Methods We assessed alectinib-associated AEs using the FDA Adverse Event Reporting System (FAERS) database from Q4 2015 to Q3 2025. AEs were categorized per MedDRA, and four disproportionality analysis algorithms were used to detect potential safety signals. Results …

27.08.2026journal-article

Frontiers in Medicine

Aggregate index of systemic inflammation and glaucoma status: population-based evidence with clinical validation

Songxin Yang, Li Li, Xianming Ouyang, Rui Zhang, Gang Lin, Sunkun Pan, Guiquan Xie, Zhen Lv, Dieran Huang, Guoyan Luo, Kunpeng Pang

Objective Glaucoma is a major cause of irreversible visual impairment, but evidence on the association between the aggregate index of systemic inflammation (AISI) and glaucoma remains limited, particularly with clinical validation. Methods We analyzed National Health and Nutrition Examination Survey (NHANES) data from participants aged 40 years and older. Weighted multivariable logistic regression models were used to examine the association between AISI and glaucoma. The primary outcome was composite glaucoma, defi …

27.08.2026journal-article

Frontiers in Medicine

Reduced heart rate variability is associated with disease severity in AL amyloidosis: a retrospective cohort study

Xiao-hang Pei, Su-qiong Zuo, Pan Zhou, Rong-jun Ma, Zun-min Zhu, Xiao-li Yuan

Background Autonomic nervous system involvement is common in systemic amyloidosis, yet the clinical relevance of heart rate variability (HRV) in immunoglobulin light-chain (AL) amyloidosis remains incompletely defined. Methods In this retrospective cohort study, 56 patients with biopsy-proven AL amyloidosis and 33 age- and sex-comparable healthy controls underwent 24 h Holter monitoring. Time- and frequency-domain HRV parameters were recorded. Associations of HRV with cardiac involvement assessed by cardiac magneti …

27.08.2026journal-article

The Canadian Journal of Chemical Engineering

A target‐adaptive latent‐temporal ensemble soft sensor for robust multi‐effluent quality prediction in full‐scale wastewater treatment plants

Toqeer Ahmed, Abid Aman, Zhenjun Ge, Yiqi Liu

Abstract Real‐time prediction of effluent quality is essential for stable wastewater treatment plant (WWTP) operation, but direct laboratory measurements of chemical oxygen demand (CODe), total nitrogen (TNe), and total phosphorus (TPe) are often delayed and discontinuous. This study proposes a target‐adaptive latent‐temporal ensemble soft‐sensing framework, named the hybrid latent‐temporal ensemble network (HEM‐Net), for simultaneous multi‐effluent quality prediction in a full‐scale wastewater treatment plant. The …

27.08.2026journal-article

Australian Health Review

Concordance of surveillance colonoscopy recommended intervals with Australian guidelines: a clinical audit in six Victorian public hospitals

Jonathan Foo, Corey Joseph, Alexandra Gorelik, Martin Hensher, Harriet Hiscock, Alison Hutchinson, Karin A. Thursky, Ralph Audehm, Andrew O'Loughlin, Grant Russell, Alan Moss, Elizabeth Hristov, Kumanan Nalankilli, Radha Nair, Anne Van Berkel, Sophie Ping, Jaclyn Bishop, Judi Debney, Kirsten Carr, Julianne Schultz, Denise A. O'Connor

Objective Appropriate intervals for repeat (surveillance) colonoscopy are important for early colorectal cancer detection and treatment, timely patient access, and minimising patient risks. This study aimed to assess the concordance of endoscopist-recommended surveillance colonoscopy intervals with those recommended by the 2018 Australian Cancer Council surveillance colonoscopy guidelines. Methods Three metropolitan and three rural public hospitals in Victoria, Australia, each retrospectively audited at least 35 co …

27.08.2026journal-article

Molecular Medicine

Short-chain fatty acids as key mediators of the microbiota–gut–brain axis in chronic cerebral hypoperfusion: mechanisms and therapeutic

