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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Clinical Psychology & Psychotherapy

Imagery Interventions and Cognitive‐Behavioural Therapy for Psychological Complaints Related to Bullying: A Systematic Review and Meta‐Analysis

Meng Liang, Gerly Tamm, Olivia De Laere, Yannick Vander Zwalmen, Ernst H. W. Koster

ABSTRACT Bullying is associated with internalizing symptoms and impaired everyday functioning. Cognitive‐behavioural therapy (CBT) and imagery interventions have been studied as treatments to improve mental health after such experiences. This meta‐analysis aimed to evaluate the effects of individual CBT and imagery interventions in targeting internalizing symptoms (negative affect, depression, anxiety and post‐traumatic stress symptoms) and improving self‐perception and coping in bullying victims. Systematic search …

27.08.2026journal-article

International Journal of Humanities and Social Science

The Geography of Everyday Exclusion: Third Spaces and Occupational Inequality in Delhi NCR

Siya Jain

Third spaces that sit between home (first space) and work (second space) are often described as neutral ground that is open and accessible to everyone. This study questions that assumption in the context of Delhi NCR (Delhi, Noida, Gurgaon, Ghaziabad), asking whether formal and informal (precarious) workers experience and access these spaces on equal terms. A structured questionnaire including largely quantitative questions was designed and administered to 116 workers, comprising 50 formal and 66 informal workers ( …

27.08.2026journal-article

Anaesthesiology Intensive Therapy

Disrupted thyroid hormone homeostasis in critical illness: clinical correlates and associations with hormone supplementation in a single-center retrospective observational study

Alicja Filipczyk, Szymon Zdanowski, Jan Kasprzyk, Karolina Niedzielska, Artur Rakhatsevich, Magdalena Anna Wujtewicz, Tomasz J. Stefaniak, Karol P. Steckiewicz

Background Thyroid hormone disturbances are a hallmark of critical illness and are commonly attributed to non-thyroidal illness syndrome. The clinical relevance of thyroid hormone supplementation in the intensive care unit (ICU) remains uncertain. This study aimed to characterize thyroid hormone concentrations in relation to disease severity in critically ill patients receiving thyroid hormone supplementation. Methods In this single-center retrospective study, data from 98 ICU patients receiving thyroid hormone sup …

27.08.2026journal-article

Frontiers in Immunology

A dual-action humanized DKK-1 antibody that activates the Wnt/β-catenin signaling pathway and inhibits the RANKL signaling pathway for osteoporosis therapy

Sheng Hou, Tianyu Gao, Yimei Wu, Hao Wang, Dapeng Zhang, Qingcheng Guo, Jin Xu, Huaizu Guo, Weizhu Qian

Introduction Osteoporosis remains a major global health challenge, and current single-pathway therapies often fail to achieve coordinated bone remodeling. Dickkopf-1 (DKK-1) is a potent inhibitor of the Wnt/β-catenin signaling pathway and plays a critical role in osteoporotic bone loss. Neutralization of DKK-1 represents a promising therapeutic strategy to promote bone formation while simultaneously inhibiting bone resorption. Methods A humanized anti-DKK-1 monoclonal antibody (IgG4) was generated via CDR grafting …

27.08.2026journal-article

Physical and Engineering Sciences in Medicine

Development of a customized three-dimensional bolus using transparent gel wax and its application in electron beam therapy

Young Jin Won, Jung Ju Jo, Su Ah Yu, Su Jung Shim, Kum Bae Kim, Jung Hoon Kim, Sang Hyoun Choi, Samju Cho

Abstract This study aimed to develop a customized bolus using commercially available transparent gel wax (TGW) without requiring 3D printing technology and to evaluate its applicability in radiotherapy, including its physical and dosimetric characteristics. A dental alginate impression was taken from the curved surface of a mastectomy phantom to replicate the patient’s skin contour. Based on this, a silicone mould was fabricated, into which TGW was poured to form the customized bolus. The fabricated bolus was evalu …

27.08.2026journal-article

Annals of the ICRP

Avoidance of errors originating from image-guided radiation therapy

A. Isambert, J. Vassileva, C.J. Martin

Since the 1990s, significant technological developments for the preparation and delivery of radiation treatment have resulted in the need for the use of more advanced imaging in radiotherapy. However, errors in treatment (events that can lead to unintended and accidental medical exposures and near misses) can occur while using these images. Several sources provide information feedback on events reported in the use of imaging. Events recorded in Radiation Oncology Incident Learning Systems, reports and newsletters f …

27.08.2026journal-article

Neuro-Oncology

109 Multi-omic integration reveals intra-tumour heterogeneity and identifies disulfiram and copper as a synergistic therapy in paediatric ependymoma

