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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Journal of Occupational & Environmental Medicine

VV-ECMO Support in Acute Respiratory Failure from Occupational Phosgene Gas Exposure: A Case Report

Mahmoud Elamin, Mays Tawayha, Wassim Mosleh, Harsh B. Jain, Xiao Jiantao, Stephen Downing, Craig Vitrano, Christopher J. Wilcox

A 56-year-old male with no antecedent respiratory disease developed acute respiratory failure following workplace exposure to phosgene gas (COCl₂), a toxic industrial compound known for its pulmonary toxicity. He developed refractory hypoxemia, was transferred to our facility, and was promptly placed on venovenous extracorporeal membrane oxygenation (VV-ECMO). The patient was successfully supported through the acute lung injury and recovery phase and was discharged from the hospital within 16 days without supplemen …

26.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Stimuli-responsive bioengineered platforms for precision cancer therapy

Hossein Omidian, Renae L. Wilson

Stimuli-responsive bioengineered platforms are redefining cancer therapy by shifting therapeutic design from systemic drug exposure toward context-dependent activation within malignant tissue. These systems are engineered to sense and respond to tumor-associated or externally applied cues, including acidic pH, redox imbalance, hypoxia, enzymatic activity, reactive oxygen species, temperature variation, light, ultrasound, and magnetic fields. Across the reviewed evidence, their principal value lies not merely in dru …

26.08.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Fu's Subcutaneous Needling Therapy Combined with Intra-Articular Injection of Hyaluronic Acid in Knee Osteoarthritis

Sujie Zhang, Xiaohong Mu

Objective This study investigated the effects of Fu's subcutaneous needling (FSN) combined with sodium hyaluronate (HA) intra-articular injection on knee function and inflammatory factor levels in patients with knee osteoarthritis (KOA). Materials and Methods A total of 122 patients with KOA were randomly assigned to an observation group (OG) or control group (CG). Outcomes included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), serum inflammatory cytokines, Lysholm Knee Scoring Scale (LKSS …

26.08.2026journal-article

Exploration of Digestive Diseases

Testosterone replacement therapy in metabolic dysfunction-associated steatotic liver disease: a bench-to-bedside narrative review

Yuchang Li, Vassilios Papadopoulos

Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with obesity, insulin resistance, and increased cardiovascular risk. Male hypogonadism has emerged as a potentially modifiable risk factor, and testosterone replacement therapy (TRT) has been proposed as a potential adjunctive treatment for MASLD and metabolic dysfunction-associated steatohepatitis (MASH) in hypogonadal men. Cross-sectional and longitudinal studies demonstrate a consistent inverse association between serum testo …

26.08.2026journal-article

BMC Cancer

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Michail Sideris, Eleni Maniati, Tanjina Kader, Sandro Santagata, Ronny Drapkin, Frances Balkwill, Ranjit Manchanda

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) remain poorly defined. Methods We performed trajectory-based transcriptomic reconstruction of Fallopian-tube epithelial regions spanning histologically normal-appearing epithelium, precursor lesions, STIC, and invasive carcinoma using pseudoti …

26.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Aerobic versus Core‑stabilization Training after Caudal Epidural Steroid İnjection for Lumbar Disc Herniation

Serpil Arslan, Ceyhun Türkmen, Kenan Şimşek, Tülin Düger

Objective: To compare the effects of adding supervised aerobic or core stabilization exercise to physiotherapy on pain and function after caudal epidural steroid injection (CESI) in individuals with lumbar disc herniation (LDH) and radicular pain. Design: Three-arm parallel-group randomized controlled trial with 12-week follow-up. Thirty-five individuals were divided into three groups. For six weeks, the control group received physiotherapy. Aerobic and stabilization groups received the same programme plus 20 min o …

26.08.2026journal-article

Journal of modern medicine

EFFECTIVENESS OF DIFFERENTIATED THERAPY FOR FIBROCYSTIC BREAST DISEASE IN WOMEN WITH OVARIAN DYSFUNCTION CONSIDERING HORMONAL STATUS

Z.R. Kholdarova, D.Sh. Polatova

<p>Fibrocystic mastopathy developing in the setting of ovarian dysfunction is a heterogeneous hormone-dependent condition whose clinical course is largely determined by disturbances in hypothalamic-pituitary-ovarian regulation. Luteal phase insufficiency, anovulatory cycles, relative estrogen excess, progesterone deficiency, and abnormalities in prolactin secretion stimulate proliferative processes in breast tissue and may reduce the effectiveness of standard unified treatment regimens.</p><p style="text-align: jus …