Junchen Si, Peijian Wang, Zhongchen Li, Jiheng Hao, Jiyue Wang, Liyong Zhang

Abstract Chronic cerebral hypoperfusion (CCH) is an important contributor to vascular cognitive impairment and neurodegenerative disorders, characterized by neuronal injury, blood–brain barrier (BBB) disruption, neuroinflammation, mitochondrial dysfunction, and synaptic impairment. Increasing evidence suggests that the microbiota–gut–brain axis plays a crucial role in ischemic brain injury. CCH is associated with gut microbiota dysbiosis, intestinal barrier dysfunction, and reduced production of microbiota-derived …

27.08.2026journal-article

Frontiers in Pediatrics

Evaluating the effectiveness of an educational curriculum on physician comfort in screening and managing eating disorders in the outpatient pediatric setting

Xhesika Begaj, Elena Lorenzana, Stephanie Marcy, Colleen Kraft

Background Eating disorders are among the most prevalent chronic conditions affecting adolescents, yet remain underdiagnosed in outpatient pediatric settings. Physician discomfort with screening and management contributes to this gap, particularly in underserved communities. This study evaluated whether a structured educational curriculum paired with an EMR-integrated clinical decision support tool improves physician comfort with eating disorder screening and management, and increases screening behavior, in an outp …

27.08.2026journal-article

Clinical Science

Maternal gut microbiota–psychotropic drug interactions and their impact on offspring neurodevelopment

Ashlee M. Craig, Kelly J. Clemens, Sarah-Jane Leigh

Abstract Pregnancy is associated with a unique and dynamic gut microbiota profile that supports fetal growth and neurodevelopment. Psychotropic drug–gut microbiota interactions are documented in the general population, yet less well described in pregnant women. Research has independently linked both perinatal psychotropic exposure and alterations to the maternal gut microbiome with potential changes to offspring neurodevelopment; therefore, it is plausible that similar interactions occur during pregnancy where they …

27.08.2026journal-article

Frontiers in Surgery

Laryngeal transplantation: from experimental feasibility to multidisciplinary clinical reality

Lu Zeng, Longhao Wang

Laryngeal transplantation represents one of the most complex forms of vascularized composite allotransplantation (VCA), aiming to restore respiration, phonation, and swallowing in patients with irreversible laryngeal dysfunction. Over the past decades, systematic preclinical research—including refinement of large-animal and rodent models, organ preservation optimization, and elucidation of immunological mechanisms—has laid the scientific foundation for clinical translation. Advances in static cold storage, emerging …

27.08.2026journal-article

Advances in Anesthesia and Pain Medicine

Low-concentration dual-baricity thoracic segmental spinal anesthesia for laparoscopic cholecystectomy: a retrospective case series

Paolo Scimia, Massimiliano Luca D'Agostino, Antonio De Cato, Franco Marinangeli, Simone Cicconi, Riccardo Moretti, Federica Venturoni, Fabrizio Fattorini, Roberto Starnari, Domenico Pietro Santonastaso, Luca Gentili

Laparoscopic cholecystectomy (LC) is usually performed under general anesthesia (GA), which provides airway protection and optimal surgical conditions but may expose vulnerable patients to cardiopulmonary stress and other anesthesia-related adverse effects. Thoracic segmental spinal anesthesia (TSSA) may represent an alternative in selected patients. We evaluated the feasibility, safety, and perioperative outcomes of a low-concentration dual-baricity TSSA protocol for LC. This retrospective descriptive case series …

27.08.2026journal-article

Journal of Intensive Care Medicine

Development and Validation of an Interpretable Machine Learning Model for Predicting In-Hospital Mortality in Diabetic Patients with Sepsis-Associated Acute Kidney Injury

Yanni Wang, Hongjie Shen, Shengze Wu, Suibi Yang, Feng Guo, Min Yang, Zhongheng Zhang

Background Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, with poor prognosis. Diabetes may further increase adverse outcomes through infection susceptibility, immune dysfunction, and renal vulnerability. However, mortality prediction models for patients with diabetes complicated by SA-AKI remain limited. This study aimed to develop and validate a machine learning-based model for early in-hospital mortality prediction in this population. Methods A tota …

