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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Statistics in Medicine

A Guide for Exploring Pleiotropic Associations in Genome‐Wide Association Studies Using Summary Statistics

Christina Y. Feng, Pierre‐Emmanuel Sugier, Nan Zou, Benoit Liquet

ABSTRACT Genome‐wide association studies (GWAS) have shown that pleiotropy, whereby a single genetic variant or gene influences multiple traits, is common in complex human diseases. Detecting cross‐phenotype associations from GWAS summary statistics remains challenging because of small effect sizes, extensive multiple testing, heterogeneous effects, and possible differences in effect direction across traits. Methods that jointly analyze multiple traits can improve the ability to detect pleiotropic signals while ret …

28.08.2026journal-article

Journal of Neurological Surgery Part A: Central European Neurosurgery

Mini-Invasive Neurosurgical Treatment of Subdural Empyema: A Two-Patient Case Series

Ejona Rifat Isakaj Lilamani, Aurora Arben Muça, Arben Jonuz Rroji, Artid Agron Lame, Arba Firdus Cecia, Mithat Ismail Demneri, Arsen Haki Seferi, Ridvan Hamid Alimehmeti

Abstract Subdural empyema is a neurosurgical emergency traditionally managed with craniotomy and prolonged intravenous antibiotic therapy. Minimally invasive approaches may represent an alternative in selected cases, particularly when combined with timely diagnosis and targeted antimicrobial treatment. We report two cases of subdural empyema treated with minimally invasive burr-hole evacuation. A 22-year-old man with developmental anomalies and postischemic stroke history presented with intermittent high fever for …

28.08.2026journal-article

INTERNATIONAL JOURNAL OF PUBLIC HEALTH RESEARCH AND DEVELOPMENT

COMPARATIVE ASSESSMENT OF PUBLIC HEALTH EMERGENCY SUPPLY CHAIN AND PHARMACEUTICAL PREPAREDNESS IN PLATEAU AND NASARAWA STATES, NIGERIA, BENCHMARKED AGAINST FEDERAL STANDARDS

James Soujah Abu, Abah Michael Idoko, Adamu Ishaku Akyala, Vincent-Vera Okwosa, Olasunkanmi Samson Coker, Onojah Matthew

Subnational health systems in Nigeria are central to public health emergency response, yet comparative, indicator-based evidence on state-level supply chain and pharmaceutical preparedness remains limited. This study compared emergency supply chain and pharmaceutical preparedness in Plateau and Nasarawa States, Nigeria, and benchmarked Nasarawa State against federal preparedness standards. A comparative, indicator-based assessment was conducted using administrative records, logistics management information system ( …

28.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Prognostic value of Amyloid PET in Real-World Amnestic MCI: Influence of reader experience and interpretation method

Beatriz Echeveste, Edgar Fernando Guillén, Elena Prieto, Katharina C. E. Hirschmüller, Mario Riverol, Javier Arbizu

Abstract Purpose This study assessed the prognostic value and inter-/intra-observer reliability of three amyloid PET interpretation methods—conventional visual reading, assisted visual interpretation and standardized uptake value ratio (SUVR)-based quantification—for predicting conversion to Alzheimer’s disease (AD). Methods This retrospective longitudinal study included 145 patients with amnestic mild cognitive impairment who underwent amyloid PET and were followed for up to 8 years at a single memory clinic. Two …

28.08.2026journal-article

New Zealand Medical Journal

How can we value what is not measured: the need for better data on women’s health and primary care

Fiona Imlach, Natalia Boven, Vanessa Selak

Decisions about healthcare funding and delivery in Aotearoa New Zealand, as well as the monitoring of health service performance and outcomes, are driven by readily available data, in particular from administrative health datasets. Most of these national health data collections are generated through the delivery of secondary health services. Further, apart from hospitalisation and mortality collections, these lack diagnostic coding, rendering the burden and cost of chronic health conditions predominantly managed in …

28.08.2026journal-article

Records Management Journal

Productive rigidity: why electronic document and records management systems still matter in Estonia’s public sector

Sidra Azmat Butt, Ingrid Pappel, Dirk Draheim, Riina Palu

Purpose This study aims to examine why electronic document and records management systems (EDRMS) continue to play a central role in digitally advanced public-sector environments, despite the rise of cloud collaboration and artificial intelligence (AI) tools, using Estonia as a case. The paper introduces productive rigidity to explain how compliance structures stabilise recordkeeping while still allowing gradual change. Design/methodology/approach A qualitative case study approach: five semi-structured interviews w …