26.08.2026journal-article

Journal of Nursing, Midwifery and Allied Health Sciences

Knowledge, Attitudes, Availability and the Use of Digital Health Tools Among Public Health Nurses in Primary Health Care Centres in Rivers State, Nigeria

Deborah Unity Atikpe, Grace Odinkenma Onyeabor

Background: Digital health adoption in primary health care remains poorly understood in Rivers State, Nigeria, where Public Health Nurses (PHNs) serve as the frontline health workforce. Most prior Nigerian studies have not measured infrastructure availability as an independent variable, limiting the accuracy of findings on adoption barriers. Objective: To assess knowledge, attitudes, availability, and utilisation of digital health tools among PHNs in Rivers State and identify independent predictors of utilisation. …

26.08.2026journal-article

Journal of Xenobiotics

Tri-Combination Antiretroviral Therapy Induces Dose- and Time-Dependent Disruption of Intestinal Epithelial Barrier Function and Repair Responses in Human T84 Cells

Yaswanthi Yanamadala, Kuppan Gokulan, Sangeeta Khare

Antiretroviral therapy (ART) is essential for controlling human immunodeficiency virus (HIV) infection, requiring strict daily adherence for lifelong viral suppression. However, this continuous oral dosing results in persistent exposure of the gastrointestinal tract (GIT), raising the need to investigate the effects of TC-ART (Tri-combination Abacavir, Dolutegravir, Lamivudine–ART) on epithelial integrity, barrier recovery mechanisms, and surface barrier architecture. TC-ART exposure (125 µM to 4000 µM) showed mark …

26.08.2026journal-article

World Journal of Stem Cells

Letter to the Editor: Metabolic reprogramming - unlocking the full potential of stem cell therapy in wound repair

Si-Feng Wang, Xiang-Wen Peng

The study by Dilimulati et al published in the World Journal of Stem Cells offers an elegant and powerful solution to the “Achilles’ heel” of stem cell therapy: Poor post-transplantation survival. The authors demonstrate that a simple pretreatment with alpha-ketoglutarate activates hypoxia-inducible factor-1α, a master metabolic switch, endowing adipose-derived stem cells with dual survival advantages: A “shield” enhances antioxidant defence via glutamine metabolism, and “sustenance” glycogen reserves to counteract …

26.08.2026journal-article

Frontiers in Neurology

Mapping traditional Chinese medicine-related complementary interventions for cerebral palsy rehabilitation: a bibliometric and visualization analysis

Zhuoluo Zhou, Ting Wang, Xiaoye Li, Bowen Deng, Houjun Zhang, Yu Jiang, Yuxin Xue, Lin Xu, Xiaohong Mu, Jinyu Li

Purpose This bibliometric and scientometric study mapped the development, collaboration structure, thematic organization, and temporal evolution of Chinese- and English-language research on traditional Chinese medicine (TCM)-related interventions for cerebral palsy (CP). Methods Publications were retrieved from Web of Science Core Collection, Scopus, PubMed, Embase, China National Knowledge Infrastructure, Wanfang Data, and the Chinese Science and Technology Journal Database from inception to July 20, 2026. Eligibl …

26.08.2026journal-article

Computational nanotechnology

The research of optimization of electric motor speed control based on an improved particle swarm algorithm for upper limb rehabilitation robot

Yu Daquan, Evgenii V. Pustovalov

To improve the stability of motor operation in upper limb rehabilitation robots, a method for tuning parameters of the sliding mode control (SMC) based on an improved particle swarm optimization algorithm has been proposed, and the output effect of the optimized control system has been simulated and validated. This paper designed a simulation model of the joint motor for an upper-limb rehabilitation robot based on a sliding-mode controller. At the same time, the traditional particle swarm optimization algorithm has …

26.08.2026journal-article

Journal of Clinical Medicine

Unintended Interruption of Caplacizumab Therapy Can Compromise Outcomes in Immune-Mediated Thrombotic Thrombocytopenic Purpura: Lessons from Two Clinical Cases

Fedai Özcan, Fahri Kiziler, Paul Brinkkoetter, Lucas Kühne, Paul Knöbl, Alexandra Brinkhoff