27.08.2026journal-article

Clinical Kidney Journal

Managing hyponatremia: fast or slow? why, when, how, and controversies

Kamel S Kamel, Ziv Harel, Martin Schreiber

Abstract Hyponatremia is the most common electrolyte disorder encountered in clinical practice. Its management is challenging because treatment must balance the risk of cerebral edema in acute hyponatremia against the risk of osmotic demyelination syndrome (ODS) from overly rapid correction of chronic hyponatremia. Recent observational studies have questioned current correction limits, prompting renewed debate regarding optimal management. This narrative review presents a physiology-based approach to the evaluation …

27.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Advancing Homologous Recombination Repair Mutation Testing in Prostate Cancer in Australia: Shifting the Focus to Hormone Sensitive Prostate Cancer

Arun A. Azad, Declan G. Murphy, Edmond M. Kwan, Anthony M. Joshua

ABSTRACT Homologous recombination repair (HRR) gene alterations are key drivers of disease in prostate cancer. This has led to great interest in HRR targeted therapies, particularly polyadenosine diphosphate‐ribose inhibitors (PARPi), in the treatment of metastatic castrate resistant prostate cancer (mCRPC). HRR alterations are typically early events in prostate cancer tumorigenesis. As a result, clinical trials are investigating the efficacy of PARPi therapy in metastatic hormone sensitive prostate cancer (mHSPC). …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Determinants of Treatment Adherence in Hepatitis C Patients in a Public Sector Setting in India

Sunvir Kaur Rai, Harpreet Singh, Simmi Oberoi, Amandev Singh, Rahul Bhargava

ABSTRACT. The National Viral Hepatitis Control Program has rapidly scaled hepatitis C virus (HCV) treatment. However, poor adherence and loss to follow-up have led to drug resistance, treatment failure, and increased healthcare costs. Given this background, the present study was conducted to evaluate the rate of loss to follow-up, assess adherence patterns to treatment, and identify factors associated with both of these among HCV patients. A prospective cohort study was conducted among 385 adult HCV patients at Gov …

27.08.2026journal-article

Molecules

Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies

Aleksandra Szychowska, Mikołaj Grabarczyk, Weronika Szczepańska, Ewa Smolińska, Andrzej Glabinski, Piotr Szpakowski

Polyphenols are a complex class of plant secondary metabolites that exert numerous beneficial effects on human health. The content of individual polyphenolic compounds varies considerably among plant species. Over the past few decades, polyphenols have attracted increasing interest because of their antioxidant and antimicrobial properties. They have also demonstrated beneficial effects in the prevention and treatment of various diseases, including cardiovascular and nervous system disorders, as well as different ty …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Predictors of the technical success of ultrasound-guided percutaneous transhepatic biliary drainage for biliary obstruction

Yun Song, Guang-Hai Chen, Lu Peng, Jian Du, Shu-Ming Tan

BACKGROUND Percutaneous transhepatic biliary drainage (PTBD) is a critical minimally invasive intervention for biliary obstruction, with technical success being a key determinant of clinical outcomes. AIM To identify and quantify the clinically modifiable factors predicting technical success of ultrasound-guided PTBD, and thereby to develop an evidence-based framework for procedural triage and standardization. METHODS A total of 263 ultrasound-guided PTBD procedures performed at three tertiary hospitals (2019-2024) …

27.08.2026journal-article

Journal of Pediatric Orthopaedics B

Radiological and clinical outcomes following pelvic support osteotomy with limb length equalization in children

Vikaas Ethanur Thuppale, Arulmurugan Arikrishnan, Jonathan Reddy, Abhay Gahukamble, Thomas Palocaren

Pelvic support osteotomy (PSO), when done in children, is subject to remodeling. This study aimed to assess the extent of remodeling at the osteotomy site and functional outcome post-PSO. A total of 28 patients were selected with a minimum follow-up of 2 years. PSO was combined with limb length equalization procedures including distal femoral lengthening, epiphysiodesis, or shoe raise, as indicated, because all patients had limb length discrepancy as part of their underlying pathology. The valgus osteotomy angle in …

27.08.2026journal-article

Frontiers in Public Health

Psychological capital, perceptions of clinical stressors, and bullying experiences among Chinese nursing students during clinical practice: a latent profile and mediation analysis

