Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Alle Themen · Seite 32

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Clinical Immunology

Preferential Retention of the LMP-1 Promoter at EBV Integration Sites in Lymphomas: Evidence from Cartilage Hair Hypoplasia and Controls

Zachery W. Dickson, Lari Pyöriä, Annika Kangas, Eetu Pello, Leo Hannolainen, Aino Mutka, Hanna-Leena Kukkola, Pasi Huttunen, Yossra H. S. Zidi-Mouaffak, Klaus Hedman, Mervi Taskinen, Panu E. Kovanen, Svetlana Vakkilainen, Maria F. Perdomo, Outi Mäkitie

Abstract Purpose Cartilage-Hair Hypoplasia (CHH), a rare ribosomopathy characterized by immune deficiency, carries a markedly increased risk of early-onset malignancy, particularly lymphoma. However, the molecular drivers of malignant transformation in CHH, and the contribution of viruses to this process, remain poorly defined. Methods We performed targeted virome sequencing of 41 DNA viruses on FFPE tumor samples (primarily lymphomas) from 15 CHH patients and three malignancy-matched controls per patient. Subseque …

28.08.2026journal-article

Molecular Medicine

Deletion of protein tyrosine phosphatase 1B in hepatocytes attenuates inflammation, steatosis, and fibrosis in a dietary mouse model of metabolic dysfunction-associated steatohepatitis

Ming-Fo Hsu, Yoshihiro Ito, Ulrik Mjaaseth, James Graham, Peter J. Havel, Fawaz G. Haj

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver-related morbidity and mortality. The current interventions are limited, underscoring the need for novel mechanism-based therapies. Protein tyrosine phosphatase 1B (PTP1B) regulates phosphotyrosine signaling and hepatic metabolism, but its role in MASH remains incompletely understood. Methods To elucidate the impact of modulating PTP1B expression in MASH, we used mice with hepatocyte-specific PTP1B disruption in t …

28.08.2026journal-article

Frontiers in Public Health

Patient perspectives on pain care pathways: informing implementation with insights from trial evidence

Lindsay A. Ballengee, Susan N. Hastings, Trevor A. Lentz, Katlin Harker, Steven Z. George

Background Few studies have examined whether patients' perceptions of low back pain (LBP) care pathways are influenced by evidence of their effectiveness. To inform future implementation efforts, we conducted an exploratory qualitative study examining how individuals with low back pain interpreted two pain care pathways that emphasized non-drug treatment options: a physical therapy–focused model (Sequenced Care Pathway) and a navigator-led model (Pain Navigator Pathway). We explored how individuals with low back pa …

28.08.2026journal-article

Frontiers in Public Health

A multicenter cross-sectional study on proactive health knowledge, attitude, and practice and its influencing factors among resident standardized training physicians in Guangxi

Qian Zeng, Jichen He, Kun Ye, Xuepeng Du, Jianzhen Chang, Qiaoying Wei, Shenglin Liang

Objective The purpose of this study is to examine the state of proactive health knowledge, attitude, and practice (KAP) among Guangxi’s resident standardized training physicians as well as the factors that affect it. The results will be used to optimize health management strategies. Methods A multicenter cross-sectional survey was conducted. Univariate analysis was used to compare differences in proactive health KAP among residents with different characteristics, and multivariate linear regression was performed to …

28.08.2026journal-article

LGBT Health

Well-Being Among Sexual and Gender Minority Victims of Intimate Partner Violence: A Scoping Review

Hannah R. Seidman, Ivy K. Ho

Purpose: This review aimed to provide an overview of the well-being outcomes identified among sexual and gender minority (SGM) victims of intimate partner violence (IPV). Methods: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines for scoping reviews. Results were extracted from APA PsycInfo, APA PsycArticles, CINAHL, CINAHL Plus with Full Text, and MEDLINE. Studies were included if participants were aged 18 or older, identified as a sexual and/or gender minority …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Antibacterial resistance in dermatology: a modern perspective on the problem and the place of amoxicillin/clavulanic acid in the treatment of bacterial skin infections

E.V. Svechnikova, S.E. Zhufina

Introduction. The problem of microbial resistance to antibacterial drugs is becoming increasingly pressing each year and poses a global threat to public health. In dermatological practice, systemic antibiotics are widely used for both skin and soft tissue infections and chronic inflammatory dermatoses (acne, rosacea, hidradenitis suppurativa), which increases the risk of resistant strain selection and microbiome disruption. Objective. To analyze current literature data and our own clinical observations, as well as …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Correction of facial skin aging signs using exosomes

T.N. Korolkova, I.A. Shepilova, T.G. Dovbeshko

Background. Skin aging is a multifactorial process caused by internal mechanisms and external influences. Gradual changes in the epidermis and dermis lead to impaired skin functions. Restoring these functions is an important task. Objective. Evaluation of the results of using a two-component complex with exosomes in patients with signs of facial skin aging. Material and methods. During this study, 22 patients (mean age 53.1±1.3 years) with Fitzpatrick skin phototypes I-III, wrinkles and other signs of facial aging …

28.08.2026journal-article

REST Journal on Data Analytics and Artificial Intelligence

A Multi-Criteria Assessment of Gastrointestinal Nursing Specialties: Insights from the MOORA Approach

Srividya Velmurugan

The quality of gastrointestinal nursing services plays an important role in improving patient outcomes and satisfaction. This study assessed five specialties—Digestive Health Nursing, GI Endoscopy Nursing, Colorectal Nursing, Hepatology Nursing, and Abdominal Nursing—using four major criteria: patient assessment and monitoring, care planning and implementation, patient education and support, and professional collaboration. The MOORA(Multi-Objective Optimization on the basis of Ratio Analysis) method was applied to …

28.08.2026journal-article

Statistics in Medicine

Penalized Cumulative Probability Model for a Continuous Outcome Subject to Detection Limits

Shuai Sun, Valeria R. Mas, Kellie J. Archer

ABSTRACT Mixed‐type outcome data occur when the outcome variable's distribution is a mixture of both continuous and discrete ordinal variables. Such mixed‐type outcomes are common in biomedical, psychological, and the health sciences, particularly for variables having either a detection or quantitation limit. When interest lies in identifying a combination of genomic features associated with a mixed‐type outcome, any method used would require a variable selection strategy for high‐dimensional data. Unfortunately, f …

28.08.2026journal-article

Medicine

Genetically proxied circulating PD-1/PD-L1 levels and broadly defined myocarditis

Fengyi Liu, Qian Yang

Myocarditis is an inflammatory myocardial disease with potentially severe outcomes. Programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) regulate immune tolerance, but the association between lifelong genetically proxied circulating PD-1/PD-L1 levels and broadly defined myocarditis remains uncertain. We investigated these associations and explored related plasma lipid species. We conducted bidirectional 2-sample Mendelian randomization using proteomic genome-wide association data from the UK …

28.08.2026journal-article

Medicine

Impact of an educational intervention on rational laboratory test ordering and healthcare costs in family medicine

Muhammet Şahinol, Hüseyin Nejat Küçükdağ

This study aims to analyze the impact of “Rational Laboratory Test Ordering” training given to family medicine residents on their test request habits, number of tests, and costs. A total of 27,085 applications made to the Family Medicine Polyclinic of Düzce University Faculty of Medicine between June 1, 2022, and June 1, 2024, were retrospectively examined. Based on the educational intervention provided to resident doctors on June 1, 2023, the periods before and after were compared in terms of the total number of t …

28.08.2026journal-article

Medicine

Temporal maintenance of an adolescent suicide attempt screening score in national surveys

Xiaotian Ma, Su Jia, Junjie Zhang

Screening scores may retain risk ranking while their probabilities become inaccurate in later populations. The information needed to repair this temporal drift is rarely quantified for adolescent suicide screening. We analyzed 5 independent national Youth Risk Behavior Survey cross sections from 2015 through 2023. Of 81,401 sampled students, 68,682 had observed past year attempt status. A survey weighted 2015 ridge score based on 14 harmonized predictors was frozen and transported to 4 later surveys. For each later …

28.08.2026journal-article

Critical Care & Emergency Medicine

Radiofrecuencia convencional y pulsada armonizada en el ganglio de Gasser para el tratamiento de la neuralgia del trigémino: resultados del protocolo Dolomedic

Francisco Javier Machuca Vigil, Rafael Orlando Vallejo Estrella, Roberto Jameson Rosales, Francesca Dolciami, Eduardo Perez Lozano

Objectives: To describe the experience with the Dolomedic protocol, which combines conventional radiofrequency (CRF) and harmonized pulsed radiofrequency (PRF) of the Gasserian ganglion, for the treatment of refractory trigeminal neuralgia. Material and Methods: A retrospective study was conducted in 77 patients with unilateral type 1 and 2 trigeminal neuralgia treated between July 2020 and July 2025 at Dolomedic Alta Especialidad (Heroica Matamoros, Mexico). The percutaneous approach to the Gasserian ganglion was …

28.08.2026journal-article

Critical Care & Emergency Medicine

Reanimación con líquidos guiada por metas en choque séptico: estado actual y controversias

Diego Escarraman Martinez

La administración de fluidos intravenosos constituye la piedra angular en la reanimación inicial del choque séptico; sin embargo, el exceso de líquidos se ha asociado directamente con peor pronóstico, edema tisular y mayor mortalidad. La presente revisión analiza el paso de una reanimación liberal a estrategias restrictivas y guiadas por parámetros dinámicos de respuesta a volumen en pacientes críticos.

28.08.2026journal-article

The Open Nursing Journal

Effectiveness of the Basic Infection Control Skills License (BICSL) Training Program on Nurses' Knowledge, Attitudes, and Practices in Makkah, Saudi Arabia

Azizah Banafi, Noor Mastura Mohd Mujar

Introduction Healthcare-associated infections (HCAIs) remain a major global health concern. In Saudi Arabia, the Basic Infection Control Skills License (BICSL) program was introduced to standardize infection prevention and control (IPC) training among healthcare workers. However, evidence on its effectiveness among nurses remains limited. Methods A multicenter, quasi-experimental, one-group pre-post study was conducted among 360 nurses from 5 public hospitals in Makkah, Saudi Arabia, during the 2024 BICSL implement …

28.08.2026journal-article

Polymers for Advanced Technologies

Advancements in Sodium Alginate‐Based Colloidal Drug Delivery Systems: Bridging Research Into Clinical Practice

Ashutosh Gupta, Aniket Navale, Debadrita Ghosh, Parekh Nirmit Jigneshkumar, Kuljeet Kaur, Aditya Dev Rajora, Soji Soman, Sally A. EL‐Zahaby

ABSTRACT Sodium alginate, an anionic polysaccharide obtained from brown algae and a versatile biomaterial for colloidal drug delivery systems. It has good biocompatibility, biodegradability, and mucoadhesive nature. Alginate has controlled and targeted drug delivery applications. This review discusses sodium alginate–based colloidal systems and presents fundamental research with potential for clinical translation. Alginate can undergo ionic crosslinking with divalent cations such as calcium with a wide range of del …

28.08.2026journal-article

Journal of Clinical Medicine

Diagnostic and Clinical Patterns of Newly Diagnosed ANCA-Associated Vasculitis Before and After the 6 February 2023 Kahramanmaraş Earthquakes: A Multicenter Retrospective Study from Affected Provinces

Sezgin Zontul, Gezmiş Kimyon, Fuat Albayram, Anıl Göçer, Rabia Sağır, Aylin Dolu Karaca, Elif İnanç, Zeynep Kaya, Mesude Seda Aydoğdu, İpek Balıkçı Çiçek, Gözde Yıldırım Çetin, Servet Yolbaş

Background/Objectives: The relationship between large-scale natural disasters and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) remains uncertain. This study compared crude case numbers, diagnostic patterns, and clinical characteristics of newly diagnosed AAV before and after the 6 February 2023 Kahramanmaraş earthquakes in Türkiye. Methods: This multicenter retrospective study included patients newly diagnosed with AAV between 6 February 2020 and 5 February 2026 at five tertiary referral c …

28.08.2026journal-article

Europe’s Journal of Psychology

Effectiveness of cognitive behavioural therapy on sleep outcome for patients with chronic fatigue syndrome in a routine clinical service

Chotiman Chinvararak, Olivia Sterry, Trudie Chalder

Objective We aimed to study the effectiveness of CBT for sleep difficulties in patients with chronic fatigue syndrome/myalgic encephalitis (CFS/ME). Method We conducted a retrospective cohort study at the Persistent Physical Symptoms Research and Treatment Unit, Maudsley Hospital, between 2014 and 2019. The primary outcome was sleep quality and other sleep parameters assessed by the Pittsburgh Sleep Quality Index (PSQI). The secondary assessments comprised the Chalder Fatigue Questionnaire (CFS), the Work and Socia …

28.08.2026journal-article

International Journal for Quality in Health Care

Cultural determinants and strategic priorities for medication safety in acute care: a multidisciplinary Delphi study

Neville Schembri, Hannah-Kim Grima Formosa, Kevin Holmes, Marie Clare Cassar, Shane Desselle, Timothy F Chen, Maria Cordina, Lorna Bonnici West

Abstract Background Organisational culture, defined as the shared values, assumptions, and norms that influence behaviour within organisations, is widely recognised as a key determinant of patient safety in healthcare systems. Within acute care settings, medication safety represents a critical component of patient safety and depends on the ability of healthcare professionals to recognise risks, communicate openly, and intervene before errors result in patient harm. However, medication use is inherently interdiscipl …

28.08.2026journal-article

CLEAN – Soil, Air, Water

Integrated Assessment of Organochlorine Pesticide Residues in Soil and Pepper: Ecological and Human Health Risks

M. B. Adekola, A. M. Taiwo, B. S. Bada, T. M. Oladipo, N. A. Amusa, A. A. Alli, J. O. Alabi, M. F. Olorunnishola, E. N. Danton, S. T. Idowu, Z. O. Afolabi, A. A. Awujoola, R. O. Mustapha, S. S. Oshiomogho, A. M. Olabode

ABSTRACT This study investigated organochlorine pesticide (OCP) residues in agricultural soils and pepper samples to assess their ecological and human health risks. Eighty soil samples (pre‐[40] and post‐[40] pesticide application) and 40 pepper samples were analysed using gas chromatography–mass spectrometry. Bioaccumulation factors (BAFs), health and ecological risk assessments were carried out. Before pesticide application, soils already contained detectable OCP residues, particularly α‐BHC (5.0–5.3 µg/kg) and γ …

28.08.2026journal-article

Acta Paediatrica

Trends in Childhood Underweight in Norwegian Children: Data From Routine Child Healthcare, 2010–2022

Sara‐Rebekka Færø Linde, Roy Miodini Nilsen, Mathieu Roelants, Melissa R. Balthasar, Jennifer L. Baker, Dorthe C. Pedersen, Boye Welde, Marjolein M. Iversen, Petur B. Juliusson, Anne‐Siri Fismen

ABSTRACT Aim This study examined age‐ and sex‐specific prevalence and trends in underweight among Norwegian children and adolescents during the pre‐pandemic period from 2010 to 2019 and COVID‐19 pandemic period from 2020 to 2022. Methods Height and weight data from 78 024 children aged 2 to 13 years in Bergen from 2010 to 2022 were obtained from public health clinic and school health service records. Underweight grades 1 to 3 were defined using the International Obesity Task Force cut‐offs. Age‐ and sex‐specific pr …

28.08.2026journal-article

The Journal of Medicine, Law & Public Health

A Comparison of Patterns, Predictors, and Help-Seeking Behaviours Related to Intimate Partner Violence Among Women in Rural and Urban Communities of Osun State

Ojediran Joke Oluwatoyin, Onayade Adedeji, Olarewaju Sunday, Akinwale John Faniyi

Background: Intimate partner violence (IPV) is a major public health problem with serious physical, psychological, sexual, and socioeconomic consequences for women. This study compared patterns, predictors, and help-seeking behaviours related to IPV among women in rural and urban communities in Osun State, Nigeria. Methods: A comparative cross-sectional mixed-methods study was conducted between May and July 2023 among 500 ever-partnered women (250 rural and 250 urban) selected through multistage sampling. Quantitat …

28.08.2026journal-article

International Journal of Innovative Technologies in Social Science

IMPACT OF OPIOID DEPRESCRIBING AND TAPERING ON MENTAL HEALTH AND SOCIAL FUNCTIONING IN PATIENTS WITH CHRONIC NON – CANCER PAIN: AN OVERVIEW OF CURRENT EVIDENCE

Mateusz Wnęk, Michał Adam Łebek, Wiktoria Zofia Komornik, Jakub Jan Piec, Damian Grębosz, Wojciech Kukiełka, Bartłomiej Andrzej Sałapski, Dominika Weronika Brożyna, Jarosław Dudek, Jakub Dawid Gałwiaczek

Background. Long-term opioid therapy for chronic non-cancer pain is associated with numerous adverse effects, including psychological distress, dependence, and impaired functioning. In response to growing concerns about opioid-related harms, opioid deprescribing and tapering strategies have gained increasing attention in clinical practice. However, their impact on patients’ mental health and social functioning remains incompletely understood. Aim. This review aimed to evaluate the available evidence on the effects …

28.08.2026journal-article

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale

26 | Health Action Zones profiling and protected discharge pathways in mental health: proposal of an integrated hospital–community care model in ASP Palermo

E. Modica, A. Di Benedetto, A. Li Puma, D. Lipari, A. Firenze

Background. Continuity of care is one of the most critical challenges in the management of patients with severe mental disorders who are at high risk of relapse and rehospitalization. Hospital discharge represents a crucial transition phase during which inadequate integration between hospital and community services may lead to treatment discontinuity and poor clinical outcomes. Analysis of psychiatric hospitalization data within ASP Palermo highlighted a high prevalence of admissions related to psychotic disorders, …