Background: Caplacizumab is a cornerstone in the management of immune-mediated thrombotic thrombocytopenic purpura (iTTP), in combination with plasma exchange (PEX) and immunosuppression. Pivotal trials and real-world data have demonstrated faster platelet count recovery and improved remission rates. Nevertheless, a subset of patients still experiences exacerbations or delayed response. Observational evidence suggests that unintended treatment interruptions may contribute to these unfavorable outcomes. Methods: We …

25.08.2026journal-article

Al Muhafidz: Jurnal Ilmu Al-Qur'an dan Tafsir

Ethics of Communication on Social Media from the Perspective of Muhammad Hasbi Ash-Shiddieqy’s Exegesis: An Analysis of the Concept of Hate Speech in the Qur’an

Muhammad Almi, Muhammad Yasir, Zailani Zailani, Masyhuri Putra, Nasrul Fatah

Technological developments have changed communication patterns, with digital platforms often triggering hate speech and social conflict. The Qur'an provides ethical speech guidelines emphasizing honesty, prohibiting slander, and promoting caution in conveying information. This study examines Muhammad Hasbi Ash-Shiddieqy's exegesis of Qur'anic verses related to hate speech and formulates ethical speech principles for social media from his perspective. Using qualitative library research with thematic exegesis (tafsir …

25.08.2026journal-article

Extensio: Revista Eletrônica de Extensão

Perfil esportivo e de lesões em atletas atendidos pelo Projeto de Extensão de Fisioterapia Desportiva (DESUFISIO)

Laura Bortolozzo Leitão, Gabriela Willinghoefer, João Carlos da Silva, Erick Becker Salgado, Livia Arcêncio do Amaral, Alessandro Haupenthal

Dada a necessidade de experiência na área esportiva e a escassez de disciplinas específicas no ensino superior, surgem projetos de extensão e ligas acadêmicas voltadas para temática. Neste estudo, o objetivo foi descrever o perfil esportivo e de lesões em atletas atendidos pelo Projeto de Extensão de Fisioterapia Desportiva (DESUFISIO), no período de 2017 a 2019. O projeto oferece serviços de fisioterapia para atletas amadores. Foram incluídos nesta análise 58 atletas, sendo 20 pacientes do sexo feminino e 38 do se …

25.08.2026journal-article

Clinical Rehabilitation

Reliability and validity of the Upper Limb Performance Assessment for functional prehension tasks in adults with stroke: A prospective study

Julie Lacombe, Solène Piagno, Benoit Lepage, Margot Morin, Judy Ranka, Camille Cormier, David Gasq, Claire Villepinte

Background Managing upper limb motor performance in daily living is a challenge for adults with stroke. Current assessments demonstrate limitations for evaluation of personalised activity performance in real environments. Objective To examine the reliability, validity, clinical utility and interpretability of a standardised ecologically task-based assessment of upper limb motor performance in post-stroke adults using the Upper Limb Performance Assessment. Design A prospective validation study. Setting A neurorehabi …

25.08.2026journal-article

American Journal of Speech-Language Pathology

Analysis of Speech-Language Pathologist and Preprofessional Student Observations of Parent–Child Play Interactions

Alaina Grissom, Rachel Sinclair, Lydia Barry, Erinn H. Finke

Purpose: Initial clinical observations help establish a strengths-based caregiver coaching relationship and guide intervention planning. This study examined what caregiver–child communication strategies speech-language pathologists (SLPs) and master's-level graduate students prioritize when making an initial observation of a naturalistic play interaction. Method: Twenty American Speech-Language-Hearing Association–certified SLPs and 20 master's-level graduate students reviewed videos of caregiver–child play interac …

25.08.2026journal-article

International Journal of Psychosexual Therapy

104: Addressing Religious Trauma with Conventionally Religious Clients

Mark Yarhouse

Clinicians have encountered increasing numbers of clients who report psychological distress associated with harmful religious experiences. While religion and spirituality are well established in the literature as potential sources of meaning, resilience, and coping, they may also function as contexts in which trauma occurs. This paper presents conceptual background to the construct of religious trauma. We then offer case studies of religious trauma to help identify the practical considerations in conceptualization …

25.08.2026journal-article

International Journal of Psychosexual Therapy

305: Reconstructing Intimacy When Painful Sex Occurs in a relationship: a male support group perspective