Fangfei Zhao, Hongchen Zhang, Ke Hui, Haixin Zheng, Zhihui He

Background Bullying experiences during clinical practice threaten nursing students' learning and professional development. However, existing studies mainly focused on variable-centered associations, with limited exploration of heterogeneous subgroups from a person-centered perspective. This study aimed to examine the mediating role of perceptions of clinical stressors (PCS) in the relationship between psychological capital (PsyCap) and bullying experiences, while identifying latent profiles of bullying experiences. …

27.08.2026journal-article

Arab Media Renewal Journal

معالجة الأزمات الإنسانية في الصحافة الرقمية المصرية والأمريكية: دراسة تحليلية مقارنة

شروق حسنين قاسم

استهدفت الدراسة رصد وتحليل معالجة الصحافة الرقمية الأمريكية والمصرية للأزمات الإنسانية، بالتطبيق على موقعَي «اليوم السابع» المصري، و»USA Today» الأمريكي، وذلك في إطار نظرية المسؤولية الاجتماعية، ونظرية المشاركة الديمقراطية. وقد اعتمدت الدراسة على استخدام منهج المسح، وأسلوب المقارنة المنهجية، بالاعتماد على استمارة تحليل المضمون لجمع بيانات الدراسة، التي شملت (603) موضوعًا صحفيًا إنسانيًا تم نشرها خلال فترتين زمنيتين مختلفتين، هما (يناير-أبريل 2017) و(يناير-أبريل 2022) بموقعي الدراسة.وأظهرت النتائج تقاربًا في الحجم ا …

27.08.2026journal-article

Healthcare

Regular AREDS2 Supplement Use in Age-Related Macular Degeneration: Factors Associated with Supplementation, Medication Adherence, and Patient-Reported Barriers

Hasan Öncül, Umut Dağ, Mehmet Fuat Alakuş

Background/Objectives: Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment, and AREDS2-based nutritional supplementation is recommended for clinically eligible patients to reduce the risk of disease progression. However, successful implementation depends on regular supplement use and sustained adherence. This study investigated demographic, socioeconomic, clinical, and physician-related factors associated with regular AREDS2 supplement use and evaluated medication adherence, …

27.08.2026journal-article

Neuro-Oncology

59 Early psychosocial support after a brain tumour diagnosis: a collaborative model between Southmead Hospital and Brain Tumour Support

Lucy Wilkinson, Emma McKeown

Abstract Introduction A pilot referral pathway between Southmead Hospital and Brain Tumour Support (BTS) was introduced to provide early psychosocial support to patients diagnosed with a brain tumour and their families. This evaluation assessed uptake, perceived value, and service impact. Method Over six months, 115 patients and family members were referred to BTS; 10 declined or did not respond. Referrals included newly diagnosed patients, individuals undergoing investigations and supporting relatives. Tumour type …

27.08.2026journal-article

Journal of Clinical Medicine

A Decade of Data from an IVF Center: Factors Contributing to Infertility, Their Prevalence, and Impact on Live Birth Rates

Hale Bayram, Yaprak Dönmez Çakıl, Belgin Selam, Mehmet Cıncık

Background: Infertility is increasingly recognized as a significant global public health concern. A thorough understanding of the diverse causes of infertility and their influence on treatment outcomes is essential for optimizing therapeutic strategies and improving success rates. Methods: In this study, we analyzed data from 9132 couples who underwent IVF treatment at a fertility center in Istanbul, Turkey, between 2010 and 2020. Results: Female factor infertility was the most prevalent among all participants (35. …

27.08.2026journal-article

American Journal of Hematology

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Samuel Urrutia, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine McMahon, Rory M. Shallis, Joshua F. Zeidner, Michael R. Savona, Shougat Barua, Namrata Sonia Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L. Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Parisa Abedi, Shai Shimony, R. Coleman Lindsley, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach

ABSTRACT Baseline IPSS‐M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo‐HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of response when adjusting for IPSS‐M risk and treatment strategy remains unclear. Hence, we used the VALIDATE database of the International Consortium for MDS (icMDS) to evaluate the impact of International Working Group (IWG) 2023 bes …