Alina Pandele, Alison Whitby, Sandra Martinez-Jarquin, Chiara Bastiancich, Donald Macarthur, Ian Kamaly-Asl, David Barrett, Richard Grundy, Dong-Hyun Kim, Ruman Rahman

Abstract Introduction Ependymoma (EPN) is the second most malignant paediatric brain tumour. The PF-A subgroup, associated with a hypoxic microenvironment, has a dismal survival rate of 50%, with clinical trials failing to demonstrate a significant survival advantage from chemotherapy to date. We present a multi-omic integration investigating whether spatially-distinct tumour microenvironments represent targetable metabolic niches in PF-A EPN. Methods Surgical sampling of spatially-distinct regions from eight PF-A …

27.08.2026journal-article

JCI Insight

Monocyte Correlates of Neurocognitive Impairment in Chronic HIV infection, Early, Persistent Changes with Antiretroviral Therapy

Hai Duc Nguyen, Andrew K. Ding-Su, Caroline Soulas, Tricia H. Burdo, Patrick Autissier, Pasiri Sithinamsuwan, Nitiya Chomchey, Jintanat Ananworanich, Victor Valcour, Silvia Ratto-Kim, Woong-Ki Kim, Kenneth C. Williams

Rationale: Persistent monocyte activation contributes to HIV-associated neurocognitive disorders (HAND), yet biomarkers that predict neurocognitive impairment before and after antiretroviral therapy (ART) remain incompletely defined. Objectives: We evaluated monocyte subsets and activation markers in participants from the SEARCH007 cohort prior to ART initiation and at 6 and 12 months following treatment. Methods and Results: Increased frequencies of CD14+CD16+ monocytes and elevated CD163 expression were associate …

27.08.2026journal-article

Scientific Reports

Non-invasive detection of obstructive sleep apnea from speech in a limited clinical dataset

Martina Skapova, Pavol Partila, Jaromir Tovarek, Tereza Lubojacka, Jana Slonkova, Ondrej Hruby, Samuel Genzor, Jan Mizera, Petr Mooz

Abstract This study investigates non-invasive detection of obstructive sleep apnea (OSA) from daytime speech in a limited polysomnography-labeled clinical cohort. The objective was to evaluate whether speaker-verification-inspired representations can support robust speech-based OSA screening under constrained clinical data conditions. We compared conventional mel-frequency cepstral coefficient (MFCC)-based classifiers with i-vector systems using cosine-similarity, support vector machine (SVM), and neural-network (N …

27.08.2026journal-article

Small

PDA‐Engineered 3D‐Printed Polymer–ZrO 2 Hybrid Scaffolds Enabling Enhanced Radiopacity, Photothermal Therapy, and Cell Migration Modulation

Sumin Kang, Yun‐Jin Jeong, Seokjae Kim, Van Du Nguyen, Songah Jeong, Juyeong Jo, Arunkumar Shanmugasundaram, Jin Uk Jeong, Dong‐Weon Lee, Eunpyo Choi, Hyungwoo Kim

ABSTRACT The clinical translation of bioresorbable polymer scaffold is limited by radiolucency, insufficient mechanical strength, and the absence of post‐implantation therapeutic control. This study introduces a multifunctional scaffold that addresses these challenges through a polymer–ceramic nanocomposite architecture and bioinspired surface modification. ZrO 2 nanoparticles are uniformly embedded into poly(ε‐caprolactone) (PCL) via solution blending and fabricated into vascular scaffold by fused deposition model …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Implementing the IMB model combined with rehabilitation nursing to promote rehabilitation and self-management in coronary heart disease patients

Jinjin Gong, Xinmei Zhang

Objective To examine the association between routine Information-Motivation-Behavioral Skills (IMB) model-based rehabilitation nursing and rehabilitation-related outcomes and self-management behaviors in patients with coronary heart disease (CHD). Methods This single-center retrospective cohort study included 150 patients with CHD admitted to Shandong Provincial Third Hospital from January 2024 to February 2025. After ethics approval, data were extracted from existing clinical and nursing records. Patients were ret …

27.08.2026journal-article

International Journal of Rehabilitation Research

Activity and participation after transient ischemic attack: a scoping review

Thea B. Ransby, Sara J.S. Hermansen, Stina Meyer Larsen, Louise M. Nielsen

Transient ischemic attack (TIA) is traditionally regarded as a condition with full recovery. However, emerging evidence suggests that some individuals experience residual symptoms, limiting their activity and participation in everyday life. The objective was to systematically map and synthesize existing evidence on activity limitations and participation restrictions following TIA. A scoping review was conducted following the framework proposed by Arksey and O’Malley and further outlined by Levac et al . A comprehen …