Ronnie Burke

Many women experience painful intercourse at some point in their lives, and this condition can profoundly impact their partners and the overall intimacy within the relationship. When painful sex occurs, couples often find themselves needing to renegotiate their connection, especially in terms of the withdrawer and pursuer dynamics that commonly arise in intimate relationships. While much attention has been given to supporting women who suffer from genital pain, there is minimal information and support available for …

25.08.2026journal-article

International Journal of Psychosexual Therapy

105: Culturally Responsive Interventions for Sexual Anxiety: Lessons from Working with Muslim Clients

Mariam Aziz

Sexual anxiety is a pervasive factor in many sexual difficulties, yet its treatment must be grounded in an understanding of the client’s cultural and religious context. Among Muslim clients, sexual anxiety often develops within complex intersections of restrictive sexual scripts, gender expectations, religious interpretations, and limited sexual education. These intersecting influences contribute to performance anxiety, guilt, and inhibition that can significantly impair sexual functioning and relational intimacy.T …

25.08.2026journal-article

Journal of Clinical Medicine

Systemic Citrate Toxicity During Regional Citrate Anticoagulation for Continuous Kidney Replacement Therapy

Sebastien Redant, Rachid Attou, Mircea T. Talpos, Patrick M. Honoré

Regional citrate anticoagulation (RCA) is the preferred anticoagulation strategy for continuous kidney replacement therapy (CKRT) because it prolongs circuit lifespan while reducing bleeding complications compared with systemic heparin. Although generally safe, systemic citrate accumulation remains the principal metabolic complication of RCA and occurs when citrate delivery exceeds the combined metabolic and extracorporeal capacity for citrate elimination. This narrative review summarizes current evidence regarding …

25.08.2026journal-article

JMIR Research Protocols

Empowered Relief vs Cognitive Behavioral Therapy for Patients With Systemic Lupus Erythematosus and Chronic Pain: Study Protocol for a National, Randomized, Noninferiority Trial

Titilola Falasinnu, Arayam Y Hailu, Emma Adair Monson, Jessica Clifton, Calia Torres, Troy C Dildine, Brittany Dorsonne, Elizabeth Heggan, Gabrielle Riazi, Kristen Slater, Heather Poupore-King, Luzmercy Perez, James Hellewell, Lu Tian, Steve Denton, Andrea DeVries, Jackie Miefert, Sean C Mackey, Matthias Cheung, Beth D Darnall

Background Systemic lupus erythematosus (SLE) presents substantial life challenges, reflecting the complex and heterogeneous nature of the disease. Pain is common and often one of the earliest manifestations. Skill-based behavioral pain treatments are often inaccessible to patients with SLE, and no SLE-specific evidence exists to guide patient and clinician treatment choices. To fill a pressing evidence gap for SLE pain treatment, the Lupus PROGRESS (Pain Relief With Online Groups That Empower Skill-Based Symptom R …

25.08.2026journal-article

CADERNOS DE EDUCAÇÃO, SAÚDE E FISIOTERAPIA

PERFIL EMPREENDEDOR DOS ACADÊMICOS DE FISIOTERAPIA DA UNIFAL-MG: ESTUDO OBSERVACIONAL

Ingrid Bárbara Campos dos Santos Campos dos Santos, Elaine Maria Ogueira, Anna Karoline Lopes Rocha Lopes Rocha, Laíza Helena Viana, Simone Botelho

Introduction and Objective: The Federal Council of Physical Therapy and Occupational Therapy (COFFITO) defines a physical therapist as a healthcare professional with higher education, qualified for diagnosis and prescription of physiotherapeutic treatments. After graduation, physical therapists face challenges that require the practical application of acquired skills, including entrepreneurial abilities. This study aimed to identify the entrepreneurial profile of students in the Physical Therapy program at the Fede …

25.08.2026journal-article

Nuclear Medicine Communications

Single-photon emission computed tomography/computed tomography-based radiomics of bone metastases for predicting epidermal growth factor receptor mutation status and targeted therapy efficacy in non-small-cell lung cancer

Xiangxiang Li, Shasha Hou, Shen Wang, Qiang Jia, Wei Zheng

Background This study aimed to develop a single-photon emission computed tomography/computed tomography (SPECT/CT)-based radiomics model using bone metastases to predict epidermal growth factor receptor (EGFR) mutation status and the efficacy of targeted therapy in patients with non-small-cell lung cancer. Methods This retrospective study included 240 patients with non-small-cell lung cancer. Among them, 205 were analyzed for the EGFR-mutation prediction model, and 210 for the targeted therapy efficacy model. Basel …