28.08.2026journal-article

International Journal of Public Health and Nursing

Mitigating the Respiratory Health Impacts of Air Pollution on Urban Youth: An Analysis of Policy, Community and Individual Protective Responses

Hai Binh Nguyen, Minh Chinh Pham

Air pollution is an increasingly consequential environmental health risk for young people in rapidly urbanizing areas. Yet respiratory risk is shaped not only by pollutant exposure but also by policy effectiveness, community support and individual protective behaviour. This study develops and tests a multilevel framework integrating air-pollution exposure, policy management and control, community action, youth protective awareness and respiratory health symptoms. The original dataset contained 438 questionnaire rec …

28.08.2026journal-article

Hypertension Research

Antihypertensive therapy tailored to the circadian blood pressure profile as precision medicine

Francesca Coccina, Chiara Cuccurullo, Rosa Scurti, Sante D. Pierdomenico

Abstract Circadian blood pressure (BP) values may be different from clinic BP values. Thus, antihypertensive therapy guided solely by clinic BP might not prove appropriate. Moreover, ambulatory BP parameters are superior to clinic BP in predicting outcomes, indicating they should receive more attention as therapeutic targets. Among all relevant 24-h BP parameters, in both untreated and treated patients, two clinically unpredictable windows with proven prognostic relevance deserve attention: the period after awakeni …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Reproductive Endocrine Mechanisms Regulating Ovarian Reserve in Polyendocrine Metabolic Ovarian Syndrome

Yixin Feng

This paper investigates the reproductive endocrine mechanisms of the ovarian reserve in polyendocrinopathy, autoimmune polyglandular syndrome type 1 (APCOS), which is a new term for polycystic ovary syndrome (PCOS). Rather than viewing ovarian reserve as a single number, the paper believes that the concept of reserve in PMOs should be understood through the interplay of follicle number, follicular arrest, granulosa-cell signalling, gonadotropin imbalance, androgen excess and metabolic disturbances. Based on the maj …

28.08.2026journal-article

Nutrition Bulletin

Plant‐Based Diet and Sleep Quality in Adults: Exploring the Role of Lifestyle and Health Mediators

Márcia de Oliveira Lima, Júlia Souza de Melo, Larissa de Lima Soares, Risia Cristina Egito de Menezes, Renan Serenini, Giovana Longo‐Silva

ABSTRACT This study investigated the association between plant‐based dietary indices (PDI) and sleep quality and examined the mediating roles of lifestyle and health‐related factors. A total of 5260 participants (18–65 years) were included. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). PDI—including overall (oPDI), healthy (hPDI), unhealthy (uPDI), and pro‐vegetarian diet index (PVDI)—was derived from a food frequency questionnaire covering 15 food groups. Associations between each PDI …

28.08.2026journal-article

Journal of Immigrant and Minority Health

Healthcare Services Use and Satisfaction Among Iraqi and Syrian Refugees in San Diego: A Qualitative Study

Nissma Bencheikh, Omar Barakat, Ariana Khayamian, Lana Bridi, Nour Makarem, Tala Al-Rousan

Abstract Arabic-speaking refugees in the United States face an elevated burden of chronic disease yet encounter significant barriers to care, and little research has examined their experiences in the U.S. primary care system. This study characterizes the patient experiences of Syrian and Iraqi refugees in San Diego to identify factors that enhance or hinder healthcare integration and satisfaction. Semi-structured interviews lasting 30 to 90 min were conducted in Arabic with 109 Syrian and Iraqi refugees residing in …

28.08.2026journal-article

Salud Medicina e Innovación Journal

Responsabilidad profesional del odontólogo frente a la sospecha de maltrato infantil: revisión sistemática de la evidencia clínica, ética y jurídica

Brayan Santiago1 Escobar-Hernández, Pablo Sacaquirín-Zhunio, Ramón Esteban Peñafiel-Maldonado, María Eugenia Mogrovejo Avila, Viviana León-Rodríguez, Miriam Fernanda Ortega López

Introduction: Child maltreatment often causes injuries to the head, neck, and oral cavity, placing dentists in a position to detect possible cases during clinical care. Evidence on their legal responsibilities remains dispersed across bioethics, forensic dentistry, and oral healthcare. Objective: To synthesize the available scientific evidence on dentists’ legal responsibilities in suspected cases of child maltreatment, with emphasis on professional duties and the legal consequences of acting or failing to act. Met …