27.08.2026journal-article

Annals of Nuclear Medicine

[18F]FDG PET/CT role in FUO among patients with end-stage renal disease on renal replacement therapy

Domenico Albano, Chong Jiang, Francesco Bertagna

Abstract Objective End-stage renal disease (ESRD) patients undergoing renal replacement therapy (RRT) are at increased risk of infections, inflammatory disorders, and malignancies because of immune dysfunction, repeated vascular access procedures, and immunosuppressive therapy after kidney transplantation. Fever of unknown origin (FUO) is particularly challenging to investigate in this population, and evidence regarding the role of [18 F]FDG PET/CT remains limited. This study evaluated the diagnostic performance, c …

27.08.2026journal-article

Frontiers in Medicine

Upper border of anal transitional zone: a new landmark for endoscopic internal hemorrhoid therapy

Jingyao Li, Huiyan Li, Hao Xu, Jing Dong, Tiantian Guo, Hongjiao Yao, Qi Yang

Background and aim Endoscopic therapies are important approaches for managing internal hemorrhoids. This study assessed the feasibility of endoscopic examination of the upper border of anal transitional zone (ATZ) and its clinical utility and underlying anatomical basis as a landmark for internal hemorrhoid. Methods Mucosal demarcation line (MDL) and the dentate line were identified and measured in 207 adults using white-light and narrow band imaging (NBI) endoscopy, with three biopsies for histologic confirmation. …

27.08.2026journal-article

Journal of Innovative Healthcare Practices

Scientific and Technological Transformation in Vestibular Rehabilitation: Neurophysiology-Based, Personalized, and Integrated Approaches

Muhammed Celal Eryılmaz

Vestibular rehabilitation therapy (VRT) is undergoing a paradigm shift toward a mechanistically informed, multisensory, and technologically integrated model. This narrative review synthesises current evidence on how this transformation is driven by advances in neurophysiology, diagnostic precision, and immersive technologies such as virtual reality (VR), which collectively enhance personalization and therapeutic efficacy. Traditional approaches that primarily targeted peripheral deficits are now complemented by str …

27.08.2026journal-article

International Journal of Environmental Research and Public Health

Micro- and Nanoplastic Exposure in Hospital Environments: A Scoping Review of Occupational Risks Among Healthcare Workers, with Particular Implications for Nursing

Otniel Alencar Bandeira, Lucas Barros de Araújo, Aline Franco da Rocha, Estefanía Coello Gonçalves Canedo, Vivian Vílchez Barboza, Weber da Silva Robazza, Gabriela Frutuozo Müller, Gilberto Costa Teodozio, Maria Lúcia do Carmo Cruz Robazzi

The extensive use of plastic-based materials in healthcare services has raised concerns about micro- and nanoplastic contamination in hospital environments, with potential implications for occupational health, environmental health, and public health nursing. This scoping review aimed to map the available evidence on occupational exposure to micro- and nanoplastics in healthcare settings, identifying exposure sources, pathways, potential health implications, and knowledge gaps, with particular attention to healthcar …

27.08.2026journal-article

Clinical Journal of Health Sciences

Dialectical Behavior Therapy for Borderline Personality Disorder: A Systematic Review

Damla Rana Altunay, Meryem Karaaziz

There are numerous studies in the literature examining the effects of Dialectical Behavior Therapy (DBT) on patients with Borderline Personality Disorder (BPD). The aim of this systematic review is to synthesize studies on DBT and Borderline Personality Disorder to examine the effects of Dialectical Behavior Therapy on patients with BPD and to observe how differences in the treatment process and content influence patient outcomes. This study was conducted using a systematic review methodology and did not involve pr …

27.08.2026journal-article

Phonetica

Integrating human linguistic insights into AI: theory-driven representation for multilingual text-to-speech

Cong Zhang, Huinan Zeng, Huang Liu, Jiewen Zheng

Abstract This paper explores the integration of human linguistic insights into multilingual text-to-speech (TTS) systems by evaluating the Featurally Underspecified Lexicon (FUL) as a theory-driven input representation. Unlike data-intensive end-to end models, FUL offers a compact, interpretable feature set grounded in phonological principles, enabling scalable and equitable TTS development for low-resource languages. We provide a mapping from language-specific phones to FUL feature vectors via a SAMPA intermediate …

27.08.2026journal-article

BMC Cancer

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Fatih Kus, Fatih Atalah, Gokhan Sahin, Caner Kapar, Damla Gunenc, Erkut Demirciler, Alper Topal, Halil Goksel Guzel, Yakup Duzkopru, Mert Erciyestepe, Ilgin Koc Kus, Omer Denizhan Tatar, Firat Sirvan, Gozde Agdas, Bilgesah Kilictas, Irem Ugurlu, Abdussamet Celebi, Goncagul Akdag, Dogan Bayram, Aysegul Merc Cetinkaya, Ilknur Deliktas Onur, Taliha Guclu, Omer Faruk Elcicek, Sendag Yaslikaya, Elif Sahin, Pinar Gursoy, Ozturk Ates, Abdullah Sakin, Harun Muglu, Murad Guliyev, Nigar Rustamova Cennet, Melike Ozcelik, Melek Karakurt Eryilmaz, Ahmet Bilici, Nebi Serkan Demirci, Mehmet Ali Sendur, Saadettin Kilickap, Derya Kivrak Salim, Ozlem Er, Gamze Gokoz Dogu

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectable, recurrent, or metastatic TC who received second-line systemic therapy after prior systemic therapy between 2010 and 2023 were retrospectively analyzed. Treatments were categorized as multidrug chemotherapy, gemcitabine monotherapy, PD-1 …

27.08.2026journal-article

Diagnostics

Digital Patient-Reported Monitoring of Functional Recovery After Robot-Assisted Radical Prostatectomy in High-Risk Prostate Cancer Treated With or Without Perioperative Hormonal Therapy

Bogdan Adrian Buhas, Alessandro Uleri, Giorgio Calleris, Guilhem Roubaud, Marine Lesourd, Benjamin Pradère, Christophe Tollon, Damien Pouessel, Bernard Malavaud, Loïc Mourey, Guillaume Ploussard

Background/Objectives: Perioperative androgen-deprivation therapy (ADT) and androgen-receptor pathway inhibitors (ARPIs) are increasingly used in high-risk prostate cancer, yet patient-centred functional-recovery data after radical prostatectomy are scarce and rarely standardized. We assessed whether a smartphone-based digital monitoring pathway could characterize social-continence recovery and capture differences associated with a perioperative hormonal therapy (PHT) strategy after robot-assisted radical prostatec …

27.08.2026journal-article

Science and Engineering Ethics

Implications for Care Relationships in Technology-Supported Stroke Rehabilitation: A Qualitative Interview Study

Julie Bechtel, Alena Buyx, Bettina M. Zimmermann

Abstract This study explores how technology-supported rehabilitation reshapes the relationships between patients and therapists. Additionally, it examines how empirical findings can inform early design decisions. Qualitative interviews with patients and therapists identified their perceptions of PhysioMio, a wearable sensor-based rehabilitation device that detects muscle activity to monitor rehabilitation progress and enable independent home-based training. Adapting an ethics of care perspective, we focus on the si …

27.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

The mediating role of social appearance anxiety in the relationship between instagram social comparison and cosmetic surgery acceptance: Implications for workplace wellbeing

Hatice Balci

Background Visually oriented social media use has increased social comparison processes and appearance-related concerns, potentially affecting psychosocial well-being, job burnout, and attitudes toward cosmetic surgery in professional settings. Objective This study examined the effects of Instagram-based social comparison, social media addiction, and social appearance anxiety on cosmetic surgery acceptance, with a focus on testing the mediating role of social appearance anxiety and investigating differences across …

27.08.2026journal-article

Nature Journal of Emerging Sciences Technologies and Innovations

<b>Deep learning-based multi-speaker separation and speech enhancement for forensic audio analysis</b>

Oluwaseun Adeniyi Ojerinde, Rasheed Taiwo Mudasiru, Ramatu Abubakar, Benjamin Ilunuamie Alenoghena

The increasing use of audio recordings in criminal investigations has created a growing demand for intelligent forensic audio analysis systems capable of recovering intelligible speech from acoustically challenging environments. Forensic recordings frequently contain overlapping speakers, background conversations, and environmental noise, making reliable speaker identification and evidence extraction difficult. This study proposed a hybrid deep learning framework for multi-speaker separation and speech enhancement …

27.08.2026journal-article

Physical Therapy Journal of Indonesia

Physical Performance Profiling of Elite Female Sepak Takraw National Athletes A Modern Sport Science Approach

I Utamayasa

Background: Sepak takraw is a high-intensity net-barrier sport requiring explosive lower-limb power, agility, speed, flexibility, and anaerobic endurance. Despite its growing international competitiveness, limited scientific evidence exists regarding comprehensive physical performance profiling specifically for elite female national athletes. Physical performance profiling has become a cornerstone of modern sport science, offering objective benchmarks to evaluate athletes’ capabilities relative to competition deman …