28.08.2026journal-article

Journal of Mechanics in Medicine and Biology

OPTIMIZING LOCKING COMPRESSION PLATE DESIGN VIA SEGMENTAL STEPPED THICKNESS: A BIOMECHANICAL SIMULATION APPROACH

GOURAV SINGH, AJAY PANDEY

Locking compression plates (LCPs) are widely utilized in orthopaedic fracture fixation due to their superior mechanical stability and reliability. However, conventional LCPs fabricated from nonbiodegradable metals often cause stress shielding, long-term biocompatibility concerns, and necessitate secondary removal surgeries. Biodegradable alternatives such as magnesium (Mg) alloys have emerged as promising substitutes owing to their biocompatibility and controlled resorption, yet they frequently exhibit insufficient …

28.08.2026journal-article

Academia Drug Development and Pharmacotherapy

Micelles in cancer nanomedicine: targeted delivery, imaging, and therapy

Amirhossein Rashnoodi, Zaynab Seraj, Niyoosha Zamani, Bahareh Khalili Najafabad

Despite advancements in oncology, conventional cancer therapies remain limited by poor specificity, systemic toxicity, and suboptimal therapeutic indices. Micellar nanostructures have emerged as a transformative platform to overcome these hurdles, leveraging their amphiphilic nature to encapsulate hydrophobic agents within aqueous biological environments. This review evaluates the current landscape of micelle-based technologies in cancer management, focusing on their integration into medical physics through diagnos …

28.08.2026journal-article

REST Journal on Data Analytics and Artificial Intelligence

Comparative Analysis of Public Economic Domains: A Weighted Product Method Approach

Manjula Selvam

This study employs the Weighted Product Method (WPM) to comprehensively evaluate and compare five critical domains of public economics: Development Economics, Political Economy, Environmental Economics, Health Economics, and Labour Economics. Health Economics, and Labour Economics. The fields are assessed using four key criteria: relevance, effectiveness in addressing market failures, criticism and limitations, and influence on inequality. The results indicate notable differences among the economic domains, with La …

28.08.2026journal-article

Annals of Public and Cooperative Economics

The market presence of cooperative banks and stability in European banking: New evidence

Hans Groeneveld

Abstract Most studies examining differences between cooperative banks (CBs) and other banking institutions rely on bank‐level data, thereby overlooking effects of the market presence of CBs on banking market structures. To address this gap, we test whether CB's domestic market share predicts national banking stability ( Z ‐scores) using a unique panel dataset for 15 European countries spanning 1991–2024 and a two‐way fixed‐effects framework. Our empirical findings confirm that CBs contribute to overall banking stab …

28.08.2026journal-article

JMIR Nursing

A One-Year Study Using Digital Biomarkers From Sensing Technologies to Assess Changes in Physical Activity Levels and Sleep Quality in Nursing Home Residents With Dementia: Observational Study

Lydia D Boyle, Monica Patrascu, Bettina S Husebo, Kristoffer Haugarvoll, Ole Martin Steihaug, Brice Marty

Abstract Background Proxy-rated questionnaires remain the standard for the assessment of activity and sleep for people with dementia living in nursing homes. Sensing technologies, such as wearables, can generate continuous data that provide quantitative insights into daily activities and behavioral and psychological symptoms, such as sleep disturbance. This study explores the use of sensing technologies in the detection of changes in physical activity levels and sleep behaviors over time. Objective This study aims …

28.08.2026journal-article

Eirene Estudios de Paz y Conflictos

Buenas prácticas y cultura de paz en una universidad pública

Antonio Gómez-Nashiki, Karin Yovana Quijada Lovatón

El artículo tuvo como objetivo recuperar valoraciones, opiniones, estrategias y propuestas de docentes sobre las buenas prácticas que promueven la cultura de paz en una universidad estatal mexicana. El estudio fue de corte cualitativo y la información se obtuvo mediante entrevistas semiestructuradas a treinta y un docentes de diferentes licenciaturas. La investigación se apoyó en el método de Teoría fundamentada, mediante un proceso de análisis constante que se desarrolló en tres fases. Entre los principales result …

28.08.2026journal-article

Journal of Radiological Protection

Angular distributions of secondary neutron and photon ambient dose equivalent in proton therapy: a systematic PHITS 3.35 study at 70–250 MeV

Thi Yen Hong Huynh, Huu Ngan Thy Truong, Hong Hai Vo, Hoa Lang Trinh

Abstract Monte Carlo simulation of secondary neutron and photon dosimetry — specifically the ambient dose equivalent H*(10) — is central to radiation protection in pencil-beam scanning (PBS) proton therapy. We report particle and heavy ion transport code system (PHITS) version 3.35 calculations of H*(10) for proton beams from 70 to 250MeV incident on a water phantom representative of the Ion Beam Applications Blue Phantom, scored at 11 emission angles at 80 cm using International Commission on Radiological Protecti …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

Social Organizations’ Embedding in Grid-Based Governance: A Resource Dependence Perspective on Pathways and Mechanisms

Jiarui Ma

With the increasing complexity of grassroots governance and diversified social demands, traditional grid-based governance faces challenges such as insufficient governance resources and limited capacity for social participation. As an important actor connecting the state and society, social organizations have become increasingly involved in grassroots governance. Based on resource dependence theory, this study explores the pathways and mechanisms of social organizations’ embedding in grid-based governance. It argues …

28.08.2026journal-article

Journal of Pediatric Hematology/Oncology

Implementation of a Digital Clinical Management Platform in a Tertiary Pediatric Hemato-Oncology Center: Impact on Clinical Outcomes and Patient Safety

Michal Singer, Uri Ilan, Guy Dolinski, Nitsan Halabi, Yuliana Edri, Nisim Rahman, Sigal Sina, Maor Sagi, Sivan Tam, Moshe Ashkenazi

Introduction: Healthcare delivery is increasingly challenged by rising demand, escalating costs, and the need for efficiency. Contributing factors such as the nursing workforce crisis, fragmented and excessive clinical data, outdated IT infrastructures, and the growing complexity of care exacerbate the risk of medical errors, treatment delays, and staff burnout. To address these challenges, we evaluated AMIT, a novel digital platform designed to support nursing practice in pediatric oncology. Methods: AMIT is a web …

28.08.2026journal-article

APIK Journal of Internal Medicine

Efficacy of N-acetylcysteine in Acute Paraquat Poisoning: An Open-label, Parallel-group, Randomized Controlled Trial

Cheekatla Venkata Santosh, Mandip Singh Bhatia, Atul Saroch, Navneet Sharma, Neeraj Singla, Saurabh Chandrabhan Sharda

Abstract Background: Paraquat poisoning is associated with high mortality due to oxidative stress-induced multiorgan failure. No specific antidote is available. N-acetylcysteine (NAC) has shown potential benefit in preclinical studies, but robust evidence of its clinical efficacy is lacking. Objectives: This study was designed to evaluate the effects of intravenous NAC on organ dysfunction and mortality among patients with acute paraquat poisoning. Methods: We conducted an open-label, parallel-group, randomised con …

28.08.2026journal-article

Scientific Bulletin of the Dnipro State University of Internal Affairs

ПУБЛІЧНІ ПОСЛУГИ ДЛЯ ЖЕРТВ ЗБРОЙНОГО КОНФЛІКТУ: ЦИФРОВІЗАЦІЯ ТА АДМІНІСТРАТИВНО-ПРАВОВЕ РЕГУЛЮВАННЯ

Михайло ЛОШИЦЬКИЙ

Статтю присвячено комплексному адміністративно-правовому аналізу системи надання публічних послуг жертвам збройного конфлікту в Україні в умовах триваючої цифровізації. Актуальність дослідження зумовлена масштабними гуманітарними наслідками збройного конфлікту, активізованого у лютому 2022 р., що виявив інституційну неготовність системи публічного адміністрування до ефективного реагування на відповідні нагальні потреби постраждалого населення. У роботі визначено концептуальні підходи до розуміння поняття «жертва зб …

28.08.2026journal-article

Clinical and Experimental Dermatology

Extramammary Paget Disease: A Review

Farishta Khan, Shweta Karakara, Zhenghao Wang, Honey Frimpong-Manso, Birgitta van Bodegraven, Jane Sterling, Paul Craig, Andrew Nordin, Zoe C Venables

Abstract Extramammary Paget disease (EMPD) is defined by the World Health Organisation (WHO), as ‘a rare adenocarcinoma characterized by a predominant intraepithelial growth of neoplastic cells originating in the skin (primary EMPD) or representing intraepithelial spread of an underlying visceral carcinoma (secondary EMPD)’(1).It affects areas rich in apocrine glands, such as genital and perianal skin. First described by Radcliffe Crocker in 1889, EMPD often remains confined to the epidermis for years